ALK
ALK inhibitors are compounds that specifically target and inhibit Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase involved in the development and progression of certain cancers, including non-small cell lung cancer and neuroblastoma. By inhibiting ALK, these compounds block signaling pathways that promote tumor cell growth and survival. At CymitQuimica, we offer ALK inhibitors to support your research in oncology, targeted cancer therapies, and signal transduction.
Found 112 products of "ALK"
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CJ-2360
CAS:<p>CJ-2360 is a potent ALK inhibitor, effective on wild-type and various mutants, with IC50 values ranging from 2.2 to 8.9 nM, also targeting 468 kinases.</p>Formula:C27H30FN5O2Color and Shape:SolidMolecular weight:475.56ALK-IN-22
CAS:<p>ALK-IN-22 suppresses ALK and mutants (IC50: 2.3-3.7 nM), hinders phosphorylation, and induces apoptosis in tumor studies.</p>Formula:C24H24ClN7O2Color and Shape:SolidMolecular weight:477.95RIPK2-IN-1
CAS:<p>RIPK2-IN-1 (compound 18f) is a potent inhibitor of RIPK2 (IC50: 51 nM) and also inhibits ALK2 (IC50: 5 nM).</p>Formula:C23H27N5O3SColor and Shape:SolidMolecular weight:453.56ALK-IN-21
CAS:<p>ALK-IN-21 (B10) inhibits ALK WT (IC50: 4.59nM), L1196M (2.07nM), G1202R (5.95nM); curbs Karpas299, H2228 cell growth; for ALCL research.</p>Formula:C35H45ClN6O6S4Color and Shape:SolidMolecular weight:809.48Con B-1
CAS:<p>ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells .</p>Formula:C38H52ClN7O6SColor and Shape:SolidMolecular weight:770.38SMU-B
CAS:<p>SMU-B is a well-tolerated c-Met/ALK dual inhibitor.</p>Formula:C26H25Cl2FN4O2Purity:98%Color and Shape:SolidMolecular weight:515.41Ficonalkib
CAS:<p>Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.</p>Formula:C29H39N7O3SColor and Shape:SolidMolecular weight:565.73ALK5-IN-30
CAS:<p>ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).</p>Formula:C24H25FN8Color and Shape:SolidMolecular weight:444.51XST-14
CAS:<p>XST-14 is a ULK1 inhibitor.XST-14 induces apoptosis and inhibits the growth of HCC cells.</p>Formula:C16H21NO4Purity:99.84% - 99.84%Color and Shape:SolidMolecular weight:291.34TRK/ALK-IN-1
<p>TRK/ALK-IN-1: Potent dual TRK & ALK inhibitor; IC50s: 2.2nM (TRKA), 9.3nM (ALK WT), 38nM (ALK L1196M); cancer research potential.</p>Formula:C31H35ClF2N8O2SColor and Shape:SolidMolecular weight:657.18ALK5-IN-29
CAS:<p>ALK5-IN-29: selective ALK inhibitor, IC50 ≤ 10 nM, curbs tumor growth, aids in cancer research.</p>Formula:C24H25FN8Color and Shape:SolidMolecular weight:444.51TP0427736 hydrochloride
CAS:<p>TP0427736 hydrochloride is a novel and selective ALK5 inhibitor, capable of inhibiting Smad2/3 phosphorylation in A549 cells.</p>Formula:C14H11ClN4S2Purity:98.99%Color and Shape:SolidMolecular weight:334.85UNC5293
CAS:<p>UNC5293: potent oral MERTK inhibitor, Ki=190 pM, IC50=0.9 nM; selective vs Axl/Tyro3/Flt3; good mouse PK; used in leukemia research.</p>Formula:C30H42N6O2Color and Shape:SolidMolecular weight:518.69ALK-IN-6
CAS:<p>ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).</p>Formula:C26H29ClD3N5O3SPurity:98%Color and Shape:SolidMolecular weight:533.1ALK/EGFR-IN-3
CAS:<p>ALK/EGFR-IN-3 is a dual ALK and EGFR inhibitor that demonstrates potent anti-proliferative effects on various cancer cell lines, including H1975, PC9, and Baf3-</p>Formula:C27H34ClN7O3SColor and Shape:SolidMolecular weight:572.12ALK/ROS1-IN-1
CAS:<p>ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).</p>Formula:C30H35F3N6O3Purity:98%Color and Shape:SolidMolecular weight:584.63ALK/EGFR-IN-1
CAS:<p>ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation.</p>Formula:C27H34ClN7O3SPurity:98%Color and Shape:SolidMolecular weight:572.12ALK/EGFR-IN-2
CAS:<p>ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells.</p>Formula:C27H34ClN7O3SColor and Shape:SolidMolecular weight:572.12ALK-IN-27
CAS:<p>Neladalkib (NVL-655) is an ALK inhibitor with antitumor activity for the study of non-small cell cancers.</p>Formula:C23H22ClFN6OPurity:99.71%Color and Shape:SolidMolecular weight:452.91KER047
CAS:<p>ALK2-IN-4, a highly effective ALK2 inhibitor.</p>Formula:C26H30FN7OPurity:98.49% - >99.99%Color and Shape:SolidMolecular weight:475.56
