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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3749 products of "Cell Cycle/Checkpoint"

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  • BSJ-01-175
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    BSJ-01-175

    CAS:
    BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.
    Formula:C30H33ClN6O2
    Color and Shape:Solid
    Molecular weight:545.08

    Ref: TM-T63841

  • DENV-IN-7
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    DENV-IN-7

    CAS:
    DENV-IN-7, a flavone analog, inhibits dengue virus at 70 nM EC50 with low toxicity to normal cells.
    Formula:C24H22O8
    Color and Shape:Solid
    Molecular weight:438.43

    Ref: TM-T73311

  • P1788
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    P1788

    CAS:
    P1788 is a dihydroorotate dehydrogenase (DHODH) inhibitor that can induce DNA damage [1].
    Formula:C15H17NO3
    Color and Shape:Solid
    Molecular weight:259.3

    Ref: TM-T60409

  • 5,10-Dideazaaminopterin
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    5,10-Dideazaaminopterin

    CAS:
    5,10-Dideazaaminopterin is an antileukemic drug.
    Formula:C21H22N6O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:438.44

    Ref: TM-T24978

  • Antibacterial agent 89
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    Antibacterial agent 89

    CAS:
    Antibacterial agent 89 blocks bacterial transcription and clostridial cytotoxins, inhibiting β'CH-σ interactions.
    Formula:C21H10Cl2F3NO5S
    Color and Shape:Solid
    Molecular weight:516.27

    Ref: TM-T63588

  • HBV-IN-14
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    HBV-IN-14

    CAS:
    HBV-IN-14: a pyridinopyrimidinone, potent cccDNA inhibitor for HBV study (patent WO2021190502A1, comp 5).
    Formula:C22H21ClN2O5
    Color and Shape:Solid
    Molecular weight:428.87

    Ref: TM-T62355

  • BMH-23
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    BMH-23

    CAS:
    BMH-23 is an RNA polymerase I inhibitor that acts by causing nucleolar stress and showing potent anticancer activity across many tumor types.
    Formula:C15H15N3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:237.3

    Ref: TM-T23803

  • Indirubin-3'-monoxime-5-sulphonic acid
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    Indirubin-3'-monoxime-5-sulphonic acid

    CAS:
    Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively.
    Formula:C16H11N3O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:357.34

    Ref: TM-T11652

  • MMV688845
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    MMV688845

    CAS:
    MMV688845: NTM RNA polymerase inhibitor, kills Mycobacterium abscessus, and fights TB.
    Formula:C24H25N3O3S
    Color and Shape:Solid
    Molecular weight:435.54

    Ref: TM-T73271

  • CDK7-IN-13
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    CDK7-IN-13

    CAS:
    CDK7-IN-13 (compound 1) is an effective CDK7 inhibitor for investigating cancers associated with transcriptional dysregulation.
    Formula:C20H23F3N6OS
    Purity:99.22%
    Color and Shape:Solid
    Molecular weight:452.5

    Ref: TM-T62759

  • TP1287
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    TP1287

    CAS:
    TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib.
    Formula:C21H21ClNO8P
    Color and Shape:Solid
    Molecular weight:481.82

    Ref: TM-T69965

  • 5,10-Dideazafolic acid
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    5,10-Dideazafolic acid

    CAS:
    5,10-Dideazafolic acid is an antileukemic drug.
    Formula:C21H21N5O6
    Color and Shape:Solid
    Molecular weight:439.42

    Ref: TM-T24979

  • 2'-Fluorothymidine
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    2'-Fluorothymidine

    CAS:
    <p>2'-Fluorothymidine is a selective substrate for TK2, related to thymidine and methyluridine.</p>
    Formula:C10H13FN2O5
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:260.22

    Ref: TM-T19101

  • 8RK64
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    8RK64

    CAS:
    8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .
    Formula:C14H16N8O2S
    Color and Shape:Solid
    Molecular weight:360.4

    Ref: TM-T69539

  • Chrysotobibenzyl
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    Chrysotobibenzyl

    CAS:
    Chrysotobibenzyl from Dendrobium pulchellum stems may trigger cell death in detached cells and hinder lung cancer growth.
    Formula:C19H24O5
    Color and Shape:Solid
    Molecular weight:332.39

    Ref: TM-T71471

  • Antibacterial agent 124
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    Antibacterial agent 124

    CAS:
    Antibacterial agent 124 inhibits Sa ProRS with an IC50 of 0.18 μM.
    Formula:C16H17ClFN3O2
    Color and Shape:Solid
    Molecular weight:337.78

    Ref: TM-T72303

  • JA2131
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    JA2131

    CAS:
    JA2131: Small PARG inhibitor, IC50 0.4μM, induces DNA damage, stalls replication, kills cancer cells.
    Formula:C13H19N5O2S2
    Color and Shape:Solid
    Molecular weight:341.45

    Ref: TM-T73479

  • Poloxipan
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    Poloxipan

    CAS:
    Poloxipan inhibits PLK1 (IC50: 3.2µM), PLK2 (1.7µM), PLK3 (3µM); minimal effect on Chk2, STAT1, STAT5b, Lck.
    Formula:C14H10BrN3O3S
    Color and Shape:Solid
    Molecular weight:380.22

    Ref: TM-T71156

  • Integrin modulator 1
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    Integrin modulator 1

    CAS:
    Integrin modulator 1 is a selective α4β1 integrin agonist (IC50 9.8 nM) that enhances adhesion with EC50 12.9 nM, aiding integrin-dependent studies.
    Formula:C13H14N2O4
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:262.26

    Ref: TM-T36291

  • CDK7-IN-20
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    CDK7-IN-20

    CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.
    Formula:C30H26N6O3
    Color and Shape:Solid
    Molecular weight:518.57

    Ref: TM-T73163

  • Zelpolib
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    Zelpolib

    CAS:
    Zelpolib is a specific inhibitor of DNA polymerase δ (Pol δ), inhibiting DNA replication. antiproliferative.
    Formula:C22H21N3O5S2
    Purity:98.79%
    Color and Shape:Solid
    Molecular weight:471.55

    Ref: TM-T68837

  • c-Myc inhibitor 9
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    c-Myc inhibitor 9

    CAS:
    c-Myc inhibitor 9 (compound 332) with logEC50 ≥6, suppresses tumors in mice, useful for cancer research.
    Formula:C27H31N5OS
    Color and Shape:Solid
    Molecular weight:473.63

    Ref: TM-T72620

  • BMS-587101
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    BMS-587101

    CAS:
    BMS-587101 is a small molecule antagonist of LFA-1, which can reduce inflammation and joint destruction in the mouse model of arthritis.
    Formula:C26H20Cl2N4O4S
    Color and Shape:Solid
    Molecular weight:555.43

    Ref: TM-T30533

  • ML372
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    ML372

    CAS:
    ML372 is a potent and selective SMN Modulator (EC50 = 12 nM, 325% increase inSMN2) with good potency, pharmacokinetics, tolerance, and CNS penetration.
    Formula:C18H20N2O4S
    Color and Shape:Solid
    Molecular weight:360.43

    Ref: TM-T28067

  • RSK-IN-1
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    RSK-IN-1

    CAS:
    RSK-IN-1 (compound 7d) shows anti-tumor activity. RSK-IN-1 is an inhibitor of RSK that inhibits the phosphorylation of YB-1 [1].
    Formula:C22H17NO2
    Color and Shape:Solid
    Molecular weight:327.38

    Ref: TM-T60922

  • ERCC1-XPF-IN-1
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    ERCC1-XPF-IN-1

    CAS:
    ERCC1-XPF-IN-1: potent ERCC1-XPF inhibitor (IC50: 0.49 μM), hampers CPD removal, boosts UV toxicity, hinders DNA repair.
    Formula:C28H32ClN5O2
    Color and Shape:Solid
    Molecular weight:506.04

    Ref: TM-T63464

  • MtTMPK-IN-6
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    MtTMPK-IN-6

    CAS:
    MtTMPK-IN-6 inhibits M. tuberculosis thymidylate kinase with IC50 of 29 μM, promising for TB research.
    Formula:C23H25N3O3
    Color and Shape:Solid
    Molecular weight:391.46

    Ref: TM-T61781

  • DIF-3
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    DIF-3

    CAS:
    DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.
    Formula:C13H17ClO4
    Purity:99.57%
    Color and Shape:Solid
    Molecular weight:272.72

    Ref: TM-T60485

  • Eprociclovir
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    Eprociclovir

    CAS:
    Eprociclovir (A-5021) is a novel acyclovir analog that is a potent inhibitor of EHV1 replication and may be used for the treatment and/or prevention of
    Formula:C11H15N5O3
    Purity:98.50% - 99.86%
    Color and Shape:Solid
    Molecular weight:265.27

    Ref: TM-T31659

  • SEL120-34A
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    SEL120-34A

    CAS:
    SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.
    Formula:C15H18Br2N4
    Purity:99.764% - 99.84%
    Color and Shape:Solid
    Molecular weight:414.14

    Ref: TM-T10744

  • Cytembena
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    Cytembena

    CAS:
    Cytembena is a cytostatic and a carcinogenic compound that may increase the incidence of fibroadenomas.Cytembena broadly inhibits DNA biosynthesis.
    Formula:C11H8BrNaO4
    Purity:99.7%
    Color and Shape:White Powder
    Molecular weight:307.07

    Ref: TM-T27112

  • CD532
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    CD532

    CAS:
    CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.
    Formula:C26H25F3N8O
    Purity:99.99%
    Color and Shape:Solid
    Molecular weight:522.52

    Ref: TM-T50110

  • CDK4/6/1 Inhibitor
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    CDK4/6/1 Inhibitor

    CAS:
    CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).
    Formula:C28H30F2N6
    Purity:97.25% - 99.72%
    Color and Shape:Solid
    Molecular weight:488.57

    Ref: TM-T10735

  • D-I03
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    D-I03

    CAS:
    D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM.
    Formula:C23H36N6S
    Purity:99.65%
    Color and Shape:Solid
    Molecular weight:428.64

    Ref: TM-T10936

  • 9-Isopropylolomoucine
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    9-Isopropylolomoucine

    CAS:
    9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.
    Formula:C17H22N6O
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:326.4

    Ref: TM-T23589

  • PCSK9-IN-10
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    PCSK9-IN-10

    CAS:
    <p>PCSK9-IN-10: potent oral PCSK9 inhibitor (IC50 = 6.4 µM), upregulates LDLR, curbs atherosclerosis, for hyperlipidemia research.</p>
    Formula:C18H23N5O4
    Purity:99.06%
    Color and Shape:Soild
    Molecular weight:373.41

    Ref: TM-T72025

  • DS18561882
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    DS18561882

    CAS:
    DS18561882: Potent MTHFD2 inhibitor (IC50=0.0063), inhibits MTHFD1 (IC50=0.57), good oral kinetics.
    Formula:C28H31F3N4O6S
    Purity:98.19% - >99.99%
    Color and Shape:Solid
    Molecular weight:608.63

    Ref: TM-T11103

  • 116-9e
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    116-9e

    CAS:
    116-9e (MAL2-11B) is an Hsp70 chaperone DNAJA1 inhibitor with antiviral properties, inhibits SV40 replication, and can be used to study cancer drug resistance.
    Formula:C31H32N2O5
    Purity:99.55%
    Color and Shape:Solid
    Molecular weight:512.6

    Ref: TM-T25770

  • Talviraline
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    Talviraline

    CAS:
    Talviraline (Bay 10-8979) is an RNA-induced DNA polymerase inhibitor.Talviraline is a potent inhibitor of HIV-1-induced cell killing and HIV-1 replication in a
    Formula:C15H20N2O3S2
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:340.46

    Ref: TM-T28918

  • UMK57
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    UMK57

    CAS:
    UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,
    Formula:C17H17N3S
    Purity:99.86%
    Color and Shape:Solid
    Molecular weight:295.4

    Ref: TM-T29059

  • Galocitabine
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    Galocitabine

    CAS:
    Galocitabine (Neofrutulon), a thymidylate synthase inhibitor, is used potentially for the treatment of cancer.
    Formula:C19H22FN3O8
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:439.39

    Ref: TM-T27399

  • hDHODH-IN-7
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    hDHODH-IN-7

    CAS:
    hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor.
    Formula:C21H23FN4O
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:366.43

    Ref: TM-T11031

  • hSMG-1 inhibitor 11e
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    hSMG-1 inhibitor 11e

    CAS:
    hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.
    Formula:C26H27N7O3S
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:517.6

    Ref: TM-T35529

  • DENV-IN-5
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    DENV-IN-5

    CAS:
    Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.
    Formula:C23H25ClF2N4OS
    Purity:99.42%
    Color and Shape:Solid
    Molecular weight:478.99

    Ref: TM-T63143

  • ITX3
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    ITX3

    CAS:
    ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM.
    Formula:C22H17N3OS
    Purity:97.28%
    Color and Shape:Solid
    Molecular weight:371.45

    Ref: TM-T15602

  • AzddMeC
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    AzddMeC

    CAS:
    <p>AzddMeC (Az-Dcme) is an HIV-1 reverse transcriptase and HIV-1 replication inhibitor with antiretroviral activity.AzddMeC is used in the study of HIV-1 infection</p>
    Formula:C10H14N6O3
    Purity:97.14% - 99.62%
    Color and Shape:Solid
    Molecular weight:266.26

    Ref: TM-T26726

  • 10-Formylfolic acid
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    10-Formylfolic acid

    CAS:
    10-Formylfolic acid is a novel and potent inhibitor of dihydrofolate reductase, which can be used in leukemia research.
    Formula:C20H19N7O7
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:469.41

    Ref: TM-T24962

  • Poloxin-2
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    Poloxin-2

    CAS:
    Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.
    Formula:C16H15NO3
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:269.3

    Ref: TM-T25969

  • GRK6-IN-1
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    GRK6-IN-1

    CAS:
    GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.
    Formula:C22H23ClN6O2
    Purity:99.37%
    Color and Shape:Solid
    Molecular weight:438.91

    Ref: TM-T62518

  • Haspin-IN-3
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    Haspin-IN-3

    CAS:
    <p>Haspin-IN-3 is a potent haspin inhibitor with an IC50 of 14 nM.Haspin-IN-3 has anticancer activity.</p>
    Formula:C16H10N2O3
    Purity:98.78%
    Color and Shape:Solid
    Molecular weight:278.26

    Ref: TM-T60512