DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(72 products)
- DNA Alkylation(17 products)
- DNA Methyltransferase(459 products)
- DNA gyrase(6 products)
- DNA-PK(49 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,422 products)
- Reverse Transcriptase(42 products)
- Sirtuin(86 products)
- Telomerase(33 products)
- Topoisomerase(132 products)
Show 3 more subcategories
Found 940 products of "DNA Damage/DNA Repair"
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25-Hydroxytachysterol3
CAS:25-Hydroxytachysterol3 is a metabolite of Vitamin D3 that inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts while promoting the differentiation of keratinocytes and the expression of antioxidant-related genes. It activates receptors including the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXRα/β), and peroxisome proliferator-activated receptor γ (PPARγ), and enhances the expression of CYP24A1.Formula:C27H44O2Color and Shape:SolidMolecular weight:400.64TRF1-TIN2 interaction-IN-1
TRF1-TIN2 interaction-IN-1 (Compound 40) is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 (KD= 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50= 67 μM). By occupying a hotspot at the TRF1-TIN2 interface, TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2. This compound can remove TRF1 from the shelterin complex, making it useful for research on shelterin-related cancers.Formula:C19H18O6SColor and Shape:SolidMolecular weight:374.4120-carboxy Arachidonic Acid
CAS:20-COOH-AA, 20-HETE metabolite, inhibits kidney ion transport, relaxes constricted vessels, and activates PPARα/γ.Formula:C20H30O4Color and Shape:SolidMolecular weight:334.456Methylation Compound Library
xnum methylation-related compounds that can be used for high-throughput and high-content screening.Color and Shape:Odour SolidRef: TM-L3510
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquire15-LOX-IN-2
15-LOX-IN-2 (Compound 2a) is an orally active inhibitor of COX-2/15-LOX and a partial agonist of PPARγ. It exhibits anti-inflammatory activity by inhibiting levels of 20-HETE, IL-1β, and TNF-α in LPS-treated RAW 264.7 cells. Additionally, it significantly enhances glucose uptake without the presence of insulin and is applicable in metabolic disease research.Color and Shape:Odour SolidNHC-triphosphate tetrasodium
NHC-triphosphate tetrasodium, a metabolite of β-d-N4-Hydroxycytidine, acts as a viral polymerase substrate affecting HCV RNA replication.Formula:C9H12N3Na4O15P3Color and Shape:SolidMolecular weight:587.08PDPH Crosslinker
CAS:PDPH crosslinker(SPDP Hydrazide) is a lytic heterobisfunctional protein crosslinker.Formula:C8H11N3OS2Color and Shape:SolidMolecular weight:229.32Drupanin
CAS:Drupanin, isolated from green propolis, selectively inhibits the AKR1C3 enzyme and shows promise for breast cancer research [1].Formula:C14H16O3Color and Shape:SolidMolecular weight:232.28N-desmethyl Rosiglitazone
CAS:N-desmethyl Rosiglitazone, a major rosiglitazone metabolite by CYP2C8, treats type 2 diabetes as a selective PPARγ ligand.Formula:C17H17N3O3SColor and Shape:SolidMolecular weight:343.4Wistin
CAS:Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] .Formula:C23H24O10Color and Shape:SolidMolecular weight:460.43DB1255 2TFA
DB1255 2TFA is an ERG/DNA binding inhibitor with an unusual and potent monomer binding pattern at the minor groove site for the study of genetic disorders.Formula:C26H20F6N4O4S2Purity:98.32%Color and Shape:SolidMolecular weight:630.58Prednimustine
CAS:Prednimustine (Leo 1031; NSC 134087), an ester of Prednisolone and Chlorambucil, is used in leukemia and lymphoma studies.Formula:C35H45Cl2NO6Color and Shape:SolidMolecular weight:646.64Pericosine A
CAS:Pericosine A, a fungal metabolite from P. byssoides, shows anticancer effects (GI50s = 0.05-24.55 μM) and EGFR inhibition (40-70% at 100 μg/ml).
Formula:C8H11ClO5Color and Shape:SolidMolecular weight:222.62nTZDpa
CAS:nTZDpa is an antibiotic with antimicrobial activity.Formula:C22H15Cl2NO2SColor and Shape:SolidMolecular weight:428.3317-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).
Formula:C22H32O3Color and Shape:SolidMolecular weight:344.495PR-104 sodium
CAS:PR-104 sodium: hypoxia-activated, tumor-targeting pre-prodrug; turns into PR-104A for research.Formula:C14H19BrN4NaO12PSColor and Shape:SolidMolecular weight:601.25Antitumor agent-63
CAS:Compound 40, a non-toxic 20(S)-O-CPT glycoconjugate, is stable, with low Topo I inhibition.Formula:C38H46N4O18Color and Shape:SolidMolecular weight:846.79Monascin
CAS:Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.Formula:C21H26O5Purity:98%Color and Shape:SolidMolecular weight:358.43GSK3735967
CAS:GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formula:C25H31N7OSColor and Shape:SolidMolecular weight:477.62Silatecan
CAS:Silatecan is a useful organic compound for research related to life sciences. The catalog number is T67968 and the CAS number is 220913-32-6.Formula:C26H30N2O5SiColor and Shape:SoildMolecular weight:478.61
