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TRP/TRPV Channel

TRP/TRPV Channel

TRP (Transient Receptor Potential) channels, including the TRPV subfamily, are a group of ion channels involved in various sensory processes, such as temperature sensation, pain perception, and osmoregulation. TRP channels are widely expressed in different tissues and play a role in physiological responses to environmental stimuli. The TRPV channels, in particular, are involved in detecting temperature changes and are implicated in conditions such as chronic pain, inflammation, and cancer. At CymitQuimica, we offer a comprehensive range of TRP/TRPV channel modulators to support your research in sensory biology, pain management, and signal transduction.

Found 92 products of "TRP/TRPV Channel"

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  • JNJ-17203212
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    JNJ-17203212

    CAS:
    <p>JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).</p>
    Formula:C17H15F6N5O
    Purity:99.18%
    Color and Shape:Solid
    Molecular weight:419.32

    Ref: TM-T7526

  • HC067047 Hydrochloride(883031-03-6 free base)
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    HC067047 Hydrochloride(883031-03-6 free base)

    CAS:
    <p>HC-067047 hydrochloride, a TRPV4 antagonist, selectively inhibits human, rat, and mouse currents with IC50s: 486 nM, 133 nM, and 17 nM.</p>
    Formula:C26H29ClF3N3O2
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:507.98

    Ref: TM-T4680L

  • ML204 hydrochloride
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    ML204 hydrochloride

    CAS:
    <p>ML204 hydrochloride (ML204 HCl) is a TRPC4/TRPC5 channel antagonist.</p>
    Formula:C15H19ClN2
    Color and Shape:Solid
    Molecular weight:262.78

    Ref: TM-T24481

  • MK6-83
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    MK6-83

    CAS:
    <p>MK6-83 is the transient receptor potential channel ML3 agonist.</p>
    Formula:C16H20N2O2S2
    Purity:99.5%
    Color and Shape:Solid
    Molecular weight:336.47

    Ref: TM-T24477

  • Evifacotrep
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    Evifacotrep

    CAS:
    <p>Evifacotrep: TRPC5 antagonist for neurological disease research (WO2020061162, compound 100).</p>
    Formula:C18H12ClF4N5O2
    Purity:98.6%
    Color and Shape:Solid
    Molecular weight:441.77

    Ref: TM-T40042

  • WS-12
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    WS-12

    CAS:
    <p>WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)</p>
    Formula:C18H27NO2
    Purity:99.99%
    Color and Shape:Whitish To White Solid Crystalline
    Molecular weight:289.41

    Ref: TM-T7416

  • RQ-00203078
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    RQ-00203078

    CAS:
    <p>RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.</p>
    Formula:C21H13ClF6N2O5S
    Purity:98% - 99.6%
    Color and Shape:Solid
    Molecular weight:554.85

    Ref: TM-T2007

  • A-967079
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    A-967079

    CAS:
    <p>A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively</p>
    Formula:C12H14FNO
    Purity:98.34% - 99.75%
    Color and Shape:Solid
    Molecular weight:207.24

    Ref: TM-T7205

  • HC-030031
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    HC-030031

    CAS:
    <p>HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2 and 5.3 μM, respectively.</p>
    Formula:C18H21N5O3
    Purity:99.69% - ≥95%
    Color and Shape:Solid
    Molecular weight:355.39

    Ref: TM-T6530

  • Chembridge-5861528
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    Chembridge-5861528

    CAS:
    <p>Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM.</p>
    Formula:C19H23N5O3
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:369.42

    Ref: TM-T2711

  • GSK2193874
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    GSK2193874

    CAS:
    <p>GSK2193874 was identified as a selective, orally active TRPV4 blocker.</p>
    Formula:C37H38BrF3N4O
    Purity:98.79% - ≥95%
    Color and Shape:Solid
    Molecular weight:691.62

    Ref: TM-T5640

  • Pyr10
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    Pyr10

    CAS:
    <p>Pyr10, a pyrazole derivative, selectively inhibits TRPC3, not STIM1/Orai1, with IC50 of 0.72 μM in TRPC3-HEK293, and 13.08 μM in BRL-2H3 cells.</p>
    Formula:C18H13F6N3O2S
    Purity:99.69% - 99.7%
    Color and Shape:Solid
    Molecular weight:449.37

    Ref: TM-T16686

  • Pico145
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    Pico145

    CAS:
    <p>Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels.</p>
    Formula:C23H20ClF3N4O5
    Purity:99.06%
    Color and Shape:Solid
    Molecular weight:524.88

    Ref: TM-T16532

  • Ononetin
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    Ononetin

    CAS:
    <p>Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).</p>
    Formula:C15H14O4
    Purity:98.06%
    Color and Shape:Solid
    Molecular weight:258.27

    Ref: TM-T23107

  • TRPM4-IN-1
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    TRPM4-IN-1

    CAS:
    <p>TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.</p>
    Formula:C15H11Cl2NO4
    Purity:97.22%
    Color and Shape:Solid
    Molecular weight:340.16

    Ref: TM-T9245

  • AMG 333
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    AMG 333

    CAS:
    <p>AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.</p>
    Formula:C20H12F5N3O4
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:453.32

    Ref: TM-T5479

  • PF-4840154
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    PF-4840154

    CAS:
    <p>PF-4840154: potent TrpA1 agonist; EC50 of 97 nM (rat) &amp; 23 nM (human); triggers nociception in mice.</p>
    Formula:C26H38N6O2
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:466.62

    Ref: TM-T4385

  • 9-Phenanthrol
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    9-Phenanthrol

    CAS:
    <p>9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.</p>
    Formula:C14H10O
    Purity:98.48%
    Color and Shape:Solid
    Molecular weight:194.23

    Ref: TM-T22537

  • SB 452533
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    SB 452533

    CAS:
    <p>SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).</p>
    Formula:C18H22BrN3O
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:376.29

    Ref: TM-T23322

  • RN-1734
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    RN-1734

    CAS:
    <p>RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, mTRPV4 and rTRPV4,respectively)</p>
    Formula:C14H22Cl2N2O2S
    Purity:99.1% - 99.3%
    Color and Shape:Solid
    Molecular weight:353.31

    Ref: TM-T7572