PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Found 179 products for "PDE".
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Carbodenafil
CAS:Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).Formula:C24H32N6O3Purity:98.96% - 99.89%Color and Shape:White SolidMolecular weight:452.55Zomepirac sodium salt
CAS:Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.Formula:C15H13ClNNaO3Purity:98.65% - ≥95%Color and Shape:Yellow SolidMolecular weight:313.71Trapidil
CAS:Trapidil (Avantrin) is a coronary vasodilator agent.Formula:C10H15N5Purity:99.42%Color and Shape:White SolidMolecular weight:205.26Enpp-1-IN-14
CAS:Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.Formula:C15H22ClN5O4SPurity:99.83%Color and Shape:SoildMolecular weight:403.88EMD57439
CAS:EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).Formula:C22H23N3O4SPurity:99.35% - 99.57%Color and Shape:White SolidMolecular weight:425.5NSP-805
CAS:NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.Formula:C17H19N3O2Purity:99.85%Color and Shape:Yellow SolidMolecular weight:297.35Ref: TM-T12267
1mg38.00€5mg86.00€1mL*10mM (DMSO)94.00€10mg129.00€25mg216.00€50mg309.00€100mg427.00€200mg577.00€N-Methylbenzamide
CAS:N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.Formula:C8H9NOPurity:99.83%Color and Shape:Physical Description Off-White Crystalline Solid (Ntp 1992)Molecular weight:135.16Amrinone
CAS:Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.Formula:C10H9N3OPurity:98.88% - 99.45%Color and Shape:SolidMolecular weight:187.2ATX inhibitor 1
CAS:ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).Formula:C21H23Cl2N2O6PPurity:99.52%Color and Shape:White SolidMolecular weight:501.3Roflumilast
CAS:Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potentialFormula:C17H14Cl2F2N2O3Purity:99.76% - 99.86%Color and Shape:SolidMolecular weight:403.21ITI-214
CAS:ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.Formula:C29H29FN7O5PPurity:98.21%Color and Shape:SolidMolecular weight:605.56Ref: TM-T11689
1mg71.00€2mg92.00€5mg158.00€1mL*10mM (DMSO)207.00€10mg286.00€25mg505.00€50mg712.00€100mg1,009.00€Pimobendan
CAS:Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).Formula:C19H18N4O2Purity:99.91%Color and Shape:White SolidMolecular weight:334.37Pumafentrine
CAS:Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.Formula:C29H39N3O3Purity:99.85%Color and Shape:White SolidMolecular weight:477.64Milrinone
CAS:Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.Formula:C12H9N3OPurity:99.22% - 99.92%Color and Shape:SolidMolecular weight:211.22Zatolmilast
CAS:Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).Formula:C21H15ClF3NO2Purity:98.20%Color and Shape:SolidMolecular weight:405.8Ref: TM-T10590
1mg66.00€5mg128.00€1mL*10mM (DMSO)141.00€10mg231.00€25mg388.00€50mg532.00€100mg740.00€200mg973.00€MR-L2
CAS:MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Formula:C19H16Cl3FN4OPurity:98.09% - 98.94%Color and Shape:SolidMolecular weight:441.71Ref: TM-T12103
1mg138.00€2mg197.00€5mg334.00€1mL*10mM (DMSO)358.00€10mg500.00€25mg807.00€50mg1,099.00€100mg1,485.00€500mg2,962.00€Theodrenaline hydrochloride
CAS:Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.Formula:C17H22ClN5O5Purity:97.05% - 98.18%Color and Shape:SolidMolecular weight:411.84PDE10A-IN-5
PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.Color and Shape:Odour SolidPDE4B-IN-4
PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.Formula:C26H27N5O5Color and Shape:SolidMolecular weight:489.52PDE4-IN-21
PDE4-IN-21 (Compound L19) is an effective PDE4 inhibitor with an IC50 of 0.48 μM. It demonstrates substantial inhibitory activity and notable metabolic stability in rat liver microsomes.Formula:C15H10Cl2N6SColor and Shape:SolidMolecular weight:377.25
