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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3739 products of "Cell Cycle/Checkpoint"

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  • IACS-4759

    CAS:
    IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes.
    Formula:C10H17N3O2
    Color and Shape:Solid
    Molecular weight:211.26
  • FINDY

    CAS:
    FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.
    Formula:C16H17NO2S2Si
    Color and Shape:Solid
    Molecular weight:347.53
  • MtTMPK-IN-6

    CAS:
    MtTMPK-IN-6 inhibits M. tuberculosis thymidylate kinase with IC50 of 29 μM, promising for TB research.
    Formula:C23H25N3O3
    Color and Shape:Solid
    Molecular weight:391.46
  • ERCC1-XPF-IN-1

    CAS:
    ERCC1-XPF-IN-1: potent ERCC1-XPF inhibitor (IC50: 0.49 μM), hampers CPD removal, boosts UV toxicity, hinders DNA repair.
    Formula:C28H32ClN5O2
    Color and Shape:Solid
    Molecular weight:506.04
  • ML372

    CAS:
    ML372 is a potent and selective SMN Modulator (EC50 = 12 nM, 325% increase inSMN2) with good potency, pharmacokinetics, tolerance, and CNS penetration.
    Formula:C18H20N2O4S
    Color and Shape:Solid
    Molecular weight:360.43
  • BMS-587101

    CAS:
    BMS-587101 is a small molecule antagonist of LFA-1, which can reduce inflammation and joint destruction in the mouse model of arthritis.
    Formula:C26H20Cl2N4O4S
    Color and Shape:Solid
    Molecular weight:555.43
  • c-Myc inhibitor 9

    CAS:
    c-Myc inhibitor 9 (compound 332) with logEC50 ≥6, suppresses tumors in mice, useful for cancer research.
    Formula:C27H31N5OS
    Color and Shape:Solid
    Molecular weight:473.63
  • CDK7-IN-20


    CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.
    Formula:C30H26N6O3
    Color and Shape:Solid
    Molecular weight:518.57
  • Integrin modulator 1

    CAS:
    Integrin modulator 1 is a selective α4β1 integrin agonist (IC50 9.8 nM) that enhances adhesion with EC50 12.9 nM, aiding integrin-dependent studies.
    Formula:C13H14N2O4
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:262.26
  • Chrysotobibenzyl

    CAS:
    Chrysotobibenzyl from Dendrobium pulchellum stems may trigger cell death in detached cells and hinder lung cancer growth.
    Formula:C19H24O5
    Color and Shape:Solid
    Molecular weight:332.39
  • 8RK64

    CAS:
    8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .
    Formula:C14H16N8O2S
    Color and Shape:Solid
    Molecular weight:360.4
  • 5,10-Dideazafolic acid

    CAS:
    <p>5,10-Dideazafolic acid is an antileukemic drug.</p>
    Formula:C21H21N5O6
    Color and Shape:Solid
    Molecular weight:439.42
  • CDK7-IN-13

    CAS:
    CDK7-IN-13 (compound 1) is an effective CDK7 inhibitor for investigating cancers associated with transcriptional dysregulation.
    Formula:C20H23F3N6OS
    Purity:99.22%
    Color and Shape:Solid
    Molecular weight:452.5
  • Indirubin-3'-monoxime-5-sulphonic acid

    CAS:
    Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively.
    Formula:C16H11N3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:357.34
  • Antibacterial agent 89

    CAS:
    Antibacterial agent 89 blocks bacterial transcription and clostridial cytotoxins, inhibiting β'CH-σ interactions.
    Formula:C21H10Cl2F3NO5S
    Color and Shape:Solid
    Molecular weight:516.27
  • P1788

    CAS:
    P1788 is a dihydroorotate dehydrogenase (DHODH) inhibitor that can induce DNA damage [1].
    Formula:C15H17NO3
    Color and Shape:Solid
    Molecular weight:259.3
  • DENV-IN-7

    CAS:
    DENV-IN-7, a flavone analog, inhibits dengue virus at 70 nM EC50 with low toxicity to normal cells.
    Formula:C24H22O8
    Color and Shape:Solid
    Molecular weight:438.43
  • BSJ-01-175

    CAS:
    BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.
    Formula:C30H33ClN6O2
    Color and Shape:Solid
    Molecular weight:545.08
  • DNA Gyrase-IN-5

    CAS:
    DNA Gyrase-IN-5 is a potent inhibitor of DNA gyrase (IC50: 0.10 μM) and has an antibacterial effect on both wild-type and drug-resistant strains.
    Formula:C25H15BrClN5
    Color and Shape:Solid
    Molecular weight:500.78
  • Syntelin

    CAS:
    Syntelin: a selective CENP-E inhibitor with an IC50 of 160 nM; distinct from GSK923295, effective on resistant mutants.
    Formula:C21H20N6O2S3
    Color and Shape:Solid
    Molecular weight:484.62
  • Zalunfiban

    CAS:
    RUC-4 is an aIIb 3 antagonist. It is also used for prehospital therapy of myocardial infarction.
    Formula:C16H18N8O2S
    Color and Shape:Solid
    Molecular weight:386.43
  • MDK6204

    CAS:
    MDK6204 is a selective inhibitor of CLK1 and CLK2.
    Formula:C20H20N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:360.41
  • Cylindrospermopsin

    CAS:
    Cylindrospermopsin: a toxic cyanobacterial uracil derivative, disrupts protein/glutathione synthesis in hepatocytes, and is genotoxic.
    Formula:C15H21N5O7S
    Color and Shape:Solid
    Molecular weight:415.42
  • Binucleine 2

    CAS:
    Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.
    Formula:C13H11ClFN5
    Color and Shape:Solid
    Molecular weight:291.71
  • IRE1α kinase-IN-7

    CAS:
    IRE1α kinase-IN-7 is a chemical compound functioning as an inhibitor of IRE1α kinase, primarily utilized in the research of diseases related to endoplasmic
    Formula:C28H25F3N6O
    Color and Shape:Solid
    Molecular weight:518.53
  • WF-536 Hydrochloride

    CAS:
    WF-536 Hydrochloride, a novel inhibitor of ROCK, inhibits tumour metastasis in some animal models.
    Formula:C14H16ClN3O
    Color and Shape:Solid
    Molecular weight:277.75
  • BA-1049

    CAS:
    BA-1049 is a selective ROCK2 inhibitor.
    Formula:C16H21N3O2S
    Color and Shape:Solid
    Molecular weight:319.42
  • XIE18-6

    CAS:
    XIE18-6 is a novel INK4C inhibitor that blocks p18 activity and promotes ex vivo expansion of human and murine hematopoietic stem cells.
    Formula:C18H15NO6S
    Purity:99.712%
    Color and Shape:Solid
    Molecular weight:373.38
  • CI-898 HCl

    CAS:
    CI-898 HCl: lipophilic antifolate, DHFR inhibitor, effective on methotrexate-resistant cancers, synergizes with other drugs in advanced P338 leukemia.
    Formula:C19H26Cl3N5O3
    Color and Shape:Solid
    Molecular weight:478.8
  • CDK4/6-IN-14

    CAS:
    CDK4/6-IN-14: potent CDK4/6 inhibitor, IC50s 10/16 nM, >60-fold selectivity over CDKs 1/2/7/9, selective across 205 kinases.
    Formula:C24H27ClFN7O
    Color and Shape:Solid
    Molecular weight:483.97
  • Trimetrexate glucuronate

    CAS:
    Trimetrexate glucuronate, a folic acid foe, blocks DNA/RNA synthesis by inhibiting purine and thymidylic acid production, may fight tumors.
    Formula:C25H33N5O10
    Color and Shape:Solid
    Molecular weight:563.564
  • TCS 2314

    CAS:
    TCS 2314 is an orally active and selective very late antigen-4 antagonist (IC50: 4.4 nM).
    Formula:C28H34N4O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:522.59
  • ROCK-IN-4

    CAS:
    ROCK-IN-4: Inhibits ROCK, sustains NO release, disrupts F-actin, hinders HTM cell respiration, aids glaucoma research.
    Formula:C20H26ClFN4O7S
    Color and Shape:Solid
    Molecular weight:520.96
  • USP28-IN-2

    CAS:
    USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.
    Formula:C23H20Cl2N2O3S
    Color and Shape:Solid
    Molecular weight:475.39
  • JH-XIV-68-3

    CAS:
    JH-XIV-68-3: Selective DYRK1A/B inhibitor; effective in HNSCC cell lines.
    Formula:C21H17F3N8O
    Color and Shape:Solid
    Molecular weight:454.41
  • Akt1&PKA-IN-2

    CAS:
    Akt1&PKA-IN-2 ((R)-29) inhibits AKT1, PKAα, CDK2 with IC50s: 0.007, 0.01, 0.69 µM respectively.
    Formula:C20H17Cl2N3O
    Color and Shape:Solid
    Molecular weight:386.27
  • CDK1-IN-1

    CAS:
    CDK1-IN-7 inhibits CDK1 at 161.2 nM, triggers p53-dependent apoptosis, and selectively targets tumor growth.
    Formula:C27H23N5O3
    Color and Shape:Solid
    Molecular weight:465.5
  • FLDP-5

    CAS:
    FLDP-5: BBB-penetrant curcuminoid, induces ROS, DNA damage, S phase arrest, suppresses tumors in LN-18 cells.
    Formula:C21H21NO5
    Color and Shape:Solid
    Molecular weight:367.4
  • CDK7-IN-2

    CAS:
    CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.
    Formula:C26H39N7O3
    Color and Shape:Solid
    Molecular weight:497.63
  • CB10-277

    CAS:
    CB10-277 is a synthetic anti-cancer drug related to dacarbazine that alkylates DNA, inhibits DNA replication and repair, and may block DNA synthesis.
    Formula:C9H11N3O2
    Color and Shape:Solid
    Molecular weight:193.2
  • Edatrexate

    CAS:
    Edatrexate (CGP 30694), a Methotrexate analog, combats MTX-resistant tumors and researches various cancers.
    Formula:C22H25N7O5
    Color and Shape:Solid
    Molecular weight:467.48
  • HBV-IN-21

    CAS:
    HBV-IN-21 inhibits HBV DNA replication (IC50: 2.2 μM) and binds HBV capsid protein well (KD: 60.0 μM).
    Formula:C17H17FN4OS2
    Color and Shape:Solid
    Molecular weight:376.47
  • CDK4/6-IN-7

    CAS:
    <p>CDK4/6-IN-7 is an oral, potent CDK4/6 inhibitor with IC50s of 1.58/4.09 nM, crucial for breast cancer studies.</p>
    Formula:C18H18ClN5O3
    Color and Shape:Solid
    Molecular weight:387.82
  • CAY10760

    CAS:
    CAY10760 inhibits RAD51-BRCA2 interaction (EC50=19 μM), reduces homologous recombination by 54%, and hinders BxPC-3/Capan-1 cancer cell proliferation.
    Formula:C28H24ClN3O3
    Color and Shape:Solid
    Molecular weight:485.96
  • DHODH-IN-19

    CAS:
    DHODH-IN-19, a strong DHODH blocker, may help treat cancer and inflammation. (Patent WO2021238881A1)
    Formula:C22H18ClF6N3O3
    Color and Shape:Solid
    Molecular weight:521.84
  • TH470

    CAS:
    TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,
    Formula:C30H31N5O5S2
    Color and Shape:Solid
    Molecular weight:605.73
  • cp028

    CAS:
    cp028 inhibits pre-mRNA splicing in vitro.
    Formula:C23H17FN2O4
    Color and Shape:Solid
    Molecular weight:404.39
  • Aurora kinase inhibitor-10

    CAS:
    Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.
    Formula:C21H19F5N6O4S
    Color and Shape:Solid
    Molecular weight:546.47
  • Dyrk1A-IN-5

    CAS:
    Potent DYRK1A inhibitor with IC50s: 6 nM overall, 0.5 μM SF3B1, 2.1 μM tau phosphorylation. Useful for Down syndrome studies.
    Formula:C16H9IN2O2
    Color and Shape:Solid
    Molecular weight:388.16
  • Crozbaciclib fumarate

    CAS:
    Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.
    Formula:C32H34F2N6O4
    Color and Shape:Solid
    Molecular weight:604.65