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Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.

Subcategories of "Membrane Transporter/Ion Channel"

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Found 2280 products of "Membrane Transporter/Ion Channel"

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  • 264W94
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    264W94

    CAS:
    <p>264W94 robustly inhibits IBAT, induces CYP7A1, and significantly reduces cholesterol.</p>
    Formula:C23H31NO4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:417.56

    Ref: TM-T10090

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    URAT1 inhibitor 3

    <p>URAT1 inhibitor 3: potent oral URAT1 blocker, IC50=0.8 nM, for gout/hyperuricemia study.</p>
    Formula:C14H8Cl2N2O2
    Color and Shape:Solid
    Molecular weight:307.13

    Ref: TM-T60724

  • NMD670
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    NMD670

    CAS:
    <p>NMD670 is an orally active, partial inhibitor of the skeletal muscle-specific chloride channel ClC-1. It enhances muscle excitability and neuromuscular transmission, restoring muscle function and mobility. NMD670 has a favorable safety profile and improves muscle function in rats, particularly in an MG rat model [1].</p>
    Formula:C12H10BrNO4
    Color and Shape:Solid
    Molecular weight:312.12

    Ref: TM-T87024

  • ML-SI1
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    ML-SI1

    CAS:
    <p>ML-SI1, a racemic mixture of diastereoisomers, is a TRPML inhibitor and acts on TRPML1 (IC50: 15 μM).</p>
    Formula:C23H26Cl2N2O3
    Color and Shape:Solid
    Molecular weight:449.37

    Ref: TM-T62692

  • Unoprostone
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    Unoprostone

    CAS:
    <p>Unoprostone is a prostaglandin F2α analogs (PGAs), and reduces intraocular pressure and is used topically for glaucoma or ocular hypertension.</p>
    Formula:C22H38O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:382.53

    Ref: TM-T13955

  • Blixeprodil
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    Blixeprodil

    CAS:
    <p>Blixeprodil (GM-1020) is an orally active NMDA receptor antagonist with an affinity of Ki = 3.25 µM in rat cortical tissue. It inhibits NR1/2A-NMDAR-mediated currents in HEK293 cells with an IC50 of 1.192 µM. Blixeprodil demonstrates antidepressant effects in rat models and exhibits blood-brain barrier permeability.</p>
    Formula:C13H16FNO
    Color and Shape:Solid
    Molecular weight:221.271

    Ref: TM-T206599

  • Insecticidal agent 21
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    Insecticidal agent 21

    CAS:
    <p>Insecticidal agent 21 (Compound 6) is an insecticide targeting Culex pipiens larvae with an LC50 of 0.4 μg/mL. It achieves multi-target neurotoxicity by inhibiting acetylcholinesterase (AChE) and simultaneously targeting other neural receptors, including nicotinic acetylcholine receptors (nAChR), voltage-gated sodium channels (VGSC), and γ-aminobutyric acid receptors (GABAAR). Insecticidal agent 21 shows potent insecticidal activity and can be utilized in the development of new insecticides to combat mosquito resistance to conventional agents.</p>
    Formula:C37H40ClN3O2
    Color and Shape:Solid
    Molecular weight:594.185

    Ref: TM-T206704

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    Cav 3.2 inhibitor 1

    <p>Cav 3.2 inhibitor 1 targets T-type calcium channels, weakly binds D2 receptors, and aids physical and visceral pain research.</p>
    Formula:C32H39N3O
    Color and Shape:Solid
    Molecular weight:481.67

    Ref: TM-T63186

  • SC-435 mesylate
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    SC-435 mesylate

    CAS:
    <p>SC-435 is an ileal apical sodium co-dependent bile acid transporter (ASBT). SC-435 inhibits plasma cholesterol.</p>
    Formula:C37H59N3O7S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:722.01

    Ref: TM-T28700

  • EF1502 free base
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    EF1502 free base

    CAS:
    <p>EF1502 is a potent and selective GABA transporter inhibitor.</p>
    Formula:C22H26N2O2S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:414.58

    Ref: TM-T27241

  • V-ATPase-IN-1
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    V-ATPase-IN-1

    CAS:
    <p>V-ATPase-IN-1 (Compound 3b-03) is an inhibitor of Vacuolar-type H+-ATPases (V-ATPase), exhibiting an inhibition constant (IC50) of 194.80 μM and effectively targeting the V-ATPase subunit A with a dissociation constant (Kd) of 0.803 μM. This compound demonstrates insecticidal activity against M. separata (LC50 = 2.64 mM), aiding in the development of chemical insecticides.</p>
    Formula:C21H20ClNO2
    Color and Shape:Solid
    Molecular weight:353.84

    Ref: TM-T200467

  • ABCG2-IN-4
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    ABCG2-IN-4

    CAS:
    <p>ABCG2-IN-4 (Compound K31) is an orally active ABCG2 inhibitor that reduces the release of Protoporphyrin IX (PPIX) from red blood cells into the plasma and prevents phototoxicity. In mouse models, ABCG2-IN-4 also demonstrates anti-inflammatory and antioxidant properties.</p>
    Formula:C24H32N4O4
    Color and Shape:Solid
    Molecular weight:440.535

    Ref: TM-T204144

  • P-gp/BCRP-IN-1
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    P-gp/BCRP-IN-1

    CAS:
    <p>P-gp/BCRP-IN-1, safe and oral, inhibits P-gp/BCRP transporters, enhancing Paclitaxel bioavailability.</p>
    Formula:C27H25ClN4O3
    Color and Shape:Solid
    Molecular weight:488.97

    Ref: TM-T63267

  • Olorigliflozin
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    Olorigliflozin

    CAS:
    <p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>
    Formula:C23H27ClO7
    Color and Shape:Solid
    Molecular weight:450.909

    Ref: TM-T205428

  • ARN23765
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    ARN23765

    CAS:
    <p>ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).</p>
    Formula:C30H22F5N3O6
    Color and Shape:Solid
    Molecular weight:615.504

    Ref: TM-T205032

  • Dehydelone
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    Dehydelone

    CAS:
    <p>Dehydelone(KOS-1584, R-1645, SK-10088) is a microtubule stabilizer that may be used in the treatment of non-small cell lung cancer.</p>
    Formula:C27H39NO5S
    Color and Shape:Solid
    Molecular weight:489.67

    Ref: TM-T31364

  • ATPase-IN-5
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    ATPase-IN-5

    CAS:
    <p>ATPase-IN-5 (Compound 11) is an antifungal Pma1p (H+ -ATPase) inhibitor (IC50 = 12.7 μM) that inhibits the growth of Candida albicans and Saccharomyces cerevisiae.</p>
    Formula:C10H10N4O3S
    Purity:99.19%
    Color and Shape:Solid
    Molecular weight:266.28

    Ref: TM-T204943

  • (S)-Albuterol
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    (S)-Albuterol

    CAS:
    <p>(S)-Albuterol functions as a muscarinic receptor and phospholipase C activator, enhancing the intracellular free calcium concentration in airway smooth muscle cells.</p>
    Formula:C13H21NO3
    Color and Shape:Solid
    Molecular weight:239.311

    Ref: TM-T206288

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    P-gp modulator 3

    <p>P-gp modulator 3 (Compound 37) is a potent, competitive, metabotropic P-glycoprotein (P-gp) modulator.</p>
    Formula:C31H37N3O5
    Color and Shape:Solid
    Molecular weight:531.64

    Ref: TM-T63745

  • Pyrimidinone 8
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    Pyrimidinone 8

    CAS:
    <p>Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 μM (hDMT1). It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.</p>
    Formula:C10H12N4O
    Color and Shape:Solid
    Molecular weight:204.229

    Ref: TM-T205042