Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(111 products)
- CDK(525 products)
- Cell Cycle Arrest(4 products)
- Chk(46 products)
- DYRK(49 products)
- Dynamin(26 products)
- Ferroptosis(224 products)
- HSP(180 products)
- Integrin(256 products)
- Kinesin(86 products)
- LIM Kinase(19 products)
- Microtubule Associated(284 products)
- PKC(111 products)
- PLK(25 products)
- ROCK(66 products)
- Rho(2 products)
- Wee1(14 products)
- c-Myc(75 products)
Show 10 more subcategories
Found 3749 products of "Cell Cycle/Checkpoint"
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VPC-70619
CAS:VPC-70619: Oral, selective N-Myc inhibitor; blocks cancer growth by hindering N-Myc-Max/DNA binding; well-absorbed.Formula:C16H8ClF3N4OColor and Shape:SolidMolecular weight:364.71SRPIN-803
CAS:SRPIN-803 is a selective dual SRPK1 and CK2 inhibitor.Formula:C14H9F3N4O3SPurity:98%Color and Shape:SolidMolecular weight:370.31SR31527
CAS:SR31527 chloride: potent KIFC1 inhibitor (IC50 6.6 µM), moderately impairs cell viability & colony growth.Formula:C15H14ClN3OSPurity:98%Color and Shape:SolidMolecular weight:319.81NSC 109555 ditosylate
CAS:Chk2 inhibitor,ATP-competitiveFormula:C26H32N10O4SPurity:98%Color and Shape:SolidMolecular weight:580.66JNJ-9676
CAS:<p>JNJ-9676 is an orally active inhibitor of the coronavirus membrane protein, thereby blocking viral assembly and release.coronavirus and SARS-CoV.</p>Formula:C28H21F2N5O2Purity:99.83%Color and Shape:SoildMolecular weight:497.5UR-3216
CAS:UR-3216 is a prodrug, selectively antagonizing GPIIb/IIIa receptors orally, with its active form, UR-2992, binding tightly to platelets.Formula:C27H29N7O7Purity:98%Color and Shape:SolidMolecular weight:563.56Atuveciclib S-Enantiomer
CAS:<p>Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.</p>Formula:C18H18FN5O2SPurity:98%Color and Shape:SolidMolecular weight:387.4314α-Demethylase/DNA Gyrase-IN-2
CAS:14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.Formula:C24H22N4O4Color and Shape:SolidMolecular weight:430.46AZD7762 HCl
CAS:AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.Formula:C17H20ClFN4O2SPurity:98%Color and Shape:SolidMolecular weight:398.88BDM44768
CAS:BDM44768 is an insulin-degrading enzyme (IDE) inhibitor that acts by inducing glucose intolerance.Formula:C24H22FN5O3Color and Shape:SolidMolecular weight:447.46OXA-06 Dihydrochloride
CAS:OXA-06 Dihydrochloride is a PANC-1 cell migration and MYPT1 phosphorylation inhibitor.Formula:C21H18FN3Purity:98%Color and Shape:SolidMolecular weight:331.39Valategrast
CAS:Valategrast: potent, oral dual α4β1/α4β7 integrin antagonist, may treat COPD and asthma.Formula:C30H32Cl3N3O4Purity:98%Color and Shape:SolidMolecular weight:604.95Aurora Kinases-IN-3
CAS:Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.Formula:C20H16F3N3O4Color and Shape:SolidMolecular weight:419.35Mps1-IN-4
CAS:Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.Formula:C26H31F3N6O2Color and Shape:SolidMolecular weight:516.56Akt1&PKA-IN-1
CAS:Akt1&PKA-IN-1 inhibits Akt/PKA: IC50 = 0.03μM (PKAa), 0.11μM (Akt), 9.8μM (CDK2); selective for CDK2.Formula:C20H17Cl2N3OColor and Shape:SolidMolecular weight:386.27PV-1115
CAS:PV-1115 is an effective and highly selective inhibitor of the Chk2.Formula:C20H19N7O3Purity:98%Color and Shape:SolidMolecular weight:405.41USP28-IN-2
CAS:USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.Formula:C23H20Cl2N2O3SColor and Shape:SolidMolecular weight:475.39CDK7-IN-8
CAS:CDK7-IN-8 is a potent inhibitor of CDK7 (IC50: 54.29 nM) and exhibits inhibitory activity against several cancer cells and in vivo tumor models.Formula:C25H38N8O3Color and Shape:SolidMolecular weight:498.62BAP1-IN-1
CAS:BAP1-IN-1 is an inhibitor of the catalytic activity of BRCA1-associated protein 1 (BAP1), which is related to cancer and can be used to study cancer.Formula:C18H16N2O2Purity:98.11%Color and Shape:SolidMolecular weight:292.33Thiarabine
CAS:Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.Formula:C9H13N3O4SPurity:98%Color and Shape:SolidMolecular weight:259.28Flurocitabine
CAS:Flurocitabine is a therapeutic agent with antineoplastic activity.Formula:C9H10FN3O4Purity:98%Color and Shape:SolidMolecular weight:243.19LY 207702
CAS:LY 207702, a difluorinated purine nucleoside, exhibits antitumor activity in preclinical models.Formula:C10H12F2N6O3Purity:98%Color and Shape:SolidMolecular weight:302.24BAY-707 acetate
CAS:BAY-707: potent, selective MTH1 inhibitor with excellent engagement and pharmacokinetics but no anticancer efficacy alone or combined.Formula:C17H24N4O4Color and Shape:SolidMolecular weight:348.18TIBI
CAS:TIBI is an ATP-competitive Rio1 inhibitor that acts in a similar manner to fungamycin and enhances the thermal stability of the enzyme.Formula:C7H2I4N2Purity:>99.99%Color and Shape:SolidMolecular weight:621.722'-Deoxy-L-guanosine
CAS:2'-Deoxy-L-guanosine is a nucleoside that shows antibiotic properties by inhibiting protein synthesis, leading to cell death.Formula:C10H13N5O4Color and Shape:SolidMolecular weight:267.24CDK4/6-IN-14
CAS:CDK4/6-IN-14: potent CDK4/6 inhibitor, IC50s 10/16 nM, >60-fold selectivity over CDKs 1/2/7/9, selective across 205 kinases.Formula:C24H27ClFN7OColor and Shape:SolidMolecular weight:483.97Crozbaciclib fumarate
CAS:Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.Formula:C32H34F2N6O4Color and Shape:SolidMolecular weight:604.65Dyrk1A-IN-5
CAS:Potent DYRK1A inhibitor with IC50s: 6 nM overall, 0.5 μM SF3B1, 2.1 μM tau phosphorylation. Useful for Down syndrome studies.Formula:C16H9IN2O2Color and Shape:SolidMolecular weight:388.16HBV-IN-15
CAS:HBV-IN-15, a flavone derivative, is a potent cccDNA inhibitor, potentially aiding HBV research.Formula:C24H23ClO6Color and Shape:SolidMolecular weight:442.89Myt1-IN-1
CAS:Myt1-IN-1 has anticancer effects that is a potent inhibitor of Myt1 with an IC 50 of <10 nM [1].Formula:C16H15ClN4O2Color and Shape:SolidMolecular weight:330.77Aurora kinase inhibitor-10
CAS:Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.Formula:C21H19F5N6O4SColor and Shape:SolidMolecular weight:546.47Eg5 Inhibitor V, trans-24
CAS:Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.Formula:C26H21N3O3Purity:99.75%Color and Shape:SolidMolecular weight:423.46LIMK1 inhibitor BMS-4
CAS:BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.Formula:C23H23N7O2SColor and Shape:SolidMolecular weight:461.54cp028
CAS:cp028 inhibits pre-mRNA splicing in vitro.Formula:C23H17FN2O4Color and Shape:SolidMolecular weight:404.39LSN 3213128
CAS:LSN 3213128: a potent oral antifolate targeting AICARFT with IC50s of 16 nM (enzyme) and 19 nM (cells), offers anti-tumor effects.Formula:C17H16FN3O4S2Color and Shape:SolidMolecular weight:409.45UR-2922
CAS:UR-2922: Oral GPIIb/IIIa blocker with <1 nM affinity, slow 90 min k(off), no LIBS or prothrombotic effects.Formula:C25H25N7O6Purity:98%Color and Shape:SolidMolecular weight:519.51SAR156497
CAS:SAR156497: selective Aurora A/B/C inhibitor; IC50: 0.5 nM (A), 1 nM (B), 3 nM (C); good metabolic stability; anti-tumoral without genetic specificity.Formula:C27H24N4O4Color and Shape:SolidMolecular weight:468.5CB 3717
CAS:CB 3717 is an enzyme inhibitor, antineoplastic agent, folic acid antagonist.Formula:C24H23N5O6Color and Shape:SolidMolecular weight:477.47HBV-IN-22
CAS:HBV-IN-22 (Compound LC5f) is an HBV DNA replication inhibitor that acts on both wild-type HBV (IC50: 0.71 μM) and drug-resistant HBV (IC50: 0.84 μM).Formula:C26H29N3O2S2Color and Shape:SolidMolecular weight:479.66DHODH-IN-15
CAS:DHODH-IN-15, a hydroxyfuran analogue of A771726, inhibits rat liver DHODH with an IC50 of 11 μM, and is used for rheumatoid arthritis.Formula:C15H11N3O3Purity:99.8%Color and Shape:SolidMolecular weight:281.27GSK3182571
CAS:GSK3182571 is a non-speci c kinase inhibitor[1].Formula:C25H31ClN8OColor and Shape:SolidMolecular weight:495.02ROCK2-IN-5
ROCK2-IN-5, a compound blending fasudil, caffeic, and ferulic acids, shows promise for ALS research involving SOD1 mutations.Formula:C23H25N3O5SColor and Shape:SolidMolecular weight:455.53PD-1-IN-22
CAS:PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor(IC50 of 92.3 nM).Formula:C25H25N5O4Purity:99.51%Color and Shape:SolidMolecular weight:459.5XIE18-6
CAS:XIE18-6 is a novel INK4C inhibitor that blocks p18 activity and promotes ex vivo expansion of human and murine hematopoietic stem cells.Formula:C18H15NO6SPurity:99.712%Color and Shape:SolidMolecular weight:373.38KIRA-7
CAS:KIRA-7: imidazopyrazine, anti-fibrotic, inhibits IRE1α RNase (IC50: 110 nM) allosterically.Formula:C27H23FN6OColor and Shape:SolidMolecular weight:466.51Aurora Kinases-IN-2
CAS:Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.Formula:C22H18ClN5O3Color and Shape:SolidMolecular weight:435.86TC-Mps1-12
CAS:<p>TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .</p>Formula:C17H20N6OPurity:98%Color and Shape:SolidMolecular weight:324.38Sibrafiban
CAS:Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.Formula:C20H28N4O6Color and Shape:SolidMolecular weight:420.46Tetrahydrouridine
CAS:Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.Formula:C9H16N2O6Purity:98%Color and Shape:SolidMolecular weight:248.23IPR-803
CAS:IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity.Formula:C27H23N3O4Purity:95%Color and Shape:SolidMolecular weight:453.49
