GRK
G protein-coupled receptor kinases (GRKs) are a family of enzymes that phosphorylate activated GPCRs, leading to receptor desensitization and regulation of receptor signaling. GRKs play critical roles in controlling the intensity and duration of GPCR signaling, making them important in the regulation of various physiological processes, including cardiovascular function, immune response, and neurotransmission. GRK inhibitors and activators are studied for their potential therapeutic applications in heart failure, cancer, and neurological disorders. At CymitQuimica, we provide a range of high-quality GRK modulators to support your research in signal transduction, receptor regulation, and therapeutic development.
Found 43 products for "GRK".
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CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Formula:C24H21F3N6OPurity:99.01% - 99.52%Color and Shape:SolidMolecular weight:466.46Endothelin-3, human, mouse, rabbit, rat
CAS:Endothelin-3, human, mouse, rabbit, rat , is a cyclic 21 amino acid peptide. It is an endogenous neuropeptide and potent vasoconstrictor.Formula:C121H168N26O33S4Purity:98%Color and Shape:SolidMolecular weight:2643.04Crustacean Cardioactive Peptide (CCAP)
CAS:Crustacean Cardioactive Peptide (CCAP) is a conserved modified cyclic nonapeptide primary structure of PFCNAFTGC-NH2, a disulfide bridge between Cys3 and Cys9.Formula:C42H58N10O12S2Purity:95.40%Color and Shape:SolidMolecular weight:959.1Corazonin
CAS:Corazonin, a neuropeptide in insects, regulates caste identity and behavior, mainly in workers/foragers.Formula:C62H84N18O18Color and Shape:SolidMolecular weight:1369.4402GRK2i TFA
GRK2i TFA inhibits Gβγ-activated GRK2, mimicking its binding domain and acts as a Gβγ antagonist.Formula:C152H257F3N50O43SMolecular weight:3598.1GRL-03022
GRL-03022 is a potent and highly selective non-covalent inhibitor of G protein-coupled receptor kinase 5 (GRK5), with an IC50 of 60 nM. It demonstrates over 16,000-fold selectivity for GRK5 compared to GRK2 (IC50 > 1000 μM). GRL-03022 is applicable in research related to heart failure and cancer.GRK2 degrader-1
CAS:GRK2 degrader-1 (compound 1) is a potent and orally active GRK2 degrader. It facilitates the degradation of GRK2 via the ubiquitin-proteasome pathway. In a pulmonary arterial hypertension (PAH) mouse model, GRK2 degrader-1 inhibits right ventricular remodeling and the increase in pulmonary arterial pressure. This compound is suitable for research in pulmonary arterial hypertension (PAH).Formula:C25H22N4O4SMolecular weight:474.54GSK270822A
CAS:GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.Formula:C24H20N4O2Purity:98.64% - 99.78%Color and Shape:SolidMolecular weight:396.4412E3 Ligase Ligand-linker Conjugate 139
CAS:E3 Ligase Ligand-linker Conjugate 139 is an E3 ubiquitin ligase ligand and linker for PROTACKB03-SLF, used in cancer research.Formula:C20H25ClF3N3O7Molecular weight:511.88GRK2i
CAS:GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.Formula:C153H256N50O41SPurity:98%Color and Shape:SolidMolecular weight:3484.08GRL018-21
GRL018-21 is a potent, highly selective inhibitor of G protein-coupled receptor kinase 5 (GRK5), exhibiting an IC50 of 10 nM [1].Color and Shape:Odour SolidGRK2-IN-1 hydrochloride
GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Formula:C24H26ClFN4O4Purity:98%Color and Shape:SolidMolecular weight:488.94GRK-IN-1
CAS:4-Amino-5-(bromomethyl)-2-methylpyrimidine used in vitamin B1 analogs and esters synthesis.Formula:C6H10Br3N3Color and Shape:SolidMolecular weight:363.879GRL-098-22
GRL-098-22 (Compound 6t) is a potent inhibitor of G protein-coupled receptor kinase 5 (GRK5) and GRK6, with IC50 values of 0.6 μM and 0.19 μM, respectively. GRL-098-22 shows potential for research in diseases such as heart failure and multiple myeloma.CCG258208 hydrochloride
CCG258208 hydrochloride is a potent, selective GRK2 inhibitor that enhances cardiomyocyte contractility and shows excellent in vivo pharmacokinetic properties.Formula:C24H26ClFN4O4Color and Shape:Transparent LiquidMolecular weight:488.94GRL093-22
GRL093-22 is an effective and selective inhibitor of G protein-coupled receptor kinases (GRK), with IC50 values of 60 nM for GRK5 and 40 nM for GRK6. It shows potential for research in heart failure and multiple myeloma.Formula:C33H29FN6O3Color and Shape:SolidMolecular weight:576.62GRK2 Inhibitor
CAS:GRK2 Inhibitor; prevents receptor desensitization; enhances signaling; cardiovascular and inflammation research.Formula:C12H9NO6Purity:98.46%Color and Shape:SolidMolecular weight:263.2031-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-5-oxo-pyrrolidine-3-carboxylic acid
CAS:1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID targets GRK2.Formula:C13H13NO5Purity:99.55%Color and Shape:SolidMolecular weight:263.246GSK180736A
CAS:GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).Formula:C19H16FN5O2Purity:98.98% - 99.51%Color and Shape:SolidMolecular weight:365.361Takeda103A
CAS:Takeda103A (CMPD103A) is the GRK2-dependent bovine tubulin oxidation effective inhibitor.Formula:C24H23F2N7OPurity:97.17%Color and Shape:White SolidMolecular weight:463.4825
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