c-Kit
c-Kit inhibitors are compounds that block the activity of the Stem Cell Factor Receptor (c-Kit), a tyrosine kinase that plays a pivotal role in cell survival, proliferation, and differentiation, particularly in hematopoietic cells. Mutations in c-Kit are linked to various cancers, including gastrointestinal stromal tumors (GIST) and leukemia. At CymitQuimica, we provide c-Kit inhibitors to support your research in oncology, hematology, and stem cell biology.
Found 117 products of "c-Kit"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
AC710
CAS:AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).Formula:C31H42N6O4Purity:99.67%Color and Shape:SolidMolecular weight:562.7APcK110
CAS:"APcK110, a potent novel Kit inhibitor, outperforms imatinib/dasatinib in halting OCI/AML3 and HMC1.2 cell growth, also inhibiting Kit-signaling."Formula:C20H16FN3O2Color and Shape:SolidMolecular weight:349.36KBP-7018
CAS:KBP-7018 is a selective TKI targeting c-KIT, RET, and PDGFR for mechanistic studies of fibrotic signaling and kinase-driven diseases.Formula:C31H30N4O5Purity:99.73%Color and Shape:SolidMolecular weight:538.59c-Kit-IN-2
CAS:c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (Formula:C25H29N9O2SPurity:98%Color and Shape:SolidMolecular weight:519.62Chiauranib
CAS:Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.
Formula:C27H21N3O3Purity:99.22%Color and Shape:SolidMolecular weight:435.47Tafetinib
CAS:Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.Formula:C24H29FN4O2Purity:96.23%Color and Shape:SolidMolecular weight:424.51Agerafenib hydrochloride
CAS:Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).Formula:C24H23ClF3N5O5Purity:98%Color and Shape:SolidMolecular weight:553.92N-desmethyl Regorafenib N-oxide
CAS:N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.Formula:C20H13ClF4N4O4Color and Shape:SolidMolecular weight:484.79Henatinib
CAS:Henatinib: orally active multi-kinase inhibitor targeting VEGFR-2, c-kit, PDGFR with antitumor effects.Formula:C25H29FN4O4Color and Shape:SolidMolecular weight:468.52Labuxtinib
CAS:Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].Formula:C20H16FN5O2Purity:99.95%Color and Shape:SolidMolecular weight:377.37Ref: TM-T79851
1mg132.00€5mg319.00€10mg512.00€25mg1,018.00€50mg1,468.00€100mg1,972.00€200mg2,655.00€1mL*10mM (DMSO)354.00€SIM010603
CAS:SIM010603, an oral RTK inhibitor, targets Kit, VEGFR-2, PDGFR-β, RET, FLT3 (IC50: 5.0-68.1 nmol/l), inhibits cell proliferation and angiogenesis.Formula:C22H25FN4O2Color and Shape:SolidMolecular weight:396.46AMG-25
CAS:AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.Formula:C23H17N5O2Purity:98.16%Color and Shape:SolidMolecular weight:395.41Protein kinase inhibitor 10
CAS:Protein kinase inhibitor 10 is a protein kinase inhibitor with IC50 values of 28.9 μM, 13.6 μM, and 2.41 μM for TAM receptors, FAK, and KIT, respectively. It can inhibit abnormal and excessive cell proliferation, showing potential for research in the field of cancer treatment.Formula:C14H9FN6S2Color and Shape:SolidMolecular weight:344.39c-Kit-IN-8
CAS:C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.Formula:C24H26FN5O4Color and Shape:SolidMolecular weight:467.49c-Kit-IN-7
CAS:c-Kit-IN-7 (compound 104) serves as an effective inhibitor of c-Kit, exhibiting an IC50 of 10 nM or less. It plays a crucial role in cancer research.Formula:C27H32FN7O3Color and Shape:SolidMolecular weight:521.59c-Kit/CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.
Color and Shape:Lyophilized PowderMolecular weight:58.50 kDa (predicted); 87.1 kDa (reducing conditions)VEGFR-IN-1
CAS:VEGFR inhibitorFormula:C19H16ClN3OPurity:98%Color and Shape:SolidMolecular weight:337.8
