Ubiquitination
Ubiquitination inhibitors are compounds that interfere with the process of ubiquitination, where proteins are tagged with ubiquitin molecules for degradation by the proteasome. These inhibitors are critical for studying protein turnover, signal transduction, and the regulation of various cellular processes. Ubiquitination plays a key role in many diseases, including cancer, neurodegenerative disorders, and immune system dysfunction. By modulating ubiquitination, these inhibitors can provide insights into the mechanisms of disease and open up new avenues for therapeutic intervention. At CymitQuimica, we offer a wide selection of high-quality ubiquitination inhibitors to support your research in cell biology, proteomics, and drug discovery.
Subcategories of "Ubiquitination"
Found 69 products for "Ubiquitination".
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NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Formula:C27H28N4O3S2Purity:99.05% - 99.85%Color and Shape:SolidMolecular weight:520.67ML240
CAS:ML240 is a selective, ATP-competitive p97 inhibitor.Formula:C23H20N6OPurity:99.73% - >99.99%Color and Shape:White SolidMolecular weight:396.44Ref: TM-T3535
1mg35.00€2mg50.00€5mg77.00€1mL*10mM (DMSO)84.00€10mg105.00€25mg178.00€50mg295.00€100mg477.00€200mg677.00€ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Formula:C23H25ClN4OPurity:99.91% - 99.97%Color and Shape:SolidMolecular weight:408.92MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Formula:C12H11N3O4SPurity:99.39%Color and Shape:SolidMolecular weight:293.3Ref: TM-T8773
1mg52.00€5mg92.00€1mL*10mM (DMSO)103.00€10mg138.00€25mg245.00€50mg363.00€100mg515.00€200mg700.00€WSB1 Degrader 1
CAS:WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.Formula:C21H22N2O2Purity:98.57%Color and Shape:SolidMolecular weight:334.41PR-619
CAS:PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.Formula:C7H5N5S2Purity:97.25% - >99.99%Color and Shape:White SolidMolecular weight:223.28BC-1382
CAS:BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).Formula:C23H29N3O5SPurity:99.15% - 99.94%Color and Shape:SolidMolecular weight:459.56Ref: TM-T8564
1mg81.00€5mg170.00€1mL*10mM (DMSO)240.00€10mg250.00€25mg505.00€50mg730.00€100mg1,018.00€200mg1,369.00€ML241
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.Formula:C23H24N4OPurity:98%Color and Shape:SolidMolecular weight:372.46COH000
CAS:COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).Formula:C25H25NO5Purity:99.23%Color and Shape:SolidMolecular weight:419.47Ref: TM-T5199
1mg170.00€5mg371.00€1mL*10mM (DMSO)409.00€10mg537.00€25mg964.00€50mg1,333.00€100mg1,882.00€ICCB-19 hydrochloride
CAS:ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.Formula:C12H22ClN3OSPurity:99.3%Color and Shape:White SolidMolecular weight:291.84Ref: TM-T8931L
5mg34.00€1mL*10mM (DMSO)34.00€10mg50.00€25mg90.00€50mg138.00€100mg198.00€200mg296.00€500mg469.00€LANOSTEROL
CAS:Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.Formula:C30H50OPurity:97.99% - 99.67%Color and Shape:SolidMolecular weight:426.72GS143
CAS:GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.Formula:C28H19FN2O4Purity:97.67%Color and Shape:SolidMolecular weight:466.46Ref: TM-T25465
2mg35.00€5mg55.00€1mL*10mM (DMSO)57.00€10mg87.00€25mg161.00€50mg245.00€100mg358.00€200mg520.00€Subasumstat
CAS:Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.Formula:C25H28ClN5O5S2Purity:97.02% - 98.22%Color and Shape:Yellow SolidMolecular weight:578.1DKM 2-93
CAS:DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).Formula:C11H14ClNO3Purity:98.37% - 99.39%Color and Shape:White SolidMolecular weight:243.69TCID
CAS:TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Formula:C9H2Cl4O2Purity:98.87% - 99.34%Color and Shape:SolidMolecular weight:283.92BI8626
CAS:BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cellsFormula:C25H28N8Purity:98.66%Color and Shape:Yellow ViscousMolecular weight:440.54Ref: TM-T14569
1mg87.00€5mg178.00€1mL*10mM (DMSO)203.00€10mg260.00€25mg462.00€50mg655.00€100mg887.00€200mg1,198.00€UP12
CAS:UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formula:C23H16ClN3O3SColor and Shape:SolidMolecular weight:449.91RNF5 agonist 1
CAS:RNF5 agonist 1 (analog-1), a structural analog of the RNF5 inhibitor inh-02, is a potent RNF5 agonist. In CFBE41o- cells expressing F508del-CFTR, RNF5 agonist 1 enhances the ubiquitination of ATG4B.Formula:C22H18N4SColor and Shape:SolidMolecular weight:370.47FX12
CAS:FX12 acts as a selective inhibitor and degrader of the RNF5 E3 ubiquitin ligase. It directly binds to RNF5, inhibiting its E3 activity in vitro and facilitates the proteasomal degradation of RNF5 in cells through ERAD.Formula:C10H8O4SColor and Shape:SolidMolecular weight:224.23UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Formula:C20H15ClN2O5SColor and Shape:SolidMolecular weight:430.86
