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Endothelin Receptor

Endothelin Receptor

Endothelin receptors are GPCRs that mediate the effects of endothelins, potent vasoconstrictor peptides that play a significant role in vascular tone regulation, blood pressure control, and cell proliferation. Endothelin receptor antagonists are used in the treatment of conditions such as pulmonary arterial hypertension and heart failure. These receptors are also important targets in research on cardiovascular diseases and cancer. At CymitQuimica, we offer a selection of high-quality endothelin receptor modulators to support your research in cardiovascular biology, oncology, and vascular physiology.

Found 76 products of "Endothelin Receptor"

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  • IRL-3630
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    IRL-3630

    CAS:
    <p>IRL 3460 is an enantiomer.</p>
    Formula:C31H40N4O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:596.74

    Ref: TM-T25541

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    Endothelin 1 (swine, human), Alexa Fluor 488-labeled

    <p>Synthetic human/swine Endothelin 1 peptide, tagged with Alexa Fluor 488, acts as a strong vasoconstrictor via ET A/B receptors.</p>
    Color and Shape:Solid
    Molecular weight:2848.4

    Ref: TM-T76081

  • Sarafotoxin S6a
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    Sarafotoxin S6a

    CAS:
    <p>Endothelin receptor agonist (EC50 values are 7.5 and &gt; 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.</p>
    Formula:C105H156N28O34S5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2514.85

    Ref: TM-TP2119

  • Sarafotoxin S6b
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    Sarafotoxin S6b

    CAS:
    <p>non-selective endothelin receptor agonist</p>
    Formula:C110H163N27O34S5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2567.96

    Ref: TM-TP2290

  • [Ala2] Endothelin-3, human
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    [Ala2] Endothelin-3, human

    CAS:
    <p>[Ala2] Endothelin-3, a linear ET-3 analog with Ala replacing Cys, stimulates endothelial cell migration.</p>
    Formula:C120H166N26O32S4
    Color and Shape:Solid
    Molecular weight:2613.02

    Ref: TM-T76305

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    BQ-123 TFA

    <p>BQ-123 TFA: Potent ETA antagonist, IC50 = 7.3 nM, Ki = 25 nM, inhibits ET-1 cell proliferation, lowers rat BP.</p>
    Formula:C33H43F3N6O9
    Color and Shape:Solid
    Molecular weight:724.72

    Ref: TM-T73877

  • Endothelin 1 (swine, human)
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    Endothelin 1 (swine, human)

    CAS:
    <p>Endothelin 1, a strong vasoconstrictor, targets ETA/ETB receptors, with a synthetic human/swine peptide sequence.</p>
    Formula:C109H159N25O32S5
    Color and Shape:White Powder
    Molecular weight:2491.9

    Ref: TM-T19309

  • CymitQuimica logo
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    Endothelin-3 (Rat,Human) (TFA)

    <p>Endothelin-3 (Rat, Human) (TFA) is a 21-amino acid vasoactive peptide of endothelial origi, an agonist for the endothelin receptor type B (EDNRB).</p>
    Formula:C123H169F3N26O35S4·xC2HF3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2757.07 (free base)

    Ref: TM-TP1173

  • Bosentan (hydrate)
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    Bosentan (hydrate)

    CAS:
    <p>Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.</p>
    Formula:C27H29N5O6S·H2O
    Purity:99.31% - 99.86%
    Color and Shape:White Powder
    Molecular weight:569.63

    Ref: TM-T6265

  • Macitentan
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    Macitentan

    CAS:
    <p>Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).</p>
    Formula:C19H20Br2N6O4S
    Purity:98% - >99.99%
    Color and Shape:Solid
    Molecular weight:588.27

    Ref: TM-T2561

  • Darusentan
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    Darusentan

    CAS:
    <p>Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries</p>
    Formula:C22H22N2O6
    Purity:98.72%
    Color and Shape:Solid
    Molecular weight:410.43

    Ref: TM-T5458

  • Ambrisentan sodium
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    Ambrisentan sodium

    CAS:
    <p>Ambrosentan (BSF 208075) sodium is a selective and oral effective antagonist of ET type A receptor ( ETAR ).</p>
    Formula:C22H21N2NaO4
    Color and Shape:Solid
    Molecular weight:400.41

    Ref: TM-T61921

  • BQ-788 sodium salt
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    BQ-788 sodium salt

    CAS:
    <p>BQ-788 sodium salt is a potent and selective antagonist of ETB receptor(ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells).</p>
    Formula:C34H51N5NaO7
    Color and Shape:Solid
    Molecular weight:664.8

    Ref: TM-T10595L

  • Atrasentan
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    Atrasentan

    CAS:
    <p>Atrasentan (ABT-627) is an endothelin receptor antagonist that can inhibit the activity of ETA.Cost-effective and quality-assured.</p>
    Formula:C29H38N2O6
    Purity:97.65% - 99.08%
    Color and Shape:Solid
    Molecular weight:510.62

    Ref: TM-TQ0259

  • Sparsentan
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    Sparsentan

    CAS:
    <p>Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM,</p>
    Formula:C32H40N4O5S
    Purity:97.94% - 98.69%
    Color and Shape:Solid
    Molecular weight:592.75

    Ref: TM-T5355

  • BMS 182874 hydrochloride
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    BMS 182874 hydrochloride

    CAS:
    <p>BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.</p>
    Formula:C17H20ClN3O3S
    Purity:97.01%
    Color and Shape:Solid
    Molecular weight:381.88

    Ref: TM-T21790

  • Endothelin-2 (49-69), human
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    Endothelin-2 (49-69), human

    CAS:
    <p>Endothelin-2 (49-69), human (Human endothelin-2) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.</p>
    Formula:C115H160N26O32S4
    Purity:98.26%
    Color and Shape:Solid
    Molecular weight:2546.92

    Ref: TM-TP1174

  • Sitaxsentan sodium
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    Sitaxsentan sodium

    CAS:
    <p>Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.</p>
    Formula:C18H14ClN2O6S2·Na
    Purity:98.39% - 99.01%
    Color and Shape:Solid
    Molecular weight:476.89

    Ref: TM-T6672

  • Aprocitentan
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    Aprocitentan

    CAS:
    <p>Aprocitentan (ACT-132577) is ETA and ETB antagonist .</p>
    Formula:C16H14Br2N6O4S
    Purity:99.17%
    Color and Shape:Solid
    Molecular weight:546.19

    Ref: TM-T7817

  • BQ-123
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    BQ-123

    CAS:
    <p>BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.</p>
    Formula:C31H42N6O7
    Purity:99.22% - ≥95%
    Color and Shape:Solid
    Molecular weight:610.7

    Ref: TM-T6792