Cyclooxygenase (COX) Inhibitors
Cyclooxygenase (COX) inhibitors are compounds that block the activity of COX enzymes, which are involved in the production of prostaglandins, key mediators of inflammation and pain. In neuroscience, COX inhibitors are studied for their potential to reduce neuroinflammation, which is implicated in various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By inhibiting COX, these compounds may help mitigate inflammatory processes in the brain and protect against neuronal damage. At CymitQuimica, we provide a range of COX inhibitors to support your research in neuroinflammation, pain management, and neurodegenerative disease.
Found 562 products of "Cyclooxygenase (COX) Inhibitors"
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Tebufelone
CAS:<p>Tebufelone is a potent NSAID, inhibits CO, has anti-inflammatory and analgesic properties, and blocks lipoxygenase products (IC50 ~20-22 microM).</p>Formula:C20H28O2Purity:99.32%Color and Shape:SolidMolecular weight:300.44Vedaprofen
CAS:<p>Vedaprofen (PM 150) is a COX-1 inhibitor with anti-inflammatory effects, blocking E. coli clamp at IC50 222 μM, Ki 131 μM.</p>Formula:C19H22O2Purity:99.24% - 99.70%Color and Shape:SolidMolecular weight:282.38COX-1/2-IN-4
<p>COX-1/2-IN-4 (compound 2b) is a dual COX-1 and COX-2 inhibitor with respective IC50 values of 0.239 μM for COX-1 and 0.191 μM for COX-2.</p>Formula:C22H24N2O2SPurity:98%Color and Shape:SolidMolecular weight:380.5COX-2/NLRP3-IN-1
<p>COX-2/NLRP3-IN-1 (Compound 6k) is an inhibitor that targets COX-2 and NLRP3, exhibiting an IC50 value of 1.53 μM for COX-2. This compound exerts anti-inflammatory effects by inhibiting the NF-κB/NLRP3 signaling pathway.</p>Formula:C24H19Cl2N5OSMolecular weight:495.06874Anti-inflammatory agent 78
<p>Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. It effectively inhibits PGE2, PGE1, COX-2, and COX-1. Additionally, Anti-inflammatory agent 78 suppresses the release of NO in LPS-stimulated RAW 264.7 cell lines.</p>Formula:C19H14ClNO4Molecular weight:355.06114Akt/NF-κB/MAPK-IN-1
<p>Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.</p>Formula:C38H56N2O4Purity:98%Color and Shape:SolidMolecular weight:604.86Anti-inflammatory agent 53
<p>Anti-inflammatory agent 52 (compound 7c) is an orally active, selective COX-2 inhibitor with demonstrated anti-HT29 metastatic activity, causing periodic arrest</p>Formula:C24H22N2O4SPurity:98%Color and Shape:SolidMolecular weight:434.51Lonazolac Calcium
CAS:<p>Lonazolac Calcium, a nonsteroidal anti-inflammatory drug (NSAID), is used to treat inflammation and pain.</p>Formula:C34H24CaCl2N4O4Purity:98%Color and Shape:SolidMolecular weight:663.56COX-2-IN-35
<p>COX-2-IN-35 (compound 7) is a selective inhibitor of COX-2, demonstrating anti-inflammatory activity, with an inhibitory concentration (IC 50) of 4.37 nM [1].</p>Formula:C22H19NO2S2Purity:98%Color and Shape:SolidMolecular weight:393.52Cafestol palmitate
CAS:<p>Cafestol palmitate is an active compound found in green coffee beans. It can enhance the activity of glutathione S-transferase (GST) in mice and also exhibits weak COX-2 inhibitory activity.</p>Formula:C36H58O4Color and Shape:SolidMolecular weight:554.843Amfenac sodium
CAS:<p>Amfenac is a nonsteroidal anti-inflammatory drug. Amfenac also has acetic acid moiety.</p>Formula:C15H12NNaO3Purity:98%Color and Shape:SolidMolecular weight:277.26Bermoprofen
CAS:<p>Bermoprofen (AD-1590) is an anti-inflammatory compound with anti-inflammatory and analgesic activity used in the study of gastric ulcers.</p>Formula:C18H16O4Purity:98.72% - 99.28%Color and Shape:SolidMolecular weight:296.32Feladilimab
CAS:<p>Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist.</p>Purity:SDS-PAGE:95% SEC-HPLC:98%Color and Shape:LiquidMolecular weight:145.24 kDaAnti-inflammatory agent 93
<p>Compound 2g (Anti-inflammatory agent 93) is an active compound that exhibits analgesic activity.</p>Formula:C27H17Cl2N3O2Color and Shape:SolidMolecular weight:486.35Guaiacol-d3
CAS:<p>Guaiacol-d3 is a deuterated form of Guaiacol, which is a phenolic compound known for its ability to inhibit COX-2 expression and NF-κB activation in response to LPS stimulation, exhibiting anti-inflammatory properties.</p>Formula:C7H8O2Color and Shape:SolidMolecular weight:127.16Flunixin
CAS:<p>Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), antipyretic, and analgesic used in pigs, horses, and cattle.</p>Formula:C14H11F3N2O2Color and Shape:SolidMolecular weight:296.24Antiviral agent 61
<p>Antiviralagent 61 (compound Z40) serves as an effective antiviral agent with activity against Tomato Spotted Wilt Virus (TSWV), exhibiting an EC50 value of 252 µg/mL. It increases the RNA expression of Ndufb9, COX6B, 7.1.2.2, E, COX5B, Ndufs4, and SDHB, while reducing the expression of Ndufb7, Ndufa5, and G.</p>Formula:C22H23N5O4SColor and Shape:SolidMolecular weight:453.51Deracoxib
CAS:Formula:C17H14F3N3O3SPurity:>98.0%(T)(HPLC)Color and Shape:White to Brown powder to crystalMolecular weight:397.37Loxoprofen Sodium Salt Dihydrate
CAS:Formula:C15H17NaO3·2H2OPurity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:304.32Butyl 2-[[3-(Trifluoromethyl)phenyl]amino]benzoate
CAS:Formula:C18H18F3NO2Purity:>98.0%(HPLC)(N)Color and Shape:Colorless to Yellow clear liquidMolecular weight:337.34DL-Lysine Acetylsalicylate
CAS:Formula:C9H8O4·C6H14N2O2Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:326.35SC-560
CAS:Formula:C17H12ClF3N2OPurity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:352.74Piroxicam D3
CAS:<p>Piroxicam D3 is deuterium labeled Piroxicam. Piroxicam is a COX inhibitor(human monocyte COX-1 and COX-2 with IC50s of 47, 25 μM , respectively) .</p>Formula:C15H13N3O4SPurity:98%Color and Shape:SolidMolecular weight:334.37Parecoxib sodium
CAS:<p>Parecoxib: COX2 inhibitor, treats short-term postoperative pain, water-soluble, injectable, valdecoxib prodrug, less GI toxicity than ketorolac.</p>Formula:C19H18N2NaO4SPurity:98%Color and Shape:SolidMolecular weight:393.41Fenbufen
CAS:Formula:C16H14O3Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:254.29Rebamipide-d4
CAS:<p>Rebamipide D4 is deuterium labeled Rebamipide.</p>Formula:C19H15ClN2O4Purity:98%Color and Shape:SolidMolecular weight:374.81Rontalizumab
CAS:<p>Rontalizumab (RhuMab IFNalpha) is a humanized monoclonal antibody that neutralizes IFNalpha, used in the research of systemic lupus erythematosus.</p>Purity:96.87% (SEC-HPLC) - 97.73% (SEC-HPLC)Color and Shape:LiquidSuprofen
CAS:Formula:C14H12O3SPurity:>98.0%(GC)Color and Shape:White to Light yellow powder to crystalMolecular weight:260.31NS-398
CAS:Formula:C13H18N2O5SPurity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:314.36Tenoxicam
CAS:Formula:C13H11N3O4S2Purity:>98.0%(HPLC)(N)Color and Shape:White to Yellow to Green powder to crystalMolecular weight:337.37Tolmetin
CAS:Formula:C15H15NO3Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:257.29Etoricoxib-d4
CAS:<p>Etoricoxib-d4 is the 2H-labeled form of Etoricoxib. Etoricoxib is a COX-2 inhibitor with antipyretic, analgesic, and potential anticancer properties.</p>Formula:C18H11D4ClN2O2SPurity:>99.99%Color and Shape:SolidMolecular weight:362.87Ketorolac Tromethamine
CAS:Formula:C15H13NO3·C4H11NO3Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:376.41Ibuprofen Impurity F
CAS:<p>Ibuprofen Impurity F, anti-inflammatory, inhibits COX-1 and COX-2 with IC50 of 13 μM and 370 μM.</p>Formula:C13H18O2Color and Shape:SolidMolecular weight:206.28Parecoxib Sodium
CAS:Formula:C19H17N2NaO4SPurity:>95.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:392.40Tryptanthrin
CAS:Formula:C15H8N2O2Purity:>98.0%(GC)Color and Shape:White to Light yellow powder to crystalMolecular weight:248.24Valeroyl Salicylate
CAS:<p>Valeroyl Salicylate is a NSAID that extends lifespan, boosts mobility with age, and enhances stress resilience.</p>Formula:C12H14O4Purity:97.512%Color and Shape:SolidMolecular weight:222.24Ibuprofen Impurity K
CAS:<p>Ibuprofen Impurity K, an Ibuprofen contaminate; targeting COX-1 (IC50: 13 μM) & COX-2 (IC50: 370 μM).</p>Formula:C10H10O3Color and Shape:SolidMolecular weight:178.18Oxaprozin
CAS:Formula:C18H15NO3Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:293.32Etofenamate
CAS:Formula:C18H18F3NO4Purity:>98.0%(GC)(T)Color and Shape:Colorless to Yellow clear liquidMolecular weight:369.34Etoricoxib
CAS:Formula:C18H15ClN2O2SPurity:>95.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:358.84Floctafenine
CAS:<p>Floctafenine (R-4318) is a non-steroidal anti-inflammatory compound that is a COX-I and COX-2 inhibitor with analgesic activity for the study of pain.</p>Formula:C20H17F3N2O4Purity:97.73%Color and Shape:SolidMolecular weight:406.36Tyrphostin AG 1478
CAS:Formula:C16H14ClN3O2Purity:>98.0%(HPLC)Color and Shape:Light orange to Yellow to Green powder to crystalMolecular weight:315.76Xanthomicrol
CAS:<p>Xanthomicrol is a useful organic compound for research related to life sciences. The catalog number is T125642 and the CAS number is 16545-23-6.</p>Formula:C18H16O7Color and Shape:SolidMolecular weight:344.319(S)-(+)-Ibuprofen D3
CAS:<p>(S)-(+)-Ibuprofen D3, deuterium-labeled S-enantiomer, COX-1/2 inhibitor with IC50s of 2.1 and 1.6 μM.</p>Formula:C13H18O2Purity:98%Color and Shape:SolidMolecular weight:209.3Loxoprofen sodium
CAS:<p>Loxoprofen sodium is a COX-1/COX-2 inhibitor (IC50: 6.5/13.5 μM) used orally for anti-inflammatory and antitumor effects.</p>Formula:C15H17NaO3Purity:99.88%Color and Shape:SolidMolecular weight:268.2834Bardoxolone Methyl
CAS:Formula:C32H43NO4Purity:>95.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:505.70Valdecoxib
CAS:Formula:C16H14N2O3SPurity:>98.0%(HPLC)(N)Color and Shape:White to Almost white powder to crystalMolecular weight:314.362-(6-Methoxynaphthalen-2-yl)acetic Acid
CAS:Formula:C13H12O3Purity:>95.0%(GC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:216.24Licofelone
CAS:Formula:C23H22ClNO2Purity:>95.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:379.88
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