ERK
ERK is a key protein in the MAPK (Mitogen-Activated Protein Kinase) signaling pathway, which is involved in transmitting signals from cell surface receptors to the DNA in the cell nucleus. ERK plays a crucial role in the regulation of various cellular processes, including proliferation, differentiation, and survival. Dysregulation of ERK signaling is associated with the development of cancer and other diseases, making it an important target for therapeutic intervention. At CymitQuimica, we offer a selection of high-quality ERK inhibitors and modulators to support your research in cell signaling, oncology, and therapeutic development.
Found 217 products of "ERK"
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Urolithin B
CAS:Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFormula:C13H8O3Purity:99.45%Color and Shape:SolidMolecular weight:212.2MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Formula:C21H18N4O2Purity:99.58%Color and Shape:SolidMolecular weight:358.39Ref: TM-T12058
1mg34.00€5mg60.00€1mL*10mM (DMSO)73.00€10mg87.00€25mg172.00€50mg250.00€100mg350.00€200mg480.00€Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formula:C14H22N2O·HCl·H2OPurity:99.95%Color and Shape:SolidMolecular weight:288.82Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Formula:C14H22N2OPurity:99.95% - >99.99%Color and Shape:Needles From Benzene Or Alcohol SolidMolecular weight:234.34MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Formula:C33H39N7O2Purity:97.3% - 99.07%Color and Shape:SolidMolecular weight:565.71Ref: TM-T16143
1mg60.00€2mg85.00€5mg124.00€1mL*10mM (DMSO)166.00€10mg195.00€25mg351.00€50mg512.00€100mg743.00€200mg982.00€LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Formula:C27H19F3N8OPurity:99.03%Color and Shape:SolidMolecular weight:528.49Methylthiouracil
CAS:Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.Formula:C5H6N2OSPurity:99.89% - >99.99%Color and Shape:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Molecular weight:142.18Honokiol
CAS:Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.Formula:C18H18O2Purity:99.65% - 99.94%Color and Shape:Dark Brown To White Fine Powder With Pleasant Odor Spicy And Slightly Bitter TasteMolecular weight:266.33(E/Z)-BCI
CAS:(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROSFormula:C22H23NOPurity:99.94%Color and Shape:SolidMolecular weight:317.42Ref: TM-T11139
1mg75.00€5mg146.00€1mL*10mM (DMSO)161.00€10mg268.00€25mg427.00€50mg605.00€100mg803.00€200mg1,063.00€Mefloquine
CAS:Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.
Formula:C17H16F6N2OPurity:99.89%Color and Shape:SolidMolecular weight:378.31Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Formula:C17H17ClF6N2OPurity:99% - 99.99%Color and Shape:Off-White To Yellow SolidMolecular weight:414.77CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Formula:C22H21F3N6O2Purity:99.42%Color and Shape:SolidMolecular weight:458.44AX-15836
CAS:AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Formula:C32H40N8O5SPurity:98.96%Color and Shape:SolidMolecular weight:648.78Ref: TM-T14360
1mg54.00€2mg77.00€5mg114.00€1mL*10mM (DMSO)164.00€10mg167.00€25mg281.00€50mg401.00€100mg567.00€500mg1,161.00€ERK5-IN-5
CAS:ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Formula:C19H16ClN3OPurity:99.89%Color and Shape:SoildMolecular weight:337.8Ref: TM-T77734
1mg81.00€2mg105.00€5mg170.00€10mg264.00€25mg532.00€50mg868.00€100mg1,378.00€500mg2,673.00€Lidocaine hydrochloride
CAS:Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.Formula:C14H23ClN2OPurity:99.81% - 99.92%Color and Shape:White Crystal PowderMolecular weight:270.798ERK5-IN-6
CAS:ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.Formula:C23H21N3Purity:98.59%Color and Shape:SoildMolecular weight:339.43MEK/PI3K-IN-1
CAS:MEK/PI3K-IN-1 (6r) is a dual MEK/PI3K inhibitor; IC50: 124 nM (MEK1), 130 nM (PI3Kα), 236 nM (PI3Kδ). It reduces pAKT, pERK1/2, and hinders tumor growth.Formula:C36H37F5IN9O6Color and Shape:SolidMolecular weight:913.63YF135
CAS:YF135 is a reversible-covalent KRAS G12C PROTAC that degrades its target via the VHL-proteasome pathway.Formula:C63H75ClN12O7SColor and Shape:SolidMolecular weight:1179.864-P-PDOT
CAS:4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.Formula:C19H21NOPurity:99.91%Color and Shape:SolidMolecular weight:279.38Astragaloside
CAS:Astragaloside, one of the main active ingredients in Astragalus membranaceus.Formula:C28H32O17Purity:99.9%Color and Shape:Odour SolidMolecular weight:640.54GSK143
CAS:GSK143: Oral SYK inhibitor, pIC50=7.5, curbs pErk, anti-inflammatory, hinders immune cells in mice.Formula:C17H22N6O2Color and Shape:SolidMolecular weight:342.403MEK/PI3K-IN-2
CAS:MEK/PI3K-IN-2 is a potent dual inhibitor (MEK1 IC50: 352 nM, PI3Kα: 107 nM, PI3Kδ: 137 nM) that reduces pAKT, pERK1/2, and hinders tumor cell growth.Formula:C38H41F5IN9O7Color and Shape:SolidMolecular weight:957.68NSC 295642
CAS:NSC 295642: phosphatase inhibitor, boosts phospho-Erk in cells, aids cancer research.Formula:C15H14ClCuN3S2Color and Shape:SolidMolecular weight:399.42Olomoucine
CAS:Olomoucine hinders Cdk2, Cdc2, CDK5, ERK1, regulates the cell cycle, and fights melanoma; IC50s: 3-25 µM.
Formula:C15H18N6OPurity:99.77%Color and Shape:White Crystalline PowderMolecular weight:298.34BRAFV600E/JNK-IN-1
BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3, and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM, and 0.009 μM, respectively. It also inhibits the phosphorylation of MEK1/2 and ERK1/2. Additionally, BRAFV600E/JNK-IN-1 suppresses tumor cell proliferation, NO release, and PGE2 production, exhibiting both antitumor and anti-inflammatory activities.Color and Shape:Odour SolidFirazorexton
CAS:Firazorexton is a potent orexin type 2 receptor (OX2R) agonist.Formula:C22H25F3N2O4SColor and Shape:SolidMolecular weight:470.51FLT3/VEGFR2-IN-1
FLT3/VEGFR2-IN-1 (Compound 26) is a potent inhibitor of FLT3, VEGFR2, and HDAC, exhibiting IC50 values of 14.5 nM, 3.9 nM, and 30.8 nM against FLT3, VEGFR2, and HDAC1, respectively. It effectively inhibits the phosphorylation of STAT3 and ERK1/2, as well as the proliferation of leukemia cells. FLT3/VEGFR2-IN-1 demonstrates antitumor activity and is applicable in research on acute myeloid leukemia.Formula:C29H35N7O5Color and Shape:SolidMolecular weight:561.63Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Color and Shape:Odour SolidRef: TM-L1600
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireMAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Color and Shape:Odour SolidRef: TM-L1400
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireRineterkib hydrochloride
CAS:Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.Formula:C26H28BrClF3N5O2Color and Shape:SolidMolecular weight:614.89PROTAC HPK1 Degrader-5
PROTACHPK1 Degrader-5 is a potent, orally active HPK1 PROTAC degrader with a DC50 of 5.0 nM and a Dmax of at least 99%. It significantly inhibits HPK1 by degrading it, reducing SLP76 phosphorylation, and enhancing ERK pathway activation, which in turn stimulates the release of IL-2 and IFN-γ. This compound effectively counteracts immune suppression induced by PGE2, NECA, or TGF-β. Alone, PROTACHPK1 Degrader-5 is capable of suppressing tumor growth in MC38 syngeneic mouse models. It is used in research for immunotherapy applications in cancers such as colorectal cancer.Color and Shape:Odour SolidPPM-3
PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.Formula:C54H69N11O6SPurity:98%Color and Shape:SolidMolecular weight:1000.26BTX6654
BTX-6654 is a cereblon-based bifunctional SOS1 PROTAC degrader. This compound exhibits antiproliferative activity against cells with various KRAS mutations by reducing the expression of downstream signaling markers pERK and pS6.Formula:C50H57F4N9O5Color and Shape:SolidMolecular weight:940.04HDAC6-IN-61
HDAC6-IN-61 (Compound 4e) is an HDAC6 inhibitor with an IC50 of 73 nM, demonstrating greater selectivity compared to other HDAC isomers. It also acts as an activator of GPR40. HDAC6-IN-61 can increase the acetylation of tubulin and phosphorylation levels of ERK. This compound is relevant for studying neuroinflammation, including Alzheimer's disease.Color and Shape:Odour SolidCGP78850
CAS:CGP78850 is a potent and selective Grb2 SH2-phosphopeptide interaction antagonist that holds potential for cancer research.Formula:C36H46N5O9PColor and Shape:SolidMolecular weight:723.764ERK1/2 inhibitor 3
CAS:ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.Formula:C28H31ClFN5O6SColor and Shape:SolidMolecular weight:620.09PROTAC MEK1 Degrader-1
CAS:PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2Formula:C53H66FIN8O11S2Purity:98%Color and Shape:SolidMolecular weight:1201.17Emodic acid
CAS:Emodic acid is a useful organic compound for research related to life sciences. The catalog number is T124807 and the CAS number is 478-45-5.Formula:C15H8O7Color and Shape:SolidMolecular weight:300.222VSLRGDTRG
CAS:VSLRGDTRG is a synthetic peptide derived from the RGD motif in cadherin17 (CDH17) that binds to the α2β1 integrin, activating its signaling pathways. By promoting high-affinity conformational changes in β1 integrins through the RGD motif, VSLRGDTRG enhances cell adhesion and the phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. This peptide is useful for research on cancers expressing CDH17, such as colorectal and pancreatic cancer.Formula:C38H69N15O14Color and Shape:SolidMolecular weight:960.047LC-SF-14
LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR, with IC50 values of 71.6 nM and 8.9 nM, respectively. It blocks FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation, and also inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). Furthermore, LC-SF-14 exhibits antitumor activity in SNU-16 xenograft mouse models, making it suitable for research on FGFR2-driven gastric cancer.Formula:C44H50Cl3N13O5SColor and Shape:SolidMolecular weight:977.28442ROCK-IN-5
CAS:ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.Formula:C16H11ClFN3OSPurity:99.72% - 99.86%Color and Shape:SolidMolecular weight:347.79TAT-DEF-Elk-1
CAS:TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor.Formula:C155H259N57O40Purity:98%Color and Shape:SolidMolecular weight:3561.136Anti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Formula:C19H30O3Color and Shape:SolidMolecular weight:306.44Anti-inflammatory agent 35
CAS:Anti-inflammatory agent 35 is a potent anti-inflammatory agent.Formula:C27H29NO8Purity:99.98%Color and Shape:SoildMolecular weight:495.52KRAS G12C inhibitor 69
KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.Formula:C29H29ClF3N5O3Color and Shape:SolidMolecular weight:588.02VSLRGDTRG acetate
VSLRGDTRG acetate is a synthetic peptide of the RGD motif from cadherin17 (CDH17), capable of binding to α2β1 integrin and activating its signaling pathways. It facilitates the high-affinity conformational change of β1 integrin via the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby promoting tumor proliferation and metastasis. VSLRGDTRG acetate is applicable in research on cancers expressing CDH17, such as colon and pancreatic cancers.Color and Shape:Odour SolidSOS1-IN-18
SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.Formula:C26H29F3N4O2Color and Shape:SolidMolecular weight:486.534′-Demethylnobiletin
CAS:4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, andFormula:C20H20O8Color and Shape:SolidMolecular weight:388.37TRV055
CAS:TRV055: Gq-biased AT1R ligand, stimulates Gq signaling, aids Gq-biased agonist development.Formula:C42H57N9O9Color and Shape:SolidMolecular weight:831.972Fulipiftide
CAS:Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.Formula:C144H227N41O47Color and Shape:SolidMolecular weight:3284.59
