ALK
ALK inhibitors are compounds that specifically target and inhibit Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase involved in the development and progression of certain cancers, including non-small cell lung cancer and neuroblastoma. By inhibiting ALK, these compounds block signaling pathways that promote tumor cell growth and survival. At CymitQuimica, we offer ALK inhibitors to support your research in oncology, targeted cancer therapies, and signal transduction.
Found 158 products for "ALK".
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Belizatinib
CAS:Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.Formula:C33H44FN5O3Purity:99.33% - 99.44%Color and Shape:SolidMolecular weight:577.7326HG-14-10-04
CAS:HG-14-10-04 is a potent and specific ALK inhibitor.Formula:C29H34ClN7OPurity:99.75% - >99.99%Color and Shape:White SolidMolecular weight:532.08Ensartinib hydrochloride
CAS:Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFormula:C26H29Cl4FN6O3Purity:98.73%Color and Shape:SolidMolecular weight:634.357X-376
CAS:X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase ALK with potential antineoplastic activity.Formula:C25H25Cl2FN6O3Purity:97.87%Color and Shape:SolidMolecular weight:547.409SB-431542
CAS:SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective.Formula:C22H16N4O3Purity:99.03% - >99.99%Color and Shape:Yellow SolidMolecular weight:384.39Repotrectinib
CAS:Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01/5.3/1.08/1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.Formula:C18H18FN5O2Purity:99.85% - >99.99%Color and Shape:SolidMolecular weight:355.3662LDN-212854
CAS:LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors.Formula:C25H22N6Purity:98% - 98.71%Color and Shape:White SolidMolecular weight:406.4824Blu-782
CAS:Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)Formula:C31H42N6O4Purity:99.51%Color and Shape:SolidMolecular weight:562.703SB 525334
CAS:SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).Formula:C21H21N5Purity:98.39% - ≥95%Color and Shape:SolidMolecular weight:343.42LDN-193189 HCl
CAS:LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor.Formula:C25H23ClN6Purity:99.49% - 99.53%Color and Shape:SolidMolecular weight:442.943Vactosertib Hydrochloride
CAS:Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.Formula:C22H19ClFN7Purity:98.03%Color and Shape:White SolidMolecular weight:435.885A 83-01 sodium salt
CAS:A 83-01 sodium salt inhibits ALK5, ALK4, and ALK7 kinases with IC50s: 12, 45, 7.5 nM.Formula:C25H19N5NaSColor and Shape:SolidMolecular weight:444.51AZ 12799734
CAS:AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.Formula:C18H18N4O3SPurity:98.95%Color and Shape:SolidMolecular weight:370.43SB-505124 hydrochloride
CAS:SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.Formula:C20H22ClN3O2Purity:98.64%Color and Shape:Yellow SolidMolecular weight:371.86Crizotinib-D5
CAS:Crizotinib-D5 is a deuterated compound of Crizotinib. Crizotinib (T1661) has a CAS number of 877399-52-5. Crizotinib (T1661) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.Formula:C21H17D5Cl2FN5OMolecular weight:455.37Alectinib-D8
CAS:Alectinib-D8 is a deuterated compound of Alectinib. Alectinib (T1936) has a CAS number of 1256580-46-7. CH5424802 is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity.Formula:C30H26D8N4O2Molecular weight:490.67ALK/ROS1-IN-5
ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.Formula:C32H28F2N4O3Color and Shape:SolidMolecular weight:554.586ALK5-IN-79
CAS:ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.Formula:C23H27N7OColor and Shape:SolidMolecular weight:417.51Prafnosbart
CAS:Prafnosbart is an anti-ACVR1 (ALK2) antibody used for research on Fibrodysplasia Ossificans Progressiva (FOP).Color and Shape:LiquidALKBH5-IN-3
CAS:ALKBH5-IN-3 (Compound 20m) is a selective ALKBH5 inhibitor (IC50=21 nM), effectively stabilizes ALKBH5 in HepG2 cells and elevates m6A levels in intact cells.Formula:C11H7F3N2O3Purity:98.32%Color and Shape:Yellow SolidMolecular weight:272.18
