Endocrinology/Hormones

ERα/ERβ antagonist-1 (Compound 10) functions as a partial antagonist of both ERα and ERβ. It reduces the activity of ERα and ERβ in HepG2 liver cells in a dose-dependent manner.

TLB 150 Benzoate (RAD150) is a modulator of the androgen receptor with an IC50 value of 0.13 μM.

R4K1 is a cell-permeable stapled peptide that binds with high affinity to estrogen receptor (ER) α, inhibiting its interaction with coactivators. It penetrates breast cancer cells, regulating gene transcription and suppressing cell proliferation. R4K1 is applicable for tumor research.

AR antagonist 9 is an orally active, selective androgen receptor (AR) antagonist that inhibits cancer by disrupting the formation of AR ligand-binding domain dimers, showing potential in overcoming drug resistance in prostate cancer (PCa). Its antagonistic activity against AR has an IC50 of 0.051 μM, comparable to Enzalutamide (IC50= 0.060 μM). This compound demonstrates superior inhibitory effects on ARF876L/T877A and ARW741C mutants compared to Enzalutamide. Additionally, AR antagonist 9 possesses favorable pharmacokinetic properties, with an oral bioavailability (F) of 66.24% in rats, and significantly inhibits tumor growth in LNCaP xenograft mouse models upon oral administration. AR antagonist 9 holds promise for research in overcoming PCa resistance.

CGP-42112 acetate is a potent angiotensin receptor AT2 agonist that inhibits the increase in protein kinase A activity produced by LPS.

ERα degrader 6 (Compound 31q) is an ERα degrader with a K I of 75 nM and also inhibits ARO with an IC50 value of 37.7 nM.

ET Receptor Antagonist 2 (Compound 16j) is an orally active ET receptor antagonist with an IC50 of 0.22 nM, suitable for pulmonary arterial hypertension (PAH)

ERD-3111 (Compound 44), an orally active PROTAC ERα degrader (DC50: 0.5 nM), exhibits efficacy in inhibiting tumor growth in both the parental MCF-7 xenograft

Compound 181, also known as 14-3-3σ/ERα Stabilizer-1, is a covalent stabilizer targeting the 14-3-3σ/ERα proteins.

WCA-814, an androgen receptor (AR) antagonist-Hsp90 inhibitor conjugate, induces degradation of both full-length and AR-V7, exhibiting cytotoxic effects in

Androgen Receptor Antagonist 9 (compound 28) serves as an antagonist to the androgen receptor [1].

Anticancer agent 135 (compound 26h) acts as a potent androgen receptor (AR) antagonist, effectively blocking AR nuclear translocation and inhibiting AR/AR-V7

ET Receptor Antagonist 1 (compound 16h), with an IC50 value of 0.18 nM, is an orally active agent that can be utilized for pulmonary arterial hypertension (PAH

"ET receptor antagonist 3 (compound 17d) is an orally active ET receptor antagonist with an IC50 of 0.26 nM, utilized for pulmonary arterial hypertension (PAH)

Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the

MK-0773 FA (MK-0773 FA (606101-58-0 Free base)) is an androgen receptor modulator used for the prevention and treatment of cancer-related muscle wasting.

Parathyroid Hormone (1-34), bovine is a PTH receptor agonist used to study osteoporosis and hypoparathyroidism.

Prednisolone valerate acetate is a prodrug anti-inflammatory and immunosuppressive,converted to the active form of Prednisolone and glucocorticoid receptor.

D4-abiraterone is the active metabolite of abiraterone.Δ4-Abiraterone is a inhibitor of CYP17A1, 3β-HSD and SRD5A, and an antagonist of the androgen receptor.

GW-1100 is a selective GPR40 and FFAR1 antagonist for the study of diabetes and metabolic diseases.

Porcine dynorphin A (1-13) is a potent κ opioid receptor agonist; it's antinociceptive and raises [Ca2+]i in neurons like NMDA.

ARD-1676 is an orally administered androgen receptor (AR) PROTAC degrader that combines an AR ligand with a cereblon ligand.

Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.

ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for the prevention and treatment of HER-positive breast canc

Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains.

Fenarimol, a pyrimidine-type fungicide, exhibits potent inhibitory activity against BR biosynthesis.

TA 0910 acid-type is a metabolite of TA 0910. TA-0910 is a metabolically stable analog of thyrotropin-releasing hormone.

SCO-267 is a full agonist of GPR40/FFAR1， stimulating insulin secretion and GLP-1 release in diabetic rats, improving glucose tolerance,type 2 diabetes.

Betamethasone acetate, the 21-acetate ester of betamethasone, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester.

Beclomethasone 17-propionate is the active metabolite of BDP. As a GR agonist, 17-BMP inhibits the production of pro-inflammatory cytokines.

BMS-986121 is a selective positive allosteric modulator (PAM) of the μ opioid receptor with analgesic effects.

Vanillylpyruvic acid is a phenylpyruvic acid derivative applicable in biochemical experiments and drug synthesis research.

PD 123319 ditrifluoroacetate is a selective non-peptide AT2 receptor antagonist with IC50 of 34 nM.

NQO1 substrate is a highly potent NQO1 substrate with potential antitumor activity for leukemia research.

Apalutamide-13C-d3 is a 13C and 2H labeled Apalutamide. Apalutamide is an androgen receptor (AR) antagonist, used in research on prostate diseases.

Monomethyl fumarate D3 is a deuterium labeled Monomethyl fumarate.

2-Bromoestradiol, an estrogen 2-hydroxylase inhibitor, reduces the irreversible binding of radiolabeled estradiol metabolite(s) to microsomal proteins [1].

5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5β-reductase.25β-DHP

Betamethasone Acetate (Standard) is the standard substance of Betamethasone Acetate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Betamethasone acetate, the 21-acetate ester of betamethasone, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester.

ZK 216348 is a selective glucocorticoid receptor agonist with an IC50 of 20.3 nM. also binds to progesterone receptors and mineralocorticoid receptors.

Olmesartan D4 is the deuterium labeled Olmesartan. Olmesartan is an antagonist of angiotensin II receptor (AT1R) used to treat high blood pressure.

Angiogenin (108-122) peptide treats cancer, infectious, fibrotic, inflammatory, neurodegenerative, autoimmune, and heart diseases.

It is an inhibitor of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)

AZD1979 is a highly potent MCHR1 (Melanin-concentrating hormone receptor 1) antagonist , CNS exposure and insulin sensitivity in steady-state model assessments,

GDC-0927 is a novel,non-steroidal, potent, orally bioavailable, selective estrogen receptor antagonist.

Pamoic acid disodium is a GPR35 agonist.

Leelamine hydrochloride, a pine bark extract, inhibits androgen receptor and CB1, reducing lipid synthesis in prostate cancer.

Tricaprin (Standard) is the standard substance of Tricaprin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Glycerol Tridecanoate is an orally active precursor (DA precursor) of caprylic acid that can be hydrolyzed to caprylic acid. It is a major component of medium chain triglycerides (MCT) and has antiandrogenic and antihyperglycemic properties. It can be used as an additive in food, pharmaceuticals and cosmetics.

CGP-42112 is an agonist of the Angiotensin-II subtype 2 receptor (AT2 R).

Corticosterone-d8 is a deuterium-labeled corticosterone, a corticosteroid with both mineralocorticoid and glucocorticoid activity.

Dienestrol (Standard) is the standard substance of Dienestrol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Dienestrol (Restrol) is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and make the vulva and urethra healthy.

Dihydromunduletone (DHM) is an adhesion G protein-coupled receptor (aGPCR) antagonist inhibits GPR56 and GPR114/ADGRG5, which have similar tethered agonists.

Azilsartan mepixetil: potent, long-acting angiotensin II blocker, safely lowers blood pressure, protects heart and kidneys.

DL-Cystine is a cysteine derivative that inhibits endothelial cell proliferation by regulating TGFβ1. a GPR inhibitor and nAChR agonist .

Losartan D4 Carboxylic Acid is the deuterium labeled Losartan, which is an angiotensin II receptor antagonist.

Hydrocortisone hemisuccinate (Standard) is the standard substance of Hydrocortisone hemisuccinate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) is a corticosteroid used as an analytical and chromatography reagent.

VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases. IC50 value: Target: Renin

Bavachin (Standard) is the standard substance of Bavachin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Bavachin (Corylifolin) is a phytoestrogen that activates the estrogen receptors ERα and ERβ.

Norleual TFA, Ang IV analog, inhibits HGF/c-Met (IC50: 3 pM), blocks AT4, and has strong antiangiogenic effects.

GPR41 agonist-1 is a GPR41 agonist, used for studying metabolic diseases such as diabetes and obesity.

Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.

Loperamide phenyl, an impurity detected in Loperamide, is an opioid receptor agonist.

DOCP, a mineralocorticoid, treats dogs with adrenal insufficiency.

Olmesartan lactone impurity, a cyclic ester from Olmesartan, aids in hypertension research as an AT1R blocker.

Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany.

Endomorphin 2 TFA, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM.

MS 15203 is a GPR171 agonist that reduces chronic neuropathic and inflammatory pain in male mice.

GPR30 agonist-1 is a compound that acts as an agonist for G protein-coupled receptor 30 (GPR30), inducing vasorelaxation.

YE 120 is a GPR35 agonist.

Candesartan D4 is the deuterium labeled Candesartan. Candesartan is an antagonist of angiotensin II receptor.

Alvimopan dihydrate is a potent, oral μ-opioid receptor blocker (IC50 1.7 nM, Ki 0.47 nM) used in postoperative ileus research.

TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1).

AMG7703 is a bioactive chemical.

Atosiban (RW22164), an oxytocin/vasopressin inhibitor, halts premature labor as an intravenous tocolytic, reducing uterine contractions rapidly.

(Rac)-PF-998425: nonsteroidal AR antagonist, potent & selective, IC50: 26 nM (binding), 90 nM (cellular), potential for androgenetic alopecia study.

GPR40 agonist 6 (Compound 7a) is a potent and selective agonist of free fatty acid receptor 1 ( FFAR1 or GPR40 ) with an EC 50 of 0.058 μM against GPR40 [1].

BAN ORL 24 dihydrochloride is a highly potent nociceptin/orphan FQ (N/OFQ) receptor (NOP) antagonist that can be used to study neurological diseases.

β-estradiol 17-valerate (EV) is a synthetic estrogen. In hormone replacement therapy drugs, it is widely used in combination with other steroid hormones.

Bazedoxifene is an orally active SERM against ERα and ERβ and inhibits IL-6/GP130, applied in postmenopausal osteoporosis and pancreatic cancer research.

(R,S)-Ivosidenib is the less active enantiomer of Ivosidenib .

AVE 0991, a nonpeptide, oral Mas agonist, binds [125I]-Ang-(1-7) with IC50 of 21±35 nM.

17β-Estradiol-2,4-d2 is a deuterated compound of 17β-Estradiol. 17β-Estradiol has a CAS number of 50-28-2. Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.

Hydrocortisone cypionate is a corticosteroid ester and synthetic glucocorticoid corticosteroid.

Azilsartan (TAK-536) D5 is the deuterium-labeled Azilsartan. Azilsartan is a specific antagonist of the angiotensin II type 1 receptor.

Dehydroepiandrosterone-d2 is a deuterated compound of Dehydroepiandrosterone.

ZQ-16 is a potent GPR84 agonist (EC50=0.213 μM) activating multiple signaling pathways.

Trans-Diethyl-1,1,1',1'-Stilbestrol-3,3',5,5'-d8 is a deuterated compound of Trans-Diethyl-Stilbestrol. Trans-Diethyl-Stilbestrol has a CAS number of 56-53-1. Diethylstilbestrol is used in the treatment of menopausal and postmenopausal disorders.

Rezvilutamide (SHR3680) is an orally available androgen receptor inhibitor that crosses the blood-brain barrier and has antitumor activity.

Valsartan Ethyl Ester, an impurity in Valsartan, treats hypertension and heart failure by blocking angiotensin II receptors.

Enalaprilat (Enalapril acid) is an ACE inhibitor used in the study of cardiovascular disease.

Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor.

Dienestrol diacetate, a derivative of the synthetic non-steroid phenolic compound, DIENESTROL, exhibits estrogenic activities.

Hydrocortisone buteprate is a medium-potent, non-halogenated double-ester of hydrocortisone with a highly favorable benefit-to-risk ratio for inflammatory skin disorders.