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Cell Cycle/Checkpoint

Cell Cycle/Checkpoint

Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.

Subcategories of "Cell Cycle/Checkpoint"

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Found 3726 products of "Cell Cycle/Checkpoint"

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  • Werner syndrome RecQ helicase-IN-2
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    Werner syndrome RecQ helicase-IN-2

    CAS:
    Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.
    Formula:C32H34F3N9O5
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:681.67

    Ref: TM-T72108

  • CDK4/6-IN-13
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    CDK4/6-IN-13

    CAS:
    Compounds 10B and 10C: potent cdk4/6 inhibitors with low nM activity, great antiproliferative effects, excellent metabolism, and good pharmacokinetics.
    Formula:C25H29N7O
    Color and Shape:Solid
    Molecular weight:443.54

    Ref: TM-T62605

  • WRN inhibitor 12
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    WRN inhibitor 12

    CAS:
    WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.
    Formula:C33H33ClF3N9O5
    Color and Shape:Solid
    Molecular weight:728.12

    Ref: TM-T201316

  • 2-CEES
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    2-CEES

    CAS:
    <p>2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.</p>
    Formula:C4H9ClS
    Color and Shape:Solid
    Molecular weight:124.632

    Ref: TM-T204286

  • MRL-436
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    MRL-436

    CAS:
    MRL-436 is an RNA polymerase inhibitor with antibacterial activity. Its effectiveness depends on the β' subunit and the 622nd residue of the RNAP ω subunit. MRL-436 can inhibit Rifampicin-resistant RNA polymerase derivatives and shows antibacterial activity against Rifampicin-resistant strains.
    Formula:C24H22N4O
    Color and Shape:Solid
    Molecular weight:382.46

    Ref: TM-T212262

  • Methyl 3-oxodecanoate
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    Methyl 3-oxodecanoate

    CAS:
    <p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>
    Formula:C11H20O3
    Color and Shape:Solid
    Molecular weight:200.275

    Ref: TM-T206384

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    4,5'-Dimethylangelicin-NHS

    NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity & photosensitivity.
    Formula:C21H19NO7S
    Color and Shape:Solid
    Molecular weight:429.44

    Ref: TM-T62365

  • DYRKs-IN-1 hydrochloride
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    DYRKs-IN-1 hydrochloride

    CAS:
    DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) & DYRK1B (8 nM IC50) with antitumor properties.
    Formula:C30H31Cl2N7O4
    Color and Shape:Solid
    Molecular weight:624.52

    Ref: TM-T72242

  • TREX1-IN-4
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    TREX1-IN-4

    CAS:
    <p>TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.</p>
    Formula:C24H19ClN6O4
    Color and Shape:Solid
    Molecular weight:490.898

    Ref: TM-T205208

  • MU1409
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    MU1409

    CAS:
    <p>MU1409 is an MRE11 nuclease inhibitor with an IC50 of 12.1 μM. It also inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. MU1409 impacts cellular DNA repair and prevents the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for studying BRCA2 mutation-induced cancers.</p>
    Formula:C20H14BrN3O3S
    Color and Shape:Solid
    Molecular weight:456.312

    Ref: TM-T205338

  • N-Isobutyryl-2', 3'-acetyl-guanosine
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    N-Isobutyryl-2', 3'-acetyl-guanosine

    CAS:
    N-Isobutyryl-2', 3'-acetyl-guanosine is a derivative of guanosine.
    Formula:C18H23N5O8
    Color and Shape:Solid
    Molecular weight:437.404

    Ref: TM-T206416

  • RAD51-IN-6
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    RAD51-IN-6

    CAS:
    RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)
    Formula:C27H40N3O5PS
    Color and Shape:Solid
    Molecular weight:549.66

    Ref: TM-T63883

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    3-deoxy-3-fluoro-β-D-Ribofuranose 25

    CAS:
    Compound 25, β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate), exhibits strong activity in inhibiting the growth of tumor cells [1].
    Formula:C17H19FO7
    Molecular weight:354.33

    Ref: TM-T87696

  • CDK9/PARP-IN-1
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    CDK9/PARP-IN-1

    CAS:
    CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.
    Formula:C38H34F2N8O3
    Color and Shape:Solid
    Molecular weight:688.725

    Ref: TM-T205731

  • CDK1-IN-7
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    CDK1-IN-7

    CAS:
    <p>CDK1-IN-7 (compound M7) is a potent CDK1 inhibitor. It effectively suppresses the proliferation and migration of HCT116 and Lovo cells, making it a valuable tool for colorectal cancer research.</p>
    Formula:C23H19ClN4O3
    Color and Shape:Solid
    Molecular weight:434.88

    Ref: TM-T207488

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    CYP2C19-IN-1

    CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.
    Formula:C26H26N2O6S
    Color and Shape:Solid
    Molecular weight:494.56

    Ref: TM-T63337

  • AR-13324 M1 metabolite
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    AR-13324 M1 metabolite

    CAS:
    <p>AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.</p>
    Formula:C19H19N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:321.37

    Ref: TM-T10358L

  • CDK4/6-IN-24
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    CDK4/6-IN-24

    CAS:
    <p>CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.</p>
    Formula:C32H41N7O3
    Color and Shape:Solid
    Molecular weight:571.713

    Ref: TM-T205628

  • LY309887
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    LY309887

    CAS:
    LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.
    Formula:C19H23N5O6S
    Color and Shape:Solid
    Molecular weight:449.48

    Ref: TM-T15813

  • KWR095
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    KWR095

    CAS:
    <p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>
    Formula:C33H31ClF3N9O4
    Color and Shape:Solid
    Molecular weight:710.105

    Ref: TM-T205595

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    Hesperadin hydrochloride

    Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.
    Formula:C29H33ClN4O3S
    Color and Shape:Solid
    Molecular weight:553.12

    Ref: TM-T63905

  • 3′-Amino-2′,3′-dideoxy-CTP
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    3′-Amino-2′,3′-dideoxy-CTP

    CAS:
    3′-Amino-2′,3′-dideoxy-CTP is an analog of nucleoside triphosphates. It selectively inhibits DNA polymerase β.
    Formula:C9H17N4O12P3
    Color and Shape:Solid
    Molecular weight:466.17

    Ref: TM-TSW-01126

  • Zorubicin
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    Zorubicin

    CAS:
    <p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>
    Formula:C34H35N3O10
    Color and Shape:Solid
    Molecular weight:645.66

    Ref: TM-T69130

  • PNR-3-80
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    PNR-3-80

    CAS:
    PNR-3-80 is a selective inhibitor of apoptotic endonuclease G (EndoG), with an IC50 of 0.67 μM, showing greater inhibition than against DNase I. It exhibits no inhibitory activity against DNase II, RNase A, proteases, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-80 effectively protects human prostate cancer cells from cell death induced by Cisplatin and Docetaxel and inhibits DNA damage and autophagy (autophagy) prompted by Etoposide. This compound is applicable in studies of cellular damage.
    Formula:C24H14ClN3O3S
    Color and Shape:Solid
    Molecular weight:459.90

    Ref: TM-T212403

  • Fradafiban
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    Fradafiban

    CAS:
    Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.
    Formula:C20H21N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:367.40

    Ref: TM-T11322

  • 3'-NH2-CTP
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    3'-NH2-CTP

    CAS:
    3'-NH2-CTP is a nucleotide analog modified with an amino group at the 3' position of CTP.
    Formula:C9H17N4O13P3
    Color and Shape:Solid
    Molecular weight:482.17

    Ref: TM-TSW-01109

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    Zalunfiban dihydrochloride

    <p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>
    Formula:C16H20Cl2N8O2S
    Color and Shape:Solid
    Molecular weight:459.35

    Ref: TM-T62878

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    α5β1 integrin agonist-1

    CAS:
    α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.
    Formula:C24H26FN5O9
    Color and Shape:Solid
    Molecular weight:547.49

    Ref: TM-T63868

  • 3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite
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    3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite

    CAS:
    3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite serves as a precursor of adenosine nucleotide monomers used in the solid-phase synthesis of oligonucleotides, particularly for modifying oligonucleotides such as terminally modified DNA strands. It features Trityl (Tr), Cyanoethyl (CE), and Dimethylformamidine (DMF) protective groups, classifying it as a ddNTP adenosine nucleoside suitable for applications like oligonucleotide solid-phase synthesis, probe design, and chain termination sequencing.
    Formula:C41H50N9O3P
    Color and Shape:Solid
    Molecular weight:747.87

    Ref: TM-TSW-01106

  • CDK7/12-IN-1
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    CDK7/12-IN-1

    CAS:
    CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.
    Formula:C25H34N8O
    Color and Shape:Solid
    Molecular weight:462.59

    Ref: TM-T62926

  • PPA-037
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    PPA-037

    CAS:
    <p>PPA-037 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It induces the degradation of Cyclin K, thereby enhancing antiproliferative effects on tumor cells. PPA-037 holds potential for use in cancer research.</p>
    Formula:C25H27N7
    Color and Shape:Solid
    Molecular weight:425.53

    Ref: TM-T207610

  • CHK-IN-1
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    CHK-IN-1

    CAS:
    CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.
    Formula:C18H19ClFN5OS
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:407.89

    Ref: TM-T13148

  • Dyrk1A-IN-12
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    Dyrk1A-IN-12

    CAS:
    <p>Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).</p>
    Formula:C22H16FN3O2S
    Color and Shape:Solid
    Molecular weight:405.445

    Ref: TM-T205530

  • Des-ethyl-carafiban
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    Des-ethyl-carafiban

    CAS:
    Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.
    Formula:C22H23N5O5
    Color and Shape:Solid
    Molecular weight:437.448

    Ref: TM-T206156

  • Galidesivir
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    Galidesivir

    CAS:
    Galidesivir (BCX4430) is an antiviral compound that inhibits viral RNA-dependent RNA polymerase (RdRp) activity and reduces lung infections in infected animals.
    Formula:C11H15N5O3
    Purity:96.73% - 99.13%
    Color and Shape:Solid
    Molecular weight:265.27

    Ref: TM-T10491

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    Anticancer agent 30

    <p>Anticancer agent 30 (6f-Z), a 3-arylidene-2-oxindole, selectively inhibits CDK2, showing potent anticancer potential.</p>
    Formula:C22H15ClFNO
    Color and Shape:Solid
    Molecular weight:363.81

    Ref: TM-T61379

  • DL-Alanosine
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    DL-Alanosine

    CAS:
    <p>DL-Alanosine is an amino acid analog with antitumor activity.</p>
    Formula:C3H7N3O4
    Color and Shape:Solid
    Molecular weight:149.105

    Ref: TM-T205451

  • L 734217
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    L 734217

    CAS:
    L 734217 is an antagonist of the fibrinogen receptor.
    Formula:C18H31N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:353.46

    Ref: TM-T24352

  • CHK1-IN-4
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    CHK1-IN-4

    CAS:
    <p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>
    Formula:C18H18BrN7O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:444.29

    Ref: TM-T10792

  • 11-Oxahomoaminopterin
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    11-Oxahomoaminopterin

    CAS:
    11-Oxahomoaminopterin exhibits antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR.
    Formula:C20H21N7O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:455.42

    Ref: TM-T24966

  • (R)-CSN5i-3
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    (R)-CSN5i-3

    CAS:
    (R)-CSN5i-3 is CSN5i-3 of the R configuration.
    Formula:C28H29F2N5O2
    Purity:99.76% - 99.97%
    Color and Shape:Solid
    Molecular weight:505.56

    Ref: TM-T12620

  • PD-1-IN-17
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    PD-1-IN-17

    CAS:
    <p>PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.</p>
    Formula:C13H22N6O7
    Purity:99.6%
    Color and Shape:Solid
    Molecular weight:374.35

    Ref: TM-T12377

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    ART615

    ART615 is a related isomer of ART558. ART615 inhibits Polθ by <10% at 12 μM and is able to act as a control for ART558 (IC50:7.9 nM).
    Formula:C21H21F3N4O2
    Color and Shape:Solid
    Molecular weight:418.41

    Ref: TM-T62186

  • BWC0977
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    BWC0977

    CAS:
    BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.
    Formula:C22H21FN6O5
    Color and Shape:Solid
    Molecular weight:468.44

    Ref: TM-T201074

  • 2'-O-MOE-GMP
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    2'-O-MOE-GMP

    CAS:
    <p>2'-O-MOE-GMP is a nucleotide analogue that can be utilized in the synthesis of oligonucleotides.</p>
    Formula:C13H20N5O9P
    Color and Shape:Solid
    Molecular weight:421.30

    Ref: TM-TSW-00967

  • LNA-GMP
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    LNA-GMP

    CAS:
    LNA-GMP, a nucleotide analogue, is utilized in the synthesis of oligonucleotides.
    Formula:C11H14N5O8P
    Color and Shape:Solid
    Molecular weight:375.23

    Ref: TM-TSW-00965

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    MtTMPK-IN-9

    MtTMPK-IN-9 moderately inhibits MtbTMPK (IC50: 48 μM), has submicromolar Mycobacterium activity, and is non-toxic, aiding tuberculosis research.
    Formula:C25H26N6O7
    Color and Shape:Solid
    Molecular weight:522.51

    Ref: TM-T63657

  • CB 30900
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    CB 30900

    CAS:
    CB30900 is a novel and effective thymidylate synthase inhibitor.
    Formula:C31H32FN5O9
    Color and Shape:Solid
    Molecular weight:637.61

    Ref: TM-T30760

  • 2'-O-MOE-GTP
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    2'-O-MOE-GTP

    CAS:
    2'-O-MOE-GTP is a nucleotide analog utilized in the synthesis of oligonucleotides.
    Formula:C13H22N5O15P3
    Color and Shape:Solid
    Molecular weight:581.26

    Ref: TM-TSW-00970

  • DS96432529
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    DS96432529

    DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.
    Formula:C18H26N4O3S
    Color and Shape:Soild
    Molecular weight:378.49

    Ref: TM-T61590