TLR
Toll-like receptors (TLRs) are a class of proteins that play a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and initiating immune responses. TLRs are involved in detecting a wide range of pathogens, including bacteria, viruses, and fungi, and are essential for the activation of inflammatory signaling pathways. Dysregulation of TLR signaling is associated with chronic inflammatory diseases, autoimmune disorders, and cancer. At CymitQuimica, we offer a variety of high-quality TLR modulators to support your research in innate immunity, inflammation, and infectious disease.
Found 66 products of "TLR"
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TLR7/8 agonist 3
CAS:<p>TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.</p>Formula:C17H23N5OPurity:99.84%Color and Shape:SolidMolecular weight:313.4CU-CPT17e
CAS:<p>CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).</p>Formula:C27H24N2O8Purity:98.49%Color and Shape:SolidMolecular weight:504.49BMS-905
CAS:<p>BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.</p>Formula:C23H29N3Purity:99.94%Color and Shape:SoildMolecular weight:347.5CU-CPT22
CAS:<p>CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).</p>Formula:C19H22O7Purity:98.66% - 99.8%Color and Shape:SolidMolecular weight:362.37IAXO-102
CAS:<p>IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.</p>Formula:C35H71NO5Purity:98.17%Color and Shape:SolidMolecular weight:585.94CU-T12-9
CAS:<p>CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).</p>Formula:C17H13F3N4O2Purity:99.84%Color and Shape:SolidMolecular weight:362.31Pam3CSK4-Biotin
CAS:<p>Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.</p>Formula:C103H192N14O17S2Purity:98%Color and Shape:SolidMolecular weight:1962.85MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA
<p>MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA is the trifluoroacetate form of MC-Val-Cit-PAB-Amide-TLR7 agonist 4,a HER2-TLR7 and HER2- TLR8 immune agonist complexes.</p>Formula:C54H73F3N12O13Purity:99.67%Color and Shape:SolidMolecular weight:1155.22CRX 527
CAS:<p>CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.</p>Formula:C81H151N2O19PColor and Shape:SolidMolecular weight:1488.04TLR8 agonist 7
CAS:<p>TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.</p>Formula:C54H63N9O16Color and Shape:SolidMolecular weight:1094.13Tomaralimab
CAS:<p>Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS).</p>Purity:100% (SEC-HPLC) - > 95%Color and Shape:LiquidMolecular weight:145.32 kDaTLR7/8 agonist 12
<p>TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.</p>Formula:C29H38N6O3Color and Shape:SolidMolecular weight:518.65TLR7 agonist 17
CAS:<p>TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].</p>Formula:C25H37N7O3Color and Shape:SolidMolecular weight:483.61TLR8 agonist 8
CAS:<p>TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.</p>Formula:C53H63N11O10Color and Shape:SolidMolecular weight:1014.14Pam2CSK4
CAS:<p>TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.</p>Formula:C65H126N10O12SPurity:98%Color and Shape:SolidMolecular weight:1271.83CU-115
CAS:<p>CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively.</p>Formula:C21H11F7INO2Purity:99.96%Color and Shape:SolidMolecular weight:569.21Ezeprogind
CAS:<p>Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can Trust</p>Formula:C25H44N6Purity:99.28%Color and Shape:SolidMolecular weight:428.66MTvkPABC-P5 TFA
<p>MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).</p>Color and Shape:Odour SolidDesethyl chloroquine diphosphate
CAS:<p>Desethyl chloroquine diphosphate is the active metabolite of Desethylchloroquine, an inhibitor of TLRs with antiplasmodial activity and inhibition of autophagy.</p>Formula:C16H28ClN3O8P2Purity:99.72%Color and Shape:SolidMolecular weight:487.81Neoseptin-3
CAS:<p>Neoseptin-3 is a novel small molecule agonist of mouse mTLR4/MD2 with EC50=18.5 μM that does not activate human TLR4/MD2.</p>Formula:C29H34N2O4Purity:98%Color and Shape:SolidMolecular weight:474.59
