Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
Found 88 products of "Sirtuin"
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Ophiopogonin D'
CAS:<p>Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.</p>Formula:C44H70O16Purity:99.77%Color and Shape:SolidMolecular weight:855.02SRT 2104
CAS:<p>SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.</p>Formula:C26H24N6O2S2Purity:98.34% - 99.82%Color and Shape:SolidMolecular weight:516.64OSS_128167
CAS:<p>OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).</p>Formula:C19H14N2O6Purity:97.47% - 98.6%Color and Shape:SolidMolecular weight:366.32AGK7
CAS:<p>AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.</p>Formula:C23H13Cl2N3O2Purity:98.31%Color and Shape:SolidMolecular weight:434.27SRT 2183
CAS:<p>SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).</p>Formula:C27H24N4O2SPurity:97.86%Color and Shape:SolidMolecular weight:468.57AK-7
CAS:<p>AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.</p>Formula:C19H21BrN2O3SPurity:98.43% - 99.34%Color and Shape:SolidMolecular weight:437.35Fisetin
CAS:<p>Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.</p>Formula:C15H10O6Purity:94.14% - 99.05%Color and Shape:Yellow To Brown Crystalline PowderMolecular weight:286.244'-bromo-Resveratrol
CAS:<p>4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)</p>Formula:C14H11BrO2Purity:99.00%Color and Shape:SolidMolecular weight:291.14SIRT7 inhibitor 97491
CAS:<p>SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.</p>Formula:C15H12ClN3OPurity:99.79%Color and Shape:SolidMolecular weight:285.73Tenovin-6 Hydrochloride
CAS:<p>Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.</p>Formula:C25H35ClN4O2SPurity:99.36%Color and Shape:SolidMolecular weight:491.09SRT 1460
CAS:<p>SRT 1460 is a SIRT1 activator.</p>Formula:C26H29N5O4SPurity:98.25%Color and Shape:SolidMolecular weight:507.6Cambinol
CAS:<p>Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.</p>Formula:C21H16N2O2SPurity:98.02% - 99.83%Color and Shape:SolidMolecular weight:360.43Sirtinol
CAS:<p>Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).</p>Formula:C26H22N2O2Purity:97.12% - 99.96%Color and Shape:SolidMolecular weight:394.47B2
CAS:<p>B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease</p>Formula:C20H17ClN4O3Purity:99.66%Color and Shape:SolidMolecular weight:396.83MDL-800
CAS:<p>MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.</p>Formula:C21H16BrCl2FN2O6S2Purity:99.95% - 99.96%Color and Shape:SolidMolecular weight:626.3SIRT5 inhibitor 5
CAS:<p>SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.</p>Formula:C21H14ClN3O3SPurity:99.33%Color and Shape:SolidMolecular weight:423.87SIRT5 inhibitor 2
CAS:<p>SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.</p>Formula:C18H12Cl2N2O3SPurity:99.38% - 99.87%Color and Shape:SolidMolecular weight:407.27SIRT2-IN-9
CAS:<p>SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.</p>Formula:C21H22N6OS2Purity:99.5%Color and Shape:SolidMolecular weight:438.57SIRT5 inhibitor 6
CAS:<p>SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.</p>Formula:C21H28N6O4SPurity:99.84%Color and Shape:SolidMolecular weight:460.55Sirt2-IN-1
CAS:<p>Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).</p>Formula:C28H27N7O2S2Purity:99.57% - 99.84%Color and Shape:SolidMolecular weight:557.69SIRT5 inhibitor 4
CAS:<p>SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.</p>Formula:C18H15N3O4SPurity:99.97%Color and Shape:SolidMolecular weight:369.39SIRT5 inhibitor 1
CAS:<p>SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.</p>Formula:C31H39FN6O6S2Purity:97.8%Color and Shape:SolidMolecular weight:674.81SIRT6-IN-5
CAS:<p>SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.</p>Formula:C19H14N2O6Purity:98.77%Color and Shape:SolidMolecular weight:366.32Sirtuin modulator 1
CAS:<p>Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.</p>Formula:C31H32ClN5O2S2Purity:99.63%Color and Shape:SolidMolecular weight:606.2WAY-354574
CAS:<p>WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].</p>Formula:C20H23ClN2O3SPurity:98%Color and Shape:SolidMolecular weight:406.93Sirtuin-1 inhibitor 1
CAS:<p>Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.</p>Formula:C20H17N3O2Purity:99.1%Color and Shape:SolidMolecular weight:331.37Epigenetic factor-IN-1
CAS:<p>Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.</p>Formula:C32H34FN5O6S2Purity:98%Color and Shape:SolidMolecular weight:667.77SRT3657
CAS:<p>SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.</p>Formula:C40H54N8O6SPurity:98%Color and Shape:SolidMolecular weight:774.97SIRT5 inhibitor 7
CAS:<p>SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.</p>Formula:C28H32ClN7O3SPurity:99.77%Color and Shape:SolidMolecular weight:582.12SIRT-IN-1
CAS:<p>SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).</p>Formula:C19H27N5O2SPurity:99.29%Color and Shape:SolidMolecular weight:389.52SIRT6-IN-3
CAS:<p>SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts</p>Formula:C21H30Br3ClN6SPurity:98%Color and Shape:SolidMolecular weight:673.73SIRT-IN-6
CAS:<p>SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of >50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.</p>Formula:C7H4ClN3OSColor and Shape:SolidMolecular weight:213.644SIRT1-IN-5
CAS:<p>SIRT1-IN-5 (215) is a modulator of the NAD-dependent protein deacetylase SIRT1.</p>Formula:C21H17N3O3SColor and Shape:SolidMolecular weight:391.443MC3138
CAS:<p>MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.</p>Formula:C25H25NO6Purity:99.57%Color and Shape:SolidMolecular weight:435.47Sirtuin-IN-2
<p>Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.</p>Formula:C28H46N8O6SColor and Shape:SolidMolecular weight:622.78SIRT6 activator 2
CAS:<p>SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.</p>Formula:C23H23N3O6Color and Shape:SolidMolecular weight:437.45DCHC
CAS:<p>DCHC is an activator of SIRT1, but it does not induce SIRT1 expression. This compound can be utilized in studies related to mitochondrial damage.</p>Formula:C15H8Cl2O3Color and Shape:SolidMolecular weight:307.128MDL-811
CAS:<p>MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),</p>Formula:C25H25BrCl2FN3O5S2Purity:98%Color and Shape:SolidMolecular weight:681.42
