Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1424 products of "Autophagy"
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JMS-17-2 hydrochloride
CAS:<p>JMS-17-2 hydrochloride: potent CX3CR1 blocker, IC50 of 0.32 nM, hinders breast cancer metastasis.</p>Formula:C25H27Cl2N3OColor and Shape:SolidMolecular weight:456.41Bergapten
CAS:<p>Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.</p>Formula:C12H8O4Purity:99.48% - ≥95%Color and Shape:Needles From Alcohol; Soln In Sulfuric Acid Is Yellow-Gold Physical Description Grayish-White Micr°Crystalline Powder Or Yellow Fluffy Solid (Ntp 1992)Molecular weight:216.19IOWH-032
CAS:<p>IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.</p>Formula:C22H15Br2N3O4Purity:98.92% - ≥95%Color and Shape:SolidMolecular weight:545.18Sinomenine
CAS:<p>Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.</p>Formula:C19H23NO4Purity:99.02% - 99.73%Color and Shape:White PowderMolecular weight:329.39Momelotinib
CAS:<p>Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.</p>Formula:C23H22N6O2Purity:97.47% - 99.56%Color and Shape:SolidMolecular weight:414.46Tanespimycin
CAS:<p>Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!</p>Formula:C31H43N3O8Purity:99.07% - 99.83%Color and Shape:Dark Purple SolidMolecular weight:585.69Dantrolene
CAS:<p>Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.</p>Formula:C14H10N4O5Purity:99.97%Color and Shape:Crystals From Aq DimethylformamideMolecular weight:314.25Pinocembrin
CAS:<p>Pinocembrin (5,7-Dihydroxyflavanone) is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.</p>Formula:C15H12O4Purity:99.61% - >99.99%Color and Shape:SolidMolecular weight:256.25MW-150 dihydrochloride dihydrate
CAS:<p>MW-150: selective CNS-penetrant p38α MAPK inhibitor, orally active, Ki 101 nM, blocks MK2 phosphorylation in glia.</p>Formula:C24H29Cl2N5O2Color and Shape:SolidMolecular weight:490.43Isorhapontigenin
CAS:<p>Isorhapontigenin: a methoxylated stilbenoid isomer of rhapontigenin, similar to resveratrol, present in Gnetum spp. and Aiphanes aculeata seeds.</p>Formula:C15H14O4Purity:98.49% - 99.85%Color and Shape:Off White Crystals PowerMolecular weight:258.27Cediranib
CAS:<p>Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, c-Kit, and more selective for VEGFR.</p>Formula:C25H27FN4O3Purity:97.21% - 99.94%Color and Shape:SolidMolecular weight:450.51Tubastatin A Hydrochloride
CAS:<p>Tubastatin A Hydrochloride (TSA HCl) is an effective and specific HDAC6 inhibitor (IC50: 15 nM).</p>Formula:C20H21N3O2·HClPurity:97.24% - 99.15%Color and Shape:SolidMolecular weight:371.86Quizartinib
CAS:<p>Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.</p>Formula:C29H32N6O4SPurity:98% - 99.42%Color and Shape:SolidMolecular weight:560.67Apigenin
CAS:<p>Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants.</p>Formula:C15H10O5Purity:97.64% - 99.66%Color and Shape:Yellow Needles From Aqueous Pyridine SolidMolecular weight:270.24U0126-EtOH
CAS:<p>U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity, inhibit autophagy. Low-Cost!</p>Formula:C18H16N6S2·C2H6OPurity:99.72% - 99.88%Color and Shape:SolidMolecular weight:426.6Tenovin-6
CAS:<p>Tenovin-6 is a p53 transcriptional activity agonist.</p>Formula:C25H34N4O2SPurity:97.71% - >99.99%Color and Shape:SolidMolecular weight:454.63AZD1208
CAS:<p>AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.</p>Formula:C21H21N3O2SPurity:97.24% - 99.83%Color and Shape:SolidMolecular weight:379.48UBCS039
CAS:<p>UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)</p>Formula:C16H13N3Purity:98.31%Color and Shape:SolidMolecular weight:247.29Ligustilide
CAS:<p>3-Butylidene-4,5-dihydrophthalide is an effective constituent extracted from Angelica sinensis.</p>Formula:C12H14O2Purity:96.03% - 98.14%Color and Shape:Yellow Brown PowderMolecular weight:190.24Pinosylvin
CAS:<p>Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.</p>Formula:C14H12O2Purity:99.89% - 99.91%Color and Shape:SolidMolecular weight:212.24Berbamine dihydrochloride
CAS:<p>Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.</p>Formula:C37H42Cl2N2O6Purity:95% - 99.99%Color and Shape:SolidMolecular weight:681.65Isosorbide Mononitrate
CAS:<p>Isosorbide Mononitrate (Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.</p>Formula:C6H9NO6Purity:98.16%Color and Shape:Isosorbide-5-Mononitrate Is A Crystalline Solid It Is Very Flammable And May Be Toxic By IngestionMolecular weight:191.14Entinostat
CAS:<p>Entinostat (MS-275) is an HDAC class I with oral activity. Entinostat has antitumor activity. Cost-effective and quality-assured.</p>Formula:C21H20N4O3Purity:98% - 99.74%Color and Shape:SolidMolecular weight:376.41CCT128930 hydrochloride
CAS:<p>CCT128930 hydrochloride: Potent AKT inhibitor (IC50=6 nM), 28x selective over PKA, 20x over p70S6K, induces cell cycle arrest & DNA damage.</p>Formula:C18H21Cl2N5Purity:98.55%Color and Shape:SolidMolecular weight:378.3Gartanin
CAS:<p>Gartanin enhances androgen receptor degradation and has neuroprotective effects by boosting HO-1, AMPK, SIRT1, and PGC-1α pathways.</p>Formula:C23H24O6Purity:99.64% - 99.85%Color and Shape:SolidMolecular weight:396.43PTC-209 hydrobromide
CAS:<p>PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in</p>Formula:C17H13Br2N5OS·HBrPurity:99.91%Color and Shape:SolidMolecular weight:576.1Autogramin-1
CAS:<p>Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.</p>Formula:C23H27N5O5SPurity:97.69% - 99.25%Color and Shape:SolidMolecular weight:485.56XL388
CAS:<p>XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.</p>Formula:C23H22FN3O4SPurity:99.39% - 99.53%Color and Shape:SolidMolecular weight:455.5NSC 185058
CAS:<p>NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.</p>Formula:C11H9N3SPurity:99.27%Color and Shape:SolidMolecular weight:215.27PF-543 hydrochloride
CAS:<p>PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2</p>Formula:C27H32ClNO4SPurity:98.9% - 99.93%Color and Shape:SolidMolecular weight:502.1URMC-099
CAS:<p>URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.</p>Formula:C27H27N5Purity:99.32% - 99.98%Color and Shape:SolidMolecular weight:421.54Autocamtide-2-related inhibitory peptide
CAS:<p>Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.</p>Formula:C64H116N22O19Purity:>99.99%Color and Shape:SolidMolecular weight:1497.74PF-06447475
CAS:<p>PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.</p>Formula:C17H15N5OPurity:98.61% - 99.62%Color and Shape:SolidMolecular weight:305.33Onjisaponin B
CAS:<p>Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-</p>Formula:C75H112O35Purity:99.20% - 99.972%Color and Shape:SolidMolecular weight:1573.67A-867744
CAS:<p>A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).</p>Formula:C20H19ClN2O3SPurity:95.66%Color and Shape:SolidMolecular weight:402.89MRT68921
CAS:<p>MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.</p>Formula:C25H34N6OPurity:99.23%Color and Shape:SolidMolecular weight:434.58TA-01
CAS:<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Formula:C20H12F3N3Purity:99.55% - 99.94%Color and Shape:SolidMolecular weight:351.32PI3Kδ-IN-15
CAS:<p>CAL-101 (Idelalisib) is a selective inhibitor of p110δ; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ.</p>Formula:C21H16FN7OPurity:99.61%Color and Shape:SolidMolecular weight:401.4Lanatoside C
CAS:<p>Lanatoside C, a cardiac glycoside, treats heart failure and arrhythmia; taken orally or IV.</p>Formula:C49H76O20Purity:98.3% - >99.99%Color and Shape:SolidMolecular weight:985.12Spautin-1
CAS:<p>Spautin-1 is an autophagy inhibitor that can suppress the deubiquitination activity of ubiquitin-specific peptidase USP10 and USP13. Cost-effective and quality-assured.</p>Formula:C15H11F2N3Purity:97.69% - 98.99%Color and Shape:SolidMolecular weight:271.26Sofalcone
CAS:<p>Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.</p>Formula:C27H30O6Purity:97.55%Color and Shape:SolidMolecular weight:450.52Hesperadin
CAS:<p>Hesperadin(IC50=250 nM) effectively inhibits Aurora B.</p>Formula:C29H32N4O3SPurity:98.04% - 99.44%Color and Shape:SolidMolecular weight:516.65Nitroprusside disodium dihydrate
CAS:<p>Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.</p>Formula:C5H4FeN6Na2O3Purity:98%Color and Shape:Bright RedMolecular weight:297.95UNC1999
CAS:<p>UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).</p>Formula:C33H43N7O2Purity:99.19% - >99.99%Color and Shape:SolidMolecular weight:569.74Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18Ivacaftor
CAS:<p>Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,</p>Formula:C24H28N2O3Purity:99% - 99.98%Color and Shape:SolidMolecular weight:392.49α-Thujone
CAS:<p>α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.</p>Formula:C10H16OPurity:97.02% - 98.41%Color and Shape:Less Or Almost Colorless Liquid With A Menthol- Like Odor (Albert-Puleo 1978; Budavari 1996) Colorless Or Almost Colorless Liquid With A Menthol- Like Odor (Albert-Puleo 1978; Budavari 1996)Molecular weight:152.23Biochanin A
CAS:<p>Biochanin A: an isoflavone from red clover with anticancer properties and inhibits FAAH.</p>Formula:C16H12O5Purity:97.1% - 98.97%Color and Shape:SolidMolecular weight:284.26Urolithin A
CAS:<p>Urolithin A is a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Cost-effective and quality-assured.</p>Formula:C13H8O4Purity:99.14% - 99.67%Color and Shape:SolidMolecular weight:228.2Omipalisib
CAS:<p>Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.</p>Formula:C25H17F2N5O3SPurity:98% - 99.8%Color and Shape:SolidMolecular weight:505.5
