DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(71 products)
- DNA Alkylation(11 products)
- DNA Methyltransferase(422 products)
- DNA gyrase(11 products)
- DNA-PK(50 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,388 products)
- Reverse Transcriptase(43 products)
- Sirtuin(88 products)
- Telomerase(33 products)
- Topoisomerase(136 products)
Show 3 more subcategories
Found 963 products of "DNA Damage/DNA Repair"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Antibacterial agent 236
CAS:<p>Anti bacterial agent 236 (Compound 4l), an orally effective inhibitor of DNA gyrase and topoisomerase IV (with IC50 values of 3.2 and 300 nM in Staphylococcus aureus, respectively), exhibits broad-spectrum antibacterial activity. It also demonstrates favorable pharmacokinetic properties in mice.</p>Formula:C26H27N5O2SColor and Shape:SolidMolecular weight:473.59ATR-IN-11
<p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>Formula:C25H30N6O2Color and Shape:SolidMolecular weight:446.54SARS-CoV-2 nsp14-IN-1
<p>SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.</p>Formula:C20H20N6O5SColor and Shape:SolidMolecular weight:456.48ATR kinase-IN-3
CAS:<p>ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.</p>Formula:C24H27F2N9O2Color and Shape:SolidMolecular weight:511.53TMU 35435
CAS:<p>TMU 35435 is an inhibitor of histone deacetylases (HDAC). It enhances radiosensitivity by inducing the accumulation of misfolded proteins and autophagy (autophagy) in TNBC, and inhibits the NHEJ pathway through ubiquitination of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).</p>Formula:C22H25N3O3Color and Shape:SolidMolecular weight:379.45Camptothecin-20(S)-O-propionate
CAS:<p>CZ-48 is a DNA topoisomerase inhibitor.</p>Formula:C23H20N2O5Color and Shape:SolidMolecular weight:404.42G-631
CAS:<p>G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.</p>Formula:C19H22F2N6O3Color and Shape:SolidMolecular weight:420.41DNA crosslinker 1 dihydrochloride
CAS:<p>DNA Crosslinker 1 binds DNA minor groove with 1.1°C affinity increase; used in cancer research.</p>Formula:C15H22Cl2N8OColor and Shape:SolidMolecular weight:401.29Atiratecan
CAS:<p>Atiratecan (TP300), a CH0793076-based camptothecin prodrug, combats BCRP+/- tumors; doesn't affect AChE.</p>Formula:C31H34N6O6Purity:98%Color and Shape:SolidMolecular weight:586.64PPARγ agonist 1
<p>PPARγ agonist 1 is a potent agonist of PPARγ that efficiently activates hPPARγ without causing full agonism, thereby avoiding adverse effects.</p>Formula:C34H39NO3Color and Shape:SolidMolecular weight:509.68Pparδ agonist 5
<p>Pparδ agonist 5 is a selective, orally active PPARδ agonist with an EC50 of 0.335 μM and better selectivity than GW0742.</p>Formula:C23H21F3N2O2SColor and Shape:SolidMolecular weight:446.49Sirtuin-IN-2
<p>Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.</p>Formula:C28H46N8O6SColor and Shape:SolidMolecular weight:622.78MC3138
CAS:<p>MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.</p>Formula:C25H25NO6Purity:99.57%Color and Shape:SolidMolecular weight:435.47DNA-PK-IN-6
CAS:<p>DNA-PK-IN-6 inhibits DNA-PKcs, disrupting tumor DNA repair and triggering apoptosis; enhances radiotherapy and targets various tumors (WO2021197159A1).</p>Formula:C19H21N7OColor and Shape:SolidMolecular weight:363.42DNA crosslinker 2 dihydrochloride
CAS:<p>Potent DNA crosslinker 2 binds minor groove, increases Tm by 1.2°C, and inhibits NCI-H460, A2780, MCF-7 cancer cells.</p>Formula:C15H22Cl2N8OColor and Shape:SolidMolecular weight:401.29ATM Inhibitor-3
<p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>Formula:C25H29FN6O3Color and Shape:SolidMolecular weight:480.53LP-284
CAS:<p>LP-284 is a DNA alkylating agent effective against solid tumors and hematologic cancers like MCL.</p>Formula:C16H20N2O4Color and Shape:SolidMolecular weight:304.34(Rac)-RG108
CAS:<p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>Formula:C19H14N2O4Color and Shape:SolidMolecular weight:334.326ATR kinase-IN-2
CAS:<p>ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.</p>Formula:C24H29F2N9O2Color and Shape:SolidMolecular weight:513.54PPARα/γ agonist 1
<p>PPARα/γ agonist 1 is a potent and dual PPARα/γ partial agonist which is a promising prototype for the research of dyslipidemia and diabetes.</p>Formula:C18H19NO2Color and Shape:SolidMolecular weight:281.35DNA-PK-IN-15
CAS:DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.Formula:C23H23N9OColor and Shape:SolidMolecular weight:441.49Topoisomerase inhibitor 5
CAS:<p>Topoisomerase inhibitor 5 (compound 158) is an inhibitor of bacterial topoisomerase, with a minimum inhibitory concentration of 0.125 μg/mL, and exhibits anti-tuberculosis activity.</p>Formula:C24H25FN4O6Color and Shape:SolidMolecular weight:484.477KU 59403
CAS:KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).Formula:C29H32N4O4S2Purity:99.10%Color and Shape:SolidMolecular weight:564.72HDAC6-IN-51
CAS:HDAC6-IN-51 (Compound 7e) is a selective inhibitor of HDAC6, exhibiting an IC50 value of 42.9 nM. This compound demonstrates effective anti-pulmonary fibrosis activity.Formula:C24H24ClN5O3Color and Shape:SolidMolecular weight:465.93Cas9-IN-1
<p>Cas9-IN-1 is a potent inhibitor of Cas9 with an IC50 value of 7.02 μM. Cas9-IN-1 acts by binding apo-Cas9 and blocking the formation of the Cas9:gRNA complex.</p>Formula:C17H11Cl2F3N2O3SColor and Shape:SolidMolecular weight:451.25SP-C01
CAS:<p>SP-C01 is an orally active soluble epoxide hydrolase (sEH) inhibitor and a partial agonist of PPARγ. It can inhibit the phosphorylation of Ser273.</p>Formula:C22H22F4N2O5Color and Shape:SolidMolecular weight:470.41TDI-015051
CAS:<p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>Formula:C22H22FN5O4SColor and Shape:SolidMolecular weight:471.505Carbacyclin
CAS:<p>Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.</p>Formula:C21H34O4Purity:98%Color and Shape:SolidMolecular weight:350.49DLK-IN-1
CAS:DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.Formula:C20H24F3N5O2Color and Shape:SolidMolecular weight:423.43WSD0628
CAS:WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].Formula:C23H23F2N5O2Color and Shape:SolidMolecular weight:439.462-Ethylhexyl diphenyl phosphate
CAS:<p>2-Ethylhexyl diphenyl phosphate is an organophosphorus flame retardant (OPFRs) and acts as a PPARG agonist (EC20: 2.04 µM). Additionally, it inhibits the transcriptional activity of ERRγ (IC50: 1.3 µM) and enhances the expression of 3β-HSD1, human chorionic gonadotropin (hCG), and progesterone secretion. This compound is applicable in studies related to female reproduction and fetal development.</p>Formula:C20H27O4PColor and Shape:SolidMolecular weight:362.40Topoisomerase II inhibitor 18
CAS:<p>Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].</p>Formula:C20H21N3OSColor and Shape:SolidMolecular weight:351.47PPARγ agonist 17
CAS:<p>PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.</p>Formula:C48H63NO7Color and Shape:SolidMolecular weight:766.016Anti-NASH agent 2
CAS:<p>Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.</p>Formula:C32H51N3O2Color and Shape:SolidMolecular weight:509.766Intoplicine
CAS:Intoplicine is an inhibitor of DNA topoisomerase I and II.Formula:C21H24N4OPurity:98%Color and Shape:SolidMolecular weight:348.44Gimatecan
CAS:Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formula:C25H25N3O5Purity:98.47%Color and Shape:SolidMolecular weight:447.48E-3030 free acid
CAS:<p>E-3030 free acid, a PPAR agonist, lowers blood glucose, triglycerides, and insulin; boosts adiponectin; reduces apo C-III; and raises lipoprotein lipase.</p>Formula:C22H23ClFNO5Purity:98%Color and Shape:SolidMolecular weight:435.87Levofloxacin mesylate
CAS:<p>Levofloxacin mesylate is an orally active antibiotic effective against both Gram-positive and Gram-negative bacteria. It inhibits DNA gyrase and topoisomerase IV enzymes. Levofloxacin mesylate is employed in research related to chronic periodontitis, airway inflammation, and BK viremia. Additionally, it possesses anti-Orthopoxvirus activity.</p>Formula:C19H24FN3O7SColor and Shape:SolidMolecular weight:457.473Namitecan
CAS:Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.Formula:C23H22N4O5Purity:98%Color and Shape:SolidMolecular weight:434.44PARP1/2-IN-4
CAS:<p>PARP1/2-IN-4 (compound 3) is an inhibitor of PARP1/2.</p>Formula:C23H30FN5O6Color and Shape:SolidMolecular weight:491.51PPARα agonist 1
<p>PPARα agonist 1 is a complete and potent PPARα agonist.</p>Formula:C27H34O4Color and Shape:SolidMolecular weight:422.56TP3011
CAS:<p>TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.</p>Formula:C26H26N4O5Purity:98%Color and Shape:SolidMolecular weight:474.51Bizelesin
CAS:<p>Bizelesin, a synthetic antineoplastic agent, binds DNA, disrupts replication, triggers cell-cycle arrest, and induces senescence.</p>Formula:C43H36Cl2N8O5Color and Shape:SolidMolecular weight:815.7Edotecarin
CAS:<p>Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).</p>Formula:C29H28N4O11Purity:98%Color and Shape:SolidMolecular weight:608.55ATR-IN-14
CAS:<p>ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.</p>Formula:C20H20FN7OColor and Shape:SolidMolecular weight:393.42ATM Inhibitor-2
<p>ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).</p>Formula:C26H31N7O3Color and Shape:SolidMolecular weight:489.57Simmitecan hydrochloride
CAS:<p>Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.</p>Formula:C34H39ClN4O6Purity:98.20% - 98.93%Color and Shape:SolidMolecular weight:635.15KU-60019
CAS:<p>KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).</p>Formula:C30H33N3O5SPurity:98.05% - 98.50%Color and Shape:SolidMolecular weight:547.67BAY-8400
<p>BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in</p>Formula:C21H17F2N5OPurity:99.53%Color and Shape:SolidMolecular weight:393.39OBI-3424
CAS:OBI-3424, a highly selective prodrug, is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent.Formula:C21H25N4O6PPurity:98%Color and Shape:SolidMolecular weight:460.427Merbarone
CAS:<p>Merbarone is a Type II DNA topoisomerase inhibitor. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the n</p>Formula:C11H9N3O3SColor and Shape:SolidMolecular weight:263.27Phenanthriplatin
CAS:<p>Phenanthriplatin, also known as cis-[Pt(NH3)2-(phenanthridine)Cl]NO3, is a new drug candidate. It belongs to a family of platinum(II)-based agents which includes cisplatin, oxaliplatin and carboplatin. Phenanthriplatin Acts As a Covalent Poison of Topoiso</p>Formula:C13H11ClN4O3PtColor and Shape:SolidMolecular weight:501.79YF438
CAS:<p>YF438 is an HDAC inhibitor that demonstrates potent anti-cancer activity both in vitro and in vivo. It inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2 from MDMX, and promoting the degradation of MDM2.</p>Formula:C23H26N4O5Color and Shape:SolidMolecular weight:438.48NSC61610
CAS:<p>NSC61610 is anti-inflammatory that activates PPARγ in vitro via LANCL2 and adenylate cyclase/cAMP-dependent pathways, thereby improving experimental colitis.</p>Formula:C34H24N6O2Purity:98%Color and Shape:SolidMolecular weight:548.59Zabofloxacin hydrochloride
CAS:<p>Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia.</p>Formula:C19H21ClFN5O4Purity:98%Color and Shape:SolidMolecular weight:437.86SR-4370
CAS:<p>SR-4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp.</p>Formula:C17H18F2N2OPurity:99.50%Color and Shape:SolidMolecular weight:304.33Fotemustine
CAS:<p>Fotemustine: antineoplastic, chloroethylates DNA, blocks synthesis, causes cell arrest/apoptosis, lipophilic, crosses blood-brain barrier.</p>Formula:C9H19ClN3O5PColor and Shape:SolidMolecular weight:315.69Mavodelpar free base
CAS:<p>Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.</p>Formula:C31H30FNO5Purity:98%Color and Shape:SolidMolecular weight:515.57ATR-IN-24
CAS:<p>ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].</p>Formula:C23H26N6O2Purity:98%Color and Shape:SolidMolecular weight:418.49Lerzeparib
CAS:<p>Lerzeparib is a PARP (ADP-ribose polymerase) inhibitor that exhibits antineoplastic activity [1].</p>Formula:C21H20FN3O2Purity:98%Color and Shape:SolidMolecular weight:365.4MDL-811
CAS:<p>MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),</p>Formula:C25H25BrCl2FN3O5S2Purity:98%Color and Shape:SolidMolecular weight:681.42Antitumor agent-104
CAS:<p>Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzyme</p>Formula:C31H33FN6O3Purity:98%Color and Shape:SolidMolecular weight:556.63PARP7-IN-16 free base
CAS:<p>PARP7-IN-16 free base is the freebase form of PARP7-IN-16. As a selective oral inhibitor of PARP-1/2/7, it demonstrates IC50 values of 0.94, 0.87, and 0.21 nM, respectively. This compound is utilized in the research of breast and prostate cancer.</p>Formula:C25H27FN4O4Color and Shape:SolidMolecular weight:466.50Ref: TM-T200703
Discontinued product
