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Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.

Subcategories of "Membrane Transporter/Ion Channel"

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Found 2280 products of "Membrane Transporter/Ion Channel"

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  • CymitQuimica logo
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    AmmTX3

    <p>KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.</p>
    Formula:C158H262N50O48S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3822.47

    Ref: TM-TP2090

  • Verruculogen
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    Verruculogen

    CAS:
    <p>Verruculogen, a toxin from Penicillium/Aspergillus, blocks Ca2+-K+ channels and halts mammalian M phase.</p>
    Formula:C27H33N3O7
    Purity:98%
    Color and Shape:White Powder
    Molecular weight:511.57

    Ref: TM-T13297

  • Furosemide sodium
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    Furosemide sodium

    CAS:
    <p>Furosemide sodium: potent NKCC inhibitor, loop diuretic, treats heart failure, hypertension, edema, selective GABAA antagonist.</p>
    Formula:C12H10ClN2NaO5S
    Purity:99.52% - >99.99%
    Color and Shape:Solid
    Molecular weight:352.73

    Ref: TM-T35336

  • GS-9191 PM
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    GS-9191 PM

    <p>GS-9191 PM: novel antitumorviral bis-amide prodrug, inhibits MDR1/BCRP, has antiproliferative activity.</p>
    Formula:C11H16N6O
    Purity:99.79%
    Color and Shape:Soild
    Molecular weight:248.28

    Ref: TM-T67821

  • SLC26A3-IN-2
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    SLC26A3-IN-2

    CAS:
    <p>Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.</p>
    Formula:C19H13ClN2O2S
    Purity:99.86%
    Color and Shape:Solid
    Molecular weight:368.84

    Ref: TM-T74815

  • SNX-482
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    SNX-482

    CAS:
    <p>Potent CaV2.3 calcium channel blocker, selective, voltage-dependent, with 30 nM IC50. Offers antinociceptive effects on C and Aδ fibres.</p>
    Formula:C192H274N52O60S7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4495.01

    Ref: TM-TP2118

  • TRPA1-IN-2
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    TRPA1-IN-2

    CAS:
    <p>TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.</p>
    Formula:C24H25F3N4O
    Purity:98.05%
    Color and Shape:Soild
    Molecular weight:442.48

    Ref: TM-T77511

  • NSC156529
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    NSC156529

    CAS:
    <p>NSC156529 suppresses AKT1, reduces cancer cell growth in vitro, and inhibits prostate tumors in vivo.</p>
    Formula:C28H21ClS2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:457.05

    Ref: TM-T28203

  • Apamin
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    Apamin

    CAS:
    <p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>
    Formula:C79H131N31O24S4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2027.34

    Ref: TM-TP1223

  • (Rac)-Tezacaftor
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    (Rac)-Tezacaftor

    CAS:
    <p>(Rac)-Tezacaftor, a racemate, corrects F508del CFTR for cystic fibrosis research.</p>
    Formula:C26H27F3N2O6
    Color and Shape:Solid
    Molecular weight:520.5

    Ref: TM-T75230

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    c-Met-IN-23

    <p>c-Met-IN-23 (Compound 12g) functions as a c-Met inhibitor with an IC50 of 0.052 μM against c-Met. It also inhibits the MDR1 and MRP1/2 pumps in cancerous HepG2 and BxPC3 cells. As such, c-Met-IN-23 serves as an anticancer agent.</p>
    Formula:C16H13N7O
    Molecular weight:319.11816

    Ref: TM-T209390

  • 3-Aminopropylphosphinic acid
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    3-Aminopropylphosphinic acid

    CAS:
    <p>3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of gamma-aminobutyric acid (GABA).</p>
    Formula:C3H10NO2P
    Color and Shape:Solid
    Molecular weight:123.092

    Ref: TM-T38438

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    Analgesic/antidepressant agent-1

    <p>Analgesic/antidepressant agent-1 (Compound k1) is an orally active N-acetylamino chloro ketone derivative capable of crossing the blood-brain barrier. It exhibits high affinity for NMDA receptors and demonstrates analgesic, anti-inflammatory, and antidepressant properties, with low psychotomimetic activity.</p>
    Formula:C22H25ClN2O2
    Color and Shape:Solid
    Molecular weight:384.9

    Ref: TM-T205604

  • ProTx II
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    ProTx II

    CAS:
    <p>Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.</p>
    Formula:C168H250N46O41S8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3826.59

    Ref: TM-TP1680

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    Astressin 2B

    CAS:
    <p>CRF2 antagonist with IC50 of 1.3 nM; &gt;500 nM for CRF1. Aids gastric emptying.</p>
    Formula:C183H307N49O53
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4041.69

    Ref: TM-TP2095

  • Dihydroisopimaric acid
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    Dihydroisopimaric acid

    CAS:
    <p>Dihydroisopimaric acid opens BKαβ1 channels - large Ca²⁺-activated K⁺ conductors, verified by whole-cell voltage clamp.</p>
    Formula:C20H32O2
    Color and Shape:Solid
    Molecular weight:304.47

    Ref: TM-T40650

  • Vedroprevir
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    Vedroprevir

    CAS:
    <p>Vedroprevir (GS9451), a selective HCV NS3 protease inhibitor, targets genotype 1 HCV.</p>
    Formula:C45H60ClN7O9S
    Color and Shape:Solid
    Molecular weight:910.53

    Ref: TM-T35043

  • NF864
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    NF864

    CAS:
    NF864, a suramin analog, is a P2X1 receptor inhibitor.
    Formula:C57H28N6Na12O41S12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2113.5

    Ref: TM-T25863

  • rac-trans-4-hydroxy Glyburide
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    rac-trans-4-hydroxy Glyburide

    CAS:
    <p>rac-trans-4-hydroxy Glyburide, a metabolite of glyburide, inhibits binding at SUR1/Kir6.2 sites with IC50 values of 0.95 and 100 nM.</p>
    Formula:C23H28ClN3O6S
    Color and Shape:Solid
    Molecular weight:510.0

    Ref: TM-T35635

  • AQP4 (201-220)
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    AQP4 (201-220)

    CAS:
    <p>AQP4 (201-220) is the encephalitogenic epitope of AQP-4. AQP4 (201-220) can induce experimental autoimmune encephalomyelitis (EAE), characterized by midline brain lesions, retinal lesions, and lesions at the gray matter/white matter boundary of the spinal cord. AQP-4 is the target antigen in neuromyelitis optica.</p>
    Formula:C97H143N27O27S
    Color and Shape:Solid
    Molecular weight:2151.4

    Ref: TM-TP3213

  • N-Arachidonoyl Taurine
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    N-Arachidonoyl Taurine

    CAS:
    <p>N-Arachidonoyl taurine, an amino acid, activates TRPV1/TRPV4, is metabolized by lipoxygenase, and affects insulin secretion and calcium flux.</p>
    Formula:C22H37NO4S
    Color and Shape:Solid
    Molecular weight:411.6

    Ref: TM-T35918

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    P2X4 antagonist-3

    <p>P2X4 antagonist-3 (Compound 14c) is a P2X4 inhibitor with an IC50 value of 1.2 μM. It holds potential for research into neuroinflammation, chronic pain, and cancer progression.</p>
    Formula:C19H20FN3O4
    Color and Shape:Solid
    Molecular weight:373.38

    Ref: TM-T205694

  • JAMI1001A
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    JAMI1001A

    CAS:
    <p>JAMI1001A enhances AMPA receptor signaling, slows deactivation/desensitization for flip/flop isoforms.</p>
    Formula:C16H17F3N4O3S
    Color and Shape:Solid
    Molecular weight:402.39

    Ref: TM-T38392

  • PDDHV
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    PDDHV

    CAS:
    <p>PDDHV: a capsaicin-like vanilloid selective for rat TRPV1; induces Ca2+ uptake in neurons, EC50 of 70 nM.</p>
    Formula:C49H72O11
    Color and Shape:Solid
    Molecular weight:837.09

    Ref: TM-T37086

  • AHN-683
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    AHN-683

    CAS:
    <p>AHN-683 is a fluorescent ligand. It was used for peripheral-type benzodiazepine receptors.</p>
    Formula:C42H32FN3O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:709.72

    Ref: TM-T23675

  • Hyp9
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    Hyp9

    CAS:
    <p>Hyp9, a specific agonist for the transient receptor potential canonical 6 (TRPC6) channel, is utilized in spinal cord injury (SCI) research [1].</p>
    Formula:C18H26O5
    Color and Shape:Solid
    Molecular weight:322.40

    Ref: TM-T75550

  • Atagabalin
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    Atagabalin

    CAS:
    <p>Atagabalin (PD 0200390), a gabamimetic for insomnia treatment and related to gabapentin, was halted due to poor trial outcomes.</p>
    Formula:C10H19NO2
    Color and Shape:Solid
    Molecular weight:185.26

    Ref: TM-T30188

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    Cyclic ADP-ribose ammonium

    <p>cADPR ammonium is a second messenger that boosts cytosolic calcium via Ryanodine receptors and TRPM2 channels.</p>
    Color and Shape:Liquid

    Ref: TM-T37687

  • Chlorotoxin
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    Chlorotoxin

    CAS:
    <p>Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.</p>
    Formula:C158H249N53O47S11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3995.71

    Ref: TM-TP1431

  • NSC265473
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    NSC265473

    CAS:
    <p>NSC265473 is an ABCG2 substrate.</p>
    Formula:C21H35N3O4S
    Color and Shape:Solid
    Molecular weight:425.58

    Ref: TM-T33753

  • Foslevcromakalim
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    Foslevcromakalim

    CAS:
    <p>Foslevcromakalim (QLS-101), an ATP-sensitive potassium channel opener, serves as a proagent for ocular hypotensive effects [1] [2].</p>
    Formula:C16H19N2O6P
    Color and Shape:Solid
    Molecular weight:366.31

    Ref: TM-T75084

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    Antidepressant agent 3

    <p>Agent 3: orally active, antidepressant, anxiolytic, boosts performance and cognition.</p>
    Formula:C17H30ClN5O2S
    Color and Shape:Solid
    Molecular weight:403.97

    Ref: TM-T75002

  • Mambalgin 1
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    Mambalgin 1

    CAS:
    <p>ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.</p>
    Formula:C272H429N85O84S10
    Purity:98%
    Color and Shape:Solid
    Molecular weight:6554.51

    Ref: TM-TP2003

  • ProTx-I
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    ProTx-I

    CAS:
    <p>Selective blocker for CaV3.1 (IC50 = 0.2 μM), CaV3.2 (31.8 μM), also inhibits NaV1.8 and blocks KV2.1 channels.</p>
    Formula:C171H245N53O47S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3987.51

    Ref: TM-TP1968

  • N-Oleoyl Glutamine
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    N-Oleoyl Glutamine

    CAS:
    <p>N-Oleoyl Glutamine (Oleoyl-L-glutamine) antagonizes TRPV1 of the transient receptor potential (TRP) calcium channel.</p>
    Formula:C23H42N2O4
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:410.59

    Ref: TM-T36064

  • 5-Hydroxy-2′,3,4′,7-tetramethoxyflavone
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    5-Hydroxy-2′,3,4′,7-tetramethoxyflavone

    CAS:
    <p>5-Hydroxy-2′,3,4′,7-tetramethoxyflavone shows weak ABCG2 inhibitory potency with IC50s of 3.27 and 3.89 µM in the Hoechst 33342 and pheophorbide A assays.</p>
    Formula:C19H18O7
    Purity:98%
    Color and Shape:Soild
    Molecular weight:358.34

    Ref: TM-TN7124

  • (±)17-HETE
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    (±)17-HETE

    CAS:
    <p>Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.</p>
    Formula:C20H32O3
    Color and Shape:Solid
    Molecular weight:320.473

    Ref: TM-T35523

  • RuBi-GABA
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    RuBi-GABA

    CAS:
    <p>Ruthenium-bipyridine-triphenylphosphine caged GABA</p>
    Formula:C42H39F6N5O2P2Ru
    Purity:98%
    Color and Shape:Solid
    Molecular weight:922.8

    Ref: TM-T23277

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    Kurtoxin

    <p>Kurtoxin is a selective Cav3 (T-type) voltage-gated Ca2+ channel gating inhibitor, exhibiting a dissociation constant (Kd) of 15 nM for the Cav3.1 (α1G T-type)</p>
    Formula:C324H478N94O90S8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:7386.36

    Ref: TM-T80496

  • GSK2332255B
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    GSK2332255B

    CAS:
    <p>GSK2332255B: potent TRPC3/6 antagonist; IC50 5 nM (TRPC3), 4 nM (TRPC6); over 100-fold selectivity vs other Ca2+ channels.</p>
    Formula:C18H19ClFN3O3S
    Color and Shape:Solid
    Molecular weight:411.88

    Ref: TM-T38780

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    HG1 Toxin

    <p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>
    Formula:C337H503N103O97S6
    Molecular weight:7736.59176

    Ref: TM-TP3643

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    L-Palmitoylcarnitine TFA

    <p>L-Palmitoylcarnitine TFA: long-chain fat metabolite that disrupts membranes in ischaemia &amp; inhibits KATP channels via Kir6.2 interaction.</p>
    Formula:C25H46F3NO6
    Color and Shape:Solid
    Molecular weight:513.63

    Ref: TM-T73764

  • Ziconotide
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    Ziconotide

    CAS:
    <p>Ziconotide: analgesic from cone snail for severe, chronic pain; synthetic ω-conotoxin.</p>
    Formula:C102H172N36O32S7
    Purity:98%
    Color and Shape:White Powder
    Molecular weight:2639.13

    Ref: TM-TP1559

  • SC 4453
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    SC 4453

    CAS:
    <p>SC 4453 is a digoxin analog and a cardiac glycoside derivative.</p>
    Formula:C41H64N2O12
    Color and Shape:Solid
    Molecular weight:776.965

    Ref: TM-T34554

  • APETx2
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    APETx2

    CAS:
    <p>ASIC3 inhibitor; IC50: 63 nM (rat), 175 nM (human). Blocks NaV1.8, NaV1.2; analgesic for acid/inflammatory pain.</p>
    Formula:C196H280N54O61S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4561.06

    Ref: TM-TP2081

  • Nav1.7-IN-8
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    Nav1.7-IN-8

    CAS:
    <p>Nav1.7-IN-8 selectively inhibits NaV1.7 over hNaV1.1/1.5, affects CYP2C9/3A4 (IC50: 0.17/0.077 μM), and provides rodent pain relief.</p>
    Formula:C21H12ClF2N5O4S2
    Color and Shape:Solid
    Molecular weight:535.93

    Ref: TM-T38911

  • Levamlodipine besylate Hemipentahydrate
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    Levamlodipine besylate Hemipentahydrate

    CAS:
    <p>Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.</p>
    Formula:C20H25ClN2O5·C6H6O3SH2O
    Color and Shape:Solid
    Molecular weight:1224.18

    Ref: TM-T204904

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    ATP Synthesis-IN-2

    <p>ATP Synthesis-IN-2 (Compound 5) serves as a potent inhibitor of ATP synthesis activity, displaying significant antibacterial properties with an IC50 value of 0.</p>
    Color and Shape:Odour Solid

    Ref: TM-T82944

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    Ebio3

    <p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>
    Formula:C19H23F2N3O2
    Color and Shape:Solid
    Molecular weight:363.4

    Ref: TM-T205242

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    Anticonvulsant agent 9

    <p>Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.</p>
    Formula:C22H24N4O2
    Color and Shape:Solid
    Molecular weight:376.45

    Ref: TM-T205256