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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1038 products of "PI3K/Akt/mTOR Signaling"

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  • PD-161570
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    PD-161570

    CAS:
    <p>PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.</p>
    Formula:C26H35Cl2N7O
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:532.51

    Ref: TM-T23127

  • Indirubin-3′-oxime
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    Indirubin-3′-oxime

    CAS:
    <p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>
    Formula:C16H11N3O2
    Purity:98.34%
    Color and Shape:Solid
    Molecular weight:277.28

    Ref: TM-T9138

  • Endoxifen (Z-isomer)
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    Endoxifen (Z-isomer)

    CAS:
    <p>Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.</p>
    Formula:C25H27NO2
    Purity:99.19% - 99.81%
    Color and Shape:Solid
    Molecular weight:373.49

    Ref: TM-T2280

  • Avitinib
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    Avitinib

    CAS:
    <p>Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,</p>
    Formula:C26H26FN7O2
    Purity:99.81% - >99.99%
    Color and Shape:Solid
    Molecular weight:487.53

    Ref: TM-T3024

  • Tyrphostin A9
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    Tyrphostin A9

    CAS:
    <p>Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor</p>
    Formula:C18H22N2O
    Purity:98.21% - 99.87%
    Color and Shape:Yellow Solid
    Molecular weight:282.38

    Ref: TM-T2479

  • AZ-5104
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    AZ-5104

    CAS:
    <p>AZ5104 is a potent EGFR inhibitor.</p>
    Formula:C27H31N7O2
    Purity:98.40% - 99.59%
    Color and Shape:Solid Powder
    Molecular weight:485.58

    Ref: TM-T2491

  • AMG 511
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    AMG 511

    CAS:
    <p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>
    Formula:C22H28FN9O3S
    Purity:≥98%
    Color and Shape:Solid
    Molecular weight:517.58

    Ref: TM-T14214

  • iMDK
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    iMDK

    CAS:
    <p>iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.</p>
    Formula:C21H13FN2O2S
    Purity:99.99%
    Color and Shape:Solid
    Molecular weight:376.4

    Ref: TM-T9460

  • GDC0084
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    GDC0084

    CAS:
    <p>GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.</p>
    Formula:C18H22N8O2
    Purity:99.72% - 99.87%
    Color and Shape:Solid
    Molecular weight:382.42

    Ref: TM-T3705

  • AG490
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    AG490

    CAS:
    <p>AG490 inhibits EGFR (0.1 μM IC50), 135x &gt; selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.</p>
    Formula:C17H14N2O3
    Purity:98.6% - 99.39%
    Color and Shape:Yellow Solid
    Molecular weight:294.3

    Ref: TM-T2600

  • Sapanisertib
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    Sapanisertib

    CAS:
    <p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>
    Formula:C15H15N7O
    Purity:99.19% - >99.99%
    Color and Shape:Solid
    Molecular weight:309.33

    Ref: TM-T1838

  • AEE788
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    AEE788

    CAS:
    <p>AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.</p>
    Formula:C27H32N6
    Purity:98% - >99.99%
    Color and Shape:Solid
    Molecular weight:440.58

    Ref: TM-T2116

  • DMNB
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    DMNB

    CAS:
    <p>DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor, an enzyme involved in the NHEJ pathway of DSB repair in human cells.</p>
    Formula:C9H9NO5
    Purity:97.87%
    Color and Shape:Yellow Solid
    Molecular weight:211.17

    Ref: TM-T8637

  • Allitinib tosylate
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    Allitinib tosylate

    CAS:
    <p>Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.</p>
    Formula:C31H26ClFN4O5S
    Purity:98.46% - 98.68%
    Color and Shape:Solid
    Molecular weight:621.08

    Ref: TM-T6331

  • (E/Z)-GSK-3β inhibitor 1
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    (E/Z)-GSK-3β inhibitor 1

    CAS:
    <p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>
    Formula:C14H10N2O
    Purity:98.60%
    Color and Shape:Solid
    Molecular weight:222.24

    Ref: TM-T9178

  • PIK-294
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    PIK-294

    CAS:
    <p>PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).</p>
    Formula:C28H23N7O2
    Purity:97.22% - >99.99%
    Color and Shape:Solid
    Molecular weight:489.53

    Ref: TM-T2297

  • PI-3065
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    PI-3065

    CAS:
    <p>PI-3065 is a novel potent and selective PI3K p110δ inhibitor.</p>
    Formula:C27H31FN6OS
    Purity:99.84% - ≥95%
    Color and Shape:Solid
    Molecular weight:506.64

    Ref: TM-T2083

  • β-Hydroxyisovalerylshikonin
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    β-Hydroxyisovalerylshikonin

    CAS:
    <p>Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor</p>
    Formula:C21H24O7
    Purity:98.16%
    Color and Shape:Solid
    Molecular weight:388.41

    Ref: TM-TN1440

  • TBB
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    TBB

    CAS:
    <p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>
    Formula:C6HBr4N3
    Purity:98.51% - 99.45%
    Color and Shape:Off-White Solid
    Molecular weight:434.71

    Ref: TM-T2695

  • Linperlisib
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    Linperlisib

    CAS:
    <p>Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3Kδ</p>
    Formula:C28H37FN6O5S
    Purity:99.01%
    Color and Shape:Solid
    Molecular weight:588.69

    Ref: TM-T6330