Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
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Exatecan
CAS:171335-80-1
Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 …
Formula:
C24H22FN3O4
Purity:
99.64% - 99.84%
Color and Shape:
Solid
Molecular weight:
435.45
Ref: TM-T11249
| 10mg | 35.00 € | ||
| 25mg | 69.00 € | ||
| 50mg | 90.00 € | ||
| 100mg | 133.00 € | ||
| 500mg | 316.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
β-Lapachone
CAS:4707-32-8
β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA …
Formula:
C15H14O3
Purity:
99.64% - 99.81%
Color and Shape:
Solid
Molecular weight:
242.27
Ref: TM-T6407
| 5mg | 47.00 € | ||
| 10mg | 60.00 € | ||
| 25mg | 95.00 € | ||
| 50mg | 182.00 € | ||
| 100mg | 301.00 € | ||
| 200mg | 451.00 € | ||
| 500mg | 741.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Indotecan
CAS:915303-09-2
Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for …
Formula:
C26H26N2O7
Purity:
97% - 98%
Color and Shape:
Solid
Molecular weight:
478.49
Ref: TM-T15578
| 1mg | 69.00 € | ||
| 5mg | 123.00 € | ||
| 10mg | 193.00 € | ||
| 25mg | 346.00 € | ||
| 50mg | 547.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Rubitecan
CAS:91421-42-0
Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.
Formula:
C20H15N3O6
Purity:
≥95%
Color and Shape:
Yellow Amorphous Powder
Molecular weight:
393.35
Ref: TM-T5853
| 5mg | 52.00 € | ||
| 10mg | 76.00 € | ||
| 25mg | 111.00 € | ||
| 50mg | 162.00 € | ||
| 100mg | 234.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Berberine
CAS:2086-83-1
1.
Formula:
C20H18NO4
Purity:
95.71% - 99.38%
Color and Shape:
Solid
Molecular weight:
336.36
Ref: TM-T4S0797
| 20mg | 54.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Levofloxacin hydrochloride
CAS:177325-13-2
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial …
Formula:
C18H21ClFN3O4
Purity:
≥98%
Color and Shape:
Solid
Molecular weight:
397.8
Ref: TM-T8747
| 1g | 44.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Coralyne chloride
CAS:38989-38-7
Coralyne chloride is a protoberberine with strong anticancer activity.
Formula:
C22H22ClNO4
Purity:
99.35%
Color and Shape:
Solid
Molecular weight:
399.87
Ref: TM-T31011
| 1mg | 38.00 € | ||
| 2mg | 49.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 125.00 € | ||
| 25mg | 271.00 € | ||
| 50mg | 427.00 € | ||
| 100mg | 631.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
EIDD-1931
CAS:3258-02-4
EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, …
Formula:
C9H13N3O6
Purity:
99.14% - 99.18%
Color and Shape:
Solid
Molecular weight:
259.22
Ref: TM-T8498
| 1mg | 39.00 € | ||
| 5mg | 84.00 € | ||
| 10mg | 116.00 € | ||
| 25mg | 188.00 € | ||
| 50mg | 275.00 € | ||
| 100mg | 392.00 € | ||
| 500mg | 875.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
1,4-Naphthoquinone
CAS:130-15-4
1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.
Formula:
C10H6O2
Purity:
99.73%
Color and Shape:
Solid
Molecular weight:
158.15
Ref: TM-T7048
| 5g | 42.00 € | ||
| 10g | 57.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Dxd
CAS:1599440-33-1
Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 …
Formula:
C26H24FN3O6
Purity:
100% - ≥98%
Color and Shape:
Solid
Molecular weight:
493.48
Ref: TM-T11249L
| 1mg | 46.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 154.00 € | ||
| 50mg | 218.00 € | ||
| 1mL*10mM (DMSO) | 81.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Topovale
CAS:500214-53-9
Topovale (ARC111) is a potent inhibitor of topoisomerase I.
Formula:
C23H23N3O5
Purity:
99.94%
Color and Shape:
Solid
Molecular weight:
421.45
Ref: TM-T9088
| 1mg | 95.00 € | ||
| 5mg | 172.00 € | ||
| 10mg | 237.00 € | ||
| 25mg | 427.00 € | ||
| 50mg | 630.00 € | ||
| 100mg | 894.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Artemisitene
CAS:101020-89-7
Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic …
Formula:
C15H20O5
Purity:
99.58%
Color and Shape:
Solid
Molecular weight:
280.32
Ref: TM-T21065
| 1mg | 95.00 € | ||
| 5mg | 188.00 € | ||
| 10mg | 330.00 € | ||
| 25mg | 560.00 € | ||
| 50mg | 801.00 € | ||
| 100mg | 1,103.00 € | ||
| 1mL*10mM (DMSO) | 282.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Topotecan
CAS:123948-87-8
Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian …
Formula:
C23H23N3O5
Purity:
95.19%
Color and Shape:
Light Yellow Needle Crystal Or Crystalline Powder
Molecular weight:
421.45
Ref: TM-T5784
| 5mg | 38.00 € | ||
| 10mg | 49.00 € | ||
| 25mg | 82.00 € | ||
| 50mg | 112.00 € | ||
| 100mg | 166.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Betulinic acid
CAS:472-15-1
Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer …
Formula:
C30H48O3
Purity:
99.7% - ≥98%
Color and Shape:
White Crystalline Powder
Molecular weight:
456.7
Ref: TM-T2830
| 50mg | 39.00 € | ||
| 100mg | 52.00 € | ||
| 500mg | 169.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Marbofloxacin
CAS:115550-35-1
Marbofloxacin (Zeniquin) is an effective, broad-spectrum antibiotic of bacterial, which inhibits DNA replication.
Formula:
C17H19FN4O4
Purity:
99.42% - 99.76%
Color and Shape:
Solid
Molecular weight:
362.36
Ref: TM-T3117
| 1g | 52.00 € | ||
| 100mg | 35.00 € | ||
| 500mg | 41.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Aurintricarboxylic acid
CAS:4431-00-9
Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.
Formula:
C22H14O9
Purity:
95%
Color and Shape:
Deep Red Coarse Crystalline Powder
Molecular weight:
422.34
Ref: TM-T8333
| 50mg | 35.00 € | ||
| 100mg | 50.00 € | ||
| 200mg | 66.00 € | ||
| 500mg | 94.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Genz-644282
CAS:529488-28-6
Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.
Formula:
C22H21N3O5
Purity:
97.49%
Color and Shape:
Solid
Molecular weight:
407.42
Ref: TM-T7187
| 1mg | 48.00 € | ||
| 2mg | 59.00 € | ||
| 5mg | 89.00 € | ||
| 10mg | 126.00 € | ||
| 25mg | 206.00 € | ||
| 50mg | 310.00 € | ||
| 100mg | 468.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Berberine hydrogen sulphate
CAS:633-66-9
Berberine hydrogen sulphate, a plant alkaloid, has broad antimicrobial effects on bacteria, fungi, and protozoa.
Formula:
C20H19NO8S
Purity:
99% - 99.79%
Color and Shape:
Yellow Crystals Off-White To Yellow Powder
Molecular weight:
433.43
Ref: TM-T5S0814
| 20mg | 41.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Belotecan hydrochloride
CAS:213819-48-8
Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential …
Formula:
C25H28ClN3O4
Purity:
99.06% - ≥95%
Color and Shape:
Solid
Molecular weight:
469.96
Ref: TM-T7551
| 1mg | 46.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 151.00 € | ||
| 50mg | 209.00 € | ||
| 100mg | 293.00 € | ||
| 1mL*10mM (DMSO) | 72.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
NU2058
CAS:161058-83-9
NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
Formula:
C12H17N5O
Purity:
98.43% - 99.95%
Color and Shape:
Solid
Molecular weight:
247.3
Ref: TM-T3186
| 5mg | 34.00 € | ||
| 10mg | 51.00 € | ||
| 25mg | 87.00 € | ||
| 50mg | 121.00 € | ||
| 100mg | 181.00 € | ||
| 200mg | 268.00 € | ||
| 1mL*10mM (DMSO) | 45.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
