DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(72 products)
- DNA Alkylation(19 products)
- DNA Methyltransferase(460 products)
- DNA gyrase(6 products)
- DNA-PK(49 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,419 products)
- Reverse Transcriptase(42 products)
- Sirtuin(86 products)
- Telomerase(34 products)
- Topoisomerase(127 products)
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Found 893 products of "DNA Damage/DNA Repair"
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Gepotidacin hydrochloride
CAS:Gepotidacin (GSK-2140944) is a potent DNA topoisomerase inhibitor, a novel antibacterial efficacious against various anaerobes.Formula:C24H29ClN6O3Color and Shape:SolidMolecular weight:484.98TP3011
CAS:TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.Formula:C26H26N4O5Purity:98%Color and Shape:SolidMolecular weight:474.51Karenitecin
CAS:Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.Formula:C25H28N2O4SiPurity:98%Color and Shape:SolidMolecular weight:448.59Anti-NASH agent 2
CAS:Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.
Formula:C32H51N3O2Color and Shape:SolidMolecular weight:509.766PPARα agonist 1
PPARα agonist 1 is a complete and potent PPARα agonist.Formula:C27H34O4Color and Shape:SolidMolecular weight:422.56SP-C01
CAS:SP-C01 is an orally active soluble epoxide hydrolase (sEH) inhibitor and a partial agonist of PPARγ. It can inhibit the phosphorylation of Ser273.Formula:C22H22F4N2O5Color and Shape:SolidMolecular weight:470.41DNA-PK-IN-9
DNA-PK-IN-9 (YK6) is a potent DNA-PK inhibitor with an IC50 of 10.47 nM, important in cancer research.Formula:C21H21N5O2Color and Shape:SolidMolecular weight:375.42DLK-IN-1
CAS:DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.Formula:C20H24F3N5O2Color and Shape:SolidMolecular weight:423.43Pparδ agonist 5
Pparδ agonist 5 is a selective, orally active PPARδ agonist with an EC50 of 0.335 μM and better selectivity than GW0742.Formula:C23H21F3N2O2SColor and Shape:SolidMolecular weight:446.49DNA crosslinker 2 dihydrochloride
CAS:Potent DNA crosslinker 2 binds minor groove, increases Tm by 1.2°C, and inhibits NCI-H460, A2780, MCF-7 cancer cells.Formula:C15H22Cl2N8OColor and Shape:SolidMolecular weight:401.29Topoisomerase II inhibitor 6
Topoisomerase II inhibitor 6, a potent tryptanthrin derivative, blocks G2 phase in CCRF-CEM cells, induces DNA breaks, and may be used for cancer research.Formula:C19H18N4O2Color and Shape:SolidMolecular weight:334.37Topoisomerase II inhibitor 18
CAS:Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].Formula:C20H21N3OSColor and Shape:SolidMolecular weight:351.47PPARγ agonist 17
CAS:PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.Formula:C48H63NO7Color and Shape:SolidMolecular weight:766.016E-3030 free acid
CAS:E-3030 free acid, a PPAR agonist, lowers blood glucose, triglycerides, and insulin; boosts adiponectin; reduces apo C-III; and raises lipoprotein lipase.Formula:C22H23ClFNO5Purity:98%Color and Shape:SolidMolecular weight:435.87Topotecan acetate
CAS:Topotecan acetate is an inhibitor of topoisomerase.Formula:C25H27N3O7Color and Shape:SolidMolecular weight:481.4982-Ethylhexyl diphenyl phosphate
CAS:2-Ethylhexyl diphenyl phosphate is an organophosphorus flame retardant (OPFRs) and acts as a PPARG agonist (EC20: 2.04 µM). Additionally, it inhibits the transcriptional activity of ERRγ (IC50: 1.3 µM) and enhances the expression of 3β-HSD1, human chorionic gonadotropin (hCG), and progesterone secretion. This compound is applicable in studies related to female reproduction and fetal development.Formula:C20H27O4PColor and Shape:SolidMolecular weight:362.40S39625
CAS:S39625 is a stable, potent topoisomerase I inhibitor with anticancer properties, resistant to efflux transporters, inducing gamma-H2AX at nanomolar levels.Formula:C25H22N2O5Purity:98%Color and Shape:SolidMolecular weight:430.45Saintopin
CAS:Saintopin is an antitumor antibiotic and an inhibitor of DNA topoisomerases I and II, which induces DNA cleavage [1] [2].Formula:C18H10O7Color and Shape:SolidMolecular weight:338.27PPARδ agonist 11
CAS:Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.Formula:C19H15F3N2O3S2Color and Shape:SolidMolecular weight:440.46TH1338
CAS:TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.
Formula:C22H21N3O4Purity:98.77%Color and Shape:SolidMolecular weight:391.42
