Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1504 products of "Autophagy"
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PFE-360
CAS:PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
Formula:C16H16N6OPurity:98.14% - 99.73%Color and Shape:SolidMolecular weight:308.34Mocetinostat
CAS:Mocetinostat (MG0103) is an orally available HDAC inhibitor with most potency for HDAC1 (IC50: 0.15 μM), 2- to 10- fold selectivity against HDAC2/3/11.Formula:C23H20N6OPurity:99% - 99.21%Color and Shape:SolidMolecular weight:396.44Sertaconazole
CAS:Sertaconazole is a broad-spectrum antifungal.Formula:C20H15Cl3N2OSPurity:99.483%Color and Shape:SolidMolecular weight:437.77Ref: TM-T50005
5mg55.00€10mg78.00€25mg119.00€50mg172.00€100mg259.00€200mg388.00€1mL*10mM (DMSO)79.00€NAcM-OPT HCl(2089293-61-6 free base)
CAS:NAcM-OPT HCL: Oral DCN1 inhibitor targeting N-Acetyl-UBE2M & DCN1, IC50=79 nM.Formula:C23H30Cl3N3OPurity:99.43%Color and Shape:SolidMolecular weight:470.86Ref: TM-T9140
2mg35.00€5mg49.00€10mg87.00€25mg140.00€50mg226.00€100mg370.00€500mg879.00€1mL*10mM (DMSO)93.00€AZD-8055
CAS:AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.Formula:C25H31N5O4Purity:98% - 99.69%Color and Shape:SolidMolecular weight:465.54ARRY-797
CAS:ARRY-797 (ARRY-371797) is a potent and selective p38α inhibitor and inhibits LPS-Induced IL-6.
Formula:C22H26F2N4O2Purity:98.97% - 99.81%Color and Shape:SolidMolecular weight:416.46Sulfosuccinimidyl oleate sodium
CAS:Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that inhibits fatty acid transport into cells.Cost-effective and quality-assured.Formula:C22H36NNaO7SPurity:96.53%Color and Shape:SolidMolecular weight:481.58Ref: TM-T13036L
1mg35.00€5mg69.00€10mg111.00€25mg177.00€50mg284.00€100mg447.00€200mg575.00€500mg888.00€Lamotrigine hydrate
CAS:Lamotrigine hydrate: oral anticonvulsant, blocks Na+ channels, stabilizes neurons, inhibits glutamate, treats epilepsy, focal seizure.Formula:C9H9Cl2N5OColor and Shape:SolidMolecular weight:274.11Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purity:98.03% - 99.61%Color and Shape:SolidMolecular weight:560.64Ref: TM-T3678
2mg42.00€5mg59.00€10mg88.00€25mg111.00€50mg168.00€100mg283.00€500mg692.00€1mL*10mM (DMSO)69.00€Quercetin
CAS:Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1.Formula:C15H10O7Purity:96.29% - 98.13%Color and Shape:Sensitive To Exposure To Air And Light Insoluble In Water Alcoholic Solutions Taste Very Bitter (Ntp 1992)Molecular weight:302.24Dronedarone
CAS:Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.Formula:C31H44N2O5SPurity:98.85% - 99.99%Color and Shape:SolidMolecular weight:556.76PF-04457845
CAS:PF-04457845 is a greatly and effctive FAAH inhibitor, and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM).Formula:C23H20F3N5O2Purity:>99.99%Color and Shape:SolidMolecular weight:455.43Ref: TM-T4323
2mg34.00€5mg50.00€10mg84.00€25mg155.00€50mg222.00€100mg396.00€200mg515.00€1mL*10mM (DMSO)55.00€MRT68921
CAS:MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.Formula:C25H34N6OPurity:99.23%Color and Shape:SolidMolecular weight:434.58KU-55933
CAS:KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.
Formula:C21H17NO3S2Purity:97.21% - >99.99%Color and Shape:SolidMolecular weight:395.49CGI-1746
CAS:CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.Formula:C34H37N5O4Purity:97.69% - 97.88%Color and Shape:SolidMolecular weight:579.69Tolvaptan
CAS:Tolvaptan (OPC-41061) is an orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia.
Formula:C26H25ClN2O3Purity:99.78% - >99.99%Color and Shape:SolidMolecular weight:448.94Telaglenastat hydrochloride
CAS:Telaglenastat (CB-839) HCl: First-in-class, oral GLS1 inhibitor, targets KGA/GAC, IC50 23-28 nM, triggers autophagy, anticancer.Formula:C26H25ClF3N7O3SColor and Shape:SolidMolecular weight:608.04SBE13
CAS:SBE13 is a selective and potent inhibitor of Plk1 (IC50: 200 pM). SBE13 has a weak effect on Plk2 or Plk3 with IC50 values of >66 μM and 875 nM respectively.Formula:C24H27ClN2O4Color and Shape:SolidMolecular weight:442.94Biochanin A
CAS:Biochanin A: an isoflavone from red clover with anticancer properties and inhibits FAAH.Formula:C16H12O5Purity:97.1% - 98.97%Color and Shape:SolidMolecular weight:284.26Nur77 modulator 1
CAS:Nur77 modulator 1: binds at 3.58 μM, boosts expression, alters location, triggers ER stress/autophagy, induces apoptosis, and fights hepatoma.Formula:C28H25N5O2SPurity:99.62%Color and Shape:SolidMolecular weight:495.6Ref: TM-T40130
1mg64.00€5mg140.00€10mg226.00€25mg373.00€50mg509.00€100mg702.00€200mg944.00€1mL*10mM (DMSO)153.00€KM11060
CAS:KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasmaFormula:C19H17Cl2N3O2SPurity:98.86%Color and Shape:SolidMolecular weight:422.33Pirarubicin HCl
CAS:Pirarubicin HCl, a less cardiotoxic doxorubicin analogue, hinders DNA replication and repairs by intercalating into DNA and inhibiting topoisomerase II.Formula:C32H38ClNO12Color and Shape:SolidMolecular weight:664.1Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formula:C14H18ClN3O2SPurity:99.54% - ≥95%Color and Shape:White SolidMolecular weight:327.83NUCC-390 dihydrochloride
CAS:NUCC-390, a selective CXCR4 agonist, promotes nerve repair by inducing CXCR4 internalization, opposite to AMD3100.Formula:C23H35Cl2N5OColor and Shape:SolidMolecular weight:468.46Venetoclax
CAS:Venetoclax (ABT-199) is a selective inhibitor of Bcl-2 (Ki < 0.010 nM), binding over 3 orders of magnitude less avidly to Bcl-xL, and Bcl-W (Kis = 48/245 nM).Formula:C45H50ClN7O7SPurity:98.00% - 99.97%Color and Shape:SolidMolecular weight:868.44EIPA
CAS:EIPA (L593754) is a TRPP3 channel inhibitor and an inhibitor of Na+/H+ exchange (NHE). EIPA inhibits megacytosis, promotes autophagy. Cost-effective and quality-assured.Formula:C11H18ClN7OPurity:96.62% - 99.981%Color and Shape:Off-White To Yellow SolidMolecular weight:299.76Ref: TM-TQ0157
2mg34.00€5mg47.00€10mg71.00€25mg101.00€50mg163.00€100mg231.00€200mg341.00€1mL*10mM (DMSO)52.00€Troglitazone
CAS:Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.Formula:C24H27NO5SPurity:98% - 99.8%Color and Shape:Yellow SolidMolecular weight:441.54Ref: TM-T3170
2mg42.00€5mg62.00€10mg88.00€25mg172.00€50mg305.00€100mg558.00€500mg1,169.00€1mL*10mM (DMSO)85.00€Glyphosate
CAS:Glyphosate (Atila) is an herbicide. It also is a possible carcinogen to humans.Formula:C3H8NO5PPurity:99.12% - 99.91%Color and Shape:White Crystals (Darkens) Ph (1% Solution In Water) 2 5 (Ntp 1992)Molecular weight:169.07GNE-7915 tosylate
CAS:GNE-7915 tosylate is a potent, selective, and brain-penetrant LRRK2 inhibitor, boasting an IC50 value of 9 nM.Formula:C26H29F4N5O6SColor and Shape:SolidMolecular weight:615.6Lapatinib tosylate
CAS:Lapatinib tosylate (GW572016) is an oral ErbB-2/EGFR inhibitor with IC50s of 10.2 nM (EGFR) & 9.8 nM (ErbB-2).Formula:C36H34ClFN4O7S2Color and Shape:SolidMolecular weight:753.26FIPI HCl
CAS:FIPI: Selective phospholipase D inhibitor, blocks mercury-induced lipid signals, protects aortic cells.Formula:C23H25ClFN5O2Color and Shape:SolidMolecular weight:457.93Fasudil hydrochloride hydrate
CAS:Fasudil HCl hydrate is a ROCK inhibitor that hinders mature CCM development and lowers portal pressure in cirrhotic rats.Formula:C28H38Cl2N6O5S2Color and Shape:SolidMolecular weight:673.67Retro-2
CAS:Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) is a plant toxin ricin inhibitor, it protects HeLa cells against Ricin, Stx1 and Stx2.
Formula:C19H16N2OSPurity:98.15%Color and Shape:SolidMolecular weight:320.41PHA-665752
CAS:PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.Formula:C32H34Cl2N4O4SPurity:97.05% - 98.82%Color and Shape:SolidMolecular weight:641.61Tacrolimus monohydrate
CAS:Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FKBP to form a complex.Formula:C44H71NO13Purity:97.07% - 98.05%Color and Shape:SolidMolecular weight:822.05Dorsomorphin
CAS:Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive.Formula:C24H25N5OPurity:98% - 99.06%Color and Shape:SolidMolecular weight:399.49Glucosamine sulfate
CAS:Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.Formula:C6H13NO5·H2SO4Purity:99.64%Color and Shape:White CrystalMolecular weight:277.25Lucanthone hydrochloride
CAS:Lucanthone hydrochloride is a novel acridine derivative which supresses autophagic degradation and triggers apoptosis in colon cancer cells.Formula:C20H25ClN2OSColor and Shape:SolidMolecular weight:376.94Cucurbitacin E
CAS:Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Formula:C32H44O8Purity:98.88% - 99.87%Color and Shape:SolidMolecular weight:556.69Ref: TM-T5S1467
1mg56.00€5mg109.00€10mg168.00€25mg284.00€50mg423.00€100mg610.00€1mL*10mM (DMSO)133.00€Vistusertib
CAS:Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.Formula:C25H30N6O3Purity:97.08% - 99.06%Color and Shape:SolidMolecular weight:462.54Ref: TM-T1961
1mg34.00€5mg71.00€10mg111.00€25mg170.00€50mg225.00€100mg358.00€200mg530.00€1mL*10mM (DMSO)79.00€Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18DBEQ
CAS:DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.Formula:C22H20N4Purity:98.93% - ≥95%Color and Shape:SolidMolecular weight:340.42Ref: TM-T1969
2mg34.00€5mg52.00€10mg85.00€25mg152.00€50mg264.00€100mg334.00€200mg494.00€1mL*10mM (DMSO)52.00€UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Formula:C16H13N3Purity:98.31%Color and Shape:SolidMolecular weight:247.29Ref: TM-T7679
1mg38.00€5mg77.00€10mg110.00€25mg215.00€50mg306.00€100mg429.00€200mg600.00€1mL*10mM (DMSO)95.00€Ataluren
CAS:Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.Formula:C15H9FN2O3Purity:99.16% - 99.84%Color and Shape:SolidMolecular weight:284.24Ref: TM-T1805
5mg35.00€10mg54.00€25mg88.00€50mg117.00€100mg178.00€200mg213.00€500mg359.00€1mL*10mM (DMSO)46.00€SRT 1720
CAS:SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.Formula:C25H23N7OSPurity:98.84%Color and Shape:SolidMolecular weight:469.56BAY 11-7082
CAS:BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM).Formula:C10H9NO2SPurity:98% - 99.92%Color and Shape:SolidMolecular weight:207.25Ref: TM-T1902
5mg48.00€10mg54.00€25mg90.00€50mg161.00€100mg251.00€200mg378.00€500mg627.00€1mL*10mM (DMSO)50.00€L-779450
CAS:L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.Formula:C20H14ClN3OPurity:≥95%Color and Shape:SolidMolecular weight:347.8Gemcitabine hydrochloride
CAS:Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis.Formula:C9H11F2N3O4·HClPurity:99.28% - 99.98%Color and Shape:White Crystalline Granular OdorlessMolecular weight:299.66BL-918
CAS:BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.Formula:C23H15F8N3OSPurity:99.4% - 99.89%Color and Shape:SolidMolecular weight:533.44Ref: TM-T8322
1mg50.00€2mg66.00€5mg99.00€10mg147.00€25mg269.00€50mg432.00€100mg708.00€500mg1,423.00€1mL*10mM (DMSO)120.00€TPEN
CAS:TPEN (TPEDA) is a specific cell-permeable heavy metal chelator.Formula:C26H28N6Purity:98% - 99.72%Color and Shape:White Crystalline PowderMolecular weight:424.54
