Fibroblast Growth Factor Receptor (FGFR)
FGFR inhibitors are targeted therapies that block the activity of fibroblast growth factor receptors (FGFRs), which are involved in cell proliferation, differentiation, and angiogenesis. FGFR signaling contributes to the formation of new blood vessels in tumors, promoting their growth and survival. Inhibiting FGFR can therefore reduce angiogenesis and tumor progression. At CymitQuimica, we provide a range of high-quality FGFR inhibitors to support your research in cancer, developmental biology, and angiogenesis.
Found 177 products of "Fibroblast Growth Factor Receptor (FGFR)"
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Aprutumab
CAS:Aprutumab, a human FGFR2 monoclonal antibody, targets FGFR2-IIIB/C and is used in antibody-drug conjugates.
Purity:98.69% (SEC-HPLC) - 98.69% (SEC-HPLC)Color and Shape:LiquidMolecular weight:150 kDaPazopanib
CAS:Pazopanib (GW786034) is an inhibitor of protein tyrosine kinases that inhibits VEGFR1/2/3. Pazopanib has antitumor activity. Cost-effective and quality-assured.Formula:C21H23N7O2SPurity:98.78% - 99.85%Color and Shape:White PowderMolecular weight:437.52Ref: TM-T0097L
10mg47.00€25mg70.00€50mg90.00€100mg138.00€200mg225.00€500mg314.00€1mL*10mM (DMSO)56.00€2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
CAS:Formula:C21H15ClF4N4O3Purity:98%Color and Shape:SolidMolecular weight:482.8154Ref: IN-DA00ICN3
1g131.00€5g255.00€10g619.00€50g617.00€100gTo inquire10mg30.00€50mg46.00€100mg56.00€250mg69.00€500mg100.00€2,5-Dihydroxybenzoic acid
CAS:2,5-Dihydroxybenzoic acid (Gentisic acid) is an active metabolite of salicylic acid degradation with a broad spectrum of biological activity.Formula:C7H6O4Purity:99.63%Color and Shape:SolidMolecular weight:154.12Pemigatinib
CAS:Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR(IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively).Formula:C24H27F2N5O4Purity:99.57% - 99.95%Color and Shape:SolidMolecular weight:487.5Ref: TM-T12401
1mg48.00€5mg96.00€10mg153.00€25mg274.00€50mg427.00€100mg568.00€1mL*10mM (DMSO)To inquireLenvatinib
CAS:Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity.Formula:C21H19ClN4O4Purity:98.46% - 99.96%Color and Shape:SolidMolecular weight:426.85Lucitanib
CAS:Lucitanib (E-3810) is a VEGFR/FGFR inhibitor targeting VEGFR1-3 and FGFR1-2 with IC50s 7-82.5 nM.Formula:C26H25N3O4Purity:96.13%Color and Shape:SolidMolecular weight:443.49Ref: TM-T15185
1mg46.00€2mg59.00€5mg93.00€10mg137.00€25mg255.00€50mg462.00€100mg672.00€1mL*10mM (DMSO)90.00€Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD
CAS:Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (PF-05231023) is a long-acting fibroblast growth factor 21 (FGF21) analog and is an FGF21-receptor agonist.Formula:C26H32N4O8Purity:99.83% - >99.99%Color and Shape:SolidMolecular weight:528.55Gunagratinib
CAS:Gunagratinib (ICP-192) is a pan-FGFR inhibitor, useful in research on FGFR-related diseases.Formula:C22H25N5O4Purity:99.68%Color and Shape:SolidMolecular weight:423.47Ref: TM-T39682
1mg69.00€5mg147.00€10mg224.00€25mg358.00€50mg512.00€100mg707.00€1mL*10mM (DMSO)164.00€Formononetin
CAS:Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.Formula:C16H12O4Purity:97.39% - 99.94%Color and Shape:SolidMolecular weight:268.26Ferulic Acid
CAS:Ferulic Acid (Coniferic acid) is a highly abundant phenolic phytochemical and a organic compound found in the Ferula assafoetida L. or Ligusticum chuanxiong.Formula:C10H10O4Purity:99.72%Color and Shape:SolidMolecular weight:194.18Triamcinolone acetonide
CAS:Triamcinolone acetonide (Azmacort) is a Corticosteroid.Formula:C24H31FO6Purity:99.61% - 99.91%Color and Shape:White To Off-White Crystalline PowderMolecular weight:434.50LC-MB12
CAS:LC-MB12 is a PROTAC FGFR2 compound that degrades FGFR2 and can be used to study gastric cancer.
Formula:C43H44Cl2N10O8Purity:99.16%Color and Shape:SolidMolecular weight:899.78Amlexanox
CAS:Amlexanox (AA673) treats ulcers by blocking leukotrienes, histamine, reducing inflammation, pain, and healing time.Formula:C16H14N2O4Purity:99.67% - ≥95%Color and Shape:White Crystalline SolidMolecular weight:298.29FGFR1/DDR2 inhibitor 1
CAS:FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108Formula:C28H22F3N5OPurity:99.43%Color and Shape:SolidMolecular weight:501.5Ref: TM-T11279
1mg96.00€5mg205.00€10mg334.00€25mg550.00€50mg760.00€100mg1,108.00€1mL*10mM (DMSO)227.00€Si5-N14
CAS:Si5-N14 is a key component of siloxane-linked lipid nanoparticles (SiLNP) with properties that enhance vascular repair and exhibit antitumor activity. In transgenic GFP mouse models, Si5-N14 mediates CRISPR-Cas9 editing. In Lewis lung carcinoma (LLC) tumor mouse models, it leads to the knockdown of vascular endothelial growth factor receptor 2 (VEGFR2), producing antitumor effects. Additionally, in mice with virus-induced lung injury, Si5-N14 facilitates the delivery of fibroblast growth factor-2 (FGF-2) mRNA, promoting vascular repair, oxygenation, and improved lung function. Si5-N14 shows potential for research in tumors, pneumonia, and cardiovascular diseases.Formula:C78H160N6O5Si2Color and Shape:SolidMolecular weight:1318.31FGFR1 inhibitor-2
CAS:FGFR1 inhibitor-2, potent at 4.55 μM IC50 in MDA-MB-231, targets triple-negative breast cancer.Formula:C25H22F5N3O3Color and Shape:SolidMolecular weight:507.461E7090
CAS:E-7090 is a fibroblast growth factor receptor inhibitor. E-7090 is a selective inhibitor of the tyrosine kinase activities of FGFR1, -2, and -3.Formula:C32H37N5O6Color and Shape:SolidMolecular weight:587.67BW710
BW710 is an orally active inhibitor specifically targeting fibroblast growth factor receptor 2 (FGFR2). It effectively inhibits the proliferation of BaF3-FGFR2 cells with an IC50 value of 2.8 nM. BW710 completely suppresses FGFR2 enzymatic activity and demonstrates selectivity among 75 tyrosine kinases, including FGFR1, FGFR3, and FGFR4, at a 1 μM concentration. Additionally, BW710 impedes FGFR2 signaling and selectively inhibits the proliferation of cancer cells driven by FGFR2. It exhibits promising pharmacokinetic properties, with an oral bioavailability of 29% in mice.
Formula:C28H29FN6O2SColor and Shape:SolidMolecular weight:532.63
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