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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1038 products of "PI3K/Akt/mTOR Signaling"

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  • AMG 511
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    AMG 511

    CAS:
    <p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>
    Formula:C22H28FN9O3S
    Purity:≥98%
    Color and Shape:Solid
    Molecular weight:517.58

    Ref: TM-T14214

  • TDZD-8
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    TDZD-8

    CAS:
    <p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>
    Formula:C10H10N2O2S
    Purity:97.13% - 99.61%
    Color and Shape:White Solid
    Molecular weight:222.26

    Ref: TM-T6187

  • HTH-01-015
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    HTH-01-015

    CAS:
    <p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>
    Formula:C26H28N8O
    Purity:98.38% - 99.70%
    Color and Shape:Solid
    Molecular weight:468.55

    Ref: TM-T2374

  • AG 1406
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    AG 1406

    CAS:
    <p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>
    Formula:C16H18N2O
    Purity:98.12%
    Color and Shape:Solid
    Molecular weight:254.33

    Ref: TM-T4554

  • Tyrphostin AG30
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    Tyrphostin AG30

    CAS:
    <p>Tyrphostin AG30 (AG30) (AG30) is a potent protein tyrosine kinases (PTK) inhibitor.</p>
    Formula:C10H7NO4
    Purity:99.02%
    Color and Shape:Solid
    Molecular weight:205.17

    Ref: TM-T7101

  • ZD-4190
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    ZD-4190

    CAS:
    <p>ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.</p>
    Formula:C19H16BrFN6O2
    Purity:99.12%
    Color and Shape:Solid
    Molecular weight:459.27

    Ref: TM-T5475

  • PP2
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    PP2

    CAS:
    <p>PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.</p>
    Formula:C15H16ClN5
    Purity:98% - 98.21%
    Color and Shape:White Solid
    Molecular weight:301.77

    Ref: TM-T6266

  • PP 3
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    PP 3

    CAS:
    <p>PP 3 is a Negative control for the Src kinase inhibitor PP 2</p>
    Formula:C11H9N5
    Purity:98.61%
    Color and Shape:Whit To Off-White Solid
    Molecular weight:211.22

    Ref: TM-T23176

  • PIK-108
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    PIK-108

    CAS:
    <p>PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).</p>
    Formula:C22H24N2O3
    Purity:98.92%
    Color and Shape:Solid
    Molecular weight:364.44

    Ref: TM-T28416

  • CC-115 hydrochloride
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    CC-115 hydrochloride

    CAS:
    <p>CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.</p>
    Formula:C16H17ClN8O
    Color and Shape:Solid
    Molecular weight:372.82

    Ref: TM-T61505

  • WYE-687 dihydrochloride
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    WYE-687 dihydrochloride

    CAS:
    <p>WYE-687 dihydrochloride is an mTOR inhibitor with IC50 of 7 nM, also targeting PI3Kα (81 nM) and PI3Kγ (3.11 μM).</p>
    Formula:C28H34Cl2N8O3
    Color and Shape:Solid
    Molecular weight:601.53

    Ref: TM-T72270

  • Derazantinib dihydrochloride
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    Derazantinib dihydrochloride

    CAS:
    <p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>
    Formula:C29H31Cl2FN4O
    Color and Shape:Solid
    Molecular weight:541.49

    Ref: TM-T70143

  • 4-Chloro-2'-bromoacetophenone
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    4-Chloro-2'-bromoacetophenone

    CAS:
    <p>4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).</p>
    Formula:C8H6BrClO
    Purity:98.34% - 99.41%
    Color and Shape:White To Beige Solid
    Molecular weight:233.49

    Ref: TM-T8908

  • WHI-P180
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    WHI-P180

    CAS:
    <p>WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.</p>
    Formula:C16H15N3O3
    Purity:99.21%
    Color and Shape:Solid
    Molecular weight:297.31

    Ref: TM-T2032

  • KU-57788
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    KU-57788

    CAS:
    <p>NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).</p>
    Formula:C25H19NO3S
    Purity:98% - >99.99%
    Color and Shape:Solid
    Molecular weight:413.49

    Ref: TM-T6276

  • AMG319
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    AMG319

    CAS:
    <p>AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, &gt;47-fold selectivity over other PI3Ks. Phase 2.</p>
    Formula:C21H16FN7
    Purity:98.9% - 99.24%
    Color and Shape:Crystalline Solid
    Molecular weight:385.4

    Ref: TM-T6757

  • SU5204
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    SU5204

    CAS:
    <p>SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and</p>
    Formula:C17H15NO2
    Purity:99.46%
    Color and Shape:Solid
    Molecular weight:265.31

    Ref: TM-T22431

  • PKD-IN-1 dihydrochloride (956121-30-5 free base)
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    PKD-IN-1 dihydrochloride (956121-30-5 free base)

    CAS:
    <p>CRT0066101 dihydrochloride is an inhibitor of PKD.</p>
    Formula:C18H21Cl3N4O
    Purity:99.5%
    Color and Shape:Solid
    Molecular weight:415.75

    Ref: TM-T8957L

  • WHI-P154
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    WHI-P154

    CAS:
    <p>WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.</p>
    Formula:C16H14BrN3O3
    Purity:98% - 99.67%
    Color and Shape:Solid
    Molecular weight:376.2

    Ref: TM-T1985

  • Olmutinib
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    Olmutinib

    CAS:
    <p>Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor</p>
    Formula:C26H26N6O2S
    Purity:99.14%
    Color and Shape:Solid
    Molecular weight:486.59

    Ref: TM-T8460