ROCK
ROCK (Rho-associated protein kinase) inhibitors target ROCK kinases, which are involved in the regulation of the cytoskeleton, cell shape, and motility. ROCK plays a significant role in the control of cell division, particularly in processes such as cytokinesis. Inhibiting ROCK can lead to changes in cell cycle dynamics, cell motility, and apoptosis, making these inhibitors valuable in cancer research, neurobiology, and cardiovascular studies. At CymitQuimica, we provide a selection of high-quality ROCK inhibitors to support your research in cell biology, cytoskeletal dynamics, and disease mechanisms.
Found 62 products of "ROCK"
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ROCK inhibitor-2
CAS:ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).Formula:C21H20N2O2Purity:99.85%Color and Shape:SolidMolecular weight:332.4Ref: TM-T12746
1mg66.00€5mg144.00€10mg216.00€25mg432.00€50mg645.00€100mg905.00€1mL*10mM (DMSO)106.00€Y-33075 dihydrochloride
CAS:Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).Formula:C16H18Cl2N4OPurity:98.88% - 99.89%Color and Shape:SolidMolecular weight:353.25Ref: TM-T13384L
1mg34.00€5mg66.00€10mg102.00€25mg192.00€50mg341.00€100mg510.00€200mg732.00€1mL*10mM (DMSO)78.00€Netarsudil Dihydrochloride
CAS:Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.Formula:C28H29Cl2N3O3Purity:99.94% - 99.98%Color and Shape:SolidMolecular weight:526.45CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Formula:C24H21F3N6OPurity:99.01% - 99.04%Color and Shape:SolidMolecular weight:466.46WAY-656935
CAS:WAY-656935 inhibits ROCK.Formula:C20H28ClN3O3SPurity:97%Color and Shape:SolidMolecular weight:425.97GKI-1 HCl
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.Formula:C15H13Cl2N3Purity:98.1%Color and Shape:SoildMolecular weight:306.19Ref: TM-T11402L
1mg71.00€5mg154.00€10mg221.00€25mg354.00€50mg497.00€100mg705.00€200mg928.00€1mL*10mM (DMSO)167.00€Ripasudil free base
CAS:Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.Formula:C15H18FN3O2SPurity:98%Color and Shape:SolidMolecular weight:323.39Ref: TM-T7492
1mg75.00€5mg150.00€10mg238.00€25mg530.00€50mg873.00€100mg1,459.00€1mL*10mM (DMSO)166.00€LX-7101 hydrochloride
CAS:LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.
Formula:C23H29N7O3xHClPurity:98.96%Color and Shape:SolidMolecular weight:487.99ROCK2-IN-9
ROCK2-IN-9 (compound 7u), a selective ROCK2 inhibitor with an IC50 value of 36.8 nM, demonstrates anticancer properties by impeding cancer cell migration and invasion. This action is achieved through the regulation of various actin cytoskeleton cellular activities. It holds potential for use in breast cancer research.Formula:C28H30N8O2Color and Shape:SolidMolecular weight:510.59Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formula:C14H17N3O2SPurity:99.79% - 99.84%Color and Shape:SolidMolecular weight:291.37GSK269962A hydrochloride
CAS:GSK269962A hydrochloride (GSK 269962 hydrochloride) is a ROCK inhibitor with anti-inflammatory and vasodilatory effects and inhibits ROCK1 and ROCK2.Formula:C29H31ClN8O5Color and Shape:SolidMolecular weight:607.06Cotosudil
CAS:Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.Formula:C16H21N3O2SPurity:98.41%Color and Shape:SolidMolecular weight:319.42Verosudil
CAS:Verosudil (AR-12286), a ROCK1/2 inhibitor (Ki: 2 nM), lowers intraocular pressure in mice by enhancing aqueous outflow.Formula:C17H17N3O2SPurity:99.68%Color and Shape:SolidMolecular weight:327.4Ref: TM-T60924
1mg55.00€5mg147.00€10mg231.00€25mg370.00€50mg522.00€100mg692.00€1mL*10mM (DMSO)161.00€Belumosudil mesylate
CAS:Belumosudil mesylate (KD025 mesylate) is a ROCK2 inhibitor with antifibrotic activity, and can be used in chronic graft-versus-host disease research.Formula:C27H28N6O5SPurity:98.73%Color and Shape:SolidMolecular weight:548.61Ref: TM-T39555
1mg34.00€2mg46.00€5mg71.00€10mg96.00€25mg155.00€50mg230.00€100mg353.00€200mg517.00€1mL*10mM (DMSO)85.00€GSK180736A
CAS:GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).Formula:C19H16FN5O2Purity:98.38% - 98.98%Color and Shape:SolidMolecular weight:365.36Ref: TM-T3513
1mg39.00€2mg50.00€5mg70.00€10mg94.00€25mg161.00€50mg290.00€100mg538.00€500mg1,161.00€1mL*10mM (DMSO)62.00€Thiazovivin
CAS:Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.Formula:C15H13N5OSPurity:98.00%Color and Shape:SolidMolecular weight:311.36Ref: TM-T2155
1mg35.00€2mg48.00€5mg67.00€10mg103.00€25mg190.00€50mg321.00€100mg469.00€1mL*10mM (DMSO)73.00€CCG-222740
CAS:CCG-222740 is an inhibitor of Rho/MRTF pathwayFormula:C23H19ClF2N2O3Purity:98.76%Color and Shape:SolidMolecular weight:444.86Ref: TM-T7764
2mg39.00€5mg62.00€10mg94.00€25mg172.00€50mg260.00€100mg371.00€200mg530.00€1mL*10mM (DMSO)66.00€RKI-1447
CAS:RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.Formula:C16H14N4O2SPurity:98% - 99.73%Color and Shape:SolidMolecular weight:326.37Ref: TM-T1898
5mg51.00€10mg87.00€25mg187.00€50mg311.00€100mg414.00€200mg520.00€500mg840.00€1mL*10mM (DMSO)57.00€Narciclasine
CAS:Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.Formula:C14H13NO7Purity:98.16% - 99.58%Color and Shape:SolidMolecular weight:307.26HA-100
CAS:HA-100 is an inhibitor of protein kinaseFormula:C13H15N3O2SPurity:99.44%Color and Shape:Pale Yellow Crystalline SolidMolecular weight:277.34RKI1313
CAS:RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFormula:C17H16N4O2SPurity:99.53% - ≥95%Color and Shape:SolidMolecular weight:340.4Ref: TM-T2011
1mg70.00€5mg142.00€10mg207.00€25mg369.00€50mg540.00€100mg772.00€500µg49.00€1mL*10mM (DMSO)160.00€Hydroxyfasudil
CAS:Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Formula:C14H17N3O3SPurity:98.13%Color and Shape:SolidMolecular weight:307.37GSK429286A
CAS:GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).Formula:C21H16F4N4O2Purity:97.68% - 98.49%Color and Shape:SolidMolecular weight:432.37SAR407899 hydrochloride
CAS:SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human andFormula:C14H17ClN2O2Purity:99.15%Color and Shape:SolidMolecular weight:280.75SAR407899
CAS:SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.Formula:C14H16N2O2Purity:99.42%Color and Shape:SolidMolecular weight:244.29Ref: TM-T7391
2mg34.00€5mg50.00€10mg75.00€25mg128.00€50mg200.00€100mg319.00€200mg474.00€1mL*10mM (DMSO)55.00€AT13148
CAS:AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Formula:C17H16ClN3OPurity:98.04% - ≥95%Color and Shape:SolidMolecular weight:313.78ROCK-IN-2
CAS:ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.Formula:C18H13ClF2N6OPurity:97.29%Color and Shape:SolidMolecular weight:402.79Ref: TM-TQ0110
1mg108.00€5mg260.00€10mg416.00€25mg690.00€50mg964.00€100mg1,305.00€1mL*10mM (DMSO)353.00€SR-3677
CAS:SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).Formula:C22H24N4O4Purity:98.46%Color and Shape:SolidMolecular weight:408.45ZINC00881524
CAS:ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
Formula:C21H20N2O3SPurity:99.48%Color and Shape:SolidMolecular weight:380.46Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formula:C14H18ClN3O2SPurity:99.54% - ≥95%Color and Shape:White SolidMolecular weight:327.83Afuresertib hydrochloride
CAS:Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
Formula:C18H18Cl3FN4OSPurity:99.96%Color and Shape:SolidMolecular weight:463.8Hydroxyfasudil Hydrochloride
CAS:Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).Formula:C14H18ClN3O3SPurity:98.05%Color and Shape:SolidMolecular weight:343.83Y-27632
CAS:Y-27632 (Y-27632) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II.Formula:C14H21N3OPurity:99.53% - 99.87%Color and Shape:SolidMolecular weight:247.34Belumosudil
CAS:Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).Formula:C26H24N6O2Purity:97.64% - 98.59%Color and Shape:SolidMolecular weight:452.51Ref: TM-T6867
2mg48.00€5mg73.00€10mg90.00€25mg166.00€50mg250.00€100mg376.00€500mg895.00€1mL*10mM (DMSO)79.00€Y-27632 dihydrochloride
CAS:View and buy Y-27632 dihydrochloride from TargetMol.Y-27632 is a selective inhibitor of ROCKs.Cited in 10 publications.Formula:C14H21N3O·2HClPurity:97.96% - 99.98%Color and Shape:SolidMolecular weight:320.26BDP5290
CAS:BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)Formula:C17H18ClN7OPurity:97.22%Color and Shape:SolidMolecular weight:371.82Ref: TM-T7301
1mg52.00€2mg77.00€5mg113.00€10mg178.00€25mg369.00€50mg535.00€100mg780.00€1mL*10mM (DMSO)124.00€Afuresertib
CAS:Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplasticFormula:C18H17Cl2FN4OSPurity:97.51% - 99.51%Color and Shape:SolidMolecular weight:427.32Ref: TM-T1911
1mg37.00€2mg52.00€5mg74.00€10mg92.00€25mg166.00€50mg259.00€100mg452.00€500mg982.00€1mL*10mM (DMSO)74.00€GSK269962A
CAS:GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.Formula:C29H30N8O5Purity:99.14% - 99.71%Color and Shape:SolidMolecular weight:570.6GSK-25
CAS:GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.Formula:C24H16Cl2F2N6OPurity:98.59%Color and Shape:SolidMolecular weight:513.33Ref: TM-T4488
1mg44.00€2mg56.00€5mg87.00€10mg111.00€25mg168.00€50mg258.00€100mg430.00€1mL*10mM (DMSO)89.00€Netarsudil mesylate
CAS:Netarsudil mesylate (AR-13324 mesylate) is a Rho-related protein kinase inhibitor used to study glaucoma and hypertension.Formula:C30H35N3O9S2Purity:99.7%Color and Shape:SolidMolecular weight:645.74Ref: TM-T10358L2
1mg34.00€5mg66.00€10mg105.00€25mg236.00€50mg409.00€100mg700.00€1mL*10mM (DMSO)96.00€H-1152
CAS:H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).Formula:C16H21N3O2SPurity:98%Color and Shape:SolidMolecular weight:319.42SB-772077B dihydrochloride
CAS:SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).Formula:C15H20Cl2N8O2Purity:98%Color and Shape:SolidMolecular weight:415.28Y-33075
CAS:Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.Formula:C16H16N4OPurity:98%Color and Shape:SolidMolecular weight:280.32CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Formula:C26H23N3O5Purity:99.71%Color and Shape:SolidMolecular weight:457.48Ref: TM-T36196
2mg35.00€5mg57.00€10mg90.00€25mg182.00€50mg274.00€100mg434.00€200mg582.00€1mL*10mM (DMSO)57.00€AS 1892802
CAS:AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.Formula:C20H19N3O2Purity:99.86%Color and Shape:SolidMolecular weight:333.38Ref: TM-T22037
1mg49.00€5mg92.00€10mg166.00€25mg358.00€50mg530.00€100mg758.00€200mg1,044.00€1mL*10mM (DMSO)109.00€Rho-Kinase-IN-1
CAS:Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.Formula:C20H24N4SPurity:99.8%Color and Shape:SolidMolecular weight:352.5Ref: TM-T12721
1mg71.00€5mg138.00€10mg205.00€25mg358.00€50mg502.00€100mg665.00€200mg893.00€1mL*10mM (DMSO)105.00€CID-5056270
CAS:CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma
Formula:C17H13N3O3SPurity:99.6%Color and Shape:SolidMolecular weight:339.37Rhodblock 6
CAS:Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.Formula:C12H13N3OPurity:99.87%Color and Shape:SolidMolecular weight:215.25LX7101
CAS:LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).Formula:C23H29N7O3Purity:99.08%Color and Shape:SolidMolecular weight:451.52ROCK-IN-8
CAS:ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,Formula:C30H25FN4O4SPurity:98%Color and Shape:SolidMolecular weight:556.61ROCK-IN-7
CAS:ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Formula:C17H17N3O2SPurity:98%Color and Shape:SolidMolecular weight:327.4ROCK-IN-9
CAS:ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.Formula:C20H20FN5O2Purity:98%Color and Shape:SolidMolecular weight:381.4ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Formula:C26H22ClF2N7OPurity:98%Color and Shape:SolidMolecular weight:521.95Chroman 1
CAS:Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Formula:C24H28N4O4Purity:99.67% - 99.84%Color and Shape:SolidMolecular weight:436.5Ref: TM-T14960
1mg73.00€5mg160.00€10mg250.00€25mg430.00€50mg645.00€100mg888.00€1mL*10mM (DMSO)173.00€ROCK2-IN-2
CAS:ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Formula:C18H12N6OSPurity:99.65%Color and Shape:SolidMolecular weight:360.39Ref: TM-T12747
1mg50.00€5mg111.00€10mg177.00€25mg304.00€50mg447.00€100mg692.00€200mg888.00€1mL*10mM (DMSO)136.00€ROCK-IN-1
CAS:ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurologicalFormula:C20H18FN3OPurity:>99.99%Color and Shape:SolidMolecular weight:335.37H-1152 dihydrochloride
CAS:H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.Formula:C16H23Cl2N3O2SPurity:99.85%Color and Shape:SolidMolecular weight:392.34Ref: TM-T35328
1mg60.00€5mg135.00€10mg215.00€25mg415.00€50mg655.00€100mg888.00€1mL*10mM (DMSO)147.00€ROCK-IN-11
CAS:ROCK-IN-11 (example 94) is an effective inhibitor of ROCK1 and ROCK2, with an IC50 of ≤ 5 μM, and plays a significant role in cancer research.Formula:C22H20N4O4SColor and Shape:SolidMolecular weight:436.484Rhodblock 1a
CAS:Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.
Formula:C20H16N2O2Color and Shape:SolidMolecular weight:316.353Zelasudil
CAS:Zelasudil (RXC007) is a Rho-related (ROCK) kinase inhibitor for the study of idiopathic pulmonary fibrosis and inflammation.Formula:C22H21F2N7OPurity:99.15%Color and Shape:SolidMolecular weight:437.445Ref: TM-T69665
1mg96.00€5mg172.00€10mg261.00€25mg444.00€50mg620.00€100mg865.00€1mL*10mM (DMSO)178.00€ROCK2-IN-6
CAS:ROCK2-IN-6 (Comp A) is a selective inhibitor of ROCK2, applicable in the study and treatment of ROCK-mediated, autoimmune, and inflammatory diseases [1].
Formula:C26H21F2N7OPurity:98%Color and Shape:SolidMolecular weight:485.49ROCK-IN-6
CAS:ROCK-IN-6, a selective ROCK2 inhibitor, exhibits potent inhibition with an IC50 of 2.19 nM and holds promise for research into glaucoma and retinal diseases [1
Formula:C19H19N5O8SPurity:98%Color and Shape:SolidMolecular weight:477.45
