ALK
ALK inhibitors are compounds that specifically target and inhibit Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase involved in the development and progression of certain cancers, including non-small cell lung cancer and neuroblastoma. By inhibiting ALK, these compounds block signaling pathways that promote tumor cell growth and survival. At CymitQuimica, we offer ALK inhibitors to support your research in oncology, targeted cancer therapies, and signal transduction.
Found 112 products of "ALK"
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ZX-29
CAS:<p>ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.</p>Formula:C23H28ClN7O3SPurity:98.32%Color and Shape:SolidMolecular weight:518.03Ascrinvacumab
CAS:<p>Ascrinvacumab (PF-03446962): humanized IgG2 anti-ALK-1 antibody, Kd 7 nM, inhibits TGF-β, for HCC research.</p>Purity:SDS-PAGE:95% SEC-HPLC:98.18%Color and Shape:LiquidMolecular weight:150 kDaALK-IN-26
CAS:<p>ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.</p>Formula:C24H23NO3SPurity:99.91%Color and Shape:SoildMolecular weight:405.51CEP-28122 mesylate salt (1022958-60-6 free base)
<p>CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).</p>Formula:C29H39ClN6O6SPurity:99.79%Color and Shape:SolidMolecular weight:635.17ALK5 Inhibitor II (hydrochloride)
CAS:<p>ALK5 Inhibitor II has IC50s: 4 nM (auto), 18 nM (TGF-β assay), 23 nM (binding, HepG2).</p>Formula:C17H13N5·HClPurity:98%Color and Shape:SolidMolecular weight:323.8ALK-IN-9
CAS:<p>ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.</p>Formula:C20H21FN6O3Color and Shape:SolidMolecular weight:412.425CPD-1224
CAS:<p>CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.</p>Formula:C43H47ClN8O7SColor and Shape:SolidMolecular weight:855.4TL13-112
CAS:<p>TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).</p>Formula:C49H60ClN9O10SPurity:98%Color and Shape:SolidMolecular weight:1002.572-Keto Crizotinib
CAS:<p>2-Keto Crizotinib is an active lactam metabolite of crizotinib.</p>Formula:C21H20Cl2FN5O2Purity:98%Color and Shape:SolidMolecular weight:464.32ALK/ROS1-IN-3
<p>ALK/ROS1-IN-3 (compound C01) is a dual inhibitor targeting ROS1 and ALK, with IC50 values of 42.3 nM for ROS1G2032R and 49.1 nM for ALKG1202R.</p>Formula:C32H32N4O2Molecular weight:504.25253INCB-000928
CAS:<p>Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.</p>Formula:C30H38N4O3Purity:98.93%Color and Shape:SolidMolecular weight:502.65PROTAC ALK degrader-3
<p>PROTAC ALK degrader-3 (4B) is an orally active PROTAC-based ALK degrader, efficiently inducing sustained degradation of ALK fusion protein and significant inhibition of downstream pathways in Karpas 299 cells with an IC50 of 119.33 nM. This compound exhibits antitumor activity.</p>Formula:C50H60ClN9O7SColor and Shape:SolidMolecular weight:966.59ALK/ROS1-IN-5
<p>ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.</p>Formula:C32H28F2N4O3Color and Shape:SolidMolecular weight:554.586dALK-3
<p>dALK-3 is a degrader of anaplastic lymphoma kinase (ALK) that effectively induces the degradation of EML4-ALK with a DC50 of 0.182 μM. It exhibits significant antiproliferative activity against H3122 cells and is applicable for tumor research.</p>Formula:C39H45ClN7O5PColor and Shape:SolidMolecular weight:758.245LAE-102
<p>LAE-102 is a monoclonal antibody that acts as an antagonist of activin receptor II-A (ACTRIIA/ACVR2). It shows potential for research in the fields of endocrine and metabolic disorders, oncology, and respiratory diseases.</p>Color and Shape:Odour LiquidALK-IN-29
<p>ALK-IN-29 (compound 4c) exhibits inhibitory effects on tyrosine protein kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, displaying a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is applicable in cancer research.</p>Formula:C29H32FN3OColor and Shape:SolidMolecular weight:457.58LDN 193688
CAS:<p>LDN 193688 is a BMP kinase inhibitor preferential for the ALK2 site, acting by binding to the ALK site,progressive osseous fibrodysplasia.</p>Formula:C22H16N4OPurity:99.16%Color and Shape:SoildMolecular weight:352.39TL13-22
CAS:<p>TL13-22 is a potent inhibitor of ALK and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 .</p>Formula:C45H55ClN10O9SPurity:99.13%Color and Shape:SolidMolecular weight:947.5M4K2234
CAS:<p>M4K2234 (26b) inhibits ALK2/ALK5 (IC50: 5/2144 nM), used as a probe for ALK1/2 kinases in cancer research.</p>Formula:C27H31FN4O2Color and Shape:SolidMolecular weight:462.56Multi-kinase-IN-6
<p>Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.</p>Purity:98%Color and Shape:Odour SolidALKBH5-IN-5
CAS:<p>ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.</p>Formula:C13H13NO3Purity:99.54%Color and Shape:SoildMolecular weight:231.25ALK-IN-13
CAS:<p>ALK-IN-13 is an ALK inhibitor.</p>Formula:C29H39ClN7O2PColor and Shape:SolidMolecular weight:584.1LDN-193189 2HCl
CAS:<p>LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.</p>Formula:C25H24Cl2N6Purity:99.78%Color and Shape:SolidMolecular weight:479.4ALK protein ligand-1
CAS:<p>ALK protein ligand-1 (Compound A1) is an ALK protein ligand, acting as a ligand for the target protein in PROTACs, demonstrating inhibitory effects on ALK. It is also useful in the synthesis of AP-1.</p>Formula:C24H29ClN6O3SColor and Shape:SolidMolecular weight:517.043TL13-110
CAS:<p>Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).</p>Formula:C49H62ClN9O9SColor and Shape:SolidMolecular weight:988.59TL13-12
CAS:<p>TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).</p>Formula:C45H53ClN10O10SPurity:98%Color and Shape:SolidMolecular weight:961.49FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Color and Shape:LiquidSIAIS164018 hydrochloride
<p>SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R.</p>Formula:C43H49Cl2N10O7PPurity:98%Color and Shape:SolidMolecular weight:919.79Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Color and Shape:Odour SolidALK-IN-12
CAS:<p>ALK-IN-12: potent ALK inhibitor (IC50: 0.18 nM), affects IGF1R and InsR (IC50: 20.3/90.6 nM), potential for cancer therapy.</p>Formula:C24H30ClN6O2PColor and Shape:SolidMolecular weight:500.97LDN-193189 Tetrahydrochloride
CAS:<p>LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.</p>Formula:C25H26Cl4N6Purity:98.21%Color and Shape:SolidMolecular weight:552.33EW-7195
CAS:<p>EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.</p>Formula:C23H18N8Purity:98.76%Color and Shape:SolidMolecular weight:406.44CEP-28122 mesylate salt
<p>CEP-28122 mesylate, a diaminopyrimidine, selectively inhibits ALK with IC50 of 1.9 nM and exhibits antitumor effects.</p>Formula:C29H39ClN6O6SColor and Shape:SolidMolecular weight:635.17GW788388
CAS:<p>GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.</p>Formula:C25H23N5O2Purity:98.03% - 99.58%Color and Shape:SolidMolecular weight:425.48Crizotinib acetate
CAS:<p>Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.</p>Formula:C23H26Cl2FN5O3Color and Shape:SolidMolecular weight:510.39LDN193189
CAS:<p>LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.</p>Formula:C25H22N6Purity:98% - 99.86%Color and Shape:SolidMolecular weight:406.48ALK kinase inhibitor-1
CAS:<p>SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.</p>Formula:C28H32FN5O3SPurity:99.84%Color and Shape:SolidMolecular weight:537.65SM 16
CAS:<p>SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).</p>Formula:C25H26N4O3Purity:99.72%Color and Shape:SolidMolecular weight:430.5CAY10594
CAS:<p>CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.</p>Formula:C26H28N4O2Purity:98%Color and Shape:SolidMolecular weight:428.53LDN-214117
CAS:<p>LDN-214117 is a potent and selective ALK2 inhibitor.</p>Formula:C25H29N3O3Purity:98% - 99.82%Color and Shape:SolidMolecular weight:419.52Brigatinib
CAS:<p>Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.</p>Formula:C29H39ClN7O2PPurity:97.18% - >99.99%Color and Shape:SolidMolecular weight:584.09DMH-1
CAS:<p>DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.</p>Formula:C24H20N4OPurity:98% - 99.92%Color and Shape:SolidMolecular weight:380.44AZD-3463
CAS:<p>AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.</p>Formula:C24H25ClN6OPurity:99.13%Color and Shape:SolidMolecular weight:448.95CEP-28122
CAS:<p>CEP-28122 is a highly potent and selective orally active ALK inhibitor.</p>Formula:C28H35ClN6O3Purity:99.87% - >99.99%Color and Shape:SolidMolecular weight:539.07RepSox
CAS:<p>RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).</p>Formula:C17H13N5Purity:98.8% - 99.73%Color and Shape:SolidMolecular weight:287.32CH5424802 analog
CAS:<p>CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.</p>Formula:C28H30N4O2Purity:98.96%Color and Shape:SolidMolecular weight:454.56A 77-01
CAS:<p>A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.</p>Formula:C18H14N4Purity:98.82% - ≥95%Color and Shape:SolidMolecular weight:286.33Vactosertib
CAS:<p>Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.</p>Formula:C22H18FN7Purity:98.85% - 99.81%Color and Shape:SolidMolecular weight:399.42R-268712
CAS:<p>R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.</p>Formula:C20H18FN5OPurity:99.61%Color and Shape:SolidMolecular weight:363.395-phenylthieno[2,3-d]pyrimidin-4-amine
CAS:<p>5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.</p>Formula:C12H9N3SPurity:97%Color and Shape:SolidMolecular weight:227.29
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