
Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase(111 products)
- CDK(525 products)
- Cell Cycle Arrest(4 products)
- Chk(46 products)
- DYRK(49 products)
- Dynamin(26 products)
- Ferroptosis(224 products)
- HSP(180 products)
- Integrin(256 products)
- Kinesin(86 products)
- LIM Kinase(19 products)
- Microtubule Associated(284 products)
- PKC(111 products)
- PLK(25 products)
- ROCK(66 products)
- Rho(2 products)
- Wee1(14 products)
- c-Myc(75 products)
Show 10 more subcategories
Found 3749 products of "Cell Cycle/Checkpoint"
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HOI-07
CAS:HOI-07 is a specific Aurora B inhibitor.Formula:C19H13NO4Color and Shape:SolidMolecular weight:319.31CDK7-IN-15
CAS:CDK7-IN-15, a pyrimidine-based potent CDK7 inhibitor, shows promise for various cancers with defective transcription.Formula:C21H24F4N6OSPurity:99.27%Color and Shape:SolidMolecular weight:484.51IACS-4759
CAS:IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes.Formula:C10H17N3O2Color and Shape:SolidMolecular weight:211.26Laromustine
CAS:Laromustine (VNP40101M) is a sulfonyl hydrolysis alkylation prodrug for cancer treatment with significant anticancer activity, inhibiting thioredoxin reductase.Formula:C6H14ClN3O5S2Purity:≥98%Color and Shape:SolidMolecular weight:307.78FINDY
CAS:FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.Formula:C16H17NO2S2SiColor and Shape:SolidMolecular weight:347.53DHFR-IN-2
CAS:DHFR-IN-2 (4e) is a potent MtDHFR uncompetitive inhibitor with a 7 μM IC50, promising for TB research.Formula:C14H13NO2Color and Shape:SolidMolecular weight:227.26IDD388
CAS:IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor.Formula:C16H12BrClFNO4Purity:99.56%Color and Shape:SolidMolecular weight:416.63Datelliptium chloride
CAS:Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride shows anti-tumor activities.Formula:C23H28ClN3OPurity:98%Color and Shape:SolidMolecular weight:397.94DNA Gyrase-IN-3
CAS:DNA Gyrase-IN-3 inhibits E. coli DNA gyrase B with IC50 5.41-15.64 μM; shows anti-TB and antibacterial properties.Formula:C18H20N6OS2Color and Shape:SolidMolecular weight:400.52Chlorozotocin
CAS:Chlorozotocin is a nitrosourea. It is used for cancer therapy.Formula:C9H16ClN3O7Color and Shape:SolidMolecular weight:313.69MtTMPK-IN-6
CAS:MtTMPK-IN-6 inhibits M. tuberculosis thymidylate kinase with IC50 of 29 μM, promising for TB research.Formula:C23H25N3O3Color and Shape:SolidMolecular weight:391.46IS-741 calcium
CAS:IS-741 calcium is a phospholipase A2 inhibitor.Formula:C30H38CaF6N6O6S2Color and Shape:SolidMolecular weight:796.86TH470
CAS:TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,Formula:C30H31N5O5S2Color and Shape:SolidMolecular weight:605.73RET-IN-19
CAS:<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Formula:C28H28N6O4SColor and Shape:SolidMolecular weight:544.62(R)-Filanesib
CAS:(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).Formula:C20H22F2N4O2SColor and Shape:SolidMolecular weight:420.48ERCC1-XPF-IN-1
CAS:ERCC1-XPF-IN-1: potent ERCC1-XPF inhibitor (IC50: 0.49 μM), hampers CPD removal, boosts UV toxicity, hinders DNA repair.Formula:C28H32ClN5O2Color and Shape:SolidMolecular weight:506.04CFI-400936
CAS:CFI-400936: potent TTK inhibitor (IC50=3.6nM), potential anticancer, active in cell assays, selective vs. human kinases.Formula:C25H27N5O3SColor and Shape:SolidMolecular weight:477.58Phelorphan
CAS:Phelorphan is an inhibitor of enkephalinase.Formula:C20H22N2O4SPurity:98%Color and Shape:SolidMolecular weight:386.46IS-741 potassium
CAS:IS-741 potassium is a phospholipase A2 inhibitor.Formula:C15H19F3KN3O3SColor and Shape:SolidMolecular weight:417.49Teloxantrone
CAS:Teloxantrone: an anthrapyrazole antibiotic inhibiting DNA replication, RNA/protein synthesis by interacting with DNA and topoisomerase II.Formula:C21H25N5O4Color and Shape:SolidMolecular weight:411.45αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).Formula:C28H35F3N6O8SPurity:98%Color and Shape:SolidMolecular weight:672.67Pyrazofurin
CAS:Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase & orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).Formula:C9H13N3O6Purity:98%Color and Shape:SolidMolecular weight:259.22ML372
CAS:ML372 is a potent and selective SMN Modulator (EC50 = 12 nM, 325% increase inSMN2) with good potency, pharmacokinetics, tolerance, and CNS penetration.Formula:C18H20N2O4SColor and Shape:SolidMolecular weight:360.43BMS-587101
CAS:BMS-587101 is a small molecule antagonist of LFA-1, which can reduce inflammation and joint destruction in the mouse model of arthritis.Formula:C26H20Cl2N4O4SColor and Shape:SolidMolecular weight:555.43CDK4/6-IN-8
CAS:CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).Formula:C18H18N6O5Color and Shape:SolidMolecular weight:398.37FAK/aurora kinase-IN-1
CAS:FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].Formula:C23H24ClN7O3Color and Shape:SolidMolecular weight:481.93IMB-10
CAS:IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.Formula:C19H15NOS2Color and Shape:SolidMolecular weight:337.46Y-33075
CAS:Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.Formula:C16H16N4OPurity:98%Color and Shape:SolidMolecular weight:280.32DNA Gyrase-IN-2
CAS:DNA Gyrase-IN-2 inhibits E. coli (IC50: 3.29-10.49 μM) and M. tuberculosis (IC50: 4.41-5.61 μM) COX, has antibacterial properties.Formula:C24H24N8OS2Color and Shape:SolidMolecular weight:504.63Enocitabine
CAS:Enocitabine is a nucleoside analog.Formula:C31H55N3O6Purity:97.22%Color and Shape:SolidMolecular weight:565.78CFM-1
CAS:CFM-1 is an antagonist of the anaphase-promoting complex (APC)-2. It also is a cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonist.Formula:C12H7BrN2O2S2Purity:98%Color and Shape:SolidMolecular weight:355.23c-Myc inhibitor 9
CAS:c-Myc inhibitor 9 (compound 332) with logEC50 ≥6, suppresses tumors in mice, useful for cancer research.Formula:C27H31N5OSColor and Shape:SolidMolecular weight:473.63Zelpolib
CAS:Zelpolib is a specific inhibitor of DNA polymerase δ (Pol δ), inhibiting DNA replication. antiproliferative.Formula:C22H21N3O5S2Purity:98.79%Color and Shape:SolidMolecular weight:471.55CP681301
CAS:CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.Formula:C17H22N4OColor and Shape:SolidMolecular weight:298.38CDK7-IN-20
CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.Formula:C30H26N6O3Color and Shape:SolidMolecular weight:518.57Integrin modulator 1
CAS:Integrin modulator 1 is a selective α4β1 integrin agonist (IC50 9.8 nM) that enhances adhesion with EC50 12.9 nM, aiding integrin-dependent studies.Formula:C13H14N2O4Purity:99.61%Color and Shape:SolidMolecular weight:262.26BI8622
CAS:BI8622 is a HUWE1 antagonist that restores levels of RP2 mutants in retinal cell lines and inhibits cellular activation of NLRP3 and AIM2 inflammatory vesicles.Formula:C25H26N6OPurity:98.28% - 98.28%Color and Shape:SolidMolecular weight:426.51CBL 0100 free base
CAS:CBL0100 is an inhibitor of viral transcriptional elongation, blocking both HIV-1 replication and reactivation.Formula:C24H26N2O2Purity:98.18% - 98.86%Color and Shape:SolidMolecular weight:374.48GW8510
CAS:GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.Formula:C21H15N5O3S2Purity:99.32%Color and Shape:SolidMolecular weight:449.51P18IN003
CAS:<p>P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of</p>Formula:C17H16N2O3Purity:98.77%Color and Shape:SolidMolecular weight:296.32RUC-1
CAS:RUC-1 is an αIIbβ3-selective ADP-induced platelet aggregation inhibitor.Formula:C11H15N5OSPurity:98%Color and Shape:SolidMolecular weight:265.33Chrysotobibenzyl
CAS:Chrysotobibenzyl from Dendrobium pulchellum stems may trigger cell death in detached cells and hinder lung cancer growth.Formula:C19H24O5Color and Shape:SolidMolecular weight:332.39DHODH-IN-19
CAS:DHODH-IN-19, a strong DHODH blocker, may help treat cancer and inflammation. (Patent WO2021238881A1)Formula:C22H18ClF6N3O3Color and Shape:SolidMolecular weight:521.84Fosteabine
CAS:Fosteabine is an oral and prodrug analog of cytarabine. It is resistant to deoxycytidine deaminase.Formula:C27H50N3O8PPurity:98%Color and Shape:SolidMolecular weight:575.67M443
CAS:M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Formula:C31H30F3N7O2Purity:98.95%Color and Shape:SolidMolecular weight:589.618RK64
CAS:8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .Formula:C14H16N8O2SColor and Shape:SolidMolecular weight:360.4CLT-28643
CAS:CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.Formula:C19H17N3O4Purity:99.89%Color and Shape:SolidMolecular weight:351.36Homocarbonyltopsentin
CAS:Homocarbonyltopsentin: Small molecule, binds TSL2 pentaloops, enhances SMN2 E7 splicing, EC50 16 μM.Formula:C21H14N4O3Purity:98%Color and Shape:SolidMolecular weight:370.36PFM03
CAS:PFM03 is a endonuclease inhibitor that specifically blocks Mre11,reduce MRN endonuclease activity, blocking hMRN-mediated endonucleotomy and nuclear exocytosis.Formula:C14H15NO2S2Purity:99.81% - 99.98%Color and Shape:SolidMolecular weight:293.4Guanoctine hydrochloride
CAS:Guanoctine hydrochloride has antihypertensive activity.Formula:C9H22ClN3Color and Shape:SolidMolecular weight:207.74
