Ubiquitination
Ubiquitination inhibitors are compounds that interfere with the process of ubiquitination, where proteins are tagged with ubiquitin molecules for degradation by the proteasome. These inhibitors are critical for studying protein turnover, signal transduction, and the regulation of various cellular processes. Ubiquitination plays a key role in many diseases, including cancer, neurodegenerative disorders, and immune system dysfunction. By modulating ubiquitination, these inhibitors can provide insights into the mechanisms of disease and open up new avenues for therapeutic intervention. At CymitQuimica, we offer a wide selection of high-quality ubiquitination inhibitors to support your research in cell biology, proteomics, and drug discovery.
Subcategories of "Ubiquitination"
Found 69 products for "Ubiquitination".
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TRIM25 ligand-1
CAS:TRIM25 ligand-1 is a covalent TRIM25 ligand enhancing TRIM25 auto-ubiquitination activity.Formula:C21H23ClN2O2Purity:99.75%Molecular weight:370.87UP158
CAS:UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Formula:C17H17ClN4O2Color and Shape:SolidMolecular weight:344.795UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Formula:C20H15ClN2O5SColor and Shape:SolidMolecular weight:430.86DT204
CAS:DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.Formula:C19H13BrClNO5SPurity:99.97%Color and Shape:SolidMolecular weight:482.73CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].Formula:C24H24N6OPurity:97.66%Color and Shape:SolidMolecular weight:412.49CC0651
CAS:CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).Formula:C20H21Cl2NO6Purity:99.03%Color and Shape:White SolidMolecular weight:442.29Cbl-b-IN-13
CAS:Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].Formula:C29H30F3N5O2Purity:98%Color and Shape:SolidMolecular weight:537.58PYZD-4409
CAS:PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.Formula:C14H7ClFN3O5Purity:99.71%Color and Shape:SolidMolecular weight:351.67UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Formula:C30H32F2N6O3SPurity:98%Color and Shape:SolidMolecular weight:594.68DI-591
CAS:DI-591 selectively inhibits DCN1-UBC12 interaction and cullin 3 neddylation.Formula:C31H47N5O4SColor and Shape:White SolidMolecular weight:585.80Ubiquitination-IN-1
CAS:Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).Formula:C21H14F3N3O2SPurity:98.39% - 99.88%Color and Shape:SolidMolecular weight:429.42Ref: TM-T13244
5mg66.00€1mL*10mM (DMSO)73.00€10mg90.00€25mg165.00€50mg264.00€100mg395.00€500mg888.00€Cbl-b-IN-12
CAS:Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100Formula:C28H29F3N6O2Purity:98%Color and Shape:SolidMolecular weight:538.56UC-764864
CAS:UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling inFormula:C19H18N2OSPurity:99.3%Color and Shape:SolidMolecular weight:322.42Cbl-b-IN-9
CAS:Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximalFormula:C30H33F3N6O2Purity:98%Color and Shape:SolidMolecular weight:566.62Cbl-b-IN-7
CAS:Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50sFormula:C29H31F4N5O2Purity:98%Color and Shape:SolidMolecular weight:557.58BC-1293
CAS:BC-1293 inhibits FBXO24, stabilizes DARS2, and elevates cytokines in mice, showing immunostimulatory potential for immune modulation research.Formula:C26H28N4O4SPurity:98.40%Color and Shape:White SolidMolecular weight:492.59p97-IN-1
CAS:p97-IN-1 is an orally active inhibitor of p97 with an IC50 of 26 nM. It significantly impedes the proliferation of tumor cells and is applicable for research in acute myeloid leukemia (AML).Formula:C25H26N6O2Color and Shape:SolidMolecular weight:442.51VCP/p97 IN-2
CAS:VCP/p97 IN-2 (Compound V13) is a VCP/p97 inhibitor with an IC50 of 32 nM for p97. It exhibits excellent antitumor activity, significantly suppressing tumor growth in a Molm-13 xenograft mouse model. VCP/p97 IN-2 is applicable for research in acute myeloid leukemia (AML).Formula:C24H23N5O2Color and Shape:SolidMolecular weight:413.47Yucasin
CAS:Yucasin is a highly potent inhibitor of auxin (IAA) biosynthesis that blocks the tryptophan-dependent pathway by specifically inhibiting the activity of YUCCA.Formula:C8H6ClN3SPurity:95.10%Color and Shape:White SolidMolecular weight:211.671NSC20116
CAS:NSC20116 is a uracil derivative that specifically targets the Set-and-Ring (SRA) domain of the oncogene UHRF1. It binds to the 5-methylcytosine (5mC) recognition pocket within the UHRF1SRA domain, with a dissociation constant (Kd) of 362 nM. NSC20116 is applicable for cancer research.Formula:C4H4N4O3Molecular weight:156.1
