ALK
ALK inhibitors are compounds that specifically target and inhibit Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase involved in the development and progression of certain cancers, including non-small cell lung cancer and neuroblastoma. By inhibiting ALK, these compounds block signaling pathways that promote tumor cell growth and survival. At CymitQuimica, we offer ALK inhibitors to support your research in oncology, targeted cancer therapies, and signal transduction.
Found 136 products of "ALK"
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CEP-28122 mesylate salt (1022958-60-6 free base)
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).Formula:C29H39ClN6O6SPurity:99.79%Color and Shape:SolidMolecular weight:635.17ALK inhibitor 2
CAS:ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.Formula:C23H28ClN7O3SPurity:99.77% - >99.99%Color and Shape:SolidMolecular weight:518.03Ascrinvacumab
CAS:Ascrinvacumab (PF-03446962): humanized IgG2 anti-ALK-1 antibody, Kd 7 nM, inhibits TGF-β, for HCC research.Purity:SDS-PAGE:95% SEC-HPLC:98.18%Color and Shape:LiquidMolecular weight:150 kDaALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Formula:C23H28BrN7O3SPurity:98.27%Color and Shape:SolidMolecular weight:562.48Ref: TM-T10285
1mg50.00€5mg110.00€10mg166.00€25mg323.00€50mg447.00€100mg610.00€1mL*10mM (DMSO)136.00€ZX-29
CAS:ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Formula:C23H28ClN7O3SPurity:98.32%Color and Shape:SolidMolecular weight:518.03Ref: TM-T13416
1mg92.00€5mg230.00€10mg364.00€25mg620.00€50mg848.00€100mg1,121.00€200mg1,510.00€1mL*10mM (DMSO)264.00€MS4078
CAS:MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.Formula:C45H52ClN9O8SPurity:98.74%Color and Shape:SolidMolecular weight:914.47Ref: TM-T16153
1mg49.00€2mg66.00€5mg90.00€10mg152.00€25mg260.00€50mg416.00€100mg615.00€1mL*10mM (DMSO)152.00€ALK-IN-26
CAS:ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.Formula:C24H23NO3SPurity:99.91%Color and Shape:SoildMolecular weight:405.51F-1
CAS:F-1: Potent ALK/ROS1 inhibitor with 2.1-3.9 nM IC50s; suppresses p-ALK signaling.Formula:C22H27ClN8O3SPurity:97.66%Color and Shape:SolidMolecular weight:519.02Ref: TM-T11254
1mg70.00€5mg133.00€10mg178.00€25mg299.00€50mg424.00€100mg587.00€200mg800.00€1mL*10mM (DMSO)165.00€ALK/ROS1-IN-3
ALK/ROS1-IN-3 (compound C01) is a dual inhibitor targeting ROS1 and ALK, with IC50 values of 42.3 nM for ROS1G2032R and 49.1 nM for ALKG1202R.Formula:C32H32N4O2Molecular weight:504.25253ALK-IN-9
CAS:ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.Formula:C20H21FN6O3Color and Shape:SolidMolecular weight:412.425LDN 193688
CAS:LDN 193688 is a BMP kinase inhibitor preferential for the ALK2 site, acting by binding to the ALK site,progressive osseous fibrodysplasia.Formula:C22H16N4OPurity:99.48%Color and Shape:SoildMolecular weight:352.39dALK-3
dALK-3 is a degrader of anaplastic lymphoma kinase (ALK) that effectively induces the degradation of EML4-ALK with a DC50 of 0.182 μM. It exhibits significant antiproliferative activity against H3122 cells and is applicable for tumor research.Formula:C39H45ClN7O5PColor and Shape:SolidMolecular weight:758.245ALK protein ligand-1
CAS:ALK protein ligand-1 (Compound A1) is an ALK protein ligand, acting as a ligand for the target protein in PROTACs, demonstrating inhibitory effects on ALK. It is also useful in the synthesis of AP-1.Formula:C24H29ClN6O3SColor and Shape:SolidMolecular weight:517.043M4K2234
CAS:M4K2234 (26b) inhibits ALK2/ALK5 (IC50: 5/2144 nM), used as a probe for ALK1/2 kinases in cancer research.Formula:C27H31FN4O2Purity:99.99%Color and Shape:SolidMolecular weight:462.56LAE-102
LAE-102 is a monoclonal antibody that acts as an antagonist of activin receptor II-A (ACTRIIA/ACVR2). It shows potential for research in the fields of endocrine and metabolic disorders, oncology, and respiratory diseases.Color and Shape:Odour LiquidALK-IN-13
CAS:ALK-IN-13 is an ALK inhibitor.
Formula:C29H39ClN7O2PColor and Shape:SolidMolecular weight:584.12-Keto Crizotinib
CAS:2-Keto Crizotinib is an active lactam metabolite of crizotinib.Formula:C21H20Cl2FN5O2Purity:98%Color and Shape:SolidMolecular weight:464.32TL13-12
CAS:TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).Formula:C45H53ClN10O10SPurity:98%Color and Shape:SolidMolecular weight:961.49TL13-110
CAS:Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).Formula:C49H62ClN9O9SColor and Shape:SolidMolecular weight:988.59INCB-000928
CAS:Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.
Formula:C30H38N4O3Purity:98.93%Color and Shape:SolidMolecular weight:502.65FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Color and Shape:LiquidKinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Color and Shape:Odour SolidRef: TM-L1600
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireALK-IN-12
CAS:ALK-IN-12: potent ALK inhibitor (IC50: 0.18 nM), affects IGF1R and InsR (IC50: 20.3/90.6 nM), potential for cancer therapy.Formula:C24H30ClN6O2PColor and Shape:SolidMolecular weight:500.97SIAIS164018 hydrochloride
SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R.Formula:C43H49Cl2N10O7PPurity:98%Color and Shape:SolidMolecular weight:919.79ALK5 Inhibitor II (hydrochloride)
CAS:ALK5 Inhibitor II has IC50s: 4 nM (auto), 18 nM (TGF-β assay), 23 nM (binding, HepG2).Formula:C17H13N5·HClPurity:98%Color and Shape:SolidMolecular weight:323.8TL13-22
CAS:TL13-22 is a potent inhibitor of ALK and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 .Formula:C45H55ClN10O9SPurity:99.13%Color and Shape:SolidMolecular weight:947.5ALK-IN-29
ALK-IN-29 (compound 4c) exhibits inhibitory effects on tyrosine protein kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, displaying a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is applicable in cancer research.Formula:C29H32FN3OColor and Shape:SolidMolecular weight:457.58PROTAC ALK degrader-3
PROTAC ALK degrader-3 (4B) is an orally active PROTAC-based ALK degrader, efficiently inducing sustained degradation of ALK fusion protein and significant inhibition of downstream pathways in Karpas 299 cells with an IC50 of 119.33 nM. This compound exhibits antitumor activity.Formula:C50H60ClN9O7SColor and Shape:SolidMolecular weight:966.59TL13-112
CAS:TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).Formula:C49H60ClN9O10SPurity:98%Color and Shape:SolidMolecular weight:1002.57Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.Purity:98%Color and Shape:Odour SolidLDN-193189 2HCl
CAS:LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.
Formula:C25H24Cl2N6Purity:99.78%Color and Shape:SolidMolecular weight:479.4ALK/ROS1-IN-5
ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.
Formula:C32H28F2N4O3Color and Shape:SolidMolecular weight:554.586CPD-1224
CAS:CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.Formula:C43H47ClN8O7SColor and Shape:SolidMolecular weight:855.4ALKBH5-IN-5
CAS:ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Formula:C13H13NO3Purity:99.54%Color and Shape:SoildMolecular weight:231.25Ref: TM-T203011
5mg34.00€10mg46.00€25mg84.00€50mg120.00€100mg178.00€200mg268.00€1mL*10mM (DMSO)49.00€MS4077
CAS:MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).Formula:C55H72ClN9O13SPurity:98%Color and Shape:SolidMolecular weight:1134.73LDN-193189 Tetrahydrochloride
CAS:LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.Formula:C25H26Cl4N6Purity:98.21%Color and Shape:SolidMolecular weight:552.33EW-7195
CAS:EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.
Formula:C23H18N8Purity:98.76%Color and Shape:SolidMolecular weight:406.44LDN193189
CAS:LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Formula:C25H22N6Purity:98% - 99.86%Color and Shape:SolidMolecular weight:406.48Ceritinib dihydrochloride
CAS:Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase with antitumour effect.Formula:C28H38Cl3N5O3SPurity:99.85% - 99.99%Color and Shape:SolidMolecular weight:631.06A 77-01
CAS:A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Formula:C18H14N4Purity:98.82% - ≥95%Color and Shape:SolidMolecular weight:286.33Ref: TM-T2098
1mg40.00€2mg52.00€5mg86.00€10mg118.00€25mg200.00€50mg280.00€100mg394.00€200mg580.00€1mL*10mM (DMSO)95.00€GW788388
CAS:GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.
Formula:C25H23N5O2Purity:98.03% - 99.58%Color and Shape:SolidMolecular weight:425.48ML347
CAS:ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.Formula:C22H16N4OPurity:99.30% - ≥95%Color and Shape:SolidMolecular weight:352.395-phenylthieno[2,3-d]pyrimidin-4-amine
CAS:5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.Formula:C12H9N3SPurity:97%Color and Shape:SolidMolecular weight:227.29Ref: TM-T50042
2mg46.00€5mg64.00€10mg95.00€25mg145.00€50mg212.00€100mg319.00€200mg455.00€1mL*10mM (DMSO)64.00€RepSox
CAS:RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Formula:C17H13N5Purity:98.8% - 99.73%Color and Shape:SolidMolecular weight:287.32Ref: TM-T6337
1mg34.00€2mg46.00€5mg63.00€10mg80.00€25mg116.00€50mg169.00€100mg241.00€500mg597.00€1mL*10mM (DMSO)69.00€Brigatinib
CAS:Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.
Formula:C29H39ClN7O2PPurity:97.18% - >99.99%Color and Shape:SolidMolecular weight:584.09SM 16
CAS:SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).Formula:C25H26N4O3Purity:99.72%Color and Shape:SolidMolecular weight:430.5ALK5-IN-10
CAS:Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Formula:C22H18BrN7Purity:99.935%Color and Shape:SolidMolecular weight:460.33Ref: TM-T9837
1mg93.00€5mg182.00€10mg269.00€25mg429.00€50mg610.00€100mg820.00€200mg1,099.00€1mL*10mM (DMSO)215.00€CH5424802 analog
CAS:CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Formula:C28H30N4O2Purity:98.96%Color and Shape:SolidMolecular weight:454.56Ref: TM-T9224
1mg124.00€5mg271.00€10mg408.00€25mg672.00€50mg945.00€100mg1,279.00€1mL*10mM (DMSO)324.00€DMH-1
CAS:DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.
Formula:C24H20N4OPurity:98% - 99.92%Color and Shape:SolidMolecular weight:380.44ALK kinase inhibitor-1
CAS:SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.Formula:C28H32FN5O3SPurity:99.84%Color and Shape:SolidMolecular weight:537.65A 83-01 sodium salt
CAS:A 83-01 sodium salt inhibits ALK5, ALK4, and ALK7 kinases with IC50s: 12, 45, 7.5 nM.Formula:C25H19N5NaSColor and Shape:SolidMolecular weight:444.51CEP-28122 mesylate salt
CEP-28122 mesylate, a diaminopyrimidine, selectively inhibits ALK with IC50 of 1.9 nM and exhibits antitumor effects.Formula:C29H39ClN6O6SColor and Shape:SolidMolecular weight:635.17Vactosertib Hydrochloride
CAS:Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.Formula:C22H19ClFN7Purity:98.03%Color and Shape:SolidMolecular weight:435.89Ref: TM-T15262
1mg34.00€5mg66.00€10mg92.00€25mg152.00€50mg230.00€100mg356.00€200mg522.00€1mL*10mM (DMSO)73.00€AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formula:C24H25ClN6OPurity:99.13%Color and Shape:SolidMolecular weight:448.95LDN-193189 HCl
CAS:LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor.Formula:C25H22N6·HClPurity:99.49% - 99.53%Color and Shape:SolidMolecular weight:442.94Ref: TM-T6158
1mg35.00€2mg48.00€5mg70.00€10mg93.00€25mg156.00€50mg227.00€100mg378.00€200mg567.00€1mL*10mM (DMSO)86.00€Crizotinib acetate
CAS:Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.Formula:C23H26Cl2FN5O3Color and Shape:SolidMolecular weight:510.39SB 525334
CAS:SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).Formula:C21H21N5Purity:98.39% - ≥95%Color and Shape:SolidMolecular weight:343.42Blu-782
CAS:Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)
Formula:C31H42N6O4Purity:99.51%Color and Shape:SolidMolecular weight:562.7LDN-212854
CAS:LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors.Formula:C25H22N6Purity:98% - 98.71%Color and Shape:SolidMolecular weight:406.48Ref: TM-T1900
1mg47.00€2mg62.00€5mg92.00€10mg172.00€25mg294.00€50mg439.00€100mg660.00€200mg945.00€1mL*10mM (DMSO)102.00€SB-431542
CAS:SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective.Formula:C22H16N4O3Purity:99.035% - >99.99%Color and Shape:SolidMolecular weight:384.39Ensartinib hydrochloride
CAS:Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFormula:C26H29Cl4FN6O3Purity:98.73%Color and Shape:SolidMolecular weight:634.36Ref: TM-T22324
1mg54.00€5mg114.00€10mg177.00€25mg356.00€50mg580.00€100mg888.00€1mL*10mM (DMSO)158.00€HG-14-10-04
CAS:HG-14-10-04 is a potent and specific ALK inhibitor.Formula:C29H34ClN7OPurity:99.75% - >99.99%Color and Shape:SolidMolecular weight:532.08Ref: TM-T4015
1mg49.00€5mg92.00€10mg152.00€25mg222.00€50mg289.00€100mg409.00€200mg590.00€1mL*10mM (DMSO)111.00€CEP-28122
CAS:CEP-28122 is a highly potent and selective orally active ALK inhibitor.Formula:C28H35ClN6O3Purity:99.87% - >99.99%Color and Shape:SolidMolecular weight:539.07Vactosertib
CAS:Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.Formula:C22H18FN7Purity:98.85% - 99.81%Color and Shape:SolidMolecular weight:399.42CAY10594
CAS:CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.Formula:C26H28N4O2Purity:98%Color and Shape:SolidMolecular weight:428.53LDN-214117
CAS:LDN-214117 is a potent and selective ALK2 inhibitor.
Formula:C25H29N3O3Purity:98% - 99.82%Color and Shape:SolidMolecular weight:419.52D4476
CAS:D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).Formula:C23H18N4O3Purity:99.7% - 99.96%Color and Shape:SolidMolecular weight:398.41Crizotinib hydrochloride
CAS:Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Formula:C21H23Cl3FN5OPurity:98.73% - 98.87%Color and Shape:SolidMolecular weight:486.8Ref: TM-T8399
5mg34.00€10mg50.00€25mg78.00€50mg94.00€100mg131.00€200mg162.00€500mg215.00€1mL*10mM (DMSO)56.00€Alectinib
CAS:Alectinib (RG-7853) is an ALK inhibitor that is selective, orally active, and ATP-competitive. Alectinib has antitumor activity. Cost-effective and quality-assured.Formula:C30H34N4O2Purity:98% - 99.38%Color and Shape:SolidMolecular weight:482.62Ref: TM-T1936
2mg47.00€5mg69.00€10mg87.00€50mg105.00€100mg168.00€200mg259.00€500mg437.00€1mL*10mM (DMSO)73.00€CEP-37440
CAS:CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Formula:C30H38ClN7O3Purity:98.86% - 99.98%Color and Shape:SolidMolecular weight:580.12GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Formula:C27H29FN8O3Purity:98.89% - >99.99%Color and Shape:SolidMolecular weight:532.57Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purity:98.03% - 99.61%Color and Shape:SolidMolecular weight:560.64Ref: TM-T3678
2mg42.00€5mg59.00€10mg88.00€25mg111.00€50mg168.00€100mg283.00€500mg692.00€1mL*10mM (DMSO)69.00€Belizatinib
CAS:Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.Formula:C33H44FN5O3Purity:99.33% - 99.44%Color and Shape:SolidMolecular weight:577.73Ref: TM-T4257
1mg40.00€2mg54.00€5mg93.00€10mg133.00€25mg259.00€50mg358.00€100mg500.00€1mL*10mM (DMSO)105.00€BIBF0775
CAS:BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).
Formula:C31H34N4O2Purity:99.45% - 99.79%Color and Shape:SolidMolecular weight:494.63Lorlatinib
CAS:Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogeneFormula:C21H19FN6O2Purity:99.77% - 99.95%Color and Shape:SolidMolecular weight:406.41Ref: TM-T3061
1mg34.00€2mg42.00€5mg60.00€10mg89.00€25mg137.00€50mg212.00€100mg374.00€1mL*10mM (DMSO)66.00€Crizotinib
CAS:Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.Formula:C21H22Cl2FN5OPurity:99% - 99.87%Color and Shape:SolidMolecular weight:450.34Ref: TM-T1661
2mgTo inquire5mg33.00€10mg49.00€25mg55.00€50mg64.00€100mg88.00€500mg147.00€1mL*10mM (DMSO)50.00€R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Formula:C20H18FN5OPurity:99.61%Color and Shape:SolidMolecular weight:363.39Ref: TM-T16708
1mg44.00€5mg93.00€10mg130.00€25mg250.00€50mg378.00€100mg537.00€200mg762.00€1mL*10mM (DMSO)92.00€ALK-IN-1
CAS:ALK-IN-1 is a potent ALK inhibitor, demonstrating the ability to overcome Crizotinib resistance mediated by an L1196M mutation.Formula:C26H34ClN6O2PPurity:99.74% - 99.80%Color and Shape:SolidMolecular weight:529.01A 83-01
CAS:A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7.Formula:C25H19N5SPurity:97% - 98.2%Color and Shape:SolidMolecular weight:421.52SB-505124
CAS:SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.Formula:C20H21N3O2Purity:97.19% - 99.92%Color and Shape:SolidMolecular weight:335.4Ref: TM-T2462
1mg38.00€2mg50.00€5mg84.00€10mg120.00€25mg210.00€50mg354.00€100mg518.00€500mg1,099.00€1mL*10mM (DMSO)132.00€Alectinib hydrochloride
CAS:Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)Formula:C30H35ClN4O2Purity:99.74% - 99.96%Color and Shape:SolidMolecular weight:519.08Ceritinib
CAS:Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.Formula:C28H36ClN5O3SPurity:98.52% - 99.77%Color and Shape:SolidMolecular weight:558.14Ensartinib
CAS:Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).Formula:C26H27Cl2FN6O3Purity:99.92%Color and Shape:SolidMolecular weight:561.44K02288
CAS:K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.Formula:C20H20N2O4Purity:98% - 99.83%Color and Shape:SolidMolecular weight:352.38AZ 12799734
CAS:AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.Formula:C18H18N4O3SPurity:98.23%Color and Shape:SolidMolecular weight:370.43SB-505124 hydrochloride
CAS:SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.Formula:C20H22ClN3O2Purity:98.71%Color and Shape:SolidMolecular weight:371.86ALK5-IN-79
CAS:ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.Formula:C23H27N7OColor and Shape:SolidMolecular weight:417.51ALK2-IN-2
CAS:ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.Formula:C28H27N5O2SPurity:99.86%Color and Shape:SolidMolecular weight:497.61Ref: TM-T10287
1mg44.00€5mg89.00€10mg142.00€25mg216.00€50mg298.00€100mg411.00€200mg560.00€1mL*10mM (DMSO)99.00€EML4-ALK kinase inhibitor 1
CAS:Potent oral EML4-ALK inhibitor with a 1 nM IC50.
Formula:C31H48N8O3Purity:99.62%Color and Shape:SolidMolecular weight:580.76TRK/ALK-IN-1
TRK/ALK-IN-1: Potent dual TRK & ALK inhibitor; IC50s: 2.2nM (TRKA), 9.3nM (ALK WT), 38nM (ALK L1196M); cancer research potential.Formula:C31H35ClF2N8O2SColor and Shape:SolidMolecular weight:657.18Con B-1
CAS:ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells .Formula:C38H52ClN7O6SColor and Shape:SolidMolecular weight:770.38RIPK2-IN-1
CAS:RIPK2-IN-1 (compound 18f) is a potent inhibitor of RIPK2 (IC50: 51 nM) and also inhibits ALK2 (IC50: 5 nM).Formula:C23H27N5O3SColor and Shape:SolidMolecular weight:453.56ALK-IN-21
CAS:ALK-IN-21 (B10) inhibits ALK WT (IC50: 4.59nM), L1196M (2.07nM), G1202R (5.95nM); curbs Karpas299, H2228 cell growth; for ALCL research.Formula:C35H45ClN6O6S4Color and Shape:SolidMolecular weight:809.48ALK5-IN-26
CAS:ALK5-IN-26 (EX-22) is an ALK (Activin receptor-like kinase) inhibitor. ALK5-IN-26 inhibits ALK5 (IC50 ≤ 1 nM).Formula:C24H25FN8Color and Shape:SolidMolecular weight:444.51ALK-IN-22
CAS:ALK-IN-22 suppresses ALK and mutants (IC50: 2.3-3.7 nM), hinders phosphorylation, and induces apoptosis in tumor studies.Formula:C24H24ClN7O2Color and Shape:SolidMolecular weight:477.95OD36
CAS:OD36: Potent RIPK2 inhibitor, IC50=5.3 nM; hinders ALK2 signaling and osteogenesis, KD=37 nM; targets ALK2 ATP pocket.Formula:C16H15ClN4O2Purity:99.45%Color and Shape:SolidMolecular weight:330.77TGFBR1-IN-1
CAS:TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).Formula:C23H17N5O2SPurity:98%Color and Shape:SolidMolecular weight:427.48OD36 hydrochloride
CAS:OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficientlyFormula:C16H16Cl2N4O2Purity:99.85%Color and Shape:SolidMolecular weight:367.23KRCA-0713
CAS:KRCA-0713 is a ALK inhibitor.Formula:C26H32ClN5O3SPurity:98%Color and Shape:SolidMolecular weight:530.08J-1048
CAS:J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/Formula:C23H17FN6S2Color and Shape:SolidMolecular weight:460.55
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