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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3749 products of "Cell Cycle/Checkpoint"

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  • HOI-07

    CAS:
    HOI-07 is a specific Aurora B inhibitor.
    Formula:C19H13NO4
    Color and Shape:Solid
    Molecular weight:319.31
  • CDK7-IN-15

    CAS:
    CDK7-IN-15, a pyrimidine-based potent CDK7 inhibitor, shows promise for various cancers with defective transcription.
    Formula:C21H24F4N6OS
    Purity:99.27%
    Color and Shape:Solid
    Molecular weight:484.51
  • IACS-4759

    CAS:
    IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes.
    Formula:C10H17N3O2
    Color and Shape:Solid
    Molecular weight:211.26
  • Laromustine

    CAS:
    Laromustine (VNP40101M) is a sulfonyl hydrolysis alkylation prodrug for cancer treatment with significant anticancer activity, inhibiting thioredoxin reductase.
    Formula:C6H14ClN3O5S2
    Purity:≥98%
    Color and Shape:Solid
    Molecular weight:307.78
  • FINDY

    CAS:
    FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.
    Formula:C16H17NO2S2Si
    Color and Shape:Solid
    Molecular weight:347.53
  • DHFR-IN-2

    CAS:
    DHFR-IN-2 (4e) is a potent MtDHFR uncompetitive inhibitor with a 7 μM IC50, promising for TB research.
    Formula:C14H13NO2
    Color and Shape:Solid
    Molecular weight:227.26
  • IDD388

    CAS:
    IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor.
    Formula:C16H12BrClFNO4
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:416.63
  • Datelliptium chloride

    CAS:
    Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride shows anti-tumor activities.
    Formula:C23H28ClN3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:397.94
  • DNA Gyrase-IN-3

    CAS:
    DNA Gyrase-IN-3 inhibits E. coli DNA gyrase B with IC50 5.41-15.64 μM; shows anti-TB and antibacterial properties.
    Formula:C18H20N6OS2
    Color and Shape:Solid
    Molecular weight:400.52
  • Chlorozotocin

    CAS:
    Chlorozotocin is a nitrosourea. It is used for cancer therapy.
    Formula:C9H16ClN3O7
    Color and Shape:Solid
    Molecular weight:313.69
  • MtTMPK-IN-6

    CAS:
    MtTMPK-IN-6 inhibits M. tuberculosis thymidylate kinase with IC50 of 29 μM, promising for TB research.
    Formula:C23H25N3O3
    Color and Shape:Solid
    Molecular weight:391.46
  • IS-741 calcium

    CAS:
    IS-741 calcium is a phospholipase A2 inhibitor.
    Formula:C30H38CaF6N6O6S2
    Color and Shape:Solid
    Molecular weight:796.86
  • TH470

    CAS:
    TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,
    Formula:C30H31N5O5S2
    Color and Shape:Solid
    Molecular weight:605.73
  • RET-IN-19

    CAS:
    <p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>
    Formula:C28H28N6O4S
    Color and Shape:Solid
    Molecular weight:544.62
  • (R)-Filanesib

    CAS:
    (R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).
    Formula:C20H22F2N4O2S
    Color and Shape:Solid
    Molecular weight:420.48
  • ERCC1-XPF-IN-1

    CAS:
    ERCC1-XPF-IN-1: potent ERCC1-XPF inhibitor (IC50: 0.49 μM), hampers CPD removal, boosts UV toxicity, hinders DNA repair.
    Formula:C28H32ClN5O2
    Color and Shape:Solid
    Molecular weight:506.04
  • CFI-400936

    CAS:
    CFI-400936: potent TTK inhibitor (IC50=3.6nM), potential anticancer, active in cell assays, selective vs. human kinases.
    Formula:C25H27N5O3S
    Color and Shape:Solid
    Molecular weight:477.58
  • Phelorphan

    CAS:
    Phelorphan is an inhibitor of enkephalinase.
    Formula:C20H22N2O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:386.46
  • IS-741 potassium

    CAS:
    IS-741 potassium is a phospholipase A2 inhibitor.
    Formula:C15H19F3KN3O3S
    Color and Shape:Solid
    Molecular weight:417.49
  • Teloxantrone

    CAS:
    Teloxantrone: an anthrapyrazole antibiotic inhibiting DNA replication, RNA/protein synthesis by interacting with DNA and topoisomerase II.
    Formula:C21H25N5O4
    Color and Shape:Solid
    Molecular weight:411.45
  • αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)


    αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).
    Formula:C28H35F3N6O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:672.67
  • Pyrazofurin

    CAS:
    Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase & orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).
    Formula:C9H13N3O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:259.22
  • ML372

    CAS:
    ML372 is a potent and selective SMN Modulator (EC50 = 12 nM, 325% increase inSMN2) with good potency, pharmacokinetics, tolerance, and CNS penetration.
    Formula:C18H20N2O4S
    Color and Shape:Solid
    Molecular weight:360.43
  • BMS-587101

    CAS:
    BMS-587101 is a small molecule antagonist of LFA-1, which can reduce inflammation and joint destruction in the mouse model of arthritis.
    Formula:C26H20Cl2N4O4S
    Color and Shape:Solid
    Molecular weight:555.43
  • CDK4/6-IN-8

    CAS:
    CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).
    Formula:C18H18N6O5
    Color and Shape:Solid
    Molecular weight:398.37
  • FAK/aurora kinase-IN-1

    CAS:
    FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].
    Formula:C23H24ClN7O3
    Color and Shape:Solid
    Molecular weight:481.93
  • IMB-10

    CAS:
    IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.
    Formula:C19H15NOS2
    Color and Shape:Solid
    Molecular weight:337.46
  • Y-33075

    CAS:
    Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.
    Formula:C16H16N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:280.32
  • DNA Gyrase-IN-2

    CAS:
    DNA Gyrase-IN-2 inhibits E. coli (IC50: 3.29-10.49 μM) and M. tuberculosis (IC50: 4.41-5.61 μM) COX, has antibacterial properties.
    Formula:C24H24N8OS2
    Color and Shape:Solid
    Molecular weight:504.63
  • Enocitabine

    CAS:
    Enocitabine is a nucleoside analog.
    Formula:C31H55N3O6
    Purity:97.22%
    Color and Shape:Solid
    Molecular weight:565.78
  • CFM-1

    CAS:
    CFM-1 is an antagonist of the anaphase-promoting complex (APC)-2. It also is a cell cycle and apoptosis regulatory protein (CARP)-1 interaction antagonist.
    Formula:C12H7BrN2O2S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:355.23
  • c-Myc inhibitor 9

    CAS:
    c-Myc inhibitor 9 (compound 332) with logEC50 ≥6, suppresses tumors in mice, useful for cancer research.
    Formula:C27H31N5OS
    Color and Shape:Solid
    Molecular weight:473.63
  • Zelpolib

    CAS:
    Zelpolib is a specific inhibitor of DNA polymerase δ (Pol δ), inhibiting DNA replication. antiproliferative.
    Formula:C22H21N3O5S2
    Purity:98.79%
    Color and Shape:Solid
    Molecular weight:471.55
  • CP681301

    CAS:
    CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.
    Formula:C17H22N4O
    Color and Shape:Solid
    Molecular weight:298.38
  • CDK7-IN-20


    CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.
    Formula:C30H26N6O3
    Color and Shape:Solid
    Molecular weight:518.57
  • Integrin modulator 1

    CAS:
    Integrin modulator 1 is a selective α4β1 integrin agonist (IC50 9.8 nM) that enhances adhesion with EC50 12.9 nM, aiding integrin-dependent studies.
    Formula:C13H14N2O4
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:262.26
  • BI8622

    CAS:
    BI8622 is a HUWE1 antagonist that restores levels of RP2 mutants in retinal cell lines and inhibits cellular activation of NLRP3 and AIM2 inflammatory vesicles.
    Formula:C25H26N6O
    Purity:98.28% - 98.28%
    Color and Shape:Solid
    Molecular weight:426.51
  • CBL 0100 free base

    CAS:
    CBL0100 is an inhibitor of viral transcriptional elongation, blocking both HIV-1 replication and reactivation.
    Formula:C24H26N2O2
    Purity:98.18% - 98.86%
    Color and Shape:Solid
    Molecular weight:374.48
  • GW8510

    CAS:
    GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.
    Formula:C21H15N5O3S2
    Purity:99.32%
    Color and Shape:Solid
    Molecular weight:449.51
  • P18IN003

    CAS:
    <p>P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of</p>
    Formula:C17H16N2O3
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:296.32
  • RUC-1

    CAS:
    RUC-1 is an αIIbβ3-selective ADP-induced platelet aggregation inhibitor.
    Formula:C11H15N5OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:265.33
  • Chrysotobibenzyl

    CAS:
    Chrysotobibenzyl from Dendrobium pulchellum stems may trigger cell death in detached cells and hinder lung cancer growth.
    Formula:C19H24O5
    Color and Shape:Solid
    Molecular weight:332.39
  • DHODH-IN-19

    CAS:
    DHODH-IN-19, a strong DHODH blocker, may help treat cancer and inflammation. (Patent WO2021238881A1)
    Formula:C22H18ClF6N3O3
    Color and Shape:Solid
    Molecular weight:521.84
  • Fosteabine

    CAS:
    Fosteabine is an oral and prodrug analog of cytarabine. It is resistant to deoxycytidine deaminase.
    Formula:C27H50N3O8P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:575.67
  • M443

    CAS:
    M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.
    Formula:C31H30F3N7O2
    Purity:98.95%
    Color and Shape:Solid
    Molecular weight:589.61
  • 8RK64

    CAS:
    8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .
    Formula:C14H16N8O2S
    Color and Shape:Solid
    Molecular weight:360.4
  • CLT-28643

    CAS:
    CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.
    Formula:C19H17N3O4
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:351.36
  • Homocarbonyltopsentin

    CAS:
    Homocarbonyltopsentin: Small molecule, binds TSL2 pentaloops, enhances SMN2 E7 splicing, EC50 16 μM.
    Formula:C21H14N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:370.36
  • PFM03

    CAS:
    PFM03 is a endonuclease inhibitor that specifically blocks Mre11,reduce MRN endonuclease activity, blocking hMRN-mediated endonucleotomy and nuclear exocytosis.
    Formula:C14H15NO2S2
    Purity:99.81% - 99.98%
    Color and Shape:Solid
    Molecular weight:293.4
  • Guanoctine hydrochloride

    CAS:
    Guanoctine hydrochloride has antihypertensive activity.
    Formula:C9H22ClN3
    Color and Shape:Solid
    Molecular weight:207.74