Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
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Belotecan hydrochloride
CAS:213819-48-8
Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential …
Formula:
C25H28ClN3O4
Purity:
99.06% - ≥95%
Color and Shape:
Solid
Molecular weight:
469.96
Ref: TM-T7551
| 1mg | 47.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 153.00 € | ||
| 50mg | 210.00 € | ||
| 100mg | 296.00 € | ||
| 1mL*10mM (DMSO) | 72.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
NU2058
CAS:161058-83-9
NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
Formula:
C12H17N5O
Purity:
98.43% - 99.95%
Color and Shape:
Solid
Molecular weight:
247.3
Ref: TM-T3186
| 5mg | 34.00 € | ||
| 10mg | 52.00 € | ||
| 25mg | 89.00 € | ||
| 50mg | 125.00 € | ||
| 100mg | 187.00 € | ||
| 200mg | 278.00 € | ||
| 1mL*10mM (DMSO) | 47.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
Gatifloxacin hydrochloride
CAS:121577-32-0
Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.
Formula:
C19H23ClFN3O4
Purity:
100% - 99.85%
Color and Shape:
Solid
Molecular weight:
411.86
Ref: TM-T8384
| 1g | 40.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
Razoxane
CAS:21416-67-1
Razoxane is used as an antimitotic agent with immunosuppressive properties.
Formula:
C11H16N4O4
Purity:
99.42%
Color and Shape:
Solid
Molecular weight:
268.27
Ref: TM-T26046
| 1mg | 99.00 € | ||
| 5mg | 235.00 € | ||
| 10mg | 344.00 € | ||
| 25mg | 588.00 € | ||
| 50mg | 777.00 € | ||
| 100mg | 1,035.00 € | ||
| 1mL*10mM (DMSO) | 215.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
Phenoxodiol
CAS:81267-65-4
Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory …
Formula:
C15H12O3
Purity:
98.07%
Color and Shape:
Solid
Molecular weight:
240.25
Ref: TM-T16522
| 1mg | 66.00 € | ||
| 2mg | 96.00 € | ||
| 5mg | 144.00 € | ||
| 10mg | 227.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 159.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
Idarubicin hydrochloride
CAS:57852-57-0
Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo …
Formula:
C26H27NO9·HCl
Purity:
100% - 99.93%
Color and Shape:
Solid
Molecular weight:
533.95
Ref: TM-T6010
| 5mg | 60.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 160.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 73.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
Voreloxin hydrochloride
CAS:175519-16-1
Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.
Formula:
C18H20ClN5O4S
Purity:
99.84%
Color and Shape:
Solid
Molecular weight:
437.9
Ref: TM-T22456
| 2mg | 42.00 € | ||
| 5mg | 64.00 € | ||
| 10mg | 101.00 € | ||
| 25mg | 163.00 € | ||
| 50mg | 261.00 € | ||
| 1mL*10mM (DMSO) | 78.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
SN-38
CAS:86639-52-3
SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, …
Formula:
C22H20N2O5
Purity:
98% - 99.97%
Color and Shape:
Light-Yellow Solid
Molecular weight:
392.4
Ref: TM-T1703
| 25mg | 47.00 € | ||
| 50mg | 60.00 € | ||
| 100mg | 85.00 € | ||
| 500mg | 147.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
Pixantrone dimaleate
CAS:144675-97-8
Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.
Formula:
C25H27N5O10
Purity:
98.70% - 99.11%
Color and Shape:
Solid
Molecular weight:
557.21
Ref: TM-T2394
| 5mg | 51.00 € | ||
| 10mg | 79.00 € | ||
| 25mg | 131.00 € | ||
| 50mg | 216.00 € | ||
| 100mg | 329.00 € | ||
| 500mg | 783.00 € | ||
| 1mL*10mM (DMSO) | 65.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
Suramin Sodium Salt
CAS:129-46-4
Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the …
Formula:
C51H34N6Na6O23S6
Purity:
97.47% - 99.97%
Color and Shape:
White
Molecular weight:
1429.15
Ref: TM-T2160
| 1mg | 48.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 142.00 € | ||
| 25mg | 235.00 € | ||
| 50mg | 350.00 € | ||
| 100mg | 527.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
(S)-10-Hydroxycamptothecin
CAS:19685-09-7
(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against …
Formula:
C20H16N2O5
Purity:
99.09% - 99.81%
Color and Shape:
Solid
Molecular weight:
364.35
Ref: TM-T2764
| 25mg | 52.00 € | ||
| 50mg | 66.00 € | ||
| 100mg | 92.00 € | ||
| 500mg | 187.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
Bisantrene
CAS:78186-34-2
Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus …
Formula:
C22H22N8
Purity:
96.07% - 98.57%
Color and Shape:
Solid
Molecular weight:
398.46
Ref: TM-T4047
| 5mg | 40.00 € | ||
| 10mg | 50.00 € | ||
| 25mg | 99.00 € | ||
| 50mg | 166.00 € | ||
| 100mg | 269.00 € | ||
| 200mg | 457.00 € | ||
| 500mg | 735.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
9-amino-CPT
CAS:91421-43-1
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
Formula:
C20H17N3O4
Purity:
97.76% - 99.82%
Color and Shape:
Orange-Yellow Powder
Molecular weight:
363.37
Ref: TM-T3S1957
| 1mg | 42.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 92.00 € | ||
| 10mg | 144.00 € | ||
| 25mg | 250.00 € | ||
| 50mg | 374.00 € | ||
| 100mg | 547.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
Isosteviol
CAS:27975-19-5
Isosteviol is a natural sweetener with anti-inflammatory, anti-tumor, glucose-lowering, and other health benefits.
Formula:
C20H30O3
Purity:
98.7% - 99.97%
Color and Shape:
Solid
Molecular weight:
318.45
Ref: TM-T3332
| 100mg | 48.00 € | ||
| 500mg | 97.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
SW044248
CAS:522650-83-5
SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.
Formula:
C22H23N5O2S
Purity:
99.56% - 99.87%
Color and Shape:
Solid
Molecular weight:
421.52
Ref: TM-T3181
| 5mg | 42.00 € | ||
| 10mg | 64.00 € | ||
| 25mg | 117.00 € | ||
| 50mg | 215.00 € | ||
| 100mg | 365.00 € | ||
| 1mL*10mM (DMSO) | 47.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
α-Lapachone
CAS:4707-33-9
α-Lapachone has antineoplastic activity, it shows an approximately trypanocidal activity against Trypanosoma cruzi.
Formula:
C15H14O3
Purity:
98.00% - 99.17%
Color and Shape:
Solid
Molecular weight:
242.27
Ref: TM-TN1375
| 1mg | 40.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 202.00 € | ||
| 50mg | 303.00 € | ||
| 100mg | 449.00 € | ||
| 1mL*10mM (DMSO) | 74.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
Cardioxane
CAS:149003-01-0
Cardioxane (ADR-529) is a cardio-protective drug.
Formula:
C11H16N4O4·HCl
Purity:
98.08%
Color and Shape:
Solid
Molecular weight:
304.73
Ref: TM-T6467
| 5mg | 35.00 € | ||
| 10mg | 50.00 € | ||
| 25mg | 78.00 € | ||
| 50mg | 90.00 € | ||
| 100mg | 118.00 € | ||
| 200mg | 178.00 € | ||
| 500mg | 301.00 € | ||
| 1mL*10mM (DMSO) | 47.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
Niranthin
CAS:50656-77-4
Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase …
Formula:
C24H32O7
Purity:
99.8%
Color and Shape:
Solid
Molecular weight:
432.51
Ref: TM-TN4660
| 1mg | 188.00 € | ||
| 5mg | 495.00 € | ||
| 10mg | 710.00 € | ||
| 25mg | 1,093.00 € | ||
| 50mg | 1,454.00 € | ||
| 100mg | 1,882.00 € | ||
| 1mL*10mM (DMSO) | 504.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
Pirarubicin
CAS:72496-41-4
Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.
Formula:
C32H37NO12
Purity:
97.61% - 98.27%
Color and Shape:
Red Crystalline Powder
Molecular weight:
627.64
Ref: TM-T6628
| 5mg | 38.00 € | ||
| 10mg | 57.00 € | ||
| 25mg | 106.00 € | ||
| 50mg | 188.00 € | ||
| 100mg | 324.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
Garenoxacin mesylate hydrate
CAS:223652-90-2
Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including …
Formula:
C23H20F2N2O4·CH4O3S·H2O
Purity:
99.56%
Color and Shape:
Solid
Molecular weight:
540.53
Ref: TM-T7804
| 1mg | 40.00 € | ||
| 5mg | 86.00 € | ||
| 10mg | 90.00 € | ||
| 25mg | 166.00 € | ||
| 50mg | 279.00 € | ||
| 100mg | 452.00 € | ||
| 1mL*10mM (DMSO) | 90.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
