Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
Found 127 products for "Topoisomerase".
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Aurintricarboxylic acid
CAS:Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Formula:C22H14O9Purity:85% - 97.1%Color and Shape:Deep Red Coarse Crystalline PowderMolecular weight:422.34Genz-644282
CAS:Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Formula:C22H21N3O5Purity:97.49%Color and Shape:SolidMolecular weight:407.42Berberine hydrogen sulphate
CAS:Berberine hydrogen sulphate, a plant alkaloid, has broad antimicrobial effects on bacteria, fungi, and protozoa.Formula:C20H19NO8SPurity:99% - 99.82%Color and Shape:Yellow Crystals Off-White To Yellow PowderMolecular weight:433.43Belotecan hydrochloride
CAS:Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activityFormula:C25H28ClN3O4Purity:99.63% - ≥95%Color and Shape:SolidMolecular weight:469.96Ref: TM-T7551
1mg34.00€5mg66.00€1mL*10mM (DMSO)69.00€10mg90.00€25mg144.00€50mg200.00€100mg280.00€200mg416.00€Gatifloxacin hydrochloride
CAS:Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.Formula:C19H23ClFN3O4Purity:99.85% - 99.89%Color and Shape:SolidMolecular weight:411.86Razoxane
CAS:Razoxane is used as an antimitotic agent with immunosuppressive properties.Formula:C11H16N4O4Purity:99.75%Color and Shape:SolidMolecular weight:268.27Phenoxodiol
CAS:Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Formula:C15H12O3Purity:98.07% - 99.18%Color and Shape:White SolidMolecular weight:240.25Ref: TM-T16522
1mg63.00€5mg137.00€1mL*10mM (DMSO)150.00€10mg215.00€25mg353.00€50mg537.00€100mg767.00€Idarubicin hydrochloride
CAS:Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Formula:C26H27NO9·HClPurity:98.91% - 99.96%Color and Shape:SolidMolecular weight:533.95Voreloxin hydrochloride
CAS:Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.Formula:C18H20ClN5O4SPurity:99.84%Color and Shape:SolidMolecular weight:437.9SN-38
CAS:SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Formula:C22H20N2O5Purity:98% - 99.97%Color and Shape:Yellow SolidMolecular weight:392.40Pixantrone dimaleate
CAS:Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.Formula:C25H27N5O10Purity:98.70% - 99.11%Color and Shape:Blue SolidMolecular weight:557.21Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formula:C51H34N6Na6O23S6Purity:97.47% - 99.97%Color and Shape:WhiteMolecular weight:1429.15(S)-10-Hydroxycamptothecin
CAS:(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Formula:C20H16N2O5Purity:99.09% - 99.81%Color and Shape:SolidMolecular weight:364.35Bisantrene
CAS:Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus the cardiotoxicity.Formula:C22H22N8Purity:96.22% - 97.13%Color and Shape:Orange SolidMolecular weight:398.469-amino-CPT
CAS:9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.Formula:C20H17N3O4Purity:99.13% - 99.82%Color and Shape:Yellow SolidMolecular weight:363.379-Hydroxycamptothecin
CAS:9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.Formula:C20H16N2O5Purity:98.28%Color and Shape:Yellow SolidMolecular weight:364.35Isosteviol
CAS:Isosteviol is a natural sweetener with anti-inflammatory, anti-tumor, glucose-lowering, and other health benefits.Formula:C20H30O3Purity:99.72% - 99.97%Color and Shape:SolidMolecular weight:318.45SW044248
CAS:SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.Formula:C22H23N5O2SPurity:99.56% - 99.87%Color and Shape:SolidMolecular weight:421.52Niranthin
CAS:Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L.Formula:C24H32O7Purity:99.8%Color and Shape:SolidMolecular weight:432.51Ref: TM-TN4660
1mg345.00€5mg762.00€1mL*10mM (DMSO)808.00€10mg1,144.00€25mg2,008.00€50mg3,213.00€100mg5,139.00€Pirarubicin
CAS:Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.Formula:C32H37NO12Purity:97.80% - 99.15%Color and Shape:SolidMolecular weight:627.64
