JAK/STAT signaling
JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.
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Products of "JAK/STAT signaling"
(Z)-SMI-4a
CAS:438190-29-5
(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of …
Formula:
C11H6F3NO2S
Purity:
97.66% - 99.44%
Color and Shape:
Solid
Molecular weight:
273.23
Ref: TM-T3058
| 5mg | 51.00 € | ||
| 10mg | 71.00 € | ||
| 25mg | 142.00 € | ||
| 50mg | 212.00 € | ||
| 100mg | 318.00 € | ||
| 200mg | 479.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
Oclacitinib
CAS:1208319-26-9
Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not …
Formula:
C15H23N5O2S
Purity:
98% - 98.12%
Color and Shape:
White To Off-White Solid
Molecular weight:
337.44
Ref: TM-T2012
| 5mg | 46.00 € | ||
| 10mg | 39.00 € | ||
| 25mg | 70.00 € | ||
| 50mg | 99.00 € | ||
| 100mg | 165.00 € | ||
| 200mg | 237.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
AZD-1480
CAS:935666-88-9
AZD1480: JAK2 inhibitor, IC50 0.26 nM; selective vs Tyk2, JAK3; less on JAK1. Used in …
Formula:
C14H14ClFN8
Purity:
97.5% - 98.55%
Color and Shape:
Solid
Molecular weight:
348.77
Ref: TM-T3069
| 5mg | 56.00 € | ||
| 10mg | 88.00 € | ||
| 25mg | 138.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
JAK-IN-5 hydrochloride
CAS:2751323-21-2
JAK-IN-5 hydrochloride is a JAK inhibitor [1].
Formula:
C27H32ClFN6O
Color and Shape:
Solid
Molecular weight:
511.03
Ref: TM-T11710L
| 25mg | 1,503.00 € | ||
| 50mg | 1,975.00 € | ||
| 100mg | 2,949.00 € |
Estimated delivery in United States, on Thursday 7 Nov 2024
NVP-BSK805
CAS:1092499-93-8
NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.
Formula:
C27H28F2N6O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
490.55
Ref: TM-T5049
| 1mg | 61.00 € | ||
| 5mg | 129.00 € | ||
| 10mg | 209.00 € | ||
| 25mg | 402.00 € |
Estimated delivery in United States, on Tuesday 19 Nov 2024
JAK1-IN-8
CAS:1973485-18-5
JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
Formula:
C22H23FN4O3S
Purity:
98.36%
Color and Shape:
Solid
Molecular weight:
442.51
Ref: TM-T35899
| 5mg | 46.00 € | ||
| 10mg | 50.00 € | ||
| 25mg | 94.00 € | ||
| 50mg | 152.00 € | ||
| 100mg | 249.00 € | ||
| 200mg | 333.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
Momelotinib Mesylate
CAS:1056636-07-7
Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity …
Formula:
C24H26N6O5S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
510.57
Ref: TM-T15037
| 25mg | 1,410.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
JAK-STAT-IN-1
CAS:1236666-76-4
JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.
Formula:
C21H21N5O2
Purity:
99.21%
Color and Shape:
Solid
Molecular weight:
375.42
Ref: TM-T78607
| 1mg | 183.00 € | ||
| 5mg | 452.00 € | ||
| 10mg | 647.00 € | ||
| 25mg | 1,009.00 € | ||
| 50mg | 1,392.00 € | ||
| 100mg | 1,841.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
CX-6258
CAS:1202916-90-2
CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good …
Formula:
C26H24ClN3O3
Purity:
95.88%
Color and Shape:
Solid
Molecular weight:
461.94
Ref: TM-T1834
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 86.00 € | ||
| 10mg | 124.00 € | ||
| 25mg | 237.00 € | ||
| 50mg | 386.00 € | ||
| 100mg | 548.00 € | ||
| 200mg | 796.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
JAK3/BTK-IN-1
CAS:2674036-91-8
JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 …
Formula:
C25H28N8O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
456.54
Ref: TM-T9814
| 1mg | 225.00 € | ||
| 5mg | 560.00 € | ||
| 10mg | 797.00 € | ||
| 25mg | 1,234.00 € | ||
| 50mg | 1,561.00 € | ||
| 100mg | 2,350.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
Izencitinib
CAS:2051918-33-1
Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative …
Formula:
C22H26N8
Purity:
99.82%
Color and Shape:
Solid
Molecular weight:
402.50
Ref: TM-T35898
| 1mg | 95.00 € | ||
| 5mg | 199.00 € | ||
| 10mg | 324.00 € | ||
| 25mg | 648.00 € | ||
| 50mg | 1,016.00 € | ||
| 100mg | 1,668.00 € | ||
| 1mL*10mM (DMSO) | 222.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
Jaspamycin
CAS:22242-96-2
Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.
Formula:
C12H12N4O5
Color and Shape:
Solid
Molecular weight:
292.25
Ref: TM-T11711
| 5mg | 278.00 € | ||
| 25mg | 916.00 € | ||
| 50mg | 1,273.00 € | ||
| 100mg | 1,741.00 € | ||
| 1mL*10mM (DMSO) | 301.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
JAK-IN-11
CAS:916742-11-5
JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the …
Formula:
C23H22FN5O4S
Purity:
99.57%
Color and Shape:
Solid
Molecular weight:
483.52
Ref: TM-T12549
| 1mg | 273.00 € | ||
| 5mg | 547.00 € | ||
| 10mg | 890.00 € | ||
| 25mg | 1,620.00 € | ||
| 50mg | 2,177.00 € | ||
| 1mL*10mM (DMSO) | 621.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
M-110
CAS:1395048-49-3
M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth …
Formula:
C22H28ClN5O3
Purity:
98.30%
Color and Shape:
Solid
Molecular weight:
445.94
Ref: TM-T15830
| 5mg | 63.00 € | ||
| 10mg | 90.00 € | ||
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 64.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
SD-1029
CAS:118372-34-2
SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation …
Formula:
C25H32Br2Cl2N2O3
Color and Shape:
Solid
Molecular weight:
639.25
Ref: TM-T24774
| 1mg | 89.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
JAK2-IN-9
CAS:2568842-26-0
Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 …
Formula:
C20H24N6O2S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
412.51
Ref: TM-T79581
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
JBJ-04-125-02
CAS:2060610-53-7
JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.
Formula:
C29H26FN5O3S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
543.61
Ref: TM-T11714
| 25mg | 1,406.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
JAK1-IN-4
CAS:2091134-35-7
JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in …
Formula:
C26H32FN9O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
521.59
Ref: TM-T15606
| 25mg | 1,549.00 € | ||
| 50mg | 2,038.00 € | ||
| 100mg | 2,617.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
JAK-IN-30
CAS:2891469-99-9
JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with …
Formula:
C19H26N8S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
398.53
Ref: TM-T79235
| 1mg | 123.00 € | ||
| 5mg | 465.00 € | ||
| 10mg | 830.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
Lorpucitinib
CAS:2230282-02-5
Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal …
Formula:
C22H28N6O2
Purity:
99.72%
Color and Shape:
Solid
Molecular weight:
408.5
Ref: TM-T62053
| 1mg | 212.00 € | ||
| 5mg | 531.00 € | ||
| 10mg | 848.00 € | ||
| 25mg | 1,606.00 € | ||
| 50mg | 2,589.00 € | ||
| 100mg | 3,498.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
