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Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.

Subcategories of "Membrane Transporter/Ion Channel"

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Found 2290 products of "Membrane Transporter/Ion Channel"

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  • TRPA1 Antagonist 1
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    TRPA1 Antagonist 1

    CAS:
    <p>TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.</p>
    Formula:C24H20F6N5Na2O7PS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:713.45

    Ref: TM-T13212

  • PF-06462894
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    PF-06462894

    CAS:
    PF-06462894: morpholinopyrimidone, mGlu5 antagonist (Ki=6nM), no immune activation in mouse model.
    Formula:C18H23N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:329.39

    Ref: TM-T28372

  • TRPV1 antagonist 10
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    TRPV1 antagonist 10

    CAS:
    <p>TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.</p>
    Formula:C16H14N2O5
    Color and Shape:Solid
    Molecular weight:314.293

    Ref: TM-T207037

  • 2-PPA
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    2-PPA

    CAS:
    2-PPA serves as a selective TMEM175 inhibitor (IC 50 =32 μM), primarily influencing lysosomal activity. Through acute inhibition of TMEM175, 2-PPA enhances lysosomal macromolecular catabolism, which in turn boosts macrophage activity and other digestive processes. This compound holds significance in Parkinson's disease research.
    Formula:C11H10N2
    Color and Shape:Solid
    Molecular weight:170.21

    Ref: TM-T89916

  • Sp-8-Br-cGMPS
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    Sp-8-Br-cGMPS

    CAS:
    <p>Sp-8-Br-cGMPS, an analogue of cGMP, acts as an agonist for cGMP gated cation channels (CNG channels) with an EC50 of 106.5 μM. While Sp-8-Br-cGMPS can induce currents, it does not stabilize channel open states as effectively as a full agonist.</p>
    Formula:C10H11BrN5O6PS
    Color and Shape:Solid
    Molecular weight:440.17

    Ref: TM-T88734

  • CRM1-IN-3
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    CRM1-IN-3

    CAS:
    <p>CRM1-IN-3 (B28), a noncovalent inhibitor of CRM1, is utilized in the research of protein localization and tumor studies [1].</p>
    Formula:C26H26ClN3O3
    Color and Shape:Solid
    Molecular weight:463.96

    Ref: TM-T86090

  • NMD670
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    NMD670

    CAS:
    <p>NMD670 is an orally active, partial inhibitor of the skeletal muscle-specific chloride channel ClC-1. It enhances muscle excitability and neuromuscular transmission, restoring muscle function and mobility. NMD670 has a favorable safety profile and improves muscle function in rats, particularly in an MG rat model [1].</p>
    Formula:C12H10BrNO4
    Color and Shape:Solid
    Molecular weight:312.12

    Ref: TM-T87024

  • Caramboxin
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    Caramboxin

    CAS:
    <p>Caramboxin, a neurotoxin, can induce acute kidney injury.</p>
    Formula:C11H13NO6
    Color and Shape:Solid
    Molecular weight:255.22

    Ref: TM-T201088

  • Kv7.2/Kv7.3 agonist 1
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    Kv7.2/Kv7.3 agonist 1

    CAS:
    <p>Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.</p>
    Formula:C14H14FN3O2
    Color and Shape:Solid
    Molecular weight:275.28

    Ref: TM-T201063

  • Dehydroindapamide
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    Dehydroindapamide

    CAS:
    <p>Dehydroindapamide, an indole form of Indapamide, is utilized to quantify the turnover rate of Indapamide in CYP3A4, which is approximately 10 times higher than that of Indoline, with slightly enhanced affinity for CYP3A4.</p>
    Formula:C16H14ClN3O3S
    Color and Shape:Solid
    Molecular weight:363.82

    Ref: TM-T200811

  • Vormatrigine
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    Vormatrigine

    CAS:
    <p>Vormatrigine effectively inhibits sodium channels (sodium channel).</p>
    Formula:C16H12F6N4O2
    Color and Shape:Solid
    Molecular weight:406.28

    Ref: TM-T201328

  • EU 1622-240
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    EU 1622-240

    CAS:
    <p>EU 1622-240 is an allosteric modulator with a preference for GluN2B, GluN2C, and GluN2D, exhibiting EC50 values of 0.57, 0.82, and 1.1 μM, respectively. It possesses favorable physicochemical properties, along with in vitro stability and permeability.</p>
    Formula:C20H14BrF2N3O2S
    Color and Shape:Solid
    Molecular weight:478.31

    Ref: TM-T207129

  • Cyproflanilide
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    Cyproflanilide

    CAS:
    <p>Cyproflanilide is a GABAR antagonist that exhibits high activity against a variety of pests, including those from the Lepidoptera, Coleoptera, and Thysanoptera orders.</p>
    Formula:C28H17BrF12N2O2
    Color and Shape:Solid
    Molecular weight:721.33

    Ref: TM-T201028

  • H052
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    H052

    CAS:
    <p>H052 is a selective inhibitor of Staphylococcus aureus α-hemolysin (Hla). It binds to the Hla monomer, disrupting its interaction with the host cell membrane, thereby blocking pore formation and inhibiting calcium influx, cytotoxicity, and inflammatory response. H052 exhibits inhibitory activity against Hla-induced calcium influx (EC50 = 30 nM in U937 cells) and holds potential for research into lung infections caused by S. aureus.</p>
    Formula:C21H15ClFN3O4S
    Color and Shape:Solid
    Molecular weight:459.88

    Ref: TM-T207113

  • Caged MK801
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    Caged MK801

    CAS:
    Caged MK801 (cMK801) is a selective, noncompetitive, and irreversible blocker of the NMDA receptor open channel. The NVOC cage is compatible in neuropharmacology and does not alter the intrinsic activity of the molecule.
    Formula:C26H24N2O6
    Color and Shape:Solid
    Molecular weight:460.48

    Ref: TM-T88745

  • S9-A13
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    S9-A13

    CAS:
    S9-A13 is a potent and selective inhibitor of SLC26A9, exhibiting an IC50 of 90.9 nM without inhibiting other members of the SLC26 family, such as SLC26A3, SLC26A4, and SLC26A6. It also inhibits the SLC26A9 Cl- current in cells lacking CFTR expression.
    Formula:C20H18ClN3O2S
    Color and Shape:Solid
    Molecular weight:399.89

    Ref: TM-T201301

  • Perfluoroheptanesulfonic acid
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    Perfluoroheptanesulfonic acid

    CAS:
    <p>Perfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid) is a perfluoroalkyl substance (PFAS). This compound has been detected in landfill leachate and has been shown to induce deformities in zebrafish larvae (EC50=168.1 μM). Exposure to PFHpS in fetuses can lead to reduced birth weight.</p>
    Formula:C7HF15O3S
    Color and Shape:Solid
    Molecular weight:450.12

    Ref: TM-T200995

  • BGT1-IN-1
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    BGT1-IN-1

    CAS:
    BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.
    Formula:C6H9NO2
    Color and Shape:Solid
    Molecular weight:127.14

    Ref: TM-T200935

  • CFTR corrector 17
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    CFTR corrector 17

    CAS:
    CFTRcorrector 17 (example 17) is a regulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It is utilized in the study of diseases mediated by CFTR.
    Formula:C18H15FN2O2
    Color and Shape:Solid
    Molecular weight:310.32

    Ref: TM-T201013

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    (R)-KMH-233

    CAS:
    <p>(R)-KMH-233 is an isomer of KMH-233, which can serve as a reference compound in experiments. KMH-233 functions as a potent, reversible, and selective inhibitor of L-type amino acid transporter 1 (LAT1), effectively hindering the uptake of LAT1 substrate, l-leucine (IC50=18 μM), and also inhibiting cell growth. Even at a low concentration of 25 μM, KMH-233 significantly enhances the efficacy of Bestatin and cisplatin.</p>
    Formula:C32H25N7O5
    Molecular weight:587.58

    Ref: TM-TYD-02664

  • EF1502 free base
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    EF1502 free base

    CAS:
    <p>EF1502 is a potent and selective GABA transporter inhibitor.</p>
    Formula:C22H26N2O2S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:414.58

    Ref: TM-T27241

  • Tamitinol
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    Tamitinol

    CAS:
    <p>Tamitinol is a neurotropic drug. It has been found to help symptoms of obsessive rumination in conjunction with maprotiline.</p>
    Formula:C12H20N2OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:240.37

    Ref: TM-T24852

  • ZK 93426 hydrochloride
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    ZK 93426 hydrochloride

    CAS:
    <p>benzodiazepine receptor antagonist,competitive</p>
    Formula:C18H21ClN2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:348.82

    Ref: TM-T23562

  • Leualacin
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    Leualacin

    CAS:
    <p>Leualacin is a novel calcium blocker from Hapsidospora irregularis.</p>
    Formula:C31H47N3O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:573.72

    Ref: TM-T25674

  • CAD204520
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    CAD204520

    CAS:
    <p>CAD204520 functions as an inhibitor of SERCA (IC50 = 0.34 μM), specifically targeting mutations in the wild-type NOTCH1 protein associated with T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL).</p>
    Formula:C23H32F3N3O2
    Color and Shape:Solid
    Molecular weight:439.51

    Ref: TM-T200097

  • Detajmium
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    Detajmium

    CAS:
    Detajmium is an anti-arrhythmia compound. It is an Na(+)-channel-blocking drug with an extremely long recovery from use-dependent sodium channel block.
    Formula:C27H42N3O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:456.64

    Ref: TM-T25312

  • AP-6
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    AP-6

    CAS:
    AP-6, a selective TMEM175 inhibitor, enhances lysosomal macromolecular catabolism by acutely inhibiting TMEM175, thus speeding up macrophage and other digestive activities. This compound holds potential for use in Parkinson's disease research due to its role in modulating lysosomal function.
    Formula:C16H14N4
    Color and Shape:Solid
    Molecular weight:262.31

    Ref: TM-T200356

  • AN-988
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    AN-988

    CAS:
    <p>AN-988 (compound 6) is a covalent CRM1 inhibitor.</p>
    Formula:C22H22N2O4S
    Color and Shape:Solid
    Molecular weight:410.49

    Ref: TM-T200424

  • Fletazepam
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    Fletazepam

    CAS:
    Fletazepam, a benzodiazepine derivative, exhibits sedative, anti-anxiety, and muscle-relaxant properties. It is utilized in neurological research.
    Formula:C17H13ClF4N2
    Color and Shape:Solid
    Molecular weight:356.74

    Ref: TM-T201147

  • Butein tetramethyl ether
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    Butein tetramethyl ether

    CAS:
    <p>Butein tetramethyl ether (Compound 20) is a potent and selective inhibitor of breast cancer resistance protein / ATP-binding cassette sub-family G member 2 (BCRP/ABCG2). It inhibits MCF-7 MX and MDCKBCRP cells with IC50 values of 2.2 μM and 1.03 μM, respectively. Butein tetramethyl ether holds potential for cancer research.</p>
    Formula:C19H20O5
    Color and Shape:Solid
    Molecular weight:328.359

    Ref: TM-T204268

  • 3-Methoxy PCE hydrochloride
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    3-Methoxy PCE hydrochloride

    CAS:
    <p>3-Methoxy PCE (3-MEO PCE) hydrochloride is an arylcyclohexylamine compound that functions as an NMDA receptor antagonist with a pKi value of 7.22.</p>
    Formula:C15H24ClNO
    Color and Shape:Solid
    Molecular weight:269.81

    Ref: TM-T204329

  • Mibefradil dihydrochloride hydrate
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    Mibefradil dihydrochloride hydrate

    CAS:
    <p>Mibefradil dihydrochloride hydrate is a long-acting antihypertensive blocking high-voltage L calcium channels.</p>
    Formula:C29H42Cl2FN3O4
    Color and Shape:Solid
    Molecular weight:586.57

    Ref: TM-T64151

  • LY 235959
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    LY 235959

    CAS:
    <p>LY 235959 is a NMDA receptor antagonist.</p>
    Formula:C11H20NO5P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:277.25

    Ref: TM-T22944

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    CRM1 degrader 1

    <p>CRM1 degrader 1 (1l) is a low-toxic CRM1 degrader that induces apoptosis in gastric carcinoma and selectively inhibits the proliferation of gastric cancer[1].</p>
    Formula:C16H20O3
    Color and Shape:Solid
    Molecular weight:260.33

    Ref: TM-T60416

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    PF-06305591 dihydrate

    <p>PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker (IC 50 = 15 nM) with an excellent preclinical in vitro ADME</p>
    Formula:C15H26N4O3
    Color and Shape:Solid
    Molecular weight:310.39

    Ref: TM-T60761

  • Unoprostone
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    Unoprostone

    CAS:
    <p>Unoprostone is a prostaglandin F2α analogs (PGAs), and reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.</p>
    Formula:C22H38O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:382.53

    Ref: TM-T13955

  • P2X4-IN-1
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    P2X4-IN-1

    CAS:
    <p>P2X4-IN-1 is an orally active P2X4 inhibitor. P2X4-IN-1 is applicable in research focused on disease prevention.</p>
    Formula:C18H14ClN5O3S
    Color and Shape:Solid
    Molecular weight:415.85

    Ref: TM-T207340

  • CFTR corrector 18
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    CFTR corrector 18

    CAS:
    <p>CFTRcorrector 18 (Compound I-99) acts as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It enhances the processing and trafficking of CFTR, thereby increasing the amount of CFTR present on the cell surface. CFTRcorrector 18 holds potential for research in cystic fibrosis (CF).</p>
    Formula:C38H40N6O5S
    Color and Shape:Solid
    Molecular weight:692.826

    Ref: TM-T206874

  • S-8510 phosphate
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    S-8510 phosphate

    CAS:
    S-8510 phosphate is an agonist of inverse Benzodiazepine (BDZ) receptor(Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively).
    Formula:C12H13N4O6P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:340.23

    Ref: TM-T12792

  • 264W94
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    264W94

    CAS:
    264W94 robustly inhibits IBAT, induces CYP7A1, and significantly reduces cholesterol.
    Formula:C23H31NO4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:417.56

    Ref: TM-T10090

  • ATP synthase inhibitor 2
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    ATP synthase inhibitor 2

    CAS:
    <p>ATP synthase inhibitor 2 blocks P. aeruginosa ATP synthase; IC50=10 μg/mL, fully inhibits at 128 μg/mL.</p>
    Formula:C21H22N2O3S
    Color and Shape:Solid
    Molecular weight:382.48

    Ref: TM-T61649

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    T-Type calcium channel inhibitor 2

    <p>Compound 6g inhibits T-type Ca channels (IC50: Cav3.1-31μM, Cav3.2-83μM), cytotoxic to A549 (IC50: 5μM) &amp; HCT-116 cells (IC50: 6.4μM).</p>
    Formula:C36H39FN4OS
    Color and Shape:Solid
    Molecular weight:594.78

    Ref: TM-T64203

  • Gabaculine HCl
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    Gabaculine HCl

    CAS:
    <p>Gabaculine, an irreversible GABA-T inhibitor (Ki: 2.9 μM), impacts plastid development and affects DPOR/GluTR levels.</p>
    Formula:C7H10ClNO2
    Color and Shape:Solid
    Molecular weight:175.61

    Ref: TM-T24080

  • SR 33805 oxalate
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    SR 33805 oxalate

    CAS:
    <p>Ca2+ channel antagonist</p>
    Formula:C34H42N2O9S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:654.77

    Ref: TM-T23391

  • Kv7.2/Kv7.3 modulator-1
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    Kv7.2/Kv7.3 modulator-1

    CAS:
    <p>Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.</p>
    Formula:C20H21F4N3O3
    Color and Shape:Solid
    Molecular weight:427.393

    Ref: TM-T206950

  • RO-275
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    RO-275

    CAS:
    <p>RO-275 is an HCN1 inhibitor that also inhibits HCN2, HCN3, and HCN4, improving working memory deficits and being used in research on cognitive disorders.</p>
    Formula:C18H14ClN5O
    Purity:98.12% - 98.3%
    Color and Shape:Solid
    Molecular weight:351.79

    Ref: TM-T87339

  • EMD-95885
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    EMD-95885

    CAS:
    <p>EMD-95885 is a selective antagonist of NMDA receptors containing NR2B subunits, with an IC50 of 3.9 nM. It does not interact with other sites on the NMDA receptor.</p>
    Formula:C22H23FN2O3
    Color and Shape:Solid
    Molecular weight:382.428

    Ref: TM-T205291

  • MSK-195
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    MSK-195

    CAS:
    <p>MSK-195 is an effective TRPV1 agonist.</p>
    Formula:C28H40N2O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:484.63

    Ref: TM-T24504

  • Olorigliflozin
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    Olorigliflozin

    CAS:
    <p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>
    Formula:C23H27ClO7
    Color and Shape:Solid
    Molecular weight:450.909

    Ref: TM-T205428

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    Cav 3.2 inhibitor 2

    <p>Cav 3.2 inhibitor 2 blocks T-type Ca2+ channels (IC50=0.09339 μM) and reduces mouse somatic/visceral pain. Used for intractable pain studies.</p>
    Formula:C32H37F2N3O
    Color and Shape:Solid
    Molecular weight:517.65

    Ref: TM-T63606