Membrane Transporter/Ion Channel
Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.
Subcategories of "Membrane Transporter/Ion Channel"
- ABC(3 products)
- ATPase(93 products)
- Adiponectin receptor(5 products)
- CFTR(64 products)
- CGRP Receptor(51 products)
- Calcium Channel(494 products)
- Chloride channel(49 products)
- GABA Receptor(336 products)
- Monoamine Transporter(23 products)
- Monocarboxylate transporter(17 products)
- NKCC(2 products)
- NPC1L1(3 products)
- Na-K-Cl cotransporter(8 products)
- OAT(27 products)
- OCT(7 products)
- P-gp(53 products)
- Potassium Channel(276 products)
- Proton pump(39 products)
- SGLT(30 products)
- Sodium Channel(202 products)
- TRP/TRPV Channel(93 products)
Show 13 more subcategories
Found 2280 products of "Membrane Transporter/Ion Channel"
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264W94
CAS:<p>264W94 robustly inhibits IBAT, induces CYP7A1, and significantly reduces cholesterol.</p>Formula:C23H31NO4SPurity:98%Color and Shape:SolidMolecular weight:417.56URAT1 inhibitor 3
<p>URAT1 inhibitor 3: potent oral URAT1 blocker, IC50=0.8 nM, for gout/hyperuricemia study.</p>Formula:C14H8Cl2N2O2Color and Shape:SolidMolecular weight:307.13NMD670
CAS:<p>NMD670 is an orally active, partial inhibitor of the skeletal muscle-specific chloride channel ClC-1. It enhances muscle excitability and neuromuscular transmission, restoring muscle function and mobility. NMD670 has a favorable safety profile and improves muscle function in rats, particularly in an MG rat model [1].</p>Formula:C12H10BrNO4Color and Shape:SolidMolecular weight:312.12ML-SI1
CAS:<p>ML-SI1, a racemic mixture of diastereoisomers, is a TRPML inhibitor and acts on TRPML1 (IC50: 15 μM).</p>Formula:C23H26Cl2N2O3Color and Shape:SolidMolecular weight:449.37Unoprostone
CAS:<p>Unoprostone is a prostaglandin F2α analogs (PGAs), and reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.</p>Formula:C22H38O5Purity:98%Color and Shape:SolidMolecular weight:382.53Blixeprodil
CAS:<p>Blixeprodil (GM-1020) is an orally active NMDA receptor antagonist with an affinity of Ki = 3.25 µM in rat cortical tissue. It inhibits NR1/2A-NMDAR-mediated currents in HEK293 cells with an IC50 of 1.192 µM. Blixeprodil demonstrates antidepressant effects in rat models and exhibits blood-brain barrier permeability.</p>Formula:C13H16FNOColor and Shape:SolidMolecular weight:221.271Insecticidal agent 21
CAS:<p>Insecticidal agent 21 (Compound 6) is an insecticide targeting Culex pipiens larvae with an LC50 of 0.4 μg/mL. It achieves multi-target neurotoxicity by inhibiting acetylcholinesterase (AChE) and simultaneously targeting other neural receptors, including nicotinic acetylcholine receptors (nAChR), voltage-gated sodium channels (VGSC), and γ-aminobutyric acid receptors (GABAAR). Insecticidal agent 21 shows potent insecticidal activity and can be utilized in the development of new insecticides to combat mosquito resistance to conventional agents.</p>Formula:C37H40ClN3O2Color and Shape:SolidMolecular weight:594.185Cav 3.2 inhibitor 1
<p>Cav 3.2 inhibitor 1 targets T-type calcium channels, weakly binds D2 receptors, and aids physical and visceral pain research.</p>Formula:C32H39N3OColor and Shape:SolidMolecular weight:481.67SC-435 mesylate
CAS:<p>SC-435 is an ileal apical sodium co-dependent bile acid transporter (ASBT). SC-435 inhibits plasma cholesterol.</p>Formula:C37H59N3O7S2Purity:98%Color and Shape:SolidMolecular weight:722.01EF1502 free base
CAS:<p>EF1502 is a potent and selective GABA transporter inhibitor.</p>Formula:C22H26N2O2S2Purity:98%Color and Shape:SolidMolecular weight:414.58V-ATPase-IN-1
CAS:<p>V-ATPase-IN-1 (Compound 3b-03) is an inhibitor of Vacuolar-type H+-ATPases (V-ATPase), exhibiting an inhibition constant (IC50) of 194.80 μM and effectively targeting the V-ATPase subunit A with a dissociation constant (Kd) of 0.803 μM. This compound demonstrates insecticidal activity against M. separata (LC50 = 2.64 mM), aiding in the development of chemical insecticides.</p>Formula:C21H20ClNO2Color and Shape:SolidMolecular weight:353.84ABCG2-IN-4
CAS:<p>ABCG2-IN-4 (Compound K31) is an orally active ABCG2 inhibitor that reduces the release of Protoporphyrin IX (PPIX) from red blood cells into the plasma and prevents phototoxicity. In mouse models, ABCG2-IN-4 also demonstrates anti-inflammatory and antioxidant properties.</p>Formula:C24H32N4O4Color and Shape:SolidMolecular weight:440.535P-gp/BCRP-IN-1
CAS:<p>P-gp/BCRP-IN-1, safe and oral, inhibits P-gp/BCRP transporters, enhancing Paclitaxel bioavailability.</p>Formula:C27H25ClN4O3Color and Shape:SolidMolecular weight:488.97Olorigliflozin
CAS:<p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>Formula:C23H27ClO7Color and Shape:SolidMolecular weight:450.909ARN23765
CAS:<p>ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).</p>Formula:C30H22F5N3O6Color and Shape:SolidMolecular weight:615.504Dehydelone
CAS:<p>Dehydelone(KOS-1584, R-1645, SK-10088) is a microtubule stabilizer that may be used in the treatment of non-small cell lung cancer.</p>Formula:C27H39NO5SColor and Shape:SolidMolecular weight:489.67ATPase-IN-5
CAS:<p>ATPase-IN-5 (Compound 11) is an antifungal Pma1p (H+ -ATPase) inhibitor (IC50 = 12.7 μM) that inhibits the growth of Candida albicans and Saccharomyces cerevisiae.</p>Formula:C10H10N4O3SPurity:99.19%Color and Shape:SolidMolecular weight:266.28(S)-Albuterol
CAS:<p>(S)-Albuterol functions as a muscarinic receptor and phospholipase C activator, enhancing the intracellular free calcium concentration in airway smooth muscle cells.</p>Formula:C13H21NO3Color and Shape:SolidMolecular weight:239.311P-gp modulator 3
<p>P-gp modulator 3 (Compound 37) is a potent, competitive, metabotropic P-glycoprotein (P-gp) modulator.</p>Formula:C31H37N3O5Color and Shape:SolidMolecular weight:531.64Pyrimidinone 8
CAS:<p>Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 μM (hDMT1). It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.</p>Formula:C10H12N4OColor and Shape:SolidMolecular weight:204.229NYX-2925
CAS:<p>NYX-2925, an oral NMDAR modulator, enhances Src in mPFC. No CAMKII impact or addictive/sedative effects. Useful for CNS disorder studies.</p>Formula:C14H23N3O4Color and Shape:SolidMolecular weight:297.35Opakalim
CAS:<p>Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.</p>Formula:C18H22F2N4OColor and Shape:SolidMolecular weight:348.39GABA-IN-4
CAS:<p>GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.</p>Formula:C17H13ClN2O2Color and Shape:SolidMolecular weight:312.75CRM1-IN-3
CAS:<p>CRM1-IN-3 (B28), a noncovalent inhibitor of CRM1, is utilized in the research of protein localization and tumor studies [1].</p>Formula:C26H26ClN3O3Color and Shape:SolidMolecular weight:463.96Suloctidil HCl
CAS:<p>Suloctidil HCl is a peripheral vascular dilator.</p>Formula:C20H36ClNOSColor and Shape:SolidMolecular weight:374.02Sp-8-Br-cGMPS
CAS:<p>Sp-8-Br-cGMPS, an analogue of cGMP, acts as an agonist for cGMP gated cation channels (CNG channels) with an EC50 of 106.5 μM. While Sp-8-Br-cGMPS can induce currents, it does not stabilize channel open states as effectively as a full agonist.</p>Formula:C10H11BrN5O6PSColor and Shape:SolidMolecular weight:440.173-Bromoamphetamine hydrochloride
CAS:<p>3-Bromoamphetamine hydrochloride is a para-substituted amphetamine that functions as a monoamine releaser.</p>Formula:C9H13BrClNColor and Shape:SolidMolecular weight:250.563(2S,3S,11bR)-Dihydrotetrabenazine
CAS:<p>(2S,3S,11bR)-Dihydrotetrabenazine ((2S,3S,11bR)-DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. It suppresses the vesicular transport of monoamine neurotransmitters, such as dopamine and serotonin, leading to reduced release into the synaptic cleft. This compound holds potential for research in Huntington's disease and other hyperkinetic movement disorders.</p>Formula:C19H29NO3Color and Shape:SolidMolecular weight:319.44Zilvetrigine
CAS:<p>Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.</p>Formula:C20H20ClN3O2Color and Shape:SolidMolecular weight:369.845NMDA agonist 1
CAS:<p>NMDA agonist 1 (compound 42d) is a potent NMDA agonist with a Ki value of 96 nM. It acts as a partial agonist of the GluN1/GluN2B complex, exhibiting an EC50 value of 78 nM.</p>Formula:C12H13N3O3SColor and Shape:SolidMolecular weight:279.315Tamitinol
CAS:<p>Tamitinol is a neurotropic drug. It has been found to help symptoms of obsessive rumination in conjunction with maprotiline.</p>Formula:C12H20N2OSPurity:98%Color and Shape:SolidMolecular weight:240.37Cav 3.2 inhibitor 2
<p>Cav 3.2 inhibitor 2 blocks T-type Ca2+ channels (IC50=0.09339 μM) and reduces mouse somatic/visceral pain. Used for intractable pain studies.</p>Formula:C32H37F2N3OColor and Shape:SolidMolecular weight:517.65KCa2 channel modulator 2
Compound 2q is a potent, subtype-selective K/Ca 2 modulator, effective on human K Ca 2.3 and rat K Ca 2.2a with EC50s of 0.60 μM and 0.64 μM.Formula:C16H15ClFN5Color and Shape:SolidMolecular weight:331.78PDE1-IN-4
<p>PDE1-IN-4: inhibits PDE1C/A/B with IC50s 10/145/354 nM, may help study idiopathic pulmonary fibrosis.</p>Formula:C33H33N3O4Color and Shape:SolidMolecular weight:535.63GABAA receptor agonist 2
<p>Compound 4c, a potent GABAA agonist with anti-depressive effects in mouse FST/TST, shows promise in depression research.</p>Formula:C22H36O5Color and Shape:SolidMolecular weight:380.52YY-23
CAS:<p>YY-23 is a selective NMDAR (containing GluN2C or GluN2D) inhibitor. By inhibiting NMDARs with GluN2D on GABAergic interneurons in the prefrontal cortex, YY-23 suppresses GABAergic neurotransmission and enhances excitatory transmission. YY-23 exhibits antidepressant activity and is useful for neurological disease research.</p>Formula:C33H54O8Color and Shape:SolidMolecular weight:578.777S-8510 phosphate
CAS:<p>S-8510 phosphate is an agonist of inverse Benzodiazepine (BDZ) receptor(Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively).</p>Formula:C12H13N4O6PPurity:98%Color and Shape:SolidMolecular weight:340.23Leualacin
CAS:<p>Leualacin is a novel calcium blocker from Hapsidospora irregularis.</p>Formula:C31H47N3O7Purity:98%Color and Shape:SolidMolecular weight:573.72Antidepressant agent 9
CAS:<p>Antidepressant agent 9 (Compound 24) is an orally active inhibitor of NMDAR and SERT, with IC50 values of 3.50 μM and 1044 nM, respectively. It exhibits good metabolic stability and plasma exposure, and demonstrates antidepressant-like effects in the forced swim test in mice.</p>Formula:C17H24N2Color and Shape:SolidMolecular weight:256.386Suzetrigine
CAS:<p>Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.</p>Formula:C21H20F5N3O4Purity:98.08% - 99.27%Color and Shape:SolidMolecular weight:473.39(+)-Tetrabenazine
CAS:<p>(+)-Tetrabenazine ((3R,11bR)-Tetrabenazine) is a reversible vesicular monoamine transporter 2 (VMAT-2) inhibitor, inhibits transport by VMAT2 with 10-fold</p>Formula:C19H27NO3Purity:98.31%Color and Shape:SolidMolecular weight:317.42SYM2206
CAS:<p>SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated</p>Formula:C20H22N4O3Purity:99.88%Color and Shape:SolidMolecular weight:366.41Odevixibat
CAS:<p>Odevixibat (A4250) is a selective oral inhibitor for ileal bile acid transport, potentially treating primary biliary cirrhosis.</p>Formula:C37H48N4O8S2Purity:99.53% - 99.83%Color and Shape:SolidMolecular weight:740.93SDZ 220-040
CAS:<p>SDZ 220-040 是一种选择性哺乳动物 NMDA 受体拮抗剂，可诱导根系生长的部分无重力模式 。</p>Formula:C16H16Cl2NO6PPurity:98.13%Color and Shape:SolidMolecular weight:420.18Umbellulone
CAS:<p>Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.</p>Formula:C10H14OPurity:98%Color and Shape:SolidMolecular weight:150.225-Hydroxylansoprazole
CAS:<p>5-Hydroxylansoprazole (AG1908) is the active metabolite of plasma Lansoprazole, inhibits the proton pump, and is used in the study of peptic ulcers.</p>Formula:C16H14F3N3O3SPurity:99.00%Color and Shape:SolidMolecular weight:385.36(-)-Bicuculline methobromide
CAS:<p>(-)-Bicuculline methobromide is a potent antagonist of GABAA receptor .</p>Formula:C21H20BrNO6Color and Shape:WhiteMolecular weight:462.29A-887826
CAS:<p>A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.</p>Formula:C26H29ClN4O3Color and Shape:SolidMolecular weight:480.99Indapamide
CAS:<p>Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.</p>Formula:C16H16ClN3O3SPurity:98.97% - 99.83%Color and Shape:SolidMolecular weight:365.83Dexivacaine
CAS:Dexivacaine is an type of anesthetic.Formula:C15H22N2OColor and Shape:SolidMolecular weight:246.35
