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Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.

Subcategories of "Membrane Transporter/Ion Channel"

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Found 2280 products of "Membrane Transporter/Ion Channel"

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  • Huwentoxin-IV
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    Huwentoxin-IV

    CAS:
    <p>Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.</p>
    Formula:C174H278N52O51S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4106.79

    Ref: TM-TP2016

  • Ethacrynic acid D5
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    Ethacrynic acid D5

    CAS:
    <p>Ethacrynic acid: a diuretic, anti-inflammatory, inhibits calcium channels, GSTs, NF-kB pathway, and modulates leukotriene; has deuterium-labeled form.</p>
    Formula:C13H12Cl2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:308.17

    Ref: TM-T11240

  • Leptomycin A
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    Leptomycin A

    CAS:
    <p>Leptomycin A from Streptomyces inhibits CRM1, reducing HIV-1 replication, less potent than Leptomycin B, blocks protein nuclear export.</p>
    Formula:C32H46O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:526.7

    Ref: TM-T11837

  • Chlorotoxin
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    Chlorotoxin

    CAS:
    <p>Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.</p>
    Formula:C158H249N53O47S11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3995.71

    Ref: TM-TP1431

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    Homocarnosine TFA

    <p>Homocarnosine TFA: brain-exclusive GABA-histidine dipeptide, neuronal, anticonvulsant, antioxidant, anti-inflammatory.</p>
    Formula:C12H17F3N4O5
    Color and Shape:Solid
    Molecular weight:354.28

    Ref: TM-T73818

  • Fumitremorgin C
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    Fumitremorgin C

    CAS:
    <p>Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.</p>
    Formula:C22H25N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:379.45

    Ref: TM-T15355

  • UCL 1684 dibromide
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    UCL 1684 dibromide

    CAS:
    <p>apamin-sensitive Ca2+-activated K+ channel (KCa2.1) blocker</p>
    Formula:C34H30Br2N4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:654.45

    Ref: TM-T23493

  • Milbemycin A4
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    Milbemycin A4

    CAS:
    <p>Milbemycin A4, a distinguished member of the macrocyclic lactones family featuring a unique spiroketal group, is derived from the fermentation of the soil bacterium Streptomyces hygroscopicus subsp. aureolacrimosus. It acts by enhancing the opening of glutamate and GABA-gated chloride channels, rendering it effective as both a nematocide and insecticide.</p>
    Formula:C32H46O7
    Color and Shape:Solid
    Molecular weight:542.713

    Ref: TM-TN7268

  • Idrevloride
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    Idrevloride

    CAS:
    <p>Idrevloride (WO2016133967) inhibits ENaC, used in skin disorder research.</p>
    Formula:C30H49ClN8O7
    Color and Shape:Solid
    Molecular weight:669.22

    Ref: TM-T38849

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    Anticonvulsant agent 9

    <p>Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.</p>
    Formula:C22H24N4O2
    Color and Shape:Solid
    Molecular weight:376.45

    Ref: TM-T205256

  • GaTx2
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    GaTx2

    CAS:
    <p>High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.</p>
    Formula:C125H199N39O47S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3192.54

    Ref: TM-TP2027

  • AZD-3161
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    AZD-3161

    CAS:
    <p>AZD-3161 is a sodium channel regulator for pain.</p>
    Formula:C23H21F3N4O4
    Color and Shape:Solid
    Molecular weight:474.43

    Ref: TM-T30256

  • Bumetanide
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    Bumetanide

    CAS:
    <p>Bumetanide (PF 1593) is a potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.</p>
    Formula:C17H20N2O5S
    Purity:99.82% - 99.9%
    Color and Shape:Solid
    Molecular weight:364.42

    Ref: TM-T0108

  • N-Oleoyl Valine Ammonium salt
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    N-Oleoyl Valine Ammonium salt

    <p>N-Oleoyl Valine Ammonium salt is an N-acyl amide compound that is a TRPV3 antagonist and can be used to study inflammation.</p>
    Formula:C23H46N2O3
    Purity:99.72%
    Color and Shape:Solid
    Molecular weight:398.62

    Ref: TM-T35921L

  • Vanzacaftor
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    Vanzacaftor

    CAS:
    <p>Vanzacaftor is a CFTR modulator improving protein processing and surface trafficking, restoring chloride transport and aiding cystic fibrosis therapy research.</p>
    Formula:C32H39N7O4S
    Purity:99.14%
    Color and Shape:Solid
    Molecular weight:617.76

    Ref: TM-T74417

  • BKCa activator-1
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    BKCa activator-1

    <p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>
    Formula:C22H23F7N2O3
    Color and Shape:Solid
    Molecular weight:496.418

    Ref: TM-T205564

  • Linoleic Acid Amide
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    Linoleic Acid Amide

    CAS:
    <p>Linoleic Acid Amide (Linoleamide) is derived from linoleic acid and regulates Ca2+ flux by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase.</p>
    Formula:C18H33NO
    Purity:98%
    Color and Shape:Solid
    Molecular weight:279.46

    Ref: TM-T36812

  • Iberiotoxin
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    Iberiotoxin

    CAS:
    <p>Selective blocker of the big conductance Ca2+-activated K+ channel.</p>
    Formula:C179H274N50O55S7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4230

    Ref: TM-TP2014

  • GX 201
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    GX 201

    CAS:
    <p>GX 201 is a selective NaV1.7 inhibitor, IC50 of &lt; 3.2 nM for hNaV1.7.</p>
    Formula:C25H27ClF4N2O4S
    Purity:99.81%
    Color and Shape:Solid
    Molecular weight:563

    Ref: TM-T9647

  • α5-GABAA receptor modulator 1
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    α5-GABAA receptor modulator 1

    <p>α5-GABAA receptor modulator 1 (Compound A-4) is a selective silent allosteric modulator (SAM) targeting the α5 subunit of GABAA receptors, useful for research into central nervous system (CNS) disorders.</p>
    Formula:C21H20FN3O4
    Color and Shape:Solid
    Molecular weight:397.4

    Ref: TM-T205217

  • TRPA1 Antagonist 3
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    TRPA1 Antagonist 3

    CAS:
    <p>TRPA1 Antagonist 3 is a compound with photoswitchable properties that acts as an agonist on the TRPA1 channel, providing the ability for optical control.</p>
    Formula:C11H8ClN3
    Color and Shape:Solid
    Molecular weight:217.66

    Ref: TM-T40822

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    Ebio3

    <p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>
    Formula:C19H23F2N3O2
    Color and Shape:Solid
    Molecular weight:363.4

    Ref: TM-T205242

  • Agitoxin-2
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    Agitoxin-2

    CAS:
    Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).
    Formula:C169H278N54O48S8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4090.87

    Ref: TM-TP2089

  • Lyso-Globotriaosylceramide (d18:1)
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    Lyso-Globotriaosylceramide (d18:1)

    CAS:
    <p>Lyso-Gb3, lacking fatty acyl, binds Stx1 with cholesterol and phosphatidylcholine, not Stx2; lowers neutrophil viability; accumulates in Fabry disease.</p>
    Formula:C36H67NO17
    Color and Shape:Solid
    Molecular weight:785.922

    Ref: TM-T37291

  • Resolvin D2 methyl ester
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    Resolvin D2 methyl ester

    CAS:
    <p>RvD2 is an anti-inflammatory lipid made from docosahexaenoic acid by 15- and 5-lipoxygenase. Its methyl ester may serve as a prodrug.</p>
    Formula:C23H34O5
    Color and Shape:Solid
    Molecular weight:390.52

    Ref: TM-T37169

  • Mesoridazine free base
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    Mesoridazine free base

    CAS:
    <p>Mesoridazine (thioridazine EP impurity B) is a phenothiazine antipsychotic with effects similar to chlorpromazine.</p>
    Formula:C21H26N2OS2
    Color and Shape:Solid
    Molecular weight:386.57

    Ref: TM-T3086L

  • Elgodipine
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    Elgodipine

    CAS:
    <p>Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.</p>
    Formula:C29H33FN2O6
    Purity:98.95% - 99.50%
    Color and Shape:Solid
    Molecular weight:524.58

    Ref: TM-T68060

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    Anticonvulsant agent 8

    <p>Anticonvulsant agent 8 (compound D4) is a chemical used in treating epilepsy by inhibiting GABAA currents. In mouse models, its ED50 values are 2.23 mg/kg for the maximal electroshock (MES) test and 24.60 mg/kg for the pentylenetetrazol (PTZ) test.</p>
    Formula:C15H11N5O
    Color and Shape:Solid
    Molecular weight:277.28

    Ref: TM-T205302

  • TRPV4 antagonist 4
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    TRPV4 antagonist 4

    CAS:
    <p>Potent TRPV4 blocker with 22.65 nM IC50; inhibits current and aids acute lung injury.</p>
    Formula:C28H32Cl2N6O
    Color and Shape:Solid
    Molecular weight:539.50

    Ref: TM-T74832

  • Levamlodipine besylate Hemipentahydrate
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    Levamlodipine besylate Hemipentahydrate

    CAS:
    <p>Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.</p>
    Formula:C20H25ClN2O5·C6H6O3SH2O
    Color and Shape:Solid
    Molecular weight:1224.18

    Ref: TM-T204904

  • Margatoxin
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    Margatoxin

    CAS:
    <p>KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx &amp; NO in endothelial cells.</p>
    Formula:C178H286N52O50S7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4178.96

    Ref: TM-TP2004

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    OD1

    <p>Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 &gt;3 μM); blocks fast inactivation; triggers pain.</p>
    Formula:C308H466N90O95S8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:7206.1

    Ref: TM-TP1972

  • Dofetilide N-oxide
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    Dofetilide N-oxide

    CAS:
    Dofetilide N-oxide (UK-116856) is a metabolite of dofetilide. Dofetilide can block potassium channels and is a tertiary antiarrhythmic drug.
    Formula:C19H27N3O6S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:457.56

    Ref: TM-T11073

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    BuChE-IN-9

    <p>BuChE-IN-9 (compound 22a), an eqBuChE (equine serum-derived butyrylcholinesterase) inhibitor, exhibits potent activity with an IC50 of 173 nM.</p>
    Formula:C28H34N4O2
    Color and Shape:Solid
    Molecular weight:458.6

    Ref: TM-T79423

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    PptT-IN-4

    <p>PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM.</p>
    Formula:C17H23N3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:269.38

    Ref: TM-T78714

  • AQP4 (205-215)
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    AQP4 (205-215)

    CAS:
    <p>AQP4 (205-215) is a fragment of the water channel protein Aquaporin-4 (AQP4). This protein is an autoimmune antigen in optic neuromyelitis and, upon binding with CD40, is upregulated and presented in B cells. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).</p>
    Formula:C48H75N13O17S
    Color and Shape:Solid
    Molecular weight:1138.25

    Ref: TM-TP3218

  • α,β-Methylene-ATP dilithium
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    α,β-Methylene-ATP dilithium

    CAS:
    <p>α,β-Methylene ATP dilithium, a phosphonic analog of ATP, serves as a ligand for P2X3 and P2X7 receptors.</p>
    Formula:C11H16Li2N5O12P3
    Color and Shape:Solid
    Molecular weight:517.07

    Ref: TM-T38444

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    Lifastuzumab

    CAS:
    <p>Sulfamethoxazole-NO (SMX-NO) is a SMX-NO derivative and is the primary immunogen for sulfonamide hypersensitivity reactions.</p>
    Purity:97% (SDS-PAGE); 99.5% (SEC-HPLC) - 97% (SDS-PAGE); 99.5% (SEC-HPLC)
    Color and Shape:Liquid
    Molecular weight:145.5 kDa

    Ref: TM-T77384

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    P-gp inhibitor 15

    <p>P-gp Inhibitor 15 (compound 7a), a nonsubstrate inhibitor of P-glycoprotein (Pgp), inhibits Pgp-ATPase activity and interferes with Pgp-mediated Rhodamine123</p>
    Formula:C35H60N2O4
    Color and Shape:Solid
    Molecular weight:572.86

    Ref: TM-T79261

  • 8-Bromo-ATP
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    8-Bromo-ATP

    CAS:
    <p>8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate) is a purinergic P2X receptor agonist and an ATP analogue.</p>
    Formula:C10H15BrN5O13P3
    Color and Shape:Solid
    Molecular weight:586.077

    Ref: TM-T39891

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    Crofelemer

    CAS:
    <p>Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.</p>
    Color and Shape:Solid

    Ref: TM-T205474

  • Way 125971
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    Way 125971

    CAS:
    <p>Way 125971 is a bioactive chemcial.</p>
    Formula:C22H28N4O5S2
    Color and Shape:Solid
    Molecular weight:492.61

    Ref: TM-T35111

  • Roquefortine C
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    Roquefortine C

    CAS:
    <p>Roquefortine C is a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins</p>
    Formula:C22H23N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:389.45

    Ref: TM-T13872

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    Analgesic/antidepressant agent-1

    <p>Analgesic/antidepressant agent-1 (Compound k1) is an orally active N-acetylamino chloro ketone derivative capable of crossing the blood-brain barrier. It exhibits high affinity for NMDA receptors and demonstrates analgesic, anti-inflammatory, and antidepressant properties, with low psychotomimetic activity.</p>
    Formula:C22H25ClN2O2
    Color and Shape:Solid
    Molecular weight:384.9

    Ref: TM-T205604

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    GluN2B-NMDAR antagonist-1

    <p>Orally active GluN2B-NMDAR antagonist with neuroprotective properties for ischemic injury research.</p>
    Formula:C26H23BrN2O2
    Color and Shape:Solid
    Molecular weight:475.38

    Ref: TM-T74854

  • (+)-Lycoctonine
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    (+)-Lycoctonine

    CAS:
    <p>Compound TJS1874 is a useful organic compound for research related to life sciences. The catalog number is TJS1874 and the CAS number is 26000-17-9.</p>
    Formula:C25H41NO7
    Color and Shape:Solid
    Molecular weight:467.6

    Ref: TM-TJS1874

  • Phrixotoxin 3
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    Phrixotoxin 3

    CAS:
    <p>Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.</p>
    Formula:C176H269N51O48S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4059.74

    Ref: TM-TP1967

  • Nav1.7-IN-8
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    Nav1.7-IN-8

    CAS:
    <p>Nav1.7-IN-8 selectively inhibits NaV1.7 over hNaV1.1/1.5, affects CYP2C9/3A4 (IC50: 0.17/0.077 μM), and provides rodent pain relief.</p>
    Formula:C21H12ClF2N5O4S2
    Color and Shape:Solid
    Molecular weight:535.93

    Ref: TM-T38911

  • Apamin acetate
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    Apamin acetate

    <p>Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.</p>
    Purity:96.97%
    Color and Shape:Solid

    Ref: TM-TP1223L

  • S-Sulfo-L-cysteine sodium salt
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    S-Sulfo-L-cysteine sodium salt

    CAS:
    <p>S-Sulfo-L-cysteine sodium salt shows a weak affinity for mGluR1α and mGluR5a at high concentrations and has potential antioxidant activity.</p>
    Formula:C3H6NNaO5S2
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:223.2

    Ref: TM-T23303