ERK
ERK is a key protein in the MAPK (Mitogen-Activated Protein Kinase) signaling pathway, which is involved in transmitting signals from cell surface receptors to the DNA in the cell nucleus. ERK plays a crucial role in the regulation of various cellular processes, including proliferation, differentiation, and survival. Dysregulation of ERK signaling is associated with the development of cancer and other diseases, making it an important target for therapeutic intervention. At CymitQuimica, we offer a selection of high-quality ERK inhibitors and modulators to support your research in cell signaling, oncology, and therapeutic development.
Found 217 products of "ERK"
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Aurothiomalate sodium
CAS:Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.Formula:C4H3AuNa2O4SPurity:99.66%Color and Shape:SoildMolecular weight:390.07SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formula:C15H8Cl2FN3OPurity:99.56%Color and Shape:SolidMolecular weight:336.15Ref: TM-T8719
1mg43.00€5mg87.00€1mL*10mM (DMSO)94.00€10mg133.00€25mg227.00€50mg344.00€100mg429.00€200mg597.00€Avatrombopag maleate
CAS:Avatrombopag (AKR-501/E5501) is an oral TPO receptor agonist for thrombocytopenia treatment, approved in 2018.Formula:C33H38Cl2N6O7S2Color and Shape:SolidMolecular weight:765.72DMU-212
CAS:DMU-212, a Resveratrol derivative, has antimitotic, antiproliferative, antioxidant properties; induces apoptosis via ERK1/2.Formula:C18H20O4Purity:99.86%Color and Shape:SolidMolecular weight:300.35Ref: TM-T36674
2mg34.00€5mg50.00€1mL*10mM (DMSO)56.00€10mg84.00€25mg152.00€50mg259.00€100mg385.00€500mg873.00€Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Formula:C36H56O13Purity:99.66% - 99.74%Color and Shape:SolidMolecular weight:696.82Ref: TM-T5S1982
1mg35.00€5mg77.00€10mg106.00€1mL*10mM (DMSO)107.00€25mg170.00€50mg253.00€100mg375.00€500mg892.00€SUN11602
CAS:SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.Formula:C26H37N5O2Purity:99.36%Color and Shape:SolidMolecular weight:451.6Corynoxeine
CAS:Corynoxeine inhibits ERK1/2, curbs VSMC growth induced by PDGF-BB, and may prevent vascular diseases and restenosis post-angioplasty.Formula:C22H26N2O4Purity:98.61% - 99.94%Color and Shape:SolidMolecular weight:382.45Theliatinib
CAS:Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).Formula:C25H26N6O2Purity:99.67%Color and Shape:SolidMolecular weight:442.51SCH772984
CAS:SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.
Formula:C33H33N9O2Purity:97.565% - 98.75%Color and Shape:SolidMolecular weight:587.67Ref: TM-T6066
1mg52.00€2mg77.00€5mg99.00€10mg148.00€25mg291.00€50mg437.00€100mg642.00€200mg914.00€500mg1,359.00€RU-301
CAS:RU-301 is a novel pan-tam inhibitorFormula:C21H19F3N4O4SPurity:98.87%Color and Shape:SolidMolecular weight:480.46Ref: TM-T7425
1mg98.00€5mg222.00€1mL*10mM (DMSO)241.00€10mg344.00€25mg587.00€50mg803.00€100mg1,063.00€ERK-IN-3
CAS:ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.Formula:C22H25ClFN7O2Purity:99.55% - 99.76%Color and Shape:SolidMolecular weight:473.93TBHQ
CAS:TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Formula:C10H14O2Purity:99.17% - 99.53%Color and Shape:White Solid PowderMolecular weight:166.22Piperlongumine
CAS:Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.Formula:C17H19NO5Purity:97.03% - 99.90%Color and Shape:SolidMolecular weight:317.34Milnacipran
CAS:Milnacipran, an SNRI with 85% bioavailability, treats fibromyalgia and is well absorbed orally.Formula:C15H22N2OColor and Shape:SolidMolecular weight:246.35Methylnissolin
CAS:Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects.Formula:C17H16O5Purity:99.68% - 99.98%Color and Shape:SolidMolecular weight:300.31SHP099
CAS:SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cellsFormula:C16H19Cl2N5Purity:98.73% - 99.4%Color and Shape:SolidMolecular weight:352.26Ref: TM-T3564
1mg34.00€2mg49.00€1mL*10mM (DMSO)57.00€5mg74.00€10mg94.00€25mg165.00€50mg213.00€100mg388.00€PD98059
CAS:PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.Formula:C16H13NO3Purity:98.63% - >99.99%Color and Shape:Yellow SolidMolecular weight:267.28Ref: TM-T2623
5mg38.00€10mg50.00€1mL*10mM (DMSO)55.00€25mg78.00€50mg101.00€100mg168.00€200mg250.00€500mg421.00€EF24
CAS:EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.Formula:C19H15F2NOPurity:99.71%Color and Shape:SolidMolecular weight:311.33Ref: TM-T27242
1mg38.00€5mg80.00€1mL*10mM (DMSO)88.00€10mg126.00€25mg222.00€50mg334.00€100mg505.00€500mg1,071.00€1g1,431.00€BIX02189
CAS:BIX 02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).Formula:C27H28N4O2Purity:97.84%Color and Shape:SolidMolecular weight:440.54Ref: TM-T21295
2mg33.00€5mg52.00€1mL*10mM (DMSO)55.00€10mg71.00€25mg119.00€50mg198.00€100mg296.00€200mg427.00€SEW2871
CAS:SEW 2871 is an orally available, highly selective S1P1 agonist. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.Formula:C20H10F6N2OSPurity:99.96%Color and Shape:White SolidMolecular weight:440.36Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Formula:C16H16F3N5Purity:99.97%Color and Shape:SolidMolecular weight:335.33Deltonin
CAS:Deltonin inhibits ERK1/2 & AKT; toxic to HepG2 (IC50: 7.66μM), C26 (IC50: 1.22μM), MDA-MB-231 cells (IC50: 1.58μM).Formula:C45H72O17Purity:98.77% - 99.79%Color and Shape:SolidMolecular weight:885.04trans-Zeatin
CAS:trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrientFormula:C10H13N5OPurity:97.13% - 98.96%Color and Shape:White To Light Yellow Crystal PowderMolecular weight:219.24Ref: TM-TMS2181
1mL*10mM (DMSO)33.00€10mg37.00€25mg52.00€50mg66.00€100mg96.00€200mg128.00€500mg205.00€Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Formula:C42H72O14Purity:99.42% - 99.65%Color and Shape:SolidMolecular weight:801.01Ravoxertinib
CAS:Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).Formula:C21H18ClFN6O2Purity:98% - 99.87%Color and Shape:SolidMolecular weight:440.86Ref: TM-T6511
1mg38.00€2mg49.00€5mg80.00€1mL*10mM (DMSO)88.00€10mg90.00€25mg164.00€50mg268.00€100mg399.00€Bohemine
CAS:Bohemine is a cyclin-dependent kinase inhibitor.Formula:C18H24N6OPurity:99.09% - 99.53%Color and Shape:SolidMolecular weight:340.42Prosaptide TX14(A) acetate
Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.Formula:C71H114N16O28Purity:95.29%Color and Shape:SolidMolecular weight:1639.76magnolin
CAS:Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.
Formula:C23H28O7Purity:98% - 99.77%Color and Shape:SolidMolecular weight:416.46FR 180204
CAS:FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.Formula:C18H13N7Purity:98% - 99.74%Color and Shape:SolidMolecular weight:327.34Ref: TM-T1956
1mg40.00€2mg52.00€5mg81.00€1mL*10mM (DMSO)89.00€10mg131.00€25mg210.00€50mg314.00€100mg470.00€MRTX1133
CAS:View and buy MRTX1133 from TargetMol.MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D.Formula:C33H31F3N6O2Purity:97.39% - 99.6%Color and Shape:SolidMolecular weight:600.63Ref: TM-T9303
1mg177.00€5mg379.00€1mL*10mM (DMSO)502.00€10mg580.00€25mg893.00€50mg1,251.00€100mg1,639.00€200mg2,215.00€KO-947
CAS:KO-947 is a potent and specific inhibitor of ERK1/2 kinases.
Formula:C21H17N5OPurity:97.84%Color and Shape:SolidMolecular weight:355.39Astragaloside IV
CAS:Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.Formula:C41H68O14Purity:99% - 99.84%Color and Shape:Hydroscopic Brown Or Yellow PowderMolecular weight:784.97Avicularin
CAS:Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.Formula:C20H18O11Purity:97.02% - 99.94%Color and Shape:White PowderMolecular weight:434.35Ref: TM-T6S0117
1mg55.00€5mg92.00€1mL*10mM (DMSO)105.00€10mg152.00€25mg268.00€50mg395.00€100mg583.00€200mg832.00€LM22B-10
CAS:LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.Formula:C27H33ClN2O4Purity:98.18%Color and Shape:SolidMolecular weight:485.01(E/Z)-BIX02188
CAS:BIX02188 inhibits MEK5 (IC50: 4.3 nM) and ERK5 (810 nM) but not MEK1/2, JNK2, or ERK2.Formula:C25H24N4O2Purity:97.39% - 98.38%Color and Shape:SolidMolecular weight:412.48Ref: TM-T6324
1mg48.00€2mg63.00€5mg119.00€1mL*10mM (DMSO)136.00€10mg216.00€25mg326.00€50mg490.00€100mg707.00€ERK1/2 inhibitor 2
CAS:ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable ERK 1/2 inhibitor, with potential antineoplastic activity.Formula:C29H31ClFN5O5Purity:98.99%Color and Shape:SolidMolecular weight:584.04AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Formula:C16H17FIN3O4Purity:98.72%Color and Shape:SolidMolecular weight:461.23Tizaterkib
CAS:Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.Formula:C24H24F2N8O2Purity:99.6% - 99.63%Color and Shape:SolidMolecular weight:494.5HS-1793
CAS:HS-1793, resveratrol-like, reduces HIF-1, VEGF in hypoxia, and curbs human breast cancer growth in mouse model.Formula:C16H12O3Purity:98.16% - 99.82%Color and Shape:SolidMolecular weight:252.26(E/Z)-BIX 02189
CAS:(E/Z)-BIX 02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.Formula:C27H28N4O2Purity:98% - 99.89%Color and Shape:SolidMolecular weight:440.54Ref: TM-T2416
1mg38.00€5mg82.00€1mL*10mM (DMSO)92.00€10mg116.00€25mg210.00€50mg358.00€100mg550.00€200mg780.00€N-tert-butyl-α-Phenylnitrone
CAS:N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Formula:C11H15NOPurity:99.46% - 99.84%Color and Shape:SolidMolecular weight:177.24Pluripotin
CAS:Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) andFormula:C27H25F3N8O2Purity:98.77% - 98.82%Color and Shape:SolidMolecular weight:550.53Ref: TM-T6948
1mg34.00€2mg48.00€5mg63.00€1mL*10mM (DMSO)74.00€10mg88.00€25mg140.00€50mg207.00€100mg333.00€Tenuifoliside A
CAS:Tenuifoliside A has anti-apoptotic , neuroprotective activity.Formula:C31H38O17Purity:98.99% - 99.91%Color and Shape:SolidMolecular weight:682.62BAY885
CAS:BAY885 is a new ERK5 inhibitor.Formula:C25H28F3N7O2Purity:99.83%Color and Shape:SolidMolecular weight:515.53Mogrol
CAS:Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.Formula:C30H52O4Purity:99.85% - 99.90%Color and Shape:SolidMolecular weight:476.73Temuterkib
CAS:LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.
Formula:C22H27N7O2SPurity:99.57% - >99.99%Color and Shape:SolidMolecular weight:453.56GPR34 receptor antagonist 2
CAS:GPR34 receptor antagonist 2 (Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-) is an anti-inflammatory agent.Formula:C31H26ClNO4Purity:97.26%Color and Shape:SolidMolecular weight:512Ref: TM-T8848
1mg110.00€5mg259.00€1mL*10mM (DMSO)288.00€10mg425.00€25mg700.00€50mg982.00€100mg1,314.00€500mg2,637.00€Ulixertinib
CAS:Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.Formula:C21H22Cl2N4O2Purity:99.31% - 99.95%Color and Shape:SolidMolecular weight:433.33Peramivir Trihydrate
CAS:Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are
Formula:C15H28N4O4·3H2OPurity:99.52% - ≥95%Color and Shape:SolidMolecular weight:382.45Ref: TM-T2522
2mg47.00€5mg70.00€10mg103.00€25mg188.00€50mg311.00€100mg439.00€200mg635.00€500mg938.00€ERK5-IN-1
CAS:ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).Formula:C25H29N7O2Purity:97.70%Color and Shape:SolidMolecular weight:459.54
