DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(72 products)
- DNA Alkylation(19 products)
- DNA Methyltransferase(460 products)
- DNA gyrase(6 products)
- DNA-PK(49 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,419 products)
- Reverse Transcriptase(42 products)
- Sirtuin(86 products)
- Telomerase(34 products)
- Topoisomerase(127 products)
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Found 893 products of "DNA Damage/DNA Repair"
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LP-284
CAS:LP-284 is a DNA alkylating agent effective against solid tumors and hematologic cancers like MCL.Formula:C16H20N2O4Color and Shape:SolidMolecular weight:304.34DNA-PK-IN-6
CAS:DNA-PK-IN-6 inhibits DNA-PKcs, disrupting tumor DNA repair and triggering apoptosis; enhances radiotherapy and targets various tumors (WO2021197159A1).Formula:C19H21N7OColor and Shape:SolidMolecular weight:363.42RU-0415529
CAS:RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.Formula:C21H29N3O4SColor and Shape:SolidMolecular weight:419.538(Rac)-RG108
CAS:(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.Formula:C19H14N2O4Color and Shape:SolidMolecular weight:334.326PPARγ agonist 1
PPARγ agonist 1 is a potent agonist of PPARγ that efficiently activates hPPARγ without causing full agonism, thereby avoiding adverse effects.Formula:C34H39NO3Color and Shape:SolidMolecular weight:509.68Topoisomerase II inhibitor 5
Topoisomerase II inhibitor 5 (Compound E24) is a DNAtopoisomerase II inhibitor with anticancer effects.Formula:C26H27N5O4Color and Shape:SolidMolecular weight:473.52DNA-PK-IN-15
CAS:DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.Formula:C23H23N9OColor and Shape:SolidMolecular weight:441.49PPARδ agonist 11
CAS:Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.Formula:C19H15F3N2O3S2Color and Shape:SolidMolecular weight:440.46Exatecan-amide-cyclopropanol
CAS:Exatecan-amide-cyclopropanol potently inhibits SK-BR-3 and U87 cancer cells (IC50 0.12 and 0.23 nM)Formula:C28H26FN3O6Purity:98.308%Color and Shape:SolidMolecular weight:519.522-Ethylhexyl diphenyl phosphate
CAS:2-Ethylhexyl diphenyl phosphate is an organophosphorus flame retardant (OPFRs) and acts as a PPARG agonist (EC20: 2.04 µM). Additionally, it inhibits the transcriptional activity of ERRγ (IC50: 1.3 µM) and enhances the expression of 3β-HSD1, human chorionic gonadotropin (hCG), and progesterone secretion. This compound is applicable in studies related to female reproduction and fetal development.Formula:C20H27O4PColor and Shape:SolidMolecular weight:362.40ATM Inhibitor-4
ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.Formula:C26H29FN6O3Color and Shape:SolidMolecular weight:492.55Gepotidacin hydrochloride
CAS:Gepotidacin (GSK-2140944) is a potent DNA topoisomerase inhibitor, a novel antibacterial efficacious against various anaerobes.Formula:C24H29ClN6O3Color and Shape:SolidMolecular weight:484.98Fonadelpar
CAS:Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.Formula:C25H23F3N2O4SPurity:98%Color and Shape:SolidMolecular weight:504.52PPARγ agonist 10
CAS:PPARγ agonist 10 (compound 33g) serves as a PPARγ agonist, enhancing insulin secretion, glucose uptake, and insulin sensitivity in βTC6 cells [1].Formula:C17H14N4O3S2Color and Shape:SolidMolecular weight:386.45Moflomycin
CAS:Moflomycin is an anthracycline derivative. It exhibits a higher antileukemic activity compared to other anthracyclines.Formula:C25H25IO10Purity:98%Color and Shape:SolidMolecular weight:612.36LMP517
CAS:LMP517 (NSC 781517), an indenoisoquinoline, is a potent dual TOP1 and TOP2 inhibitor that shows better antitumor activity than its parent compound LMP744 against H82 (Small Cell Lung Cancer) xenografts, inducing TOP1 cleavage complexes (TOP1ccs) and TOP2ccs [1].Formula:C22H19FN2O5Color and Shape:SolidMolecular weight:410.4S39625
CAS:S39625 is a stable, potent topoisomerase I inhibitor with anticancer properties, resistant to efflux transporters, inducing gamma-H2AX at nanomolar levels.Formula:C25H22N2O5Purity:98%Color and Shape:SolidMolecular weight:430.45Antibacterial agent 236
CAS:Anti bacterial agent 236 (Compound 4l), an orally effective inhibitor of DNA gyrase and topoisomerase IV (with IC50 values of 3.2 and 300 nM in Staphylococcus aureus, respectively), exhibits broad-spectrum antibacterial activity. It also demonstrates favorable pharmacokinetic properties in mice.Formula:C26H27N5O2SColor and Shape:SolidMolecular weight:473.59Saintopin
CAS:Saintopin is an antitumor antibiotic and an inhibitor of DNA topoisomerases I and II, which induces DNA cleavage [1] [2].Formula:C18H10O7Color and Shape:SolidMolecular weight:338.27ATR-IN-14
CAS:ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.Formula:C20H20FN7OColor and Shape:SolidMolecular weight:393.42
