ERK

CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.

AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).

MK2-IN-3 hydrate is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of …

Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.

Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and …

ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 …

Gardenin A has antihyperlipidemic and hepatoprotective effects , it also promotes neuritogenesis through the activation …

Tauroursodeoxycholate dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate significantly decreases …

JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 will be a much-needed …

PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).

Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. …

AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) and …

PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).

Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 …

Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis …

Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically …

(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol may promote melanin synthesis via USF1 dependent fashion and could be used as a …

Muramyl dipeptide is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a …

4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which …

1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan …

Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing …

1. Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with …

Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows …

1. Cornuside has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and …

1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, …

Notoginsenoside R1 has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.

NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding …

Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, …

1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic …

MK-8353 is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM …

Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both …

KO-947 is a potent and specific inhibitor of ERK1/2 kinases.

Trans-Zeatina is the member of the plant growth hormone family known as cytokinins, which regulate …

1. Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors. …

LY-3214996 is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (ERK) …

AZD-0364 is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1 (example 18; IC50: …

FR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.

XMD17-109 is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).

DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.

BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and …

Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo …

Sophocarpine has anti-cancer, anti-inflammatory, anti-nociceptive, and antivirus activities, it can prevent implant loosening through inhibiting …

ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 …

ISRIB is a potent and selective PERK inhibitor.

Mogrol is a biometabolite of mogrosides. Mogrol acts via inhibition of the ERK1/2 and STAT3 …

ML-191 is an inhibitor of LPI-induced phosphorylation of ERK1/2.

GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free …

ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 …

GDC-0994 is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).

1. Avicularin exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW …

Ulixertinib (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is …

1. Tetrahydrocoptisine has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on …

Asperulosidic acid has anti-tumor, anti-oxidant, and anti-inflammatory activities.ASPA is related to the inhibition of inflammatory …

1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic …

Xanthyletin has anti-inflammatory, anti-tumor and anti-bacterial activities, it also inhibits symbiotic fungus cultivated by leaf-cutting …

1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. …

1. Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and may be …

ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 …

ERK-IN-3 is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low …

BAY885 is a new ERK5 inhibitor.