JAK/STAT signaling
JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.
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Products of "JAK/STAT signaling"
SC99
CAS:882290-02-0
SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.
Formula:
C15H8Cl2FN3O
Purity:
99.56%
Color and Shape:
Solid
Molecular weight:
336.15
Ref: TM-T8719
| 1mg | 46.00 € | ||
| 5mg | 93.00 € | ||
| 10mg | 140.00 € | ||
| 25mg | 240.00 € | ||
| 50mg | 363.00 € | ||
| 100mg | 452.00 € | ||
| 200mg | 630.00 € | ||
| 1mL*10mM (DMSO) | 99.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
WP1066
CAS:857064-38-1
WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in …
Formula:
C17H14BrN3O
Purity:
98.92% - 99.73%
Color and Shape:
Solid
Molecular weight:
356.22
Ref: TM-T2156
| 5mg | 52.00 € | ||
| 10mg | 81.00 € | ||
| 25mg | 131.00 € | ||
| 50mg | 213.00 € | ||
| 100mg | 299.00 € | ||
| 500mg | 730.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
AZ960
CAS:905586-69-8
AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).
Formula:
C18H16F2N6
Purity:
96.02% - 98.51%
Color and Shape:
Solid
Molecular weight:
354.36
Ref: TM-T6309
| 1mg | 73.00 € | ||
| 2mg | 89.00 € | ||
| 5mg | 124.00 € | ||
| 10mg | 197.00 € | ||
| 25mg | 363.00 € | ||
| 50mg | 540.00 € | ||
| 1mL*10mM (DMSO) | 97.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
![WDR5-0103 hydrochloride[890190-22-4(free base)]](https://static.cymitquimica.com/products/TM/thumb/T5140.jpg)
WDR5-0103 hydrochloride[890190-22-4(free base)]
WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 …
Formula:
C21H26ClN3O4
Purity:
99.81%
Color and Shape:
Solid
Molecular weight:
419.9
Ref: TM-T5140
| 2mg | 35.00 € | ||
| 5mg | 48.00 € | ||
| 10mg | 80.00 € | ||
| 25mg | 129.00 € | ||
| 50mg | 215.00 € | ||
| 100mg | 270.00 € | ||
| 200mg | 396.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
Brevilin A
CAS:16503-32-5
Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis …
Formula:
C20H26O5
Purity:
100% - 99.74%
Color and Shape:
Solid
Molecular weight:
346.42
Ref: TM-T4672
| 1mg | 96.00 € | ||
| 5mg | 215.00 € | ||
| 10mg | 369.00 € | ||
| 25mg | 610.00 € | ||
| 50mg | 840.00 € | ||
| 100mg | 1,130.00 € | ||
| 500mg | 2,308.00 € | ||
| 1mL*10mM (DMSO) | 235.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
Hispidulin
CAS:1447-88-7
Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor …
Formula:
C16H12O6
Purity:
97.54% - 98.53%
Color and Shape:
Solid
Molecular weight:
300.26
Ref: TM-TQ0201
| 10mg | 89.00 € | ||
| 1mL*10mM (DMSO) | 69.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
AMG-47a
CAS:882663-88-9
AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.
Formula:
C29H28F3N5O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
535.56
Ref: TM-T7123
| 1mg | 46.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 153.00 € | ||
| 25mg | 249.00 € | ||
| 50mg | 369.00 € | ||
| 100mg | 545.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
Decernotinib
CAS:944842-54-0
Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki …
Formula:
C18H19F3N6O
Purity:
100% - 99.45%
Color and Shape:
Solid
Molecular weight:
392.38
Ref: TM-T2636
| 1mg | 52.00 € | ||
| 2mg | 69.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 133.00 € | ||
| 25mg | 261.00 € | ||
| 50mg | 465.00 € | ||
| 100mg | 653.00 € | ||
| 500mg | 1,359.00 € | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
Fedratinib hydrochloride hydrate
CAS:1374744-69-0
Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active …
Formula:
C27H40Cl2N6O4S
Purity:
98.96%
Color and Shape:
Solid
Molecular weight:
615.61
Ref: TM-T9251
| 5mg | 47.00 € | ||
| 10mg | 60.00 € | ||
| 25mg | 86.00 € | ||
| 50mg | 100.00 € | ||
| 100mg | 119.00 € | ||
| 200mg | 187.00 € | ||
| 1mL*10mM (DMSO) | 66.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
G5-7
CAS:939681-36-4
G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.
Formula:
C22H19F2NO3
Purity:
97.30%
Color and Shape:
Solid
Molecular weight:
383.39
Ref: TM-T8742
| 1mg | 50.00 € | ||
| 5mg | 97.00 € | ||
| 10mg | 145.00 € | ||
| 25mg | 259.00 € | ||
| 50mg | 374.00 € | ||
| 100mg | 523.00 € | ||
| 200mg | 710.00 € | ||
| 1mL*10mM (DMSO) | 105.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
(E/Z)-Zotiraciclib
CAS:937270-47-8
(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 …
Formula:
C23H24N4O
Purity:
97% - 98.03%
Color and Shape:
Solid
Molecular weight:
372.46
Ref: TM-T21503
| 1mg | 46.00 € | ||
| 2mg | 59.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 119.00 € | ||
| 25mg | 210.00 € | ||
| 50mg | 349.00 € | ||
| 100mg | 507.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
TG101209
CAS:936091-14-4
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.
Formula:
C26H35N7O2S
Purity:
100% - 99%
Color and Shape:
Solid
Molecular weight:
509.67
Ref: TM-T3065
| 2mg | 48.00 € | ||
| 5mg | 66.00 € | ||
| 10mg | 93.00 € | ||
| 25mg | 106.00 € | ||
| 50mg | 124.00 € | ||
| 100mg | 197.00 € | ||
| 1mL*10mM (DMSO) | 73.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
GDC-0214
CAS:1831144-46-7
GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).
Formula:
C28H28ClF2N9O3
Purity:
98.54%
Color and Shape:
Solid
Molecular weight:
612.03
Ref: TM-T9826
| 1mg | 87.00 € | ||
| 5mg | 192.00 € | ||
| 10mg | 284.00 € | ||
| 25mg | 452.00 € | ||
| 50mg | 645.00 € | ||
| 100mg | 867.00 € | ||
| 200mg | 1,159.00 € | ||
| 1mL*10mM (DMSO) | 259.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
Baricitinib
CAS:1187594-09-7
Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. …
Formula:
C16H17N7O2S
Purity:
100% - 99.79%
Color and Shape:
Solid
Molecular weight:
371.42
Ref: TM-T2485
| 5mg | 50.00 € | ||
| 10mg | 73.00 € | ||
| 25mg | 90.00 € | ||
| 50mg | 115.00 € | ||
| 100mg | 144.00 € | ||
| 200mg | 188.00 € | ||
| 500mg | 311.00 € | ||
| 1mL*10mM (DMSO) | 69.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
TCS PIM-1 1
CAS:491871-58-0
TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an …
Formula:
C18H11BrN2O2
Purity:
97% - 99.64%
Color and Shape:
Solid
Molecular weight:
367.2
Ref: TM-T2253
| 1mg | 35.00 € | ||
| 5mg | 64.00 € | ||
| 10mg | 88.00 € | ||
| 25mg | 187.00 € | ||
| 50mg | 284.00 € | ||
| 100mg | 424.00 € | ||
| 200mg | 612.00 € | ||
| 1mL*10mM (DMSO) | 97.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
Pyridone 6
CAS:457081-03-7
Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 …
Formula:
C18H16FN3O
Purity:
97.10% - 98.74%
Color and Shape:
Solid
Molecular weight:
309.34
Ref: TM-T3080
| 1mg | 82.00 € | ||
| 2mg | 106.00 € | ||
| 5mg | 162.00 € | ||
| 10mg | 221.00 € | ||
| 25mg | 449.00 € | ||
| 50mg | 658.00 € | ||
| 100mg | 939.00 € | ||
| 500mg | 1,882.00 € | ||
| 1mL*10mM (DMSO) | 177.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
WHI-P97
CAS:211555-05-4
WHI-P97 is a rationally designed potent inhibitor of JAK-3.
Formula:
C16H13Br2N3O3
Purity:
99.93%
Color and Shape:
Solid
Molecular weight:
455.1
Ref: TM-T4657
| 5mg | 52.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 131.00 € | ||
| 50mg | 190.00 € | ||
| 100mg | 284.00 € | ||
| 200mg | 400.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
SGI-1776
CAS:1025065-69-3
SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, …
Formula:
C20H22F3N5O
Purity:
100% - 99.84%
Color and Shape:
Solid
Molecular weight:
405.42
Ref: TM-T3078
| 2mg | 52.00 € | ||
| 5mg | 97.00 € | ||
| 10mg | 172.00 € | ||
| 25mg | 304.00 € | ||
| 50mg | 437.00 € | ||
| 100mg | 562.00 € | ||
| 1mL*10mM (DMSO) | 99.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
Itacitinib
CAS:1334298-90-6
Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic …
Formula:
C26H23F4N9O
Purity:
96.4% - 99.01%
Color and Shape:
Solid
Molecular weight:
553.51
Ref: TM-T3998
| 1mg | 49.00 € | ||
| 2mg | 71.00 € | ||
| 5mg | 111.00 € | ||
| 10mg | 180.00 € | ||
| 25mg | 325.00 € | ||
| 50mg | 543.00 € | ||
| 100mg | 780.00 € | ||
| 500mg | 1,549.00 € | ||
| 1mL*10mM (DMSO) | 137.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
Tofacitinib
CAS:477600-75-2
Tofacitinib (Tasocitinib) is an orally Janus kinase inhibitor. Tofacitinib is used for the treatment of …
Formula:
C16H20N6O
Purity:
100% - 99.71%
Color and Shape:
Solid
Molecular weight:
312.37
Ref: TM-T6321
| 5mg | 35.00 € | ||
| 10mg | 51.00 € | ||
| 25mg | 65.00 € | ||
| 50mg | 85.00 € | ||
| 100mg | 97.00 € | ||
| 200mg | 144.00 € | ||
| 500mg | 261.00 € |
Estimated delivery in United States, on Tuesday 11 Mar 2025
