Antibacterial

<p>Gremubamab (MEDI3902) is a bivalent humanised monoclonal antibody, binds to PAPcrV protein and Psl extracellular polysaccharide, Pseudomonas aeruginosa.</p>

<p>Bezlotoxumab is a monoclonal antibody that binds Clostridium difficile toxin B, preventing epithelial damage, colitis, and infection recurrence.</p>

<p>Tosylchloramide sodium salt is a N-chlorinated and N-deprotonated sulfonamide used as a biocide and a mild disinfectant.</p>

<p>Dihydrostreptomycin is an antibiotic.</p>

<p>Proflavine dihydrochloride is a topical antiseptic.</p>

<p>Demecycline is an antibiotic.</p>

<p>Fibracillin is a penicillin antibiotic.</p>

<p>Panobacumab (KBPA101) is a human IgM/κ monoclonal antibody targeting P. aeruginosa serotype O11 LPS O polysaccharide.</p>

Azlocillin is a semisynthetic ampicillin-derived penicillin belonging to acylureido.

<p>Obiltoxaximab is a monoclonal antibody targeting the free protective antigen (PA) of Bacillus anthracis, inhalational anthrax</p>

<p>Tosatoxumab (AR-301; KBSA301) is a fully human immunoglobulin-class monoclonal antibody that targets and neutralises S. aureus α-toxin antibiotic-adjuvant</p>

<p>6-Quinoxalinecarboxylic acid, 2,3-bis(bromomethyl)-, derived from 2,3-Bis(bromomethyl)quinoxaline, displays antibacterial properties.</p>

<p>Edetate Sodium (Trilon B, Na₄EDTA) is a metal chelating agent that binds to divalent and trivalent metal cations, antibacterial and anticoagulant.</p>

<p>Pagibaximab, a chimeric IgG1, targets lipoteichoic acid to prevent staph sepsis from S. aureus/epidermidis.</p>

<p>Methicillin: Narrow-spectrum beta-lactam, penicillin-type antibiotic for certain gram-positive bacterial infections.</p>

<p>Omodenbamab (514-G3) is a humanised monoclonal antibody that neutralises SpA (Staphylococcus Protein A), on the cell wall of S. aureus.</p>

<p>NSC 31153 is a bioactive chemical.</p>

<p>Brobactam is a beta lactamase inhibitor with antibacterial activity.</p>

FOL7185 is an inhibitor of IspD and IspE enzymes isolated from bacteria.

<p>"Sulfacytine, an oral short-acting sulfonamide antibiotic, treats infections by blocking bacterial folic acid synthesis."</p>

<p>1-O-(4-Hydroxybenzoyl)-glycerol is an antibacterial agent that inhibits the growth of Staphylococcus aureus, Escherichia coli, Saccharomyces cerevisiae, and Fusarium culmorum, achieving a maximum inhibition rate of 70% at 20 mM. It exhibits mild skin irritancy.</p>

<p>Suvratoxumab (MEDI4893) is a long-lasting humanized IgG1κ monoclonal antibody targeting S. aureus α-toxin, enhancing survival in pneumonia.</p>

<p>the primary metabolite of ceftiofur</p>

<p>Propylparaben-d4 is a deuterated compound of Propylparaben. Propylparaben has a CAS number of 94-13-3. Propylparaben is an antimicrobial agent, preservative, flavouring agent</p>

<p>Clavulanate potassium,β-Lactamase inhibitor with antibiotic activity.</p>

<p>Benzoxiquine (NSC 3951) is a cosmetic biocide that inhibits oral microbial growth and in vitro plaque formation.</p>

<p>Cortisol-1,2-d2 is a deuterated compound of Cortisol. Cortisol has a CAS number of 50-23-7. Hydrocortisone, a glucocorticoid receptor agonist, promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. Therapeutic Hydrocortisone is a synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects.</p>

<p>Ethyl parahydroxybenzoate-d4 is a deuterated compound of Ethyl parahydroxybenzoate. Ethyl parahydroxybenzoate has a CAS number of 120-47-8. Ethylparaben is a Standardized Chemical Allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity.</p>

<p>Trimosulfa is a combination of trimethoprim and sulfamethoxazole, an antibiotic combination. Sulfamethoxazole inhibits dihydropteroate synthase, while trimethoprim inhibits dihydrofolate reductase (dihydrofolate reductase), making it effective for mild to moderate bacterial infections against many Gram-negative and Gram-positive bacteria.</p>

<p>Olanexidine gluconate is an antiseptic/disinfectant compound with potent bactericidal activity against Gram-negative and Gram-positive bacteria.</p>

<p>C18G, a synthetic α-helical peptide derived from human platelet factor IV, exhibits biological activity with pronounced antibacterial properties against</p>

<p>GWP-042 is an effective inhibitor of Mycobacterium alanine dehydrogenase (Ald) Rv2780, with an IC50 of 0.21 μM. It exhibits antibacterial activity against Mycobacterium tuberculosis (M. tuberculosis) infections in vivo.</p>

<p>DprE1-IN-10 (hit 2), an inhibitor of Decaprenylphosphoryl-β-D-ribose-2′-epimerase (DprE1), holds potential for the study of tuberculosis.</p>

<p>Stearyldiethanolamine (2,2'-(Octadecylazanediyl)diethanol) can be used in studies about antibacterial nonwoven fabric and antibacterial freshness-keeping film.</p>

<p>Acetylazide is a synthetic broad-spectrum bacteriostatic antibiotic.</p>

<p>N-(3-Hydroxytetradecanoyl)-DL-homoserine lactone has antibacterial activity.</p>

<p>Cephradine monohydrate is a β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens.</p>

<p>Ro 20-0657/000 is a metabolite of Trimethoprim, a dihydrofolate reductase inhibitor used as an antibacterial in medicine.</p>

<p>Sulfathiazole Sodium is an organosulfur compound. It also has been used as a short-acting sulfa drug.</p>

<p>Sulfiram is an ectoparasiticide and is a drug applied topically to treat scabies.</p>

<p>Golotimod TFA (SCV 07 TFA) is a dipeptide exhibiting immunomodulatory and antibacterial activity, alleviates radiation-induced oral mucositis.</p>

<p>BB2-50F is a potent, multi-targeting bioenergetic bactericidal inhibitor of M. tuberculosis that sterilizes both replicating and non-replicating M. tuberculosis. It inhibits succinate oxidation, decreases the activity of the tricarboxylic acid (TCA) cycle, and results in succinate secretion from M. tuberculosis. [1]</p>

<p>cis-Nerolidol, a sesquiterpene alcohol present in numerous plants, exhibits antioxidant and antibacterial properties.</p>

<p>Benzoylacetone (AI3 10572) exhibits antibacterial activity.</p>

<p>Tebipenem is an orally available carbapenem antibiotic. It displays broad-spectrum activity against Gram-positive and -negative bacteria.</p>

<p>Dodine: fungicide for scab in apples/pears/pecans, peach brown rot, foliar diseases in strawberries/cherries, and as biocide/preservative.</p>

<p>Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.</p>

<p>Bacampicillin is an improved oral bioavailability penicillin antibiotic which is a prodrug of ampicillin.</p>

<p>21272541 is a potent FabI protein inhibitor that significantly reduces infections caused by Gram-negative organisms [1].</p>

<p>Sulisatin, a laxative, becomes BHMI in the large intestine, causing its effect.</p>