DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(72 products)
- DNA Alkylation(19 products)
- DNA Methyltransferase(460 products)
- DNA gyrase(6 products)
- DNA-PK(49 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,419 products)
- Reverse Transcriptase(42 products)
- Sirtuin(86 products)
- Telomerase(34 products)
- Topoisomerase(127 products)
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Found 893 products of "DNA Damage/DNA Repair"
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PPARγ agonist 2
PPARγ agonist 2 is a highly effective compound that acts as a partial agonist for PPARγ.Formula:C24H20O5Color and Shape:SolidMolecular weight:388.41ATR-IN-17
CAS:ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).Formula:C22H28N6O2SColor and Shape:SolidMolecular weight:440.56NU5455
CAS:NU5455 is a potent DNA-PKcs inhibitor, oral, boosts doxorubicin in liver tumors, amplifies topoisomerase inhibitors, no adverse effects.Formula:C34H33N3O5SColor and Shape:SolidMolecular weight:595.71PPARα/γ agonist 1
PPARα/γ agonist 1 is a potent and dual PPARα/γ partial agonist which is a promising prototype for the research of dyslipidemia and diabetes.Formula:C18H19NO2Color and Shape:SolidMolecular weight:281.35Namitecan
CAS:Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.Formula:C23H22N4O5Purity:98%Color and Shape:SolidMolecular weight:434.44HDAC8-IN-12
CAS:HDAC8-IN-12 (compound 5k), a non-hydroxamic acid derivative, serves as a selective HDAC8 inhibitor with an IC 50 of 0.12 nM and demonstrates potent efficacy against breast cancer. This compound enhances anti-tumor immunity by activating T cells, elevating M1 macrophage levels, and reducing M2 macrophage proportions. In an orthotopic mouse model of breast cancer, HDAC8-IN-12, administered at 50 mg/kg, effectively suppresses tumor growth.Formula:C16H17N3O5Color and Shape:SolidMolecular weight:331.32TDI-015051
CAS:TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.Formula:C22H22FN5O4SColor and Shape:SolidMolecular weight:471.505ATR kinase-IN-3
CAS:ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.Formula:C24H27F2N9O2Color and Shape:SolidMolecular weight:511.53Cas9-IN-1
Cas9-IN-1 is a potent inhibitor of Cas9 with an IC50 value of 7.02 μM. Cas9-IN-1 acts by binding apo-Cas9 and blocking the formation of the Cas9:gRNA complex.Formula:C17H11Cl2F3N2O3SColor and Shape:SolidMolecular weight:451.25ATM Inhibitor-11
CAS:ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.Formula:C27H33FN6O2Color and Shape:SolidMolecular weight:492.59TERT ligand-1
CAS:TERT ligand-1 is a PROTAC target protein ligand used in the synthesis of PROTAC NU-PRO-1. NU-PRO-1 can induce the degradation of TERT in cancer cells.Formula:C21H23F2N3O4Color and Shape:SolidMolecular weight:419.42DNA-PK-IN-2
CAS:DNA-PK-IN-2 is an inhibitor of the DNA-PK enzyme complex, useful in cancer research.Formula:C20H23N5O3Color and Shape:SolidMolecular weight:381.43DNA crosslinker 3 dihydrochloride
CAS:Compound 1: a DNA minor groove binder with 1.4°C ΔTm; useful in cancer research.Formula:C15H22Cl2N8OColor and Shape:SolidMolecular weight:401.29TERT activator-2
CAS:TERT activator-2 (Compound 1030) is an activator of telomerase reverse transcriptase (TERT), which enhances the expression levels of TERT within cells. TERT activator-2 is applicable to research related to cellular lifespan and telomere functions.Formula:C21H22N2O2Color and Shape:SolidMolecular weight:334.412PPARγ modulator-2
CAS:PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.Formula:C26H21NO7S3SeColor and Shape:SolidMolecular weight:634.6(1S,2R,7S)-Sitafloxacin
CAS:(1S,2R,7S)-Sitafloxacin (DU-6856) is an enantiomer of Sitafloxacin and functions as a topoisomerase inhibitor. As an antibiotic, it demonstrates inhibitory activity against Escherichia coli DNA gyrase (IC50 0.18 μg/mL) and Staphylococcus aureus topoisomerase IV. (1S,2R,7S)-Sitafloxacin exhibits antibacterial properties and is utilized in the study of various bacterial infections.Formula:C19H18ClF2N3O3Color and Shape:SolidMolecular weight:409.81(S)-WSD0628
CAS:(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.Formula:C23H23F2N5O2Color and Shape:SolidMolecular weight:439.458(1R,2S,7R)-Sitafloxacin
CAS:(R)-Sitafloxacin (DU-6857) is an enantiomer of Sitafloxacin (DU-6859a) and functions as a topoisomerase inhibitor, demonstrating an IC50 of 0.18 μg/mL against DNA gyrase.Formula:C19H18ClF2N3O3Color and Shape:SolidMolecular weight:409.814Amezalpat
CAS:Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.Formula:C34H41N3O4Color and Shape:SolidMolecular weight:555.707ATR-IN-19
CAS:ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].Formula:C18H19N7OSColor and Shape:SolidMolecular weight:381.45
