JAK/STAT signaling
JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.
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Products of "JAK/STAT signaling"
RO8191
CAS:691868-88-9
RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
Formula:
C14H5F6N5O
Purity:
98.85% - ≥98%
Color and Shape:
Solid
Molecular weight:
373.21
Ref: TM-T22142
| 1mg | 45.00 € | ||
| 2mg | 58.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 142.00 € | ||
| 25mg | 301.00 € | ||
| 50mg | 478.00 € | ||
| 100mg | 698.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
JAK3-IN-6
CAS:1443235-95-7
JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM
Formula:
C19H18N4O3
Purity:
97.46% - 99.94%
Color and Shape:
Solid
Molecular weight:
350.37
Ref: TM-T5492
| 2mg | 40.00 € | ||
| 5mg | 59.00 € | ||
| 10mg | 93.00 € | ||
| 25mg | 153.00 € | ||
| 50mg | 237.00 € | ||
| 100mg | 370.00 € | ||
| 1mL*10mM (DMSO) | 67.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
RGB-286638 free base
CAS:784210-88-4
RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.
Formula:
C29H35N7O4
Purity:
97.29% - 99.91%
Color and Shape:
Solid
Molecular weight:
545.63
Ref: TM-T2378
| 1mg | 46.00 € | ||
| 2mg | 60.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 144.00 € | ||
| 25mg | 263.00 € | ||
| 50mg | 396.00 € | ||
| 100mg | 554.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
FLLL32
CAS:1226895-15-3
FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).
Formula:
C28H32O6
Purity:
96.39% - 99.8%
Color and Shape:
Solid
Molecular weight:
464.55
Ref: TM-T6838
| 2mg | 45.00 € | ||
| 5mg | 66.00 € | ||
| 10mg | 92.00 € | ||
| 25mg | 122.00 € | ||
| 50mg | 193.00 € | ||
| 100mg | 343.00 € | ||
| 500mg | 822.00 € | ||
| 1mL*10mM (DMSO) | 72.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
JANEX-1
CAS:202475-60-3
JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.
Formula:
C16H15N3O3
Purity:
98% - 99.73%
Color and Shape:
Solid
Molecular weight:
297.31
Ref: TM-T2045
| 2mg | 34.00 € | ||
| 5mg | 51.00 € | ||
| 10mg | 88.00 € | ||
| 25mg | 149.00 € | ||
| 50mg | 258.00 € | ||
| 100mg | 377.00 € | ||
| 200mg | 536.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
TP-3654
CAS:1361951-15-6
TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).
Formula:
C22H25F3N4O
Purity:
97.72% - 99.95%
Color and Shape:
Solid
Molecular weight:
418.46
Ref: TM-T4523
| 5mg | 56.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 148.00 € | ||
| 50mg | 231.00 € | ||
| 100mg | 345.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
Cerdulatinib
CAS:1198300-79-6
Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.
Formula:
C20H27N7O3S
Purity:
98.74% - 99.64%
Color and Shape:
Solid
Molecular weight:
445.54
Ref: TM-T2487
| 1mg | 44.00 € | ||
| 2mg | 54.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 104.00 € | ||
| 25mg | 181.00 € | ||
| 50mg | 280.00 € | ||
| 100mg | 429.00 € | ||
| 200mg | 601.00 € | ||
| 500mg | 931.00 € | ||
| 1mL*10mM (DMSO) | 85.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
Upadacitinib
CAS:1310726-60-3
Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.
Formula:
C17H19F3N6O
Purity:
99.41% - 99.93%
Color and Shape:
Solid
Molecular weight:
380.37
Ref: TM-T7503
| 1mg | 46.00 € | ||
| 2mg | 61.00 € | ||
| 5mg | 88.00 € | ||
| 10mg | 127.00 € | ||
| 25mg | 217.00 € | ||
| 50mg | 302.00 € | ||
| 100mg | 427.00 € | ||
| 200mg | 650.00 € | ||
| 500mg | 1,142.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
BD750
CAS:892686-59-8
BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 …
Formula:
C14H13N3OS
Purity:
99.02%
Color and Shape:
Solid
Molecular weight:
271.34
Ref: TM-T8546
| 5mg | 51.00 € | ||
| 10mg | 86.00 € | ||
| 25mg | 142.00 € | ||
| 50mg | 231.00 € | ||
| 100mg | 382.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
SMI-16a
CAS:587852-28-6
SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive …
Formula:
C13H13NO3S
Purity:
99.05%
Color and Shape:
Solid
Molecular weight:
263.31
Ref: TM-T3989
| 1mg | 35.00 € | ||
| 2mg | 47.00 € | ||
| 5mg | 69.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 158.00 € | ||
| 50mg | 231.00 € | ||
| 100mg | 346.00 € | ||
| 1mL*10mM (DMSO) | 92.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
HJ-PI01
CAS:6192-43-4
HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in …
Formula:
C14H11NO2
Purity:
99.55%
Color and Shape:
Solid
Molecular weight:
225.24
Ref: TM-T9583
| 1mg | 35.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 112.00 € | ||
| 25mg | 251.00 € | ||
| 50mg | 370.00 € | ||
| 100mg | 526.00 € | ||
| 200mg | 714.00 € | ||
| 1mL*10mM (DMSO) | 75.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
WHI-P97 HCl
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.
Formula:
C16H14Br2ClN3O3
Purity:
98.55%
Color and Shape:
Solid
Molecular weight:
491.56
Ref: TM-T4657L
| 1mg | 41.00 € | ||
| 1ml | 95.00 € | ||
| 5mg | 65.00 € | ||
| 10mg | 112.00 € | ||
| 25mg | 194.00 € | ||
| 50mg | 267.00 € | ||
| 100mg | 381.00 € | ||
| 200mg | 542.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
WHI-P154
CAS:211555-04-3
WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.
Formula:
C16H14BrN3O3
Purity:
98% - 99.6%
Color and Shape:
Solid
Molecular weight:
376.2
Ref: TM-T1985
| 5mg | 39.00 € | ||
| 10mg | 56.00 € | ||
| 25mg | 106.00 € | ||
| 50mg | 182.00 € | ||
| 100mg | 311.00 € | ||
| 200mg | 447.00 € | ||
| 1mL*10mM (DMSO) | 41.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
AZD1208
CAS:1204144-28-4
AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency …
Formula:
C21H21N3O2S
Purity:
97.24% - 98.87%
Color and Shape:
Solid
Molecular weight:
379.48
Ref: TM-T2300
| 2mg | 38.00 € | ||
| 5mg | 51.00 € | ||
| 10mg | 74.00 € | ||
| 25mg | 117.00 € | ||
| 50mg | 210.00 € | ||
| 100mg | 370.00 € | ||
| 200mg | 487.00 € | ||
| 500mg | 778.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
Atractylenolide I
CAS:73069-13-3
Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to …
Formula:
C15H18O2
Purity:
97.55%
Color and Shape:
Solid
Molecular weight:
230.3
Ref: TM-T5S0167
| 1mg | 42.00 € | ||
| 5mg | 85.00 € | ||
| 10mg | 128.00 € | ||
| 25mg | 237.00 € | ||
| 50mg | 414.00 € | ||
| 100mg | 579.00 € | ||
| 1mL*10mM (DMSO) | 94.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
XL019
CAS:945755-56-6
XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold …
Formula:
C25H28N6O2
Purity:
99.23%
Color and Shape:
Solid
Molecular weight:
444.53
Ref: TM-T3072
| 5mg | 48.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 128.00 € | ||
| 50mg | 205.00 € | ||
| 100mg | 304.00 € | ||
| 200mg | 439.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
TCS-PIM-1-4a
CAS:327033-36-3
SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).
Formula:
C11H6F3NO2S
Purity:
99.89%
Color and Shape:
Solid
Molecular weight:
273.23
Ref: TM-T4215
| 5mg | 51.00 € | ||
| 10mg | 75.00 € | ||
| 25mg | 122.00 € | ||
| 50mg | 210.00 € | ||
| 100mg | 315.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
SHR0302
CAS:1445987-21-2
SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity …
Formula:
C18H22N8O2S
Purity:
99.11%
Color and Shape:
Solid
Molecular weight:
414.48
Ref: TM-T9195
| 1mg | 157.00 € | ||
| 5mg | 384.00 € | ||
| 10mg | 606.00 € | ||
| 25mg | 1,012.00 € | ||
| 50mg | 1,447.00 € | ||
| 100mg | 1,837.00 € | ||
| 1mL*10mM (DMSO) | 445.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
WP1066
CAS:857064-38-1
WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in …
Formula:
C17H14BrN3O
Purity:
98.92% - 99.73%
Color and Shape:
Solid
Molecular weight:
356.22
Ref: TM-T2156
| 5mg | 52.00 € | ||
| 10mg | 80.00 € | ||
| 25mg | 129.00 € | ||
| 50mg | 209.00 € | ||
| 100mg | 293.00 € | ||
| 500mg | 714.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
AZ960
CAS:905586-69-8
AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).
Formula:
C18H16F2N6
Purity:
96.02% - 98.51%
Color and Shape:
Solid
Molecular weight:
354.36
Ref: TM-T6309
| 1mg | 77.00 € | ||
| 2mg | 94.00 € | ||
| 5mg | 127.00 € | ||
| 10mg | 198.00 € | ||
| 25mg | 360.00 € | ||
| 50mg | 534.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
