Chloride channel

<p>Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.</p>

<p>T16Ainh-A01 is a potent TMEM16A chloride channel inhibitor with a 1 μM IC50, targeting CaCC.</p>

<p>Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.</p>

<p>DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM</p>

<p>Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.</p>

<p>Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.</p>

<p>Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.</p>

<p>Halothane (Anestan) 可以减弱内皮依赖性舒张作用。</p>

<p>Eact is a potent TMEM16A activator that also triggers TRPV1, causing itch, pain, and heat sensitivity.</p>

<p>NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.</p>

<p>Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.</p>

<p>Chlorotoxin(linear): 36-amino-acid peptide from Egyptian scorpion venom, used in research as chloride channel blocker.</p>

<p>Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.</p>

<p>High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.</p>

<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>

<p>ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.</p>

<p>Lubiprostone (hemiketal) (RU-0211 (hemiketal)), a selective activator of the chloride channel 2 (CLCN2), facilitates the treatment of chronic idiopathic constipation and opioid-induced constipation. It functions by enhancing CLCN2 channel activity, which boosts chloride ion secretion in the intestines, subsequently increasing fluid secretion and improving intestinal peristalsis. Additionally, Lubiprostone (hemiketal) may be utilized in research related to chronic constipation and cancer.</p>

<p>Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.</p>

<p>Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats.</p>

<p>Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.</p>