Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
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Aldoxorubicin hydrochloride
CAS:1361563-03-2
Aldoxorubicin hydrochloride is an albumin-binding prodrug of Doxorubicin, a DNA topoisomerase II inhibitor.
Formula:
C37H43ClN4O13
Purity:
100%
Color and Shape:
Soild
Molecular weight:
787.21
Ref: TM-T11090L1
| 1mg | 63.00 € | ||
| 2mg | 85.00 € | ||
| 5mg | 115.00 € | ||
| 10mg | 153.00 € | ||
| 25mg | 298.00 € | ||
| 50mg | 442.00 € | ||
| 100mg | 648.00 € | ||
| 500mg | 1,378.00 € |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Topixantrone 2HCl
CAS:2514569-86-7
Topixantrone 2HCl is a DNA topoisomerase inhibitor with antitumor activity for the study of gastric …
Formula:
C21H28Cl2N6O2
Purity:
98.18% - 99.96%
Color and Shape:
Soild
Molecular weight:
467.39
Ref: TM-T28994L
| 1mg | 185.00 € | ||
| 5mg | 459.00 € | ||
| 10mg | 657.00 € | ||
| 25mg | 1,026.00 € | ||
| 50mg | 1,415.00 € | ||
| 100mg | 1,872.00 € |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Rebeccamycin
CAS:93908-02-2
Rebeccamycin: an antitumor antibiotic; targets DNA topoisomerase I; minor effect on kinase C and topo …
Formula:
C27H21Cl2N3O7
Purity:
98%
Color and Shape:
Solid
Molecular weight:
570.38
Ref: TM-T16726
| 500µg | 423.00 € | ||
| 2500µg | 1,882.00 € |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Doxorubicin
CAS:23214-92-8
Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
Formula:
C27H29NO11
Purity:
98%
Color and Shape:
Red Crystalline Solid Solid
Molecular weight:
543.52
Ref: TM-T1456
| 10mg | To inquire |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Topoisomerase II inhibitor 13
CAS:451515-89-2
WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.
Formula:
C22H23N9
Purity:
98.4%
Color and Shape:
Soild
Molecular weight:
413.48
Ref: TM-T67899
| 2mg | 35.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 85.00 € | ||
| 25mg | 129.00 € | ||
| 50mg | 187.00 € | ||
| 100mg | 278.00 € | ||
| 200mg | 394.00 € |
Estimated delivery in United States, on Tuesday 15 Apr 2025
TAK1 inhibitor
CAS:1326712-16-6
TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with …
Formula:
C22H19ClN6O2S
Purity:
98%
Color and Shape:
Soild
Molecular weight:
466.94
Ref: TM-T67909
| 5mg | 2,347.00 € | ||
| 50mg | 4,731.00 € | ||
| 100mg | 6,650.00 € |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Gimatecan HCl
Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable …
Formula:
C25H26ClN3O5
Purity:
97.04%
Color and Shape:
Soild
Molecular weight:
483.94
Ref: TM-T21319L
| 1mg | 47.00 € | ||
| 2mg | 58.00 € | ||
| 5mg | 80.00 € | ||
| 10mg | 119.00 € | ||
| 25mg | 188.00 € | ||
| 50mg | 283.00 € |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Oxaquin TEA
Oxaquin TEA (MCB-3837 TEA), a precursor compound to MCB3681, is a DNA topoisomerase inhibitor that …
Formula:
C37H48F2N5O11P
Purity:
99.79%
Color and Shape:
Liquid
Molecular weight:
807.77
Ref: TM-T12337L
| 1mg | 185.00 € | ||
| 5mg | 409.00 € | ||
| 10mg | 605.00 € | ||
| 25mg | 938.00 € | ||
| 50mg | 1,293.00 € | ||
| 100mg | 1,738.00 € |
Estimated delivery in United States, on Tuesday 15 Apr 2025
(rac)-Exatecan Intermediate 1
CAS:102978-40-5
(rac)-Exatecan Intermediate 1 is a camptothecin derivative, a potential topoisomerase I inhibitor, used in tumor …
Formula:
C13H13NO5
Color and Shape:
Liquid
Molecular weight:
263.25
Ref: TM-T88858
| 5mg | 35.00 € | ||
| 10mg | 50.00 € | ||
| 25mg | 80.00 € | ||
| 50mg | 114.00 € | ||
| 100mg | 177.00 € |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Mauritianin
CAS:109008-28-8
Mauritianin, a kaempferol glycoside from Acalypha indica, inhibits topoisomerase I and has cytoprotective properties.
Formula:
C33H40O19
Purity:
97.5%
Color and Shape:
Solid
Molecular weight:
740.66
Ref: TM-TN1917
| 1mg | 93.00 € | ||
| 5mg | 236.00 € | ||
| 10mg | 416.00 € | ||
| 25mg | 662.00 € |
Estimated delivery in United States, on Tuesday 15 Apr 2025
DiPT-4
DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and …
Formula:
C32H22FN5O4S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
591.61
Ref: TM-T78747
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 15 Apr 2025
CH-0793076
CAS:534605-78-2
CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).
Formula:
C26H26N4O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
458.51
Ref: TM-T14945
| 25mg | 2,727.00 € | ||
| 50mg | 3,591.00 € | ||
| 100mg | 4,940.00 € | ||
| 500mg | To inquire |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Ledoxantrone trihydrochloride
CAS:119221-49-7
Ledoxantrone trihydrochloride is a Top II inhibitor with anticancer activity and is used in the …
Formula:
C21H30Cl3N5OS
Purity:
98.13%
Color and Shape:
Soild
Molecular weight:
506.92
Ref: TM-T68091L
| 1mg | 270.00 € | ||
| 5mg | 595.00 € | ||
| 10mg | 893.00 € | ||
| 25mg | 1,520.00 € | ||
| 50mg | 2,280.00 € | ||
| 100mg | 3,420.00 € |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Topoisomerase I/II inhibitor 6
TopoisomeraseI/II inhibitor 6 (compound 3i) acts as an effective inhibitor of topoisomerase I and II, …
Formula:
C31H28F2N4O6S
Color and Shape:
Liquid
Molecular weight:
622.64
Ref: TM-T201278
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Topoisomerases/ribosomes-IN-1
Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory …
Formula:
C53H83FN6O15
Color and Shape:
Liquid
Molecular weight:
1063.26
Ref: TM-T200217
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered …
Formula:
C21H21N3O2
Color and Shape:
Liquid
Molecular weight:
347.41
Ref: TM-T200315
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 15 Apr 2025
XR-11576 HCl
XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor …
Formula:
C23H25ClN4O2
Purity:
98.89%
Color and Shape:
Soild
Molecular weight:
424.92
Ref: TM-T26339L
| 1mg | 185.00 € | ||
| 5mg | 409.00 € | ||
| 10mg | 605.00 € | ||
| 25mg | 938.00 € | ||
| 50mg | 1,293.00 € | ||
| 100mg | 1,738.00 € | ||
| 500mg | 3,496.00 € |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Antitumor agent-102
Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose …
Formula:
C70H82N8O18S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
1355.51
Ref: TM-T79263
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Pyronaridine tetraphosphate
CAS:76748-86-2
Pyronaridine tetraphosphate is a DNA topoisomerase 2 inhibitor with antimalarial and antitumor activity for the …
Formula:
C29H44ClN5O18P4
Purity:
99.82%
Color and Shape:
Solid
Molecular weight:
910.03
Ref: TM-T16697
| 10mg | 34.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Tuesday 15 Apr 2025
Lurtotecan
CAS:149882-10-0
Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer …
Formula:
C28H30N4O6
Purity:
97.08%
Color and Shape:
Soild
Molecular weight:
518.56
Ref: TM-T60163
| 1mg | 301.00 € | ||
| 5mg | 733.00 € | ||
| 10mg | 1,026.00 € | ||
| 25mg | 1,501.00 € | ||
| 50mg | 2,052.00 € | ||
| 100mg | 2,775.00 € |
Estimated delivery in United States, on Tuesday 15 Apr 2025
