Tyrosine Kinase/Adaptors
Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.
Subcategories of "Tyrosine Kinase/Adaptors"
- ALK(112 products)
- CSF-1R(42 products)
- EGFR(572 products)
- Ephrin Receptor(23 products)
- FLT(92 products)
- Fibroblast Growth Factor Receptor (FGFR)(169 products)
- HER(5 products)
- Hck(3 products)
- IGF-1R(87 products)
- PDGFR(126 products)
- PYK2(7 products)
- Src(79 products)
- TAM Receptor(32 products)
- Tie-2(20 products)
- Trk receptor(59 products)
- Tyrosine Kinases(26 products)
- VEGFR(268 products)
- c-Fms(108 products)
- c-Kit(101 products)
- c-Met/HGFR(128 products)
- c-RET(51 products)
Show 13 more subcategories
Found 1372 products of "Tyrosine Kinase/Adaptors"
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GSK1838705A
CAS:<p>GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.</p>Formula:C27H29FN8O3Purity:98.89% - >99.99%Color and Shape:SolidMolecular weight:532.57HPK1-IN-2
CAS:<p>HPK1-IN-2 is a strong, oral HPK1 inhibitor (IC50<0.05 μM), also blocking Lck, Flt3 kinases, with anticancer properties.</p>Formula:C19H20N6OSPurity:97.31%Color and Shape:SolidMolecular weight:380.47AAL-993
CAS:<p>AAL-993: VEGFR inhibitor; IC50: 130 nM (1), 23 nM (2), 18 nM (3); weak on other tyrosine kinases; antiangiogenic & antitumor.</p>Formula:C20H16F3N3OPurity:99.65%Color and Shape:SolidMolecular weight:371.36Neratinib
CAS:<p>Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.</p>Formula:C30H29ClN6O3Purity:96.17% - 99.85%Color and Shape:SolidMolecular weight:557.04(E/Z)-Zotiraciclib
CAS:<p>(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.</p>Formula:C23H24N4OPurity:97.75% - 99.92%Color and Shape:SolidMolecular weight:372.46(E)-AG 99
CAS:<p>(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).</p>Formula:C10H8N2O3Purity:99.23%Color and Shape:SolidMolecular weight:204.18TL-895
CAS:<p>TL-895 is a potent, selective ATP-competitive BTK inhibitor (IC50 = 1.5 nM, Ki = 11.9 nM).</p>Formula:C25H26FN5O2Purity:99.96%Color and Shape:SolidMolecular weight:447.5Entrectinib
CAS:<p>Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.</p>Formula:C31H34F2N6O2Purity:98.03% - 99.61%Color and Shape:SolidMolecular weight:560.64AG-494
CAS:<p>AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.</p>Formula:C16H12N2O3Purity:98.69%Color and Shape:SolidMolecular weight:280.28CP-724714
CAS:<p>CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2</p>Formula:C27H27N5O3Purity:97.1% - 98.82%Color and Shape:SolidMolecular weight:469.54LY2874455
CAS:<p>LY2874455 has been used in trials studying the treatment of Advanced Cancer.</p>Formula:C21H19Cl2N5O2Purity:97.22% - 99.46%Color and Shape:SolidMolecular weight:444.31LDN193189
CAS:<p>LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.</p>Formula:C25H22N6Purity:98% - 99.86%Color and Shape:SolidMolecular weight:406.48SU5205
CAS:<p>SU5205 is a VEGFR2 inhibitor.</p>Formula:C15H10FNOPurity:99.62% - 99.67%Color and Shape:SolidMolecular weight:239.24G5-7
CAS:<p>G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.</p>Formula:C22H19F2NO3Purity:97.3%Color and Shape:SolidMolecular weight:383.39AZD8931 diFuMaric acid
CAS:<p>AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).</p>Formula:C31H33ClFN5O11Purity:99.92%Color and Shape:SolidMolecular weight:706.1Theliatinib
CAS:<p>Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).</p>Formula:C25H26N6O2Purity:99.67%Color and Shape:SolidMolecular weight:442.51Theliatinib tartrate
CAS:<p>Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.</p>Formula:C29H32N6O8Color and Shape:SolidMolecular weight:592.6LDN-214117
CAS:<p>LDN-214117 is a potent and selective ALK2 inhibitor.</p>Formula:C25H29N3O3Purity:98% - 99.82%Color and Shape:SolidMolecular weight:419.52Decernotinib
CAS:<p>Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.</p>Formula:C18H19F3N6OPurity:99.28% - >99.99%Color and Shape:SolidMolecular weight:392.38RepSox
CAS:<p>RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).</p>Formula:C17H13N5Purity:98.8% - 99.73%Color and Shape:SolidMolecular weight:287.32Dovitinib lactate
CAS:<p>Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).</p>Formula:C24H27FN6O4Purity:99.54% - 99.77%Color and Shape:SolidMolecular weight:482.51R112
CAS:<p>R112 ((E)-Elafibranor) is an ATP-competitive inhibitor of Syk kinase.</p>Formula:C16H13FN4O2Purity:99.27% - 99.84%Color and Shape:SolidMolecular weight:312.3Butein
CAS:<p>Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.</p>Formula:C15H12O5Purity:98.76% - >99.99%Color and Shape:SolidMolecular weight:272.25NRC-2694
CAS:<p>NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.</p>Formula:C24H26N4O3Purity:99.90%Color and Shape:SolidMolecular weight:418.49SYR127063
CAS:<p>SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.</p>Formula:C23H20ClF3N4O3Purity:98.57%Color and Shape:SolidMolecular weight:492.88Ponatinib
CAS:<p>Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively</p>Formula:C29H27F3N6OPurity:98% - 99.60%Color and Shape:SolidMolecular weight:532.56LDC1267
CAS:<p>LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).</p>Formula:C30H26F2N4O5Purity:99.38% - 99.88%Color and Shape:SolidMolecular weight:560.55Oritinib mesylate
CAS:<p>Oritinib mesylate (SH-1028), an oral pyrimidine EGFR blocker with 18 nM IC50, targets both sensitive and T790M resistant mutations.</p>Formula:C32H41N7O5SColor and Shape:SolidMolecular weight:635.78Pralsetinib
CAS:<p>Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T</p>Formula:C27H32FN9O2Purity:97.88% - 99.8%Color and Shape:SolidMolecular weight:533.6RG14620
CAS:<p>RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.</p>Formula:C14H8Cl2N2Purity:99.82% - 99.87%Color and Shape:SolidMolecular weight:275.13AG-13958
CAS:<p>AG-13958 (AG-013958) (AG-013958), a potent VEGFR tyrosine kinase inhibitor, for the treatment of age-related macular degeneration.</p>Formula:C26H22FN7OPurity:99.4%Color and Shape:SolidMolecular weight:467.5AMG-47a
CAS:<p>AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.</p>Formula:C29H28F3N5O2Purity:98%Color and Shape:SolidMolecular weight:535.56Remibrutinib
CAS:<p>Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood.</p>Formula:C27H27F2N5O3Purity:99.5% - 99.81%Color and Shape:SolidMolecular weight:507.53Ruxolitinib (S enantiomer)
CAS:<p>Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.</p>Formula:C17H18N6Purity:99.37% - 99.79%Color and Shape:SolidMolecular weight:306.36Vatalanib free base
CAS:<p>Vatalanib is a VEGFR2/KDR inhibitor (IC50: 37 nM).</p>Formula:C20H15ClN4Purity:99.52%Color and Shape:SolidMolecular weight:346.81ZM 306416
CAS:<p>ZM 306416 (CB 676475), a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM).</p>Formula:C16H13ClFN3O2Purity:99.37% - ≥95%Color and Shape:SolidMolecular weight:333.74Crenolanib
CAS:<p>Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).</p>Formula:C26H29N5O2Purity:98.40% - 99.73%Color and Shape:SolidMolecular weight:443.54AG490
CAS:<p>AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.</p>Formula:C17H14N2O3Purity:98.6% - 99.39%Color and Shape:Yellow SolidMolecular weight:294.31-Naphthyl PP1
CAS:<p>1-Naphthyl PP1 (1-NA-PP 1) is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively)</p>Formula:C19H19N5Purity:99.85%Color and Shape:White Cyrstalline SolidMolecular weight:317.39Tolimidone
CAS:<p>Tolimidone (NSC 314335) is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.</p>Formula:C11H10N2O2Purity:99.85% - 99.85%Color and Shape:SolidMolecular weight:202.21Motesanib
CAS:<p>Motesanib (AMG 706) orally blocks VEGFR, PDGFR, Kit, Ret; curbing angiogenesis and cancer cell growth.</p>Formula:C22H23N5OPurity:98% - 99.09%Color and Shape:SolidMolecular weight:373.45Pexmetinib
CAS:<p>Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.</p>Formula:C31H33FN6O3Purity:99.07% - 99.66%Color and Shape:SolidMolecular weight:556.63Entospletinib
CAS:<p>Entospletinib (GS-9973) is a Syk inhibitor (IC50=7.7 nM) with selective, oral activity. High-Quality, Low-Cost!</p>Formula:C23H21N7OPurity:98.54% - 99.51%Color and Shape:SolidMolecular weight:411.46Fisogatinib
CAS:<p>Fisogatinib (BLU-554) is a highly potent, selective, and orally active FGFR4 inhibitor.Cost-effective and quality-assured.</p>Formula:C24H24Cl2N4O4Purity:99.27% - ≥95%Color and Shape:SolidMolecular weight:503.38Chrysophanol
CAS:<p>Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.</p>Formula:C15H10O4Purity:99.44% - 99.91%Color and Shape:Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CMolecular weight:254.24DMH-1
CAS:<p>DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.</p>Formula:C24H20N4OPurity:98% - 99.92%Color and Shape:SolidMolecular weight:380.44CH5424802 analog
CAS:<p>CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.</p>Formula:C28H30N4O2Purity:98.96%Color and Shape:SolidMolecular weight:454.56Linsitinib
CAS:<p>OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.</p>Formula:C26H23N5OPurity:99.71% - ≥95%Color and Shape:SolidMolecular weight:421.49Tyrphostin B44, (+) enantiomer
CAS:<p>Tyrphostin B44, (+) enantiomer is an inhibitor of epidermal growth factor receptor (EGFR) kinase with IC50 of 0.86 μM and has less active than the (-)</p>Formula:C18H16N2O3Purity:97.18%Color and Shape:SolidMolecular weight:308.33Nampt-IN-1
CAS:<p>Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.</p>Formula:C20H25N3O5SPurity:99.28% - 99.4%Color and Shape:SolidMolecular weight:419.49
