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Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.

Subcategories of "Membrane Transporter/Ion Channel"

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Found 2280 products of "Membrane Transporter/Ion Channel"

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  • Lu AF90103
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    Lu AF90103

    CAS:
    <p>Lu AF90103 (Compound 42e) is the methyl ester prodrug of compound 42d, capable of crossing the blood-brain barrier. Compound 42d acts as a partial agonist of the GluN1/GluN2B complex, with an efficacy of 24% and an EC50 value of 78 nM. Lu AF90103 plays a significant role in neuropsychiatric disorder research.</p>
    Formula:C13H15N3O3S
    Color and Shape:Solid
    Molecular weight:293.342

    Ref: TM-T204820

  • 2-PPA
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    2-PPA

    CAS:
    2-PPA serves as a selective TMEM175 inhibitor (IC 50 =32 μM), primarily influencing lysosomal activity. Through acute inhibition of TMEM175, 2-PPA enhances lysosomal macromolecular catabolism, which in turn boosts macrophage activity and other digestive processes. This compound holds significance in Parkinson's disease research.
    Formula:C11H10N2
    Color and Shape:Solid
    Molecular weight:170.21

    Ref: TM-T89916

  • Antidepressant agent 8
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    Antidepressant agent 8

    CAS:
    <p>Antidepressant agent 8 (Compound 1f) acts as a selective antagonist for the NMDA receptor GluN1/2A (NMDA receptorGluN1/2A), with an IC50 of 2.94 μmol/L. In a hydrocortisone-induced zebrafish depression model, it demonstrates antidepressant-like effects and shows good blood-brain barrier penetration.</p>
    Formula:C18H23FN4OS2
    Color and Shape:Solid
    Molecular weight:394.53

    Ref: TM-T205232

  • CymitQuimica logo
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    Cav 2.2/3.2 blocker 1

    <p>Compound 9e is a Cav 2.2/3.2 blocker; IC50: 1.22 μM &amp; 80 μM, respectively; penetrates CNS.</p>
    Formula:C28H30N2O3
    Color and Shape:Solid
    Molecular weight:442.55

    Ref: TM-T62586

  • NSC73306
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    NSC73306

    CAS:
    <p>NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.</p>
    Formula:C16H14N4O2S
    Color and Shape:Solid
    Molecular weight:326.373

    Ref: TM-T204744

  • Sesamodil
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    Sesamodil

    CAS:
    <p>Sesamodil (SD 3211) is a novel calcium antagonist that can be used to study hypertension.</p>
    Formula:C29H32N2O6S
    Purity:98.58% - 99.01%
    Color and Shape:Solid
    Molecular weight:536.64

    Ref: TM-T28759

  • PD-217014
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    PD-217014

    CAS:
    <p>PD-217014 is an α2δ ligand that exhibits visceral analgesic activity and can suppress visceral hypersensitivity. Its antihyperalgesic effects are dose-dependent.</p>
    Formula:C10H17NO2
    Color and Shape:Solid
    Molecular weight:183.25

    Ref: TM-T200642

  • Lorajmine
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    Lorajmine

    CAS:
    Lorajmine, a monochloroacetyl derivative of ajmaline, is a class Ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases.
    Formula:C22H27ClN2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:402.91

    Ref: TM-T25755

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    URAT1 inhibitor 2

    <p>URAT1 inhibitor 2: oral URAT1/CYP blocker, IC50 of 1.36μM (URAT1), 16.97μM (CYP1A2), 5.22μM (CYP2C9); potential gout treatment.</p>
    Formula:C21H18BrN3O2S
    Color and Shape:Solid
    Molecular weight:456.36

    Ref: TM-T62825

  • Onfasprodil
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    Onfasprodil

    CAS:
    <p>Onfasprodil, NR2B inhibitor &amp; GABA regulator, potential for Alzheimer's research. (Patent CN111481543A)</p>
    Formula:C20H23FN2O3
    Color and Shape:Solid
    Molecular weight:358.41

    Ref: TM-T61319

  • LY 215490
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    LY 215490

    CAS:
    <p>LY 215490 is a selective AMPA receptor antagonist with neuroprotective properties in rat ischemia.</p>
    Formula:C13H21N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:279.34

    Ref: TM-T27897

  • SOAT-IN-1
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    SOAT-IN-1

    CAS:
    <p>SOAT-IN-1 (compound 40) is a potent and selective inhibitor targeting the sodium-dependent organic anion transporter (SOAT), exhibiting IC50 values of 1.6 µM for SOAT and 14.3 µM for NTCP.</p>
    Formula:C20H16ClN3O6S
    Color and Shape:Solid
    Molecular weight:461.88

    Ref: TM-T201002

  • Coleon-U-quinone
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    Coleon-U-quinone

    CAS:
    <p>Coleon-U-quinone, a P-gp inhibitor, reduces cancer cell viability and enhances Doxorubicin sensitivity in resistant cells.</p>
    Formula:C20H24O5
    Color and Shape:Solid
    Molecular weight:344.4

    Ref: TM-T72735

  • TRPV1 antagonist 10
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    TRPV1 antagonist 10

    CAS:
    <p>TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.</p>
    Formula:C16H14N2O5
    Color and Shape:Solid
    Molecular weight:314.293

    Ref: TM-T207037

  • CFTR corrector 16
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    CFTR corrector 16

    CAS:
    <p>CFTRcorrector 16 (Compound 39) is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), utilized in the research of cystic fibrosis disease.</p>
    Formula:C27H26ClN5O2S
    Color and Shape:Solid
    Molecular weight:520.05

    Ref: TM-T200113

  • Ro-51
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    Ro-51

    CAS:
    <p>dual P2X3 and P2X2/3 antagonist</p>
    Formula:C17H23IN4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:474.29

    Ref: TM-T23245

  • Quinacainol dihydrochloride
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    Quinacainol dihydrochloride

    CAS:
    <p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>
    Formula:C21H32Cl2N2O
    Color and Shape:Solid
    Molecular weight:399.398

    Ref: TM-T204878

  • Butein tetramethyl ether
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    Butein tetramethyl ether

    CAS:
    <p>Butein tetramethyl ether (Compound 20) is a potent and selective inhibitor of breast cancer resistance protein / ATP-binding cassette sub-family G member 2 (BCRP/ABCG2). It inhibits MCF-7 MX and MDCKBCRP cells with IC50 values of 2.2 μM and 1.03 μM, respectively. Butein tetramethyl ether holds potential for cancer research.</p>
    Formula:C19H20O5
    Color and Shape:Solid
    Molecular weight:328.359

    Ref: TM-T204268

  • Olisutrigine bromide
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    Olisutrigine bromide

    CAS:
    <p>Olisutrigine bromide is a sodium channel blocker used as an analgesic.</p>
    Formula:C25H35BrN2
    Color and Shape:Solid
    Molecular weight:443.463

    Ref: TM-T205479

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    DAD dichloride

    <p>DAD dichloride is a 3rd-gen photoelectric switch, blocks K+ channels, and helps in visual function research.</p>
    Formula:C26H42Cl2N6O
    Color and Shape:Solid
    Molecular weight:525.56

    Ref: TM-T63684

  • P-gp inhibitor 2
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    P-gp inhibitor 2

    CAS:
    <p>Potent P-gp inhibitor 2 reverses Doxorubicin resistance in colorectal carcinoma cells with IC50 of 0.22 µM.</p>
    Formula:C29H26N2O6
    Color and Shape:Solid
    Molecular weight:498.53

    Ref: TM-T72739

  • ICA-105665
    Targetmol
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    ICA-105665

    CAS:
    <p>ICA-105665 is an orally active Kv7.2/7.3/7.5 channel opener, CNS-penetrant with antiseizure effects, and low hepatocyte cytotoxicity.</p>
    Formula:C19H15F2N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:355.34

    Ref: TM-T11606

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    DAD

    <p>DAD is an ion channel blocker (blocks voltage-gated potassium channels) and is a third generation photoelectric switch that responds to visible light.</p>
    Formula:C26H40N6O
    Color and Shape:Solid
    Molecular weight:452.64

    Ref: TM-T62770

  • TRPA1 Antagonist 1
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    TRPA1 Antagonist 1

    CAS:
    <p>TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.</p>
    Formula:C24H20F6N5Na2O7PS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:713.45

    Ref: TM-T13212

  • (RS)-AMPA hydrobromide
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    (RS)-AMPA hydrobromide

    CAS:
    AMPAR agonist
    Formula:C7H11BrN2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:267.08

    Ref: TM-T23267

  • SR 33805 oxalate
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    SR 33805 oxalate

    CAS:
    <p>Ca2+ channel antagonist</p>
    Formula:C34H42N2O9S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:654.77

    Ref: TM-T23391

  • cis-KV1.3-IN-1
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    cis-KV1.3-IN-1

    CAS:
    <p>cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.</p>
    Formula:C23H30N2O4S
    Color and Shape:Solid
    Molecular weight:430.56

    Ref: TM-T201783

  • Dehydroindapamide
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    Dehydroindapamide

    CAS:
    <p>Dehydroindapamide, an indole form of Indapamide, is utilized to quantify the turnover rate of Indapamide in CYP3A4, which is approximately 10 times higher than that of Indoline, with slightly enhanced affinity for CYP3A4.</p>
    Formula:C16H14ClN3O3S
    Color and Shape:Solid
    Molecular weight:363.82

    Ref: TM-T200811

  • Cyazofamid
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    Cyazofamid

    CAS:
    <p>Cyazofamid functions as a fungicide by impairing the production of ATP. It inhibits Organic Cation Transporter 3 (OCT3) and OAT1 with IC50 values of 1.54 and 17.3 μM, respectively.</p>
    Formula:C13H13ClN4O2S
    Color and Shape:Solid
    Molecular weight:324.79

    Ref: TM-T201605

  • CFTR corrector 18
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    CFTR corrector 18

    CAS:
    <p>CFTRcorrector 18 (Compound I-99) acts as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It enhances the processing and trafficking of CFTR, thereby increasing the amount of CFTR present on the cell surface. CFTRcorrector 18 holds potential for research in cystic fibrosis (CF).</p>
    Formula:C38H40N6O5S
    Color and Shape:Solid
    Molecular weight:692.826

    Ref: TM-T206874

  • S9-A13
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    S9-A13

    CAS:
    <p>S9-A13 is a potent and selective inhibitor of SLC26A9, exhibiting an IC50 of 90.9 nM without inhibiting other members of the SLC26 family, such as SLC26A3, SLC26A4, and SLC26A6. It also inhibits the SLC26A9 Cl- current in cells lacking CFTR expression.</p>
    Formula:C20H18ClN3O2S
    Color and Shape:Solid
    Molecular weight:399.89

    Ref: TM-T201301

  • BGT1-IN-1
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    BGT1-IN-1

    CAS:
    <p>BGT1-IN-1 (compound 9) is an effective inhibitor of BGT1, demonstrating IC50 values of 13.9 µM for hBGT1 and 58.3 µM for GAT3. It exhibits no cytotoxic effects and possesses neuroprotective activity.</p>
    Formula:C6H9NO2
    Color and Shape:Solid
    Molecular weight:127.14

    Ref: TM-T200935

  • Caramboxin
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    Caramboxin

    CAS:
    <p>Caramboxin, a neurotoxin, can induce acute kidney injury.</p>
    Formula:C11H13NO6
    Color and Shape:Solid
    Molecular weight:255.22

    Ref: TM-T201088

  • RO-275
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    RO-275

    CAS:
    <p>RO-275 is an HCN1 inhibitor that also inhibits HCN2, HCN3, and HCN4, improving working memory deficits and being used in research on cognitive disorders.</p>
    Formula:C18H14ClN5O
    Purity:98.12% - 98.3%
    Color and Shape:Solid
    Molecular weight:351.79

    Ref: TM-T87339

  • CFTR corrector 17
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    CFTR corrector 17

    CAS:
    <p>CFTRcorrector 17 (example 17) is a regulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It is utilized in the study of diseases mediated by CFTR.</p>
    Formula:C18H15FN2O2
    Color and Shape:Solid
    Molecular weight:310.32

    Ref: TM-T201013

  • LY503430
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    LY503430

    CAS:
    <p>LY503430: Oral AMPA enhancer with nootropic, neuroprotective properties, mitigates 6-OHDA/MPTP brain damage.</p>
    Formula:C20H25FN2O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:392.49

    Ref: TM-T27959

  • 4α-PDD
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    4α-PDD

    CAS:
    <p>4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through PKC.</p>
    Formula:C40H64O8
    Color and Shape:Solid
    Molecular weight:672.93

    Ref: TM-T26386

  • Kv7.2/Kv7.3 activator-1
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    Kv7.2/Kv7.3 activator-1

    CAS:
    <p>Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.</p>
    Formula:C19H22F2N4O
    Color and Shape:Solid
    Molecular weight:360.40

    Ref: TM-T89880

  • SGE-516
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    SGE-516

    CAS:
    <p>SGE516: neuroactive steroid, enhances GABAA, lowers neuronal activity, protects from seizures.</p>
    Formula:C23H35N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:385.54

    Ref: TM-T28766

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    MRS4738

    <p>MRS4738 is a potent antagonist with high affinity for the P2Y14R receptor. It demonstrates in vivo anti-hyperallodynic and antiasthmatic activity [1].</p>
    Formula:C30H24F3NO2
    Color and Shape:Solid
    Molecular weight:487.51

    Ref: TM-T63242

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    VU0463271 quarterhydrate

    <p>VU0463271 quarterhydrate is a potent KCC2 antagonist, with an IC 50 of 61 nM [1].</p>
    Formula:C19H20N4O2S2
    Color and Shape:Solid
    Molecular weight:387

    Ref: TM-T61725

  • (RS)-AMPA monohydrate
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    (RS)-AMPA monohydrate

    CAS:
    <p>(RS)-AMPA monohydrate, potent glutamate analogue, selectively activates L-glutamic acid without affecting kainic acid or NMDA receptors.</p>
    Formula:C7H12N2O5
    Color and Shape:Solid
    Molecular weight:204.182

    Ref: TM-T60242

  • Moxetomidate
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    Moxetomidate

    CAS:
    <p>Moxetomidate is a GABAA receptor (GABAA receptor) agonist with hypnotic properties.</p>
    Formula:C15H18N2O3
    Color and Shape:Solid
    Molecular weight:274.315

    Ref: TM-T205308

  • hURAT1 inhibitor 2
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    hURAT1 inhibitor 2

    CAS:
    <p>hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. It also exhibits some inhibitory activity against OATP1B1, with an IC50 of 0.73 μM. hURAT1 inhibitor 2 can be used in research related to hyperuricemia, gout, and other diseases associated with abnormal uric acid metabolism.</p>
    Formula:C17H11Br2FO3
    Color and Shape:Solid
    Molecular weight:442.074

    Ref: TM-T206558

  • Lubeluzole dihydrochloride
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    Lubeluzole dihydrochloride

    CAS:
    <p>Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.</p>
    Formula:C22H27Cl2F2N3O2S
    Color and Shape:Solid
    Molecular weight:506.44

    Ref: TM-T200178

  • PDE2 inhibitor 6
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    PDE2 inhibitor 6

    CAS:
    <p>PDE2 inhibitor6 (Compound 1) is an orally active phosphodiesterase (PDE) inhibitor, effectively inhibiting PDE2A, PDE3B, and PDE10A2 with IC50 values of 0.95 nM, 6.17 μM (pIC50=5.21), and 87.1 nM (pIC50=7.06), respectively. It modulates AMPA receptor activity, enhances synaptic plasticity, and improves learning and memory in rat models. Furthermore, PDE2 inhibitor6 possesses blood-brain barrier permeability.</p>
    Formula:C20H22F2N6O
    Color and Shape:Solid
    Molecular weight:400.425

    Ref: TM-T206498

  • Ro 0437626
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    Ro 0437626

    CAS:
    <p>P2X1 purinergic receptor antagonist</p>
    Formula:C27H35N5O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:525.66

    Ref: TM-T23241

  • Probenecid sodium
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    Probenecid sodium

    CAS:
    <p>Probenecid sodium is the sodium salt of Probenecid, a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Additionally, Probenecid acts as an inhibitor of pannexin 1 channels.</p>
    Formula:C13H18NNaO4S
    Color and Shape:Solid
    Molecular weight:307.341

    Ref: TM-T204136

  • Metaphit methylsulfate
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    Metaphit methylsulfate

    CAS:
    <p>Metaphit methylsulfate is a specific PCP antagonist and an acylating agent for the [3H] phencyclidine binding site in rat brain homogenate. It inhibits PCP-induced motor activity through a presynaptic mechanism.</p>
    Formula:C19H28N2O3S2
    Color and Shape:Solid
    Molecular weight:396.567

    Ref: TM-T204740

  • EMD-95885
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    EMD-95885

    CAS:
    <p>EMD-95885 is a selective antagonist of NMDA receptors containing NR2B subunits, with an IC50 of 3.9 nM. It does not interact with other sites on the NMDA receptor.</p>
    Formula:C22H23FN2O3
    Color and Shape:Solid
    Molecular weight:382.428

    Ref: TM-T205291