Chloride channel
Chloride channels are membrane proteins that control the movement of chloride ions across cellular membranes, playing a vital role in maintaining cell volume, electrical excitability, and acid-base balance. Dysregulation of chloride channels is linked to diseases such as cystic fibrosis, epilepsy, and kidney disorders. At CymitQuimica, we offer a variety of chloride channel modulators to support your research in ion transport, cellular homeostasis, and disease mechanisms.
Found 54 products of "Chloride channel"
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Niflumic acid
CAS:Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
Formula:C13H9F3N2O2Purity:99.47%Color and Shape:SolidMolecular weight:282.22NS1652
CAS:NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
Formula:C15H11F3N2O3Purity:99.62%Color and Shape:SolidMolecular weight:324.25Eact
CAS:Eact is a potent TMEM16A activator that also triggers TRPV1, causing itch, pain, and heat sensitivity.
Formula:C22H24N2O5SPurity:98.14%Color and Shape:SolidMolecular weight:428.5Afoxolaner
CAS:Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.Formula:C26H17ClF9N3O3Purity:99.1% - 99.38%Color and Shape:SolidMolecular weight:625.87Halothane
CAS:Halothane (Anestan) 可以减弱内皮依赖性舒张作用。Formula:C2HBrClF3Purity:99.80% - >99.99%Color and Shape:Colorless Volatile Liquid Density 1 875 G / Cm3 Boiling Point 122 4°F (50 2°C) NoncombustibleMolecular weight:197.38Endovion
CAS:Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.Formula:C16H9BrF6N6OPurity:98.51%Color and Shape:SolidMolecular weight:495.18T16Ainh-A01
CAS:T16Ainh-A01 is a potent TMEM16A chloride channel inhibitor with a 1 μM IC50, targeting CaCC.Formula:C19H20N4O3S2Purity:97.18% - 98.15%Color and Shape:SolidMolecular weight:416.52Ref: TM-T13059
1mg35.00€5mg66.00€10mg97.00€25mg183.00€50mg280.00€100mg425.00€200mg615.00€1mL*10mM (DMSO)87.00€DCPIB
CAS:DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μMFormula:C22H28Cl2O4Purity:99.79% - 99.87%Color and Shape:SolidMolecular weight:427.36Ref: TM-T10979
2mg39.00€5mg57.00€10mg87.00€25mg177.00€50mg301.00€100mg485.00€200mg690.00€1mL*10mM (DMSO)63.00€Flufenamic acid
CAS:Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.Formula:C14H10F3NO2Purity:98.68%Color and Shape:White To Light Yellow Crystalline PowderMolecular weight:281.23Meticrane
CAS:Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.Formula:C10H13NO4S2Purity:99.16%Color and Shape:SolidMolecular weight:275.34Chlorotoxin(linear)
Chlorotoxin(linear): 36-amino-acid peptide from Egyptian scorpion venom, used in research as chloride channel blocker.Formula:C158H256N52O48S11Purity:98%Color and Shape:SolidMolecular weight:4004.76ANO1-IN-4
CAS:ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.Formula:C19H19BrF2N2O2SColor and Shape:SolidMolecular weight:457.33Chlorotoxin TFA
Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.Formula:C160H250F3N53O49S11Color and Shape:SolidMolecular weight:4109.74Chlorotoxin
CAS:Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.Formula:C158H249N53O47S11Purity:98%Color and Shape:SolidMolecular weight:3995.71GaTx2
CAS:High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.Formula:C125H199N39O47S6Purity:98%Color and Shape:SolidMolecular weight:3192.54Umifoxolaner
CAS:Umifoxolaner is an anti-parasitic agent (veterinary).Formula:C26H16ClF10N3O3Color and Shape:SolidMolecular weight:643.87Ion Channel Targeted Library
A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;
Color and Shape:Odour SolidLubiprostone hemiketal
CAS:Lubiprostone (hemiketal) (RU-0211 (hemiketal)), a selective activator of the chloride channel 2 (CLCN2), facilitates the treatment of chronic idiopathic constipation and opioid-induced constipation. It functions by enhancing CLCN2 channel activity, which boosts chloride ion secretion in the intestines, subsequently increasing fluid secretion and improving intestinal peristalsis. Additionally, Lubiprostone (hemiketal) may be utilized in research related to chronic constipation and cancer.Formula:C20H32F2O5Color and Shape:SolidMolecular weight:390.46Afoxolaner (Standard)
CAS:Afoxolaner (Standard) is the standard substance of Afoxolaner, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.Formula:C26H17ClF9N3O3Molecular weight:625.87Adjudin
CAS:Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.Formula:C15H12Cl2N4OPurity:96.51% - ≥95%Color and Shape:SolidMolecular weight:335.19
