MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
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Deoxyelephantopin
CAS:29307-03-7
Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.
Formula:
C19H20O6
Purity:
99.6% - 99.69%
Color and Shape:
Solid
Molecular weight:
344.36
Ref: TM-TN1079
| 1mg | 94.00 € | ||
| 5mg | 230.00 € | ||
| 10mg | 342.00 € | ||
| 25mg | 553.00 € | ||
| 50mg | 801.00 € | ||
| 1mL*10mM (DMSO) | 239.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
Pamapimod
CAS:449811-01-2
Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.
Formula:
C19H20F2N4O4
Purity:
97.63% - 99.99%
Color and Shape:
Solid
Molecular weight:
406.38
Ref: TM-T6927
| 1mg | 55.00 € | ||
| 5mg | 118.00 € | ||
| 10mg | 183.00 € | ||
| 25mg | 369.00 € | ||
| 50mg | 595.00 € | ||
| 100mg | 833.00 € | ||
| 500mg | 1,672.00 € | ||
| 1mL*10mM (DMSO) | 130.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
RO4987655
CAS:874101-00-5
RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for …
Formula:
C20H19F3IN3O5
Purity:
98.21%
Color and Shape:
Solid
Molecular weight:
565.28
Ref: TM-T5412
| 1mg | 80.00 € | ||
| 2mg | 104.00 € | ||
| 5mg | 182.00 € | ||
| 10mg | 280.00 € | ||
| 25mg | 468.00 € | ||
| 50mg | 650.00 € | ||
| 100mg | 1,009.00 € | ||
| 1mL*10mM (DMSO) | 225.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
BCI-215
CAS:1245792-67-9
BCI-215 causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling
Formula:
C22H22BrNO
Purity:
≥95%
Color and Shape:
Solid
Molecular weight:
396.32
Ref: TM-T7323
| 1mg | 49.00 € | ||
| 5mg | 93.00 € | ||
| 10mg | 144.00 € | ||
| 25mg | 265.00 € | ||
| 50mg | 417.00 € | ||
| 100mg | 606.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
Lonafarnib
CAS:193275-84-2
Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 …
Formula:
C27H31Br2ClN4O2
Purity:
98% - 99.04%
Color and Shape:
Solid
Molecular weight:
638.82
Ref: TM-T6302
| 1mg | 48.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 149.00 € | ||
| 25mg | 292.00 € | ||
| 50mg | 462.00 € | ||
| 100mg | 646.00 € | ||
| 1mL*5mM (DMSO) | 164.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
RWJ-67657
CAS:215303-72-3
RWJ-67657 is a selective oral p38α/β MAPK inhibitor with IC50s of 1/11μM; inactive on p38γ/δ …
Formula:
C27H24FN3O
Purity:
99.66%
Color and Shape:
Solid
Molecular weight:
425.5
Ref: TM-T16812
| 2mg | 46.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 214.00 € | ||
| 50mg | 346.00 € | ||
| 100mg | 557.00 € | ||
| 500mg | 1,161.00 € | ||
| 1mL*10mM (DMSO) | 76.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
Tizaterkib
CAS:2097416-76-5
Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.
Formula:
C24H24F2N8O2
Purity:
99.24% - 99.6%
Color and Shape:
Solid
Molecular weight:
494.5
Ref: TM-T10429
| 1mg | 93.00 € | ||
| 2mg | 135.00 € | ||
| 5mg | 216.00 € | ||
| 10mg | 365.00 € | ||
| 25mg | 615.00 € | ||
| 50mg | 876.00 € | ||
| 1mL*10mM (DMSO) | 229.00 € |
Estimated delivery in United States, on Friday 27 Dec 2024
NCB-0846
CAS:1792999-26-8
NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
Formula:
C21H21N5O2
Purity:
97.04% - 99.46%
Color and Shape:
Solid
Molecular weight:
375.42
Ref: TM-T4011
| 1mg | 36.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 118.00 € | ||
| 25mg | 245.00 € | ||
| 50mg | 418.00 € | ||
| 100mg | 615.00 € | ||
| 1mL*10mM (DMSO) | 86.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
VX-702
CAS:745833-23-2
VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.
Formula:
C19H12F4N4O2
Purity:
100% - 99%
Color and Shape:
Solid
Molecular weight:
404.32
Ref: TM-T2513
| 10mg | 54.00 € | ||
| 25mg | 83.00 € | ||
| 50mg | 131.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
6H05
CAS:1469338-01-9
6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
Formula:
C20H30ClN3O2S3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
476.12
Ref: TM-T1931
| 5mg | 124.00 € | ||
| 10mg | 212.00 € | ||
| 25mg | 348.00 € | ||
| 50mg | 516.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
FMK
CAS:821794-92-7
FMK is an irreversible inhibitor of RSK2 kinase.
Formula:
C18H19FN4O2
Purity:
98.93%
Color and Shape:
Solid
Molecular weight:
342.37
Ref: TM-TQ0310
| 1mg | 73.00 € | ||
| 2mg | 94.00 € | ||
| 5mg | 171.00 € | ||
| 10mg | 295.00 € | ||
| 25mg | 502.00 € | ||
| 50mg | 722.00 € | ||
| 100mg | 1,016.00 € | ||
| 500mg | 2,023.00 € | ||
| 1mL*10mM (DMSO) | 186.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
PLX7904
CAS:1393465-84-3
PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it …
Formula:
C24H22F2N6O3S
Purity:
96.27% - 96.27%
Color and Shape:
Solid
Molecular weight:
512.53
Ref: TM-T6949
| 5mg | 49.00 € | ||
| 10mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Vincristine
CAS:57-22-7
Vincristine, a microtubule disruptor, inhibits mitosis in cancer cells, useful in leukemia research.
Formula:
C46H56N4O10
Purity:
100%
Color and Shape:
Solid
Molecular weight:
824.96
Ref: TM-T3S0209
| 20mg | 143.00 € | ||
| 1mL*10mM (DMSO) | 118.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Sulindac sulfide
CAS:49627-27-2
Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid …
Formula:
C20H17FO2S
Purity:
99.68%
Color and Shape:
Solid
Molecular weight:
340.41
Ref: TM-T13037
| 10mg | 36.00 € | ||
| 25mg | 52.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
IM-54
CAS:861891-50-1
IM-54 is a cell-permeable, effective, and selective necrosis inhibitor.
Formula:
C19H23N3O2
Purity:
99.05%
Color and Shape:
Solid
Molecular weight:
325.4
Ref: TM-T24160
| 1mg | 57.00 € | ||
| 5mg | 125.00 € | ||
| 10mg | 181.00 € | ||
| 25mg | 306.00 € | ||
| 50mg | 456.00 € | ||
| 100mg | 653.00 € | ||
| 500mg | 1,328.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
ERK1/2 inhibitor 1
CAS:2095719-90-5
ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 …
Formula:
C29H32ClN5O4
Purity:
99.09%
Color and Shape:
Solid
Molecular weight:
550.05
Ref: TM-T11226
| 1mg | 122.00 € | ||
| 5mg | 295.00 € | ||
| 10mg | 426.00 € | ||
| 25mg | 653.00 € | ||
| 50mg | 873.00 € | ||
| 100mg | 1,191.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
MEK inhibitor
CAS:334951-92-7
MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity …
Formula:
C26H26N4O2
Color and Shape:
Solid
Molecular weight:
426.51
Ref: TM-T11993
| 1mg | 105.00 € | ||
| 5mg | 256.00 € | ||
| 10mg | 356.00 € | ||
| 25mg | 590.00 € | ||
| 50mg | 831.00 € | ||
| 1mL*10mM (DMSO) | 280.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
NSC-70220
CAS:4551-00-2
SOS1-IN-1 is an inhibitor of SOS1.
Formula:
C22H15NO2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
325.36
Ref: TM-T12978
| 2mg | 225.00 € | ||
| 5mg | 278.00 € | ||
| 25mg | 916.00 € | ||
| 50mg | 1,264.00 € | ||
| 100mg | 1,722.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
Nek2-IN-5
CAS:1507367-00-1
Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).
Formula:
C15H12N6O
Purity:
98.11%
Color and Shape:
Solid
Molecular weight:
292.3
Ref: TM-T28141
| 1mg | 442.00 € | ||
| 5mg | 916.00 € | ||
| 10mg | 1,311.00 € | ||
| 25mg | 1,867.00 € | ||
| 50mg | 2,631.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
DS12881479
CAS:2373065-59-7
DS12881479 can be used in cancer research which is a potent and selective inhibitor of …
Formula:
C16H19N3OS
Purity:
100%
Color and Shape:
Liquid
Molecular weight:
301.41
Ref: TM-T60681
| 1mg | 96.00 € | ||
| 5mg | 236.00 € | ||
| 10mg | 354.00 € | ||
| 25mg | 637.00 € | ||
| 50mg | 857.00 € | ||
| 100mg | 1,126.00 € | ||
| 200mg | 1,537.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
